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  1. AU="Anna Maria Aloisi"
  2. AU="Na, Li"
  3. AU="Beatriz Aguiar Jordão Paranhos"
  4. AU="johnson, Michael"
  5. AU=Hunt S A
  6. AU="Gniazdowski, Victoria"
  7. AU="Griffin, Matthew E"
  8. AU="Bean, Paris"
  9. AU="Elomaa, Paula"
  10. AU="Robert Fowler"
  11. AU="Nielsen, Stine"
  12. AU="Chabartier, Cyrille"

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  1. Artikel ; Online: Things Able to Treat Pain

    Anna Maria Aloisi

    International Journal of Molecular Sciences, Vol 24, Iss 10346, p

    2023  Band 10346

    Abstract: Chronic pain is a medical condition that affects a considerable number of people of all ages [.] ...

    Abstract Chronic pain is a medical condition that affects a considerable number of people of all ages [.]
    Schlagwörter n/a ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Sprache Englisch
    Erscheinungsdatum 2023-06-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Editorial

    Parisa Gazerani / Anna Maria Aloisi / Hiroshi Ueda

    Frontiers in Neuroscience, Vol

    Differences in Pain Biology, Perception, and Coping Strategies: Towards Sex and Gender Specific Treatments

    2021  Band 15

    Schlagwörter sex ; pain ; gender ; pain perception ; pain biology ; pain treatement ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571
    Sprache Englisch
    Erscheinungsdatum 2021-06-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Very-Low-Calorie Ketogenic Diet

    Elvira Rostanzo / Marco Marchetti / Ilenia Casini / Anna Maria Aloisi

    International Journal of Environmental Research and Public Health, Vol 18, Iss 12802, p

    A Potential Treatment for Binge Eating and Food Addiction Symptoms in Women. A Pilot Study

    2021  Band 12802

    Abstract: Background: many patients who struggle to lose weight are unable to cut down certain ultra-processed, refined types of food with a high glycemic index. This condition is linked to responses similar to addiction that lead to overeating. A very-low-calorie ...

    Abstract Background: many patients who struggle to lose weight are unable to cut down certain ultra-processed, refined types of food with a high glycemic index. This condition is linked to responses similar to addiction that lead to overeating. A very-low-calorie ketogenic diet (VLCKD) with adequate protein intake could be considered a valid dietary approach. The aim of the present study was to evaluate the feasibility of a VLCKD in women with binge eating and/or food addiction symptoms. Methods: subjects diagnosed with binge eating and/or food addiction symptoms (measured with the Binge Eating Scale and the Yale Food Addiction Scale 2.0) were asked to follow a VLCKD with protein replacement for 5–7 weeks (T1) and a low-calorie diet for 11–21 weeks (T2). Self-reported food addiction and binge eating symptoms and body composition were tested at T0 (baseline) and at the end of each diet (T1 and T2 respectively); Results: five women were included in the study. Mean age was 36.4 years (SEM = 4.95) and mean BMI was 31.16 (SEM = 0.91). At T0, two cases of severe food addiction, one case of mild food addiction, one case of binge eating with severe food addiction, and one case of binge eating were recorded. Weight loss was recorded at both T1 and T2 (ranging from 4.8% to 11.6% of the initial body weight at T1 and from 7.3% to 12.8% at T2). No case of food addiction and/or binge eating symptoms was recorded at T2. Muscle mass was preserved. Conclusions: recent findings have highlighted the potential therapeutic role of ketogenic diets for the treatment of addiction to high-calorie, ultra-processed and high-glycemic food. Our pilot study demonstrates the feasibility of a ketogenic diet in women with addictive-like eating disorders seeking to lose weight.
    Schlagwörter VLCKD ; ketogenic diet ; eating disorders ; food addiction ; binge eating ; YFAS ; Medicine ; R
    Thema/Rubrik (Code) 590
    Sprache Englisch
    Erscheinungsdatum 2021-12-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Calceolarioside A, a Phenylpropanoid Glycoside from Calceolaria spp., Displays Antinociceptive and Anti-Inflammatory Properties

    Stefano Pieretti / Anella Saviano / Adriano Mollica / Azzurra Stefanucci / Anna Maria Aloisi / Marcello Nicoletti

    Molecules, Vol 27, Iss 2183, p

    2022  Band 2183

    Abstract: Phenylpropanoid glycosides are a class of natural substances of plant origin with interesting biological activities and pharmacological properties. This study reports the antinociceptive and anti-inflammatory effects of calceolarioside A, a ... ...

    Abstract Phenylpropanoid glycosides are a class of natural substances of plant origin with interesting biological activities and pharmacological properties. This study reports the antinociceptive and anti-inflammatory effects of calceolarioside A, a phenylpropanoid glycoside previously isolated from various Calceolaria species. In models of acute nociception induced by thermal stimuli, such as the hot plate and tail flick test, calceolarioside administered at doses of 1, 5, and 10 μg in the left cerebral ventricles did not modify the behavioral response of mice. In an inflammatory based persistent pain model as the formalin test, calceolarioside A at the high dose tested (100 μg/paw) reduced the licking activity induced by formalin by 35% in the first phase and by 75% in the second phase of the test. In carrageenan-induced thermal hyperalgesia, calceolarioside A (50 and 100 μg/paw) was able to significantly reverse thermal hyperalgesia induced by carrageenan. The anti-inflammatory activity of calceolarioside A was then assessed using the zymosan-induced paw edema model. Calceolarioside A (50 and 100 μg/paw) induced a significant reduction in the edema from 1 to 4 h after zymosan administration. Measuring IL-6, TNFα, and IL-1β pro-inflammatory cytokines released from LPS-stimulated THP-1 cells, calceolarioside A in a concentration-dependent manner reduced the release of these cytokines from THP-1 cells. Taken together, our results highlight, for the first time, the potential and selective anti-inflammatory properties of this natural-derived compound, prompting its rationale use for further investigations.
    Schlagwörter calceolarioside A ; nociception ; inflammation ; phenylpropanoid glycosides ; Calceolaria ; Organic chemistry ; QD241-441
    Sprache Englisch
    Erscheinungsdatum 2022-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: New Insights on Formyl Peptide Receptor Type 2 Involvement in Nociceptive Processes in the Spinal Cord

    Mariantonella Colucci / Azzurra Stefanucci / Adriano Mollica / Anna Maria Aloisi / Francesco Maione / Stefano Pieretti

    Life, Vol 12, Iss 500, p

    2022  Band 500

    Abstract: Formyl peptide receptor type 2 (FPR2/ALX) belongs to the formyl peptide receptors (FPRs) family clustered on chromosome 19 and encodes a family of three Class A of G protein-coupled receptors (GPCRs). A short N-terminal region, an NPXXY motif in ... ...

    Abstract Formyl peptide receptor type 2 (FPR2/ALX) belongs to the formyl peptide receptors (FPRs) family clustered on chromosome 19 and encodes a family of three Class A of G protein-coupled receptors (GPCRs). A short N-terminal region, an NPXXY motif in transmembrane (TM) region 7 and an E/DRY motif that bridges TM3 and TM6 stabilizing inactive receptor conformations characterize this class of receptors. In recognizing pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs), FPRs play a crucial role in innate immune responses. FPR2/ALX is highly expressed in myeloid cells, as well as in chondrocytes, fibroblasts, endothelial, epithelial and smooth muscle cells. FPR2/ALX mRNA expression was recently reported in the rat brainstem, spinal cord, thalamus/hypothalamus, cerebral neocortex, hippocampus, cerebellum and striatum. The central nervous system (CNS) distribution of FPR2/ALX suggests important functions in nociception. Thus, the present study was carried out to investigate the possible role of FPR2/ALX in nociception in mice. Intrathecal administration of the formyl peptide receptor type 1 (FPR1) agonist fMLF and the FPR2/ALX agonist BML-111 relieved nociception and these effects were reduced by contemporary administration of the FPR2/ALX antagonist WRW 4 . Furthermore, measurement of cytokines and brain-derived neurotrophic factor (BDNF) in the spinal cord of neuropathic mice demonstrated that the antinociceptive effects of BML-111 might depend on the reduction in cytokine release and BDNF in the spinal cord. These results suggest a possible role of FPR2/ALX for pain control in the spinal cord.
    Schlagwörter annexin ; formyl peptide receptors ; nociception ; pain ; spinal cord ; Science ; Q
    Thema/Rubrik (Code) 571
    Sprache Englisch
    Erscheinungsdatum 2022-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Effects of Intracerebroventricular and Intra-Arcuate Nucleus Injection of Ghrelin on Pain Behavioral Responses and Met-Enkephalin and β-Endorphin Concentrations in the Periaqueductal Gray Area in Rats

    Samaneh Pirzadeh / Javad Sajedianfard / Anna Maria Aloisi / Mahboobeh Ashrafi

    International Journal of Molecular Sciences, Vol 20, Iss 10, p

    2019  Band 2475

    Abstract: Ghrelin is an endogenous ligand for orphan growth hormone secretagogue receptors. Ghrelin receptors have been found in central nervous system (CNS) areas responsible for pain modulation and transmission. This study investigated the effects of ... ...

    Abstract Ghrelin is an endogenous ligand for orphan growth hormone secretagogue receptors. Ghrelin receptors have been found in central nervous system (CNS) areas responsible for pain modulation and transmission. This study investigated the effects of intracerebroventricular (ICV) and intra-arcuate nucleus (ARC) injection of ghrelin on pain behavioral responses and levels of β-endorphin (β-EP) and met-enkephalin (MENK) in the periaqueductal gray area (PAG) during the formalin test in rats. Thirty-five male rats were studied in five groups. Ghrelin was injected into the left lateral ventricle (ICV, 5 µL) or into the ARC (1 µL). After 15 min, formalin (2.5%) was subcutaneously injected into the left hind paw. Behavioral nociceptive scores were recorded for 60 min. MENK and β-EP were collected by microdialysis in the PAG and determined by high-performance liquid chromatography (HPLC). ICV and ARC injection of ghrelin significantly reduced pain in all phases of the formalin test ( p < 0.001). Dialysate concentrations of MENK and β-EP in the PAG increased in all the phases ( p < 0.01). In conclusion, the present study shows that the ARC nucleus and the endogenous opioid system are involved in ghrelin-induced pain modulation.
    Schlagwörter ghrelin ; formalin test ; met-enkephalin ; beta-endorphin ; microdialysis ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Sprache Englisch
    Erscheinungsdatum 2019-05-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Universality vs experience

    Giulia Prete / Danilo Bondi / Vittore Verratti / Anna Maria Aloisi / Prabin Rai / Luca Tommasi

    PeerJ, Vol 8, p e

    a cross-cultural pilot study on the consonance effect in music at different altitudes

    2020  Band 9344

    Abstract: Background Previous studies have shown that music preferences are influenced by cultural “rules”, and some others have suggested a universal preference for some features over others. Methods We investigated cultural differences on the “consonance effect”, ...

    Abstract Background Previous studies have shown that music preferences are influenced by cultural “rules”, and some others have suggested a universal preference for some features over others. Methods We investigated cultural differences on the “consonance effect”, consisting in higher pleasantness judgments for consonant compared to dissonant chords—according to the Western definition of music: Italian and Himalayan participants were asked to express pleasantness judgments for consonant and dissonant chords. An Italian and a Nepalese sample were tested both at 1,450 m and at 4,750 m of altitude, with the further aim to evaluate the effect of hypoxia on this task. A third sample consisted of two subgroups of Sherpas: lowlanders (1,450 m of altitude), often exposed to Western music, and highlanders (3,427 m of altitude), less exposed to Western music. All Sherpas were tested where they lived. Results Independently from the altitude, results confirmed the consonance effect in the Italian sample, and the absence of such effect in the Nepalese sample. Lowlander Sherpas revealed the consonance effect, but highlander Sherpas did not show this effect. Conclusions Results of this pilot study show that neither hypoxia (altitude), nor demographic features (age, schooling, or playing music), nor ethnicity per se influence the consonance effect. We conclude that music preferences are attributable to music exposure.
    Schlagwörter Consonance ; Dissonance ; Music pleasantness ; Hypoxia ; Culture ; Altitude ; Medicine ; R
    Thema/Rubrik (Code) 780
    Sprache Englisch
    Erscheinungsdatum 2020-07-01T00:00:00Z
    Verlag PeerJ Inc.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: GONADAL HORMONES, WOMEN AND PAIN

    Anna Maria Aloisi / Paolo Fiorenzani

    Journal of the Siena Academy of Sciences, Vol 5, Iss 1, Pp 23-

    2013  Band 27

    Abstract: The clear presence of sex differences in chronic pain and the number of studies showing the power of gonadal hormones to modify pain-induced behavioral responses appear to have convinced clinicians and researchers. In the present review, the old and new ... ...

    Abstract The clear presence of sex differences in chronic pain and the number of studies showing the power of gonadal hormones to modify pain-induced behavioral responses appear to have convinced clinicians and researchers. In the present review, the old and new literature is summarized to put together data on pain and its modulation by gonadal hormones, particularly estrogens. Targets of these hormones are discussed.
    Schlagwörter pain ; sex differences ; CNS ; pain mechanisms ; gonadal hormones ; Medicine (General) ; R5-920 ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2013-12-01T00:00:00Z
    Verlag PAGEPress Publications
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Superior Properties of N-Acetylcysteine Ethyl Ester over N-Acetyl Cysteine to Prevent Retinal Pigment Epithelial Cells Oxidative Damage

    Gian Marco Tosi / Daniela Giustarini / Lorenzo Franci / Alberto Minetti / Francesco Imperatore / Elena Caldi / Paolo Fiorenzani / Anna Maria Aloisi / Anna Sparatore / Ranieri Rossi / Mario Chiariello / Maurizio Orlandini / Federico Galvagni

    International Journal of Molecular Sciences, Vol 22, Iss 2, p

    2021  Band 600

    Abstract: Oxidative stress plays a key role in the pathophysiology of retinal diseases, including age-related macular degeneration (AMD) and diabetic retinopathy, which are the major causes of irreversible blindness in developed countries. An excess of reactive ... ...

    Abstract Oxidative stress plays a key role in the pathophysiology of retinal diseases, including age-related macular degeneration (AMD) and diabetic retinopathy, which are the major causes of irreversible blindness in developed countries. An excess of reactive oxygen species (ROS) can directly cause functional and morphological impairments in retinal pigment epithelium (RPE), endothelial cells, and retinal ganglion cells. Antioxidants may represent a preventive/therapeutic strategy and reduce the risk of progression of AMD. Among antioxidants, N-acetyl-L-cysteine (NAC) is widely studied and has been proposed to have therapeutic benefit in treating AMD by mitigating oxidative damage in RPE. Here, we demonstrate that N-acetyl-L-cysteine ethyl ester (NACET), a lipophilic cell-permeable cysteine derivative, increases the viability in oxidative stressed RPE cells more efficiently than NAC by reacting directly and more rapidly with oxidizing agents, and that NACET, but not NAC, pretreatment predisposes RPE cells to oxidative stress resistance and increases the intracellular reduced glutathione (GSH) pool available to act as natural antioxidant defense. Moreover, we demonstrate the ability of NACET to increase GSH levels in rats’ eyes after oral administration. In conclusion, even if experiments in AMD animal models are still needed, our data suggest that NACET may play an important role in preventing and treating retinal diseases associated with oxidative stress, and may represent a valid and more efficient alternative to NAC in therapeutic protocols in which NAC has already shown promising results.
    Schlagwörter oxidative stress ; retinopathy ; retinal pigment epithelium ; age-related macular degeneration ; N-acetyl-L-cysteine ; N-acetyl-L-cysteine ethyl ester ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel: Determination of protein thiolation index (PTI) as a biomarker of oxidative stress in human serum

    Giustarini, Daniela / Federico Galvagni / Graziano Colombo / Isabella Dalle-Donne / Aldo Milzani / Anna Maria Aloisi / Ranieri Rossi

    Analytical biochemistry. 2017,

    2017  

    Abstract: We have introduced protein thiolation index (PTI), i.e. the molar ratio of the sum of all low molecular mass thiols bound to plasma proteins to protein free cysteinyl residues, as a sensitive biomarker of oxidative stress. According to the original ... ...

    Abstract We have introduced protein thiolation index (PTI), i.e. the molar ratio of the sum of all low molecular mass thiols bound to plasma proteins to protein free cysteinyl residues, as a sensitive biomarker of oxidative stress. According to the original procedure its determination requires a rapid separation of plasma and a specific treatment of samples to stabilize thiols. Here we demonstrate that samples can be collected without use of any anticoagulant to prevent blood clotting and without any stabilization of thiols too. This simplification of the determination of PTI makes its analysis more feasible also in routine clinical laboratories.
    Schlagwörter anticoagulants ; biomarkers ; blood coagulation ; blood proteins ; blood serum ; humans ; molecular weight ; oxidative stress ; thiols
    Sprache Englisch
    Umfang p. .
    Erscheinungsort Elsevier Inc.
    Dokumenttyp Artikel
    Anmerkung Pre-press version
    ZDB-ID 1110-1
    ISSN 1096-0309 ; 0003-2697
    ISSN (online) 1096-0309
    ISSN 0003-2697
    DOI 10.1016/j.ab.2017.09.010
    Datenquelle NAL Katalog (AGRICOLA)

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