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  1. Article ; Online: China's evolving fracture burden

    Anna J Dare / Guoqing Hu

    The Lancet Global Health, Vol 5, Iss 8, Pp e736-e

    2017  Volume 737

    Keywords Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2017-08-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: External injuries, trauma and avoidable deaths in Agincourt, South Africa

    Justine Davies / Idara J Edem / Anna J Dare / Andy J M Leather

    BMJ Open, Vol 9, Iss

    a retrospective observational and qualitative study

    2019  Volume 6

    Abstract: ObjectiveInjury burden is highest in low-income and middle-income countries. To reduce avoidable deaths, it is necessary to identify health system deficiencies preventing timely, quality care. We developed criteria to use verbal autopsy (VA) data to ... ...

    Abstract ObjectiveInjury burden is highest in low-income and middle-income countries. To reduce avoidable deaths, it is necessary to identify health system deficiencies preventing timely, quality care. We developed criteria to use verbal autopsy (VA) data to identify avoidable deaths and associated health system deficiencies.SettingAgincourt, a rural Bushbuckridge municipality, Mpumalanga Province, South Africa.ParticipantsAgincourt Health and Socio-Demographic Surveillance System and healthcare providers (HCPs) from local hospitals.MethodsA literature review to explore definitions of avoidable deaths after trauma and barriers to access to care using the ‘three delays framework’ (seeking, reaching and receiving care) was performed. Based on these definitions, this study developed criteria, applicable for use with VA data, for identifying avoidable death and which of the three delays contributed to avoidable deaths. These criteria were then applied retrospectively to the VA-defined category external injury deaths (EIDs—a subset of which are trauma deaths) from 2012 to 2015. The findings were validated by external expert review. Key informant interviews (KIIs) with HCPs were performed to further explore delays to care.ResultsUsing VA data, avoidable death was defined with a focus on survivability, using level of consciousness at the scene and ability to seek care as indicators. Of 260 EIDs (189 trauma deaths), there were 104 (40%) avoidable EIDs and 78 (30%) avoidable trauma deaths (41% of trauma deaths). Delay in receiving care was the largest contributor to avoidable EIDs (61%) and trauma deaths (59%), followed by delay in seeking care (24% and 23%) and in reaching care (15% and 18%). KIIs revealed context-specific factors contributing to the third delay, including difficult referral systems.ConclusionsA substantial proportion of EIDs and trauma deaths were avoidable, mainly occurring due to facility-based delays in care. Interventions, including strengthening referral networks, may substantially reduce trauma deaths.
    Keywords Medicine ; R
    Subject code 360
    Language English
    Publishing date 2019-06-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Renal failure deaths and their risk factors in India 2001–13 – Authors' reply

    Anna J Dare / Calvin Ke / Wilson Suraweera / Peter Rodriguez / Prabhat Jha

    The Lancet Global Health, Vol 5, Iss 5, Pp e483-e

    2017  Volume 484

    Keywords Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2017-05-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Protection against renal ischemia–reperfusion injury in vivo by the mitochondria targeted antioxidant MitoQ

    Anna J. Dare / Eleanor A. Bolton / Gavin J. Pettigrew / J. Andrew Bradley / Kourosh Saeb-Parsy / Michael P. Murphy

    Redox Biology, Vol 5, Iss , Pp 163-

    2015  Volume 168

    Abstract: Ischemia–reperfusion (IR) injury to the kidney occurs in a range of clinically important scenarios including hypotension, sepsis and in surgical procedures such as cardiac bypass surgery and kidney transplantation, leading to acute kidney injury (AKI). ... ...

    Abstract Ischemia–reperfusion (IR) injury to the kidney occurs in a range of clinically important scenarios including hypotension, sepsis and in surgical procedures such as cardiac bypass surgery and kidney transplantation, leading to acute kidney injury (AKI). Mitochondrial oxidative damage is a significant contributor to the early phases of IR injury and may initiate a damaging inflammatory response. Here we assessed whether the mitochondria targeted antioxidant MitoQ could decrease oxidative damage during IR injury and thereby protect kidney function. To do this we exposed kidneys in mice to in vivo ischemia by bilaterally occluding the renal vessels followed by reperfusion for up to 24 h. This caused renal dysfunction, measured by decreased creatinine clearance, and increased markers of oxidative damage. Administering MitoQ to the mice intravenously 15 min prior to ischemia protected the kidney from damage and dysfunction. These data indicate that mitochondrial oxidative damage contributes to kidney IR injury and that mitochondria targeted antioxidants such as MitoQ are potential therapies for renal dysfunction due to IR injury. Keywords: Kidney, Ischemia–reperfusion injury, Mitochondria, Oxidative damage, Mitochondria targeted antioxidants, MitoQ
    Keywords Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2015-08-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Colorectal cancer screening with fecal immunochemical testing

    Olusegun I Alatise, ProfMD / Anna J Dare, PhD / Patrick A Akinyemi, PhD / Fatimah B Abdulkareem, ProfMD / Samuel A Olatoke, MD / Gregory C Knapp, MD / T Peter Kingham, MD / Olusegun I. Alatise, MD / T. Peter Kingham, MD / Fatimah B Abdulkareem, MD / Samuel A. Olatoke, MD / Anna J. Dare, PhD / Patrick A. Akinyemi, PhD / Gregory C. Knapp, MD / Oluwabusayomi R. Ademakinwa, PhD / Ademola A. Adeyeye, MD / Olayide S. Agodirin, MD / Kabir B. Badmus, MD / Mathew O. Bojuwoye, MD /
    Matteo Di Bernardo, BA / Rivka Kahn, CCRP / Abdulrazzaq O. Lawal, MD / Emuobor A. Odeghe, MD / Samson G. Ogunleye, MSc / Olalekan O. Olasehinde, MD / Olajide T Olagboyega, MD / Christina Olcese, BS / Abdulfatai B. Olokoba, MD / Tosin Omoyiola, MD / Nnamdi O. Orah, MD / Adedapo O. Osinowo, MD / Ganiyat K. Oyeleke, MD / Israel A. Owoade, MD / Katherine Randolph, BA / Ranelle Tulloch, MPH

    The Lancet Global Health, Vol 10, Iss 7, Pp e1012-e

    a community-based, cross-sectional study in average-risk individuals in Nigeria

    2022  Volume 1022

    Abstract: Summary: Background: The estimated incidence of colorectal cancer is rising in Nigeria, where most patients present with advanced disease. Earlier detection of colorectal cancer is a goal of the Nigerian National Cancer Control Plan, but the utility of ... ...

    Abstract Summary: Background: The estimated incidence of colorectal cancer is rising in Nigeria, where most patients present with advanced disease. Earlier detection of colorectal cancer is a goal of the Nigerian National Cancer Control Plan, but the utility of fecal-based screening is unclear. This study aimed to assess the fecal immunochemical test as a colorectal cancer screening modality in average-risk individualS in Nigeria. Methods: A population-based, cross-sectional study of qualitative fecal immunochemical test-based colorectal cancer screening was done in asymptomatic, average-risk participants aged 45–75 years in three states in Nigeria (Osun, Kwara, and Lagos). Participants were invited to enrol using age-stratified and sex-stratified convenience sampling following community outreach. Exclusion criteria included a personal history of colorectal cancer or rectal bleeding in the previous 6 months, a first-degree relative with a known diagnosis of colorectal cancer, or a comorbidity that would preclude conscious sedation or general anesthesia. Participants with positive fecal immunochemical test results underwent colonoscopy, and the positive predictive value of fecal immunochemical testing for colorectal cancer and advanced adenomas (≥10 mm, tubulovillous or villous or high-grade dysplasia) was calculated. Data on demographics and acceptability of fecal immunochemical testing and colonoscopy were collected. Findings: Between January and April 2021, 2330 participants were enrolled in the study and received a fecal immunochemical test, which was returned by 2109 participants. 1677 participants tested negative and 432 tested positive. Of these 432 participants, 285 underwent a colonoscopy (235 showed no polyps or cancer, 47 had polyps identified, and three had colorectal cancer identified). Of the 47 participants who had polyps identified, 20 had advanced adenomas diagnosed. The median age was 57 years (IQR 50–63), 958 (41%) were male and 1372 (59%) were female, and 68% had at least a secondary-level education. ...
    Keywords Public aspects of medicine ; RA1-1270
    Subject code 150 ; 610
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Geospatial, racial, and educational variation in firearm mortality in the USA, Mexico, Brazil, and Colombia, 1990–2015

    Anna J Dare, PhD / Hyacinth Irving, MA / Carlos Manuel Guerrero-López, MSc / Leah K Watson, MSc / Patrycja Kolpak, MSA / Luz Myriam Reynales Shigematsu, PhD / Marcos Sanches, MSc / David Gomez, PhD / Hellen Gelband, MHS / Prabhat Jha, ProfDPhil

    The Lancet Public Health, Vol 4, Iss 6, Pp e281-e

    a comparative analysis of vital statistics data

    2019  Volume 290

    Abstract: Summary: Background: Firearm mortality is a leading, and largely avoidable, cause of death in the USA, Mexico, Brazil, and Colombia. We aimed to assess the changes over time and demographic determinants of firearm deaths in these four countries between ... ...

    Abstract Summary: Background: Firearm mortality is a leading, and largely avoidable, cause of death in the USA, Mexico, Brazil, and Colombia. We aimed to assess the changes over time and demographic determinants of firearm deaths in these four countries between 1990 and 2015. Methods: In this comparative analysis of firearm mortality, we examined national vital statistics data from 1990–2015 from four publicly available data repositories in the USA, Mexico, Brazil, and Colombia. We extracted medically-certified deaths and underlying population denominators to calculate the age-specific and sex-specific firearm deaths and the risk of firearm mortality at the national and subnational level, by education for all four countries, and by race or ethnicity for the USA and Brazil. Analyses were stratified by intent (homicide, suicide, unintentional, or undetermined). We quantified avoidable mortality for each country using the lowest number of subnational age-specific and period-specific death rates. Findings: Between 1990 and 2015, 106·3 million medically-certified deaths were recorded, including 2 472 000 firearm deaths, of which 851 000 occurred in the USA, 272 000 in Mexico, 855 000 in Brazil, and 494 000 in Colombia. Homicides accounted for most of the firearm deaths in Mexico (225 000 [82·7%]), Colombia (463 000 [93·8%]), and Brazil (766 000 [89·5%]). Suicide accounted for more than half of all firearm deaths in the USA (479 000 [56·3%]). In each country, firearm mortality was highest among men aged 15–34 years, accounting for up to half of the total risk of death in that age group. During the study period, firearm mortality risks increased in Mexico and Brazil but decreased in the USA and Colombia, with marked national and subnational geographical variation. Young men with low educational attainment were at increased risk of firearm homicide in all four countries, and in the USA and Brazil, black and brown men, respectively, were at the highest risk. The risk of firearm homicide was 14 times higher in black men in the USA ...
    Keywords Public aspects of medicine ; RA1-1270
    Subject code 360
    Language English
    Publishing date 2019-06-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Renal failure deaths and their risk factors in India 2001–13

    Anna J Dare, PhD / Sze Hang Fu, MSA / Jayadeep Patra, PhD / Peter S Rodriguez, MSA / J S Thakur, ProfMD / Prabhat Jha, ProfDPhil

    The Lancet Global Health, Vol 5, Iss 1, Pp e89-e

    nationally representative estimates from the Million Death Study

    2017  Volume 95

    Abstract: Summary: Background: Renal failure represents a growing but mostly undocumented cause of premature mortality in low-income and middle-income countries. We investigated changes in adult renal failure mortality and its key risk factors in India using the ... ...

    Abstract Summary: Background: Renal failure represents a growing but mostly undocumented cause of premature mortality in low-income and middle-income countries. We investigated changes in adult renal failure mortality and its key risk factors in India using the nationally representative Million Death Study. Methods: In this cross-sectional analysis of population-based data, two trained physicians independently assigned underlying causes to 150 018 deaths at ages 15–69 years from a nationally-representative mortality survey in India for 2001–03 and 2010–13, using the International Classification of Diseases, 10th version (ICD-10). We applied the age-specific proportion of renal failure deaths for the 2010–13 period to the 2015 UN estimates of total deaths in India and calculated age-standardised death rates for renal failure by rural or urban residence, state, and age group. We used proportional mortality of renal deaths (cases) to injuries (controls) to calculate the odds of renal death in the presence of different comorbidities and stratified risks by decade of birth. Findings: In 2001–03, 2·1% of total deaths among 15–69 year olds were from renal failure (1266 [2·2%] of 58 871; unweighted). By 2010–13, the proportion of deaths from renal failure had risen to 2·9% (2943 [3·2%] of 91 147; unweighted) of total deaths and corresponding to 136 000 renal failure deaths (range 108 000–150 000) of 4 688 000 total deaths nationally in 2015. Age-standardised renal death rates were highest in the southern and eastern states, particularly among adults aged 45–69 years in 2010–13. Diabetes, hypertension, and cardiovascular disease were all significantly associated with increased renal failure deaths, with diabetes the strongest predictor—odds ratio (OR) vs control 9·2 (95% CI 6·7–12·7) in 2001–03, rising to 15·1 (12·6–18·1) in 2010–13. In the 2010–13 study population, the diabetes to non-diabetes OR was twice as large in adults born in the 1970s (25·5, 95% CI 17·6–37·1) as in those individuals born during or before the 1950s (11·7, ...
    Keywords Public aspects of medicine ; RA1-1270
    Subject code 310
    Language English
    Publishing date 2017-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Prioritizing Surgical Care on National Health Agendas

    Anna J Dare / Katherine C Lee / Josh Bleicher / Alex E Elobu / Thaim B Kamara / Osborne Liko / Samuel Luboga / Akule Danlop / Gabriel Kune / Lars Hagander / Andrew J M Leather / Gavin Yamey

    PLoS Medicine, Vol 13, Iss 5, p e

    A Qualitative Case Study of Papua New Guinea, Uganda, and Sierra Leone.

    2016  Volume 1002023

    Abstract: Little is known about the social and political factors that influence priority setting for different health services in low- and middle-income countries (LMICs), yet these factors are integral to understanding how national health agendas are established. ...

    Abstract Little is known about the social and political factors that influence priority setting for different health services in low- and middle-income countries (LMICs), yet these factors are integral to understanding how national health agendas are established. We investigated factors that facilitate or prevent surgical care from being prioritized in LMICs.We undertook country case studies in Papua New Guinea, Uganda, and Sierra Leone, using a qualitative process-tracing method. We conducted 74 semi-structured interviews with stakeholders involved in health agenda setting and surgical care in these countries. Interviews were triangulated with published academic literature, country reports, national health plans, and policies. Data were analyzed using a conceptual framework based on four components (actor power, ideas, political contexts, issue characteristics) to assess national factors influencing priority for surgery. Political priority for surgical care in the three countries varies. Priority was highest in Papua New Guinea, where surgical care is firmly embedded within national health plans and receives significant domestic and international resources, and much lower in Uganda and Sierra Leone. Factors influencing whether surgical care was prioritized were the degree of sustained and effective domestic advocacy by the local surgical community, the national political and economic environment in which health policy setting occurs, and the influence of international actors, particularly donors, on national agenda setting. The results from Papua New Guinea show that a strong surgical community can generate priority from the ground up, even where other factors are unfavorable.National health agenda setting is a complex social and political process. To embed surgical care within national health policy, sustained advocacy efforts, effective framing of the problem and solutions, and country-specific data are required. Political, technical, and financial support from regional and international partners is also important.
    Keywords Medicine ; R
    Subject code 360
    Language English
    Publishing date 2016-05-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Impact of malnutrition on early outcomes after cancer surgery

    Aya Riad / Stephen R Knight / Dhruv Ghosh / Pamela A Kingsley / Marie Carmela Lapitan / Marie Dione Parreno-Sacdalan / Sudha Sundar / Ahmad Uzair Qureshi / Apple P Valparaiso / Riinu Pius / Catherine A Shaw / Thomas M Drake / Lisa Norman / Adesoji O Ademuyiwa / Adewale O Adisa / Maria Lorena Aguilera / Sara W Al-Saqqa / Ibrahim Al-Slaibi / Aneel Bhangu /
    Bruce M Biccard / Peter Brocklehurst / Sorrel Burden / Kathryn Chu / Ainhoa Costas-Chavarri / Anna J Dare / Muhammed Elhadi / Cameron J Fairfield / J Edward Fitzgerald / James Glasbey / Mark I. van Berge Henegouwen / J.C. Allen Ingabire / T Peter Kingham / Ismaïl Lawani / Bettina Lieske / Richard Lilford / Laura Magill / Mayaba Maimbo / Janet Martin / Sonia Mathai / Kenneth A McLean / Rachel Moore / Dion Morton / Dmitri Nepogodiev / John Norrie / Faustin Ntirenganya / Francesco Pata / Thomas Pinkney / Rajkumar Kottayasamy Seenivasagam / Antonio Ramos-De la Medina / Tracey E Roberts

    The Lancet Global Health, Vol 11, Iss 3, Pp e341-e

    an international, multicentre, prospective cohort study

    2023  Volume 349

    Abstract: Summary: Background: Malnutrition represents a key priority for global health policy, yet the impact of nutritional state on cancer surgery worldwide remains poorly described. We aimed to analyse the effect of malnutrition on early postoperative outcomes ...

    Abstract Summary: Background: Malnutrition represents a key priority for global health policy, yet the impact of nutritional state on cancer surgery worldwide remains poorly described. We aimed to analyse the effect of malnutrition on early postoperative outcomes following elective surgery for colorectal or gastric cancer. Methods: We did an international, multicentre, prospective cohort study of patients undergoing elective surgery for colorectal or gastric cancer between April 1, 2018, and Jan 31, 2019. Patients were excluded if the primary pathology was benign, they presented with cancer recurrence, or if they underwent emergency surgery (within 72 h of hospital admission). Malnutrition was defined with the Global Leadership Initiative on Malnutrition criteria. The primary outcome was death or a major complication within 30 days of surgery. Multilevel logistic regression and a three-way mediation analysis were done to establish the relationship between country income group, nutritional status, and 30-day postoperative outcomes. Findings: This study included 5709 patients (4593 with colorectal cancer and 1116 with gastric cancer) from 381 hospitals in 75 countries. The mean age was 64·8 years (SD 13·5) and 2432 (42·6%) patients were female . Severe malnutrition was present in 1899 (33·3%) of 5709 patients, with a disproportionate burden in upper-middle-income countries (504 [44·4%] of 1135) and low-income and lower-middle-income countries (601 [62·5%] of 962). After adjustment for patient and hospital risk factors, severe malnutrition was associated with an increased risk of 30-day mortality across all country income groups (high income: adjusted odds ratio [aOR] 1·96 [95% CI 1·14–3·37], p=0·015; upper-middle income: 3·05 [1·45–6·42], p=0·003; low income and lower-middle income: 11·57 [5·87–22·80], p<0·0001). Severe malnutrition mediated an estimated 32% of early deaths in low-income and lower-middle-income countries (aOR 1·41 [95% CI 1·22–1·64]) and an estimated 40% of early deaths in upper-middle-income countries ...
    Keywords Public aspects of medicine ; RA1-1270
    Subject code 610
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Global economic consequences of selected surgical diseases

    Dr. Blake C Alkire, MD / Mark G Shrime, MD / Anna J Dare, PhD / Prof. Jeffrey R Vincent, PhD / John G Meara, MD

    The Lancet Global Health, Vol 3, Iss S2, Pp S21-S

    a modelling study

    2015  Volume 27

    Abstract: Background: The surgical burden of disease is substantial, but little is known about the associated economic consequences. We estimate the global macroeconomic impact of the surgical burden of disease due to injury, neoplasm, digestive diseases, and ... ...

    Abstract Background: The surgical burden of disease is substantial, but little is known about the associated economic consequences. We estimate the global macroeconomic impact of the surgical burden of disease due to injury, neoplasm, digestive diseases, and maternal and neonatal disorders from two distinct economic perspectives. Methods: We obtained mortality rate estimates for each disease for the years 2000 and 2010 from the Institute of Health Metrics and Evaluation Global Burden of Disease 2010 study, and estimates of the proportion of the burden of the selected diseases that is surgical from a paper by Shrime and colleagues. We first used the value of lost output (VLO) approach, based on the WHO's Projecting the Economic Cost of Ill-Health (EPIC) model, to project annual market economy losses due to these surgical diseases during 2015–30. EPIC attempts to model how disease affects a country's projected labour force and capital stock, which in turn are related to losses in economic output, or gross domestic product (GDP). We then used the value of lost welfare (VLW) approach, which is conceptually based on the value of a statistical life and is inclusive of non-market losses, to estimate the present value of long-run welfare losses resulting from mortality and short-run welfare losses resulting from morbidity incurred during 2010. Sensitivity analyses were performed for both approaches. Findings: During 2015–30, the VLO approach projected that surgical conditions would result in losses of 1·25% of potential GDP, or $20·7 trillion (2010 US$, purchasing power parity) in the 128 countries with data available. When expressed as a proportion of potential GDP, annual GDP losses were greatest in low-income and middle-income countries, with up to a 2·5% loss in output by 2030. When total welfare losses are assessed (VLW), the present value of economic losses is estimated to be equivalent to 17% of 2010 GDP, or $14·5 trillion in the 175 countries assessed with this approach. Neoplasm and injury account for greater than 95% ...
    Keywords Public aspects of medicine ; RA1-1270
    Subject code 339
    Language English
    Publishing date 2015-04-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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