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  1. Article ; Online: Preventing Sudden Cardiac Death in Mitral Valve Prolapse

    Anna Giulia Pavon / Luca Bergamaschi / Marco Guglielmo

    Journal of Clinical Medicine, Vol 11, Iss 5112, p

    When Multimodality Imaging Is the Key to Success

    2022  Volume 5112

    Abstract: Mitral valve prolapse (MVP) is a common cardiac anomaly that is estimated to affect 1–3% of the general population [.] ...

    Abstract Mitral valve prolapse (MVP) is a common cardiac anomaly that is estimated to affect 1–3% of the general population [.]
    Keywords n/a ; Medicine ; R
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Mitral Valve Prolapse, Arrhythmias, and Sudden Cardiac Death

    Anna Giulia Pavon / Pierre Monney / Juerg Schwitter

    Diagnostics, Vol 11, Iss 683, p

    The Role of Multimodality Imaging to Detect High-Risk Features

    2021  Volume 683

    Abstract: Mitral valve prolapse (MVP) was first described in the 1960s, and it is usually a benign condition. However, a subtype of patients are known to have a higher incidence of ventricular arrhythmias and sudden cardiac death, the so called “arrhythmic MVP.” ... ...

    Abstract Mitral valve prolapse (MVP) was first described in the 1960s, and it is usually a benign condition. However, a subtype of patients are known to have a higher incidence of ventricular arrhythmias and sudden cardiac death, the so called “arrhythmic MVP.” In recent years, several studies have been published to identify the most important clinical features to distinguish the benign form from the potentially lethal one in order to personalize patient’s treatment and follow-up. In this review, we specifically focused on red flags for increased arrhythmic risk to whom the cardiologist must be aware of while performing a cardiovascular imaging evaluation in patients with MVP.
    Keywords mitral valve prolapse ; arrhythmias ; cardiovascular magnetic resonance ; Medicine (General) ; R5-920
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Cardiac MR fingerprinting with a short acquisition window in consecutive patients referred for clinical CMR and healthy volunteers

    Simone Rumac / Anna Giulia Pavon / Jesse I. Hamilton / David Rodrigues / Nicole Seiberlich / Juerg Schwitter / Ruud B. van Heeswijk

    Scientific Reports, Vol 12, Iss 1, Pp 1-

    2022  Volume 13

    Abstract: Abstract Cardiac Magnetic Resonance Fingerprinting (cMRF) has been demonstrated to enable robust and accurate T1 and T2 mapping for the detection of myocardial fibrosis and edema. However, the relatively long acquisition window (250 ms) used in previous ... ...

    Abstract Abstract Cardiac Magnetic Resonance Fingerprinting (cMRF) has been demonstrated to enable robust and accurate T1 and T2 mapping for the detection of myocardial fibrosis and edema. However, the relatively long acquisition window (250 ms) used in previous cMRF studies might leave it vulnerable to motion artifacts in patients with high heart rates. The goal of this study was therefore to compare cMRF with a short acquisition window (154 ms) and low-rank reconstruction to routine cardiac T1 and T2 mapping at 1.5 T. Phantom studies showed that the proposed cMRF had a high T1 and T2 accuracy over a wider range than routine mapping techniques. In 9 healthy volunteers, the proposed cMRF showed small but significant myocardial T1 and T2 differences compared to routine mapping (ΔT1 = 1.5%, P = 0.031 and ΔT2 = − 7.1%, P < 0.001). In 61 consecutive patients referred for CMR, the native T1 values were slightly lower (ΔT1 = 1.6%; P = 0.02), while T2 values did not show statistical difference (ΔT2 = 4.3%; P = 0.11). However, the difference was higher in post-contrast myocardial T1 values (ΔT1 = 12.3%; P < 0.001), which was reflected in the extracellular volume (ΔECV = 2.4%; P < 0.001). Across all subjects, the proposed cMRF had a lower precision when compared to routine techniques, although its higher spatial resolution enabled the visualization of smaller details.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: The Non-Invasive Diagnosis of Chronic Coronary Syndrome

    Léon Groenhoff / Giulia De Zan / Pietro Costantini / Agnese Siani / Eleonora Ostillio / Serena Carriero / Giuseppe Muscogiuri / Luca Bergamaschi / Giuseppe Patti / Carmine Pizzi / Sandro Sironi / Anna Giulia Pavon / Alessandro Carriero / Marco Guglielmo

    Journal of Clinical Medicine, Vol 12, Iss 3793, p

    A Focus on Stress Computed Tomography Perfusion and Stress Cardiac Magnetic Resonance

    2023  Volume 3793

    Abstract: Coronary artery disease is still a major cause of death and morbidity worldwide. In the setting of chronic coronary disease, demonstration of inducible ischemia is mandatory to address treatment. Consequently, scientific and technological efforts were ... ...

    Abstract Coronary artery disease is still a major cause of death and morbidity worldwide. In the setting of chronic coronary disease, demonstration of inducible ischemia is mandatory to address treatment. Consequently, scientific and technological efforts were made in response to the request for non-invasive diagnostic tools with better sensitivity and specificity. To date, clinicians have at their disposal a wide range of stress-imaging techniques. Among others, stress cardiac magnetic resonance (S-CMR) and computed tomography perfusion (CTP) techniques both demonstrated their diagnostic efficacy and prognostic value in clinical trials when compared to other non-invasive ischemia-assessing techniques and invasive fractional flow reserve measurement techniques. Standardized protocols for both S-CMR and CTP usually imply the administration of vasodilator agents to induce hyperemia and contrast agents to depict perfusion defects. However, both methods have their own limitations, meaning that optimizing their performance still requires a patient-tailored approach. This review focuses on the characteristics, drawbacks, and future perspectives of these two techniques.
    Keywords coronary artery disease ; cardiac coronary syndrome ; stress imaging ; cardiac computed tomography perfusion ; stress magnetic cardiac resonance ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Multimodality Imaging Evaluation to Detect Subtle Right Ventricular Involvement in Patients with Acute Myocarditis and Preserved Left Ventricular Ejection Fraction

    Michela Bonanni / Gianmarco Angelini / Laura Anna Leo / Susanne Anna Schlossbauer / Luca Bergamaschi / Antonio Landi / Giuseppe Massimo Sangiorgi / Cinzia Forleo / Elena Pasotti / Giovanni Pedrazzini / Marco Valgimigli / Francesco F. Faletra / Marco Guglielmo / Anna Giulia Pavon

    Journal of Clinical Medicine, Vol 12, Iss 4308, p

    2023  Volume 4308

    Abstract: Background: Evaluation of the right ventricle (RV) in patients with acute myocarditis (MY) remains challenging with both 2D transthoracic echocardiography (TTE) and cardiovascular magnetic resonance (CMR). We examined the incremental diagnostic value of ... ...

    Abstract Background: Evaluation of the right ventricle (RV) in patients with acute myocarditis (MY) remains challenging with both 2D transthoracic echocardiography (TTE) and cardiovascular magnetic resonance (CMR). We examined the incremental diagnostic value of CMR feature tracking (FT) to evaluate RV involvement in patients with myocarditis. Methods: We enrolled 54 patients with myocarditis and preserved left ventricle (LV) ejection fraction (EF). The CMR protocol included T2-weighted images for edema detection and late gadolinium enhancement (LGE) images. Global longitudinal strain (GLS) of the left ventricle (LV) and RV free wall strain (CMR-FWS) were obtained with CMR-FT. We identified 34 patients (62%) with inferior and lateral segment (IL-MY) involvement and 20 (38%) noIL-MY in case of any other myocardial segment involved. Here, 20 individuals who underwent CMR for suspected cardiac disease, which was not confirmed thereafter, were considered as the control population. Results: TTE and CMR showed normal RV function in all patients without visible RV involvement at the LGE or T2-weighted sequences. At CMR, LV-GLS values were significantly lower in patients with MY compared to the control group (median −19.0% vs. −21.0%, p = 0.029). Overall, CMR RV-FWS was no different between MY patients and controls (median −21.2% vs. −23.2 %, p = 0.201) while a significant difference was found between RV FWS in IL-MY and noIL-MY (median −18.17% vs. −24.2%, p = 0.004). Conclusions: CMR-FT has the potential to unravel subclinical RV involvement in patients with acute myocarditis, specifically in those with inferior and lateral injuries that exhibit lower RV-FWS values. In this setting, RV deformation analysis at CMR may be effectively implemented for a comprehensive functional assessment.
    Keywords cardiovascular magnetic resonance ; right ventricle ; acute myocarditis feature tracking CMR ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: The Role of Non-Invasive Multimodality Imaging in Chronic Coronary Syndrome

    Luca Bergamaschi / Anna Giulia Pavon / Francesco Angeli / Domenico Tuttolomondo / Marta Belmonte / Matteo Armillotta / Angelo Sansonetti / Alberto Foà / Pasquale Paolisso / Andrea Baggiano / Saima Mushtaq / Giulia De Zan / Serena Carriero / Maarten-Jan Cramer / Arco J. Teske / Lysette Broekhuizen / Ivo van der Bilt / Giuseppe Muscogiuri / Sandro Sironi /
    Laura Anna Leo / Nicola Gaibazzi / Luigi Lovato / Gianluca Pontone / Carmine Pizzi / Marco Guglielmo

    Diagnostics, Vol 13, Iss 2083, p

    Anatomical and Functional Pathways

    2023  Volume 2083

    Abstract: Coronary artery disease (CAD) is one of the major causes of mortality and morbidity worldwide, with a high socioeconomic impact. Currently, various guidelines and recommendations have been published about chronic coronary syndromes (CCS). According to ... ...

    Abstract Coronary artery disease (CAD) is one of the major causes of mortality and morbidity worldwide, with a high socioeconomic impact. Currently, various guidelines and recommendations have been published about chronic coronary syndromes (CCS). According to the recent European Society of Cardiology guidelines on chronic coronary syndrome, a multimodal imaging approach is strongly recommended in the evaluation of patients with suspected CAD. Today, in the current practice, non-invasive imaging methods can assess coronary anatomy through coronary computed tomography angiography (CCTA) and/or inducible myocardial ischemia through functional stress testing (stress echocardiography, cardiac magnetic resonance imaging, single photon emission computed tomography—SPECT, or positron emission tomography—PET). However, recent trials (ISCHEMIA and REVIVED) have cast doubt on the previous conception of the management of patients with CCS, and nowadays it is essential to understand the limitations and strengths of each imaging method and, specifically, when to choose a functional approach focused on the ischemia versus a coronary anatomy-based one. Finally, the concept of a pathophysiology-driven treatment of these patients emerged as an important goal of multimodal imaging, integrating ‘anatomical’ and ‘functional’ information. The present review aims to provide an overview of non-invasive imaging modalities for the comprehensive management of CCS patients.
    Keywords chronic coronary syndrome ; echocardiography ; cardiac magnetic resonance ; coronary computed tomography angiography ; nuclear medicine ; ischemia ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Aortic Valvuloplasty as Bridging for TAVI in High-Risk Patients with Heyde’s Syndrome

    Cosmo Godino / Anna Giulia Pavon / Antonio Mangieri / Alberto Margonato

    Case Reports in Medicine, Vol

    A Case Report

    2012  Volume 2012

    Abstract: There is a frequent association between aortic valve stenosis and gastrointestinal bleeding, also known as Heyde’s syndrome. In these patients, the aortic valve replacement should be recommended as “gold standard.” In high-surgical-risk patients, the ... ...

    Abstract There is a frequent association between aortic valve stenosis and gastrointestinal bleeding, also known as Heyde’s syndrome. In these patients, the aortic valve replacement should be recommended as “gold standard.” In high-surgical-risk patients, the Transcatheter Aortic Valve Implantation (TAVI) is an alternative option. However, the risk of bleeding recurrence, related to double antiplatelet therapy started after TAVI, cannot be excluded especially in the first months. We present a case of a patient with a severe aortic valve stenosis and a history of previously documented angiodysplasia and recurrence of gastrointestinal bleeding initially treated only with balloon aortic valvuloplasty that excluded recurrence of bleeding during the subsequent six months of followup. Therefore, a definite transfemoral Edwards XT valve implantation was planned to be performed in case of recurrence of aortic stenosis.
    Keywords Medicine ; R
    Subject code 610
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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