Article: Minisci-Photoredox-Mediated α-Heteroarylation of N-Protected Secondary Amines: Remarkable Selectivity of Azetidines
Organic letters. 2018 Sept. 25, v. 20, no. 19
2018
Abstract: The development of a general, mild, and functional-group-tolerant direct functionalization of N-heteroarenes by C–H functionalization with N-protected amines, including azetidines under Minisci-mediated photoredox conditions, is reported. A broad scope ... ...
| Abstract | The development of a general, mild, and functional-group-tolerant direct functionalization of N-heteroarenes by C–H functionalization with N-protected amines, including azetidines under Minisci-mediated photoredox conditions, is reported. A broad scope of substituted azetidines, including spirocyclic derivatives, and heterocycles were explored. This reaction enables the production of sp3-rich complex druglike structures in one step from unactivated feedstock amines and heterocycles. |
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| Keywords | carbon-hydrogen bond activation ; chemical structure ; feedstocks ; redox reactions ; secondary amines |
| Language | English |
| Dates of publication | 2018-0925 |
| Size | p. 6003-6006. |
| Publishing place | American Chemical Society |
| Document type | Article |
| ISSN | 1523-7052 |
| DOI | 10.1021/acs.orglett.8b00991 |
| Database | NAL-Catalogue (AGRICOLA) |
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