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Article ; Online: To pay or not to pay for artificial intelligence applications in radiology

Franziska Lobig / Dhinagar Subramanian / Michael Blankenburg / Ankur Sharma / Archana Variyar / Oisin Butler

npj Digital Medicine, Vol 6, Iss 1, Pp 1-

2023 Volume 9

Abstract: Artificial Intelligence-supported digital applications (AI applications) are expected to transform radiology. However, providers need the motivation and incentives to adopt these technologies. For some radiology AI applications, the benefits of the ... ...

Abstract	Artificial Intelligence-supported digital applications (AI applications) are expected to transform radiology. However, providers need the motivation and incentives to adopt these technologies. For some radiology AI applications, the benefits of the application itself may sufficiently serve as the incentive. For others, payers may have to consider reimbursing the AI application separate from the cost of the underlying imaging studies. In such circumstances, it is important for payers to develop a clear set of criteria to decide which AI applications should be paid for separately. In this article, we propose a framework to help serve as a guide for payers aiming to establish such criteria and for technology vendors developing radiology AI applications. As a rule of thumb, we propose that radiology AI applications with a clinical utility must be reimbursed separately provided they have supporting evidence that the improved diagnostic performance leads to improved outcomes from a societal standpoint, or if such improved outcomes can reasonably be anticipated based on the clinical utility offered.
Keywords	Computer applications to medicine. Medical informatics ; R858-859.7
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: An unusual cause of ‘tree-in-bud’ appearance in CT-chest during COVID-19 pandemic

Ankur Sharma / Balakrishnan Narayanan / Nilay Pal / Sunny Taye

Monaldi Archives for Chest Disease, Vol 90, Iss

2020 Volume 3

Abstract: Tree-in-bud’ (TIB) appearance in computed tomography (CT) chest is most commonly a manifestation of infection. We here describe an unusual cause of TIB during the COVID-19 pandemic. A young male patient who had a history of fever, cough, and respiratory ...

Abstract	‘Tree-in-bud’ (TIB) appearance in computed tomography (CT) chest is most commonly a manifestation of infection. We here describe an unusual cause of TIB during the COVID-19 pandemic. A young male patient who had a history of fever, cough, and respiratory distress presented in the emergency department. As these symptoms matched with coronavirus infection, the COVID-19 test was done, which was found negative. He was then moved to the intensive care unit where he developed severe acute respiratory distress syndrome and was put on mechanical ventilation. Further workup did not reveal any source of infection, as all his cultures were negative, but his CT chest showed a tree-in-bud appearance. After obtaining a detailed history from his friends, the patient was found a chronic abuser of inhaled cocaine and treated with intravenous steroids. Subsequently, he was weaned from the ventilator and discharged from the intensive care unit after becoming asymptomatic.
Keywords	Computed tomography ; tree-in-bud ; cocaine ; unsual ; Medicine ; R ; covid19
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	PAGEPress Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Unusual cause of difficult mask ventilation in patients of mucormycosis – Another challenge in the Covid era

Himanshu Aneejwal / Tanvi M Meshram / Darshana Rathod / Kamlesh Kumari / Ankur Sharma

Journal of Family Medicine and Primary Care, Vol 11, Iss 10, Pp 6602-

2022 Volume 6603

Keywords	Medicine ; R
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Refractory Hypotension Despite High Dose Inotropic Support

Sunit Kumar Gupta / Mussavvir Agha / Ankur Sharma / Varuna Vyas

Türk Yoğun Bakım Dergisi, Vol 18, Iss 1, Pp 60-

An Unusual Cause

2020 Volume 62

Keywords	central venous catheter ; hypotension ; ultrasound ; Medicine ; R ; Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9
Language	Turkish
Publishing date	2020-03-01T00:00:00Z
Publisher	Galenos Yayinevi
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Vesical calculus on the end of forgotten DJ stent

Ankur Sharma / Darshanjit Singh Walia

International Journal of Research in Medical Sciences, Vol 4, Iss 6, Pp 2455-

a case report

2016 Volume 2457

Abstract: Double J stent provides a convenient way of draining upper urinary tract. However it is associated with many complications of which forgotten stent and associated comorbidity is an important factor. Careful monitoring of patients could exclude any ... ...

Abstract	Double J stent provides a convenient way of draining upper urinary tract. However it is associated with many complications of which forgotten stent and associated comorbidity is an important factor. Careful monitoring of patients could exclude any possibility of a stent being forgotten at all. We present a case report of such complication of forgotten stent with formation of stone at the vesical end of DJ stent. [Int J Res Med Sci 2016; 4(6.000): 2455-2457]
Keywords	Forgotten stent ; Vesical calculus ; Encrustrations ; Medicine (General) ; R5-920 ; Medicine ; R
Language	English
Publishing date	2016-06-01T00:00:00Z
Publisher	Medip Academy
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Role of Routine Subhepatic Abdominal Drain Placement following Uncomplicated Laparoscopic Cholecystectomy

ANKUR SHARMA / SUSHIL MITTAL

Journal of Clinical and Diagnostic Research, Vol 10, Iss 12, Pp PC03-PC

A Prospective Randomised Study

2016 Volume 05

Abstract: Introduction: Routine abdominal drainage after laparoscopy cholecystectomy is an issue of considerable debate. Reason for draining is to detect early bile/blood leak and allow CO2 insufflate during laparoscopy to escape via drain site thereby decreased ... ...

Abstract	Introduction: Routine abdominal drainage after laparoscopy cholecystectomy is an issue of considerable debate. Reason for draining is to detect early bile/blood leak and allow CO2 insufflate during laparoscopy to escape via drain site thereby decreased shoulder tip pain and post-operative nausea and vomiting. But some studies show no difference in post-operative nausea / vomiting/pain between drain and no drain group. Aim: To assess the role of drains following uncomplicated laparoscopic cholecystectomy. Materials and Methods: This prospective randomized study was conducted in the Department of General Surgery, Government Medical College and Rajindra Hospital, Patiala. Hundred patients of symptomatic gallstones satisfying the selection and exclusion criteria, undergoing uncomplicated laparoscopic cholecystectomy were included in this study, 50 cases with drains in right subhepatic space (Group I) and 50 cases without drains (Group II). Both groups were compared in terms of post-operative shoulder pain, analgesic requirement, nausea and vomiting, hospital stay and analgesic requirement in patient with drains and without drains. SPSS version 16.0 (Chi-Square Test and Fisher-Exact Test) were used for statistical analysis. Results: In this study, average operative time in both the groups was same (p-value 0.977). There was more incidence of nausea /vomiting in no drain group than in drain group. Shoulder tip pain was lower in drain group in first 12 hours post-operative. However, after 12 hours, drain group had higher shoulder tip pain than no drain group. Analgesic requirement was higher in no drain group upto 12 hours after which it was higher in drain group (statistically not significant). In terms of hospital stay patients in drain group had a longer stay in hospital as compared to no drain group (2.96 vs 2.26; p <0.001 statistically significant). Conclusion: Use of drains in uncomplicated laparoscopic cholecystectomy is not advantageous; its role in reducing postoperative nausea/vomiting is insignificant. It ...
Keywords	acidosis ; analgesia ; pneumoperitoneum ; shoulder tip ; Medicine ; R
Subject code	796
Language	English
Publishing date	2016-12-01T00:00:00Z
Publisher	JCDR Research and Publications Private Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Pharmacokinetics and interspecies scaling of a novel, orally-bioavailable anti-cancer drug, SHetA2.

Ankur Sharma / Doris Mangiaracina Benbrook / Sukyung Woo

PLoS ONE, Vol 13, Iss 4, p e

2018 Volume 0194046

Abstract: SHetA2 is a small molecule drug with promising cancer prevention and therapeutic activity and a high preclinical safety profile. The study objectives were to perform interspecies scaling and pharmacokinetic (PK) modeling of SHetA2 for human PK prediction. ...

Abstract	SHetA2 is a small molecule drug with promising cancer prevention and therapeutic activity and a high preclinical safety profile. The study objectives were to perform interspecies scaling and pharmacokinetic (PK) modeling of SHetA2 for human PK prediction. The PK data obtained from mice, rats, and dogs after intravenous and oral doses were used for simultaneous fitting to PK models. The disposition of SHetA2 was best described by a two-compartment model. The absorption kinetics was well characterized with a first-order absorption model for mice and rats, and a gastrointestinal transit model for dogs. Oral administration of SHetA2 showed a relatively fast absorption in mice, prolonged absorption (i.e., flip-flop kinetics) toward high doses in rats, and an early peak followed by a secondary peak at high doses in dogs. The oral bioavailability was 17.7-19.5% at 20-60 mg/kg doses in mice, <1.6% at 100-2000 mg/kg in rats, and 11.2% at 100 mg/kg decreasing to 3.45% at 400 mg/kg and 1.11% at 1500 mg/kg in dogs. The disposition parameters were well correlated with the body weight for all species using the allometric equation, which predicted values of CL (17.3 L/h), V1 (36.2 L), V2 (68.5 L) and CLD (15.2 L/h) for a 70-kg human. The oral absorption rate and bioavailability of SHetA2 was highly dependent on species, doses, formulations, and possibly other factors. The limited bioavailability at high doses was taken into consideration for the suggested first-in-human dose, which was much lower than the dose estimated based on toxicology studies. In summary, the present study provided the PK model for SHetA2 that depicted the disposition and absorption kinetics in preclinical species, and computational tools for human PK prediction.
Keywords	Medicine ; R ; Science ; Q
Subject code	500
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of 38% silver diamine fluoride on control of dental caries in primary dentition

Zohra Jabin / V Vishnupriya / Nidhi Agarwal / Iffat Nasim / Meena Jain / Ankur Sharma

Journal of Family Medicine and Primary Care, Vol 9, Iss 3, Pp 1302-

A Systematic review

2020 Volume 1307

Abstract: Silver diamine fluoride (SDF) has been extensively researched and proven effective for caries prevention and arrest in children. Limited studies support its effectiveness in primary dentition at 38%. This systematic review examines the effectiveness of ... ...

Abstract	Silver diamine fluoride (SDF) has been extensively researched and proven effective for caries prevention and arrest in children. Limited studies support its effectiveness in primary dentition at 38%. This systematic review examines the effectiveness of 38% silver diamine fluoride on control of dental caries in primary dentition. Multiple search engines and databases were searched in accordance with predefined inclusion-exclusion criteria. Quality assessment was done using Centre for Evidence-Based Medicine worksheets. Scientific works of literature were searched in October 2019 for articles. Four studies were identified that addressed the effectiveness of 38% SDF on deciduous dentition in children. All the four studies selected were controlled clinical trials. The cumulative results of the studies showed that 38% SDF application is efficacious and safe for the control of dental caries in primary teeth. Its advantages over different other techniques or placebo have been demonstrated. Based on this systematic review, 38% SDF is one of the best treatment approaches in control of dental caries in primary dentition.
Keywords	arrest ; caries ; children ; primary dentition ; safety ; silver diamine fluoride ; systematic review ; Medicine ; R
Subject code	610
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Chronic Inflammation’s Transformation to Cancer

Sayed Sartaj Sohrab / Riya Raj / Amka Nagar / Susan Hawthorne / Ana Cláudia Paiva-Santos / Mohammad Amjad Kamal / Mai M. El-Daly / Esam I. Azhar / Ankur Sharma

Molecules, Vol 28, Iss 4413, p

A Nanotherapeutic Paradigm

2023 Volume 4413

Abstract: The body’s normal immune response against any invading pathogen that causes infection in the body results in inflammation. The sudden transformation in inflammation leads to the rise of inflammatory diseases such as chronic inflammatory bowel disease, ... ...

Abstract	The body’s normal immune response against any invading pathogen that causes infection in the body results in inflammation. The sudden transformation in inflammation leads to the rise of inflammatory diseases such as chronic inflammatory bowel disease, autoimmune disorders, and colorectal cancer (different types of cancer develop at the site of chronic infection and inflammation). Inflammation results in two ways: short-term inflammation i.e., non-specific, involves the action of various immune cells; the other results in long-term reactions lasting for months or years. It is specific and causes angiogenesis, fibrosis, tissue destruction, and cancer progression at the site of inflammation. Cancer progression relies on the interaction between the host microenvironment and tumor cells along with the inflammatory responses, fibroblast, and vascular cells. The two pathways that have been identified connecting inflammation and cancer are the extrinsic and intrinsic pathways. Both have their own specific role in linking inflammation to cancer, involving various transcription factors such as Nuclear factor kappa B, Activator of transcription, Single transducer, and Hypoxia-inducible factor, which in turn regulates the inflammatory responses via Soluble mediators cytokines (such as Interleukin-6, Hematopoietin-1/Erythropoietin, and tumor necrosis factor), chemokines (such as Cyclooxygenase-2, C-X-C Motif chemokines ligand-8, and IL-8), inflammatory cells, cellular components (such as suppressor cells derived from myeloid, tumor-associated macrophage, and acidophils), and promotes tumorigenesis. The treatment of these chronic inflammatory diseases is challenging and needs early detection and diagnosis. Nanotechnology is a booming field nowadays for its rapid action and easy penetration inside the infected destined cells. Nanoparticles are widely classified into different categories based on their different factors and properties such as size, shape, cytotoxicity, and others. Nanoparticles emerged as excellent with highly ...
Keywords	cancer ; inflammation ; nanoparticles ; drug delivery ; inflammatory pathways ; Organic chemistry ; QD241-441
Subject code	610
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Plasma neutrophil gelatinase-associated lipocalin and Interleukin-18 as predictors of acute kidney injury in renal transplant recipients

Karthik T Ponnappan / Mohd Qurram Parveez / Chandra Kant Pandey / Ankur Sharma / Manish Tandon / Vikas Jain / Vijay Kant Pandey / Sherin Thomas

Saudi Journal of Kidney Diseases and Transplantation, Vol 32, Iss 2, Pp 355-

A pilot study

2021 Volume 363

Abstract: Urine neutrophil gelatinase-associated lipocalin (NGAL) and interleukin-18 (IL- 18) have shown promise for predicting renal graft recovery. However, urinary flow rate variations may cause variable biomarker dilution. Plasma NGAL and IL-18 may form a ... ...

Abstract	Urine neutrophil gelatinase-associated lipocalin (NGAL) and interleukin-18 (IL- 18) have shown promise for predicting renal graft recovery. However, urinary flow rate variations may cause variable biomarker dilution. Plasma NGAL and IL-18 may form a biomarker panel that may help predict delayed graft function and slow graft function (SGF) in renal transplant recipients within the first two postoperative days earlier than serum creatinine. There are only a few studies in the literature using plasma NGAL for predicting renal graft recovery. Hence, we planned this study. This observational single-center, prospective cohort study was conducted in renal transplant recipients above 18 years of age. In 22 consecutive renal transplant recipients, we collected ethylenediaminetetraacetic acid-plasma samples 1 h before surgery and subsequently at 6 h, 24 h, and 48 h after surgery for NGAL and IL-18 by sandwich enzyme-linked immuno-sorbent assay technique. Serum creatinine was measured as a part of routine transplant protocol. In renal transplant recipients, neither serum levels of NGAL and IL-18 nor their trends could reliably predict SGF. The only significant correlation existed between serum creatinine at day 2 and IL-18 at day 2 with P = 0.023. Serum NGAL did not correlate with serum creatinine in this setting of renal transplantation. Patients with immediate graft function had a greater percentage decrease of creatinine at day 1 and day 2 (P = 0.002 and 0.001) The percentage change in IL-18 at 24 h and 48 h after transplant from baseline could predict the occurrence of early graft loss (EGL) (P = 0.05, 0.04). The cutoffs were -4.12% at day 1 and +3.39% at day 2 with area under receiver operator characteristics of 0.82 and 0.83, respectively. The percentage change in IL-18 may be a useful marker of EGL in renal transplant recipients. Serum NGAL and creatinine were not able to predict EGL.
Keywords	Medicine ; R
Subject code	630
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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