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  1. Article ; Online: Interconnected PolymerS TeChnology (IPSTiC)

    Ortensia Ilaria Parisi / Luca Scrivano / Fabio Amone / Rocco Malivindi / Mariarosa Ruffo / Anna Francesca Vattimo / Vincenzo Pezzi / Francesco Puoci

    Journal of Functional Biomaterials, Vol 9, Iss 3, p

    An Effective Approach for the Modulation of 5α-Reductase Activity in Hair Loss Conditions

    2018  Volume 44

    Abstract: Hair loss represents a condition that adversely affects the social life of patients. The most common cause is androgenetic alopecia (AGA), which is a genetically determined progressive hair-loss condition involving 5α-reductase. In this study, a novel ... ...

    Abstract Hair loss represents a condition that adversely affects the social life of patients. The most common cause is androgenetic alopecia (AGA), which is a genetically determined progressive hair-loss condition involving 5α-reductase. In this study, a novel anti-baldness agent based on Interconnected PolymerS TeChnology (IPSTiC), which is an effective strategy for the delivery of bioactive molecules, was developed. This product (IPSTiC patch hair) is based on a polymeric blend consisting of high molecular weight hyaluronic acid and soybean proteins and is able to improve efficacy and stability of bioactive ingredients such as Origanum vulgare leaf extract, Camellia Sinensis leaf extract, and Capsicum Annuum fruit extract. The efficacy of the developed anti-baldness agent was investigated by performing several tests including NO radical and 5α-reductase inhibition assays, stability studies under different conditions, and in vitro diffusion studies using Franz cells. The biocompatibility of IPSTiC patch hair was also evaluated by in vitro analysis of the pro-sensitising potential and EPISKIN model. The obtained results confirmed both the efficacy and safety of IPSTiC patch hair supporting the potential use of this product in the topical treatment of AGA.
    Keywords hair loss ; androgenetic alopecia (AGA) ; 5α-reductase ; polymeric blend ; hyaluronic acid ; soybean proteins ; Origanum vulgare leaf extract ; Camellia Sinensis leaf extract ; Capsicum Annuum fruit extract ; EPISKIN model ; Biotechnology ; TP248.13-248.65 ; Medicine (General) ; R5-920
    Subject code 660
    Language English
    Publishing date 2018-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Molecularly Imprinted Microrods via Mesophase Polymerization

    Ortensia Ilaria Parisi / Luca Scrivano / Sebastiano Candamano / Mariarosa Ruffo / Anna Francesca Vattimo / Maria Vittoria Spanedda / Francesco Puoci

    Molecules, Vol 23, Iss 1, p

    2017  Volume 63

    Abstract: The aim of the present research work was the synthesis of molecularly imprinted polymers (MIPs) with a rod-like geometry via “mesophase polymerization”. The ternary lyotropic system consisting of sodium dodecyl sulfate (SDS), water, and decanol was ... ...

    Abstract The aim of the present research work was the synthesis of molecularly imprinted polymers (MIPs) with a rod-like geometry via “mesophase polymerization”. The ternary lyotropic system consisting of sodium dodecyl sulfate (SDS), water, and decanol was chosen to prepare a hexagonal mesophase to direct the morphology of the synthesized imprinted polymers using theophylline, methacrylic acid, and ethylene glycol dimethacrylate as a drug model template, a functional monomer, and a crosslinker, respectively. The obtained molecularly imprinted microrods (MIMs) were assessed by performing binding experiments and in vitro release studies, and the obtained results highlighted good selective recognition abilities and sustained release properties. In conclusion, the adopted synthetic strategy involving a lyotropic mesophase system allows for the preparation of effective MIPs characterized by a rod-like morphology.
    Keywords molecularly imprinted polymers ; polymeric microrods ; mesophase polymerization ; theophylline ; Organic chemistry ; QD241-441
    Subject code 540
    Language English
    Publishing date 2017-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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