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Article ; Online: Gestion de crise et éducation au Québec

Olivier Lemieux / Jean Bernatchez / Anne-Michèle Delobbe

Interventions Économiques pour une Alternative Sociale, Vol

les représentations des directions d’établissement sur les rôles et les responsabilités des acteurs scolaires en temps de COVID-19

2021 Volume 66

Abstract: The COVID-19 pandemic has led to reflections in Quebec regarding the sharing of roles and responsibilities of school actors in the context of crisis and with a view to the pursuit of the mission of Quebec schools. This research is based primarily on 12 ... ...

Abstract	The COVID-19 pandemic has led to reflections in Quebec regarding the sharing of roles and responsibilities of school actors in the context of crisis and with a view to the pursuit of the mission of Quebec schools. This research is based primarily on 12 semi-structured interviews conducted during the summer of 2020 with school principals in compulsory education (primary and secondary). It allows us to identify their representations regarding the roles and responsibilities of school stakeholders according to their functions and positions within the school organization. The analysis allows us to observe a variable geometry sharing of the perceived roles and responsibilities of the actors about communication, leadership, maintaining well-being and the pursuit of regular activities.
Keywords	school-based crisis management ; COVID-19 ; sharing of roles and responsibilities ; school management ; semi-directed interview ; Economic history and conditions ; HC10-1085 ; Economics as a science ; HB71-74
Subject code	370
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Association d'Economie Politique
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: THE MANAGEMENT OF THE PANDEMIC COVID-19 CRISIS BY QUEBEC SCHOOL PRINCIPALS

Jean BERNATCHEZ / Olivier LEMIEUX / Anne-Michèle DELOBBE

Analele Universităţii din Craiova. Psihologie, Pedagogie, Vol 43, Iss 1, Pp 7-

PRACTICES, ISSUES AND LEARNINGS

2021 Volume 22

Abstract: Our study focuses on the management of schools in the context of a pandemic. School principals in Quebec are faced with the management of the COVID-19 pandemic crisis in 2020 and 2021, without having any prior training or experience in crisis management. ...

Abstract	Our study focuses on the management of schools in the context of a pandemic. School principals in Quebec are faced with the management of the COVID-19 pandemic crisis in 2020 and 2021, without having any prior training or experience in crisis management. What practices did they deploy in response to the urgency of the situation? What issues were brought to light? What have they learned that could be useful in the future? Our article aims to answer these three questions, after having posed the problem and defined the concepts. The research strategies used were a literature review of scientific documents on crisis management and the profession of school management; a monitoring of current events in the school sector; and semi-structured interviews (N=15) with school principals. In terms of practices, eight management principles are identified, related to financial and human resources, leadership, planning and communication. In terms of issues, those of an administrative and pedagogical nature emerge. In terms of learning, several skills developed in the context of managing the COVID-19 crisis can have a positive, lasting effect on the practices of school principals.
Keywords	crisis management ; covid-19 ; school principals ; Social sciences (General) ; H1-99 ; Education ; L ; Psychology ; BF1-990
Subject code	370
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Universitaria Publishing House, Craiova
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Relations Between Cultural Life Scripts, Individual Life Stories, and Psychological Distress.

Anne, Michele / Janssen, Steve M J

Psychological reports

2020 Volume 124, Issue 2, Page(s) 521–542

Abstract: Cultural life scripts are shared knowledge about personal events expected to be experienced by individuals within a society and used as a framework for life story narration. Differences in cultural life scripts for individuals with depression and trauma, ...

Abstract	Cultural life scripts are shared knowledge about personal events expected to be experienced by individuals within a society and used as a framework for life story narration. Differences in cultural life scripts for individuals with depression and trauma, and their relations to anxiety, stress, and well-being, have not been investigated. Malaysian participants (
MeSH term(s)	Adolescent ; Adult ; Anxiety/psychology ; Culture ; Depression/psychology ; Female ; Humans ; Life Change Events ; Male ; Narration ; Psychological Distress ; Psychological Trauma/psychology ; Stress Disorders, Post-Traumatic/psychology ; Stress, Psychological/psychology ; Young Adult
Language	English
Publishing date	2020-03-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	205658-6
ISSN	1558-691X ; 0033-2941
ISSN (online)	1558-691X
ISSN	0033-2941
DOI	10.1177/0033294120913490
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Article ; Online: Life Positions and Depression: The Role of Convictions.

Anne, Michele / Boholst, Fredrick A

Psychological reports

2020 Volume 124, Issue 3, Page(s) 1015–1030

Abstract: Life Position, one of the central concepts in Transactional Analysis, is a person's convictions about the worth of the self and others-a basic psychological stand, which is deeply ingrained. There are four Life Positions: "I'm OK-You're OK", "I'm OK-You' ... ...

Abstract	Life Position, one of the central concepts in Transactional Analysis, is a person's convictions about the worth of the self and others-a basic psychological stand, which is deeply ingrained. There are four Life Positions: "I'm OK-You're OK", "I'm OK-You're not OK", "I'm not OK-You're OK", and "I'm not OK-You're not OK". Contradicting Berne's theory of only one depressive position ("I'm not OK-You're OK"), past findings showed that both "I'm not OK-You're OK" and "I'm not OK-You're not OK" positions relate to depression, with the "I'm not OK-You're not OK" position relating to depression more strongly than the "I'm not OK-You're OK" position. The disparity between Berne's original theorizing of depression and the empirical findings may support an alternative conceptualization of the depressive's Life Position, which was the theoretical gap of this research. This research aimed to investigate the differences in how each Life Position relates to depression, and how the underlying convictions of Life Position predict depression. The Life Position Scale and Center for Epidemiologic Studies Depression Scale were filled in by individuals of the general population. Post hoc analysis revealed that the "I'm not OK-You're not OK" position related most to depression, followed by the "I'm not OK-You're OK" position, the "I'm OK-You're not OK" position, and finally the "I'm OK-You're OK" position. The results also showed that both negative convictions of the self and others contributed significantly to depression, but the former predicted depression more than the latter. Applications of these findings into theoretical and therapy settings were explored.
MeSH term(s)	Adolescent ; Adult ; Depression/psychology ; Female ; Humans ; Male ; Middle Aged ; Thinking ; Young Adult
Language	English
Publishing date	2020-06-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	205658-6
ISSN	1558-691X ; 0033-2941
ISSN (online)	1558-691X
ISSN	0033-2941
DOI	10.1177/0033294120928273
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Article ; Online: Embracing the Science of Motherhood: Pregnancy's Transformative Effects on the Central Nervous System and the Radiance of Maternal Hormones and Immune Responses.

Marsili, Luca / Magnusen, Albert Frank / Trivedi, Vyoma Snehal / Slavotinek, Anne Michele / Pandey, Manoj Kumar

Discovery medicine

2023 Volume 35, Issue 178, Page(s) 673–696

Abstract: Pregnancy is often thought of as a time of happiness and anticipation, however, for some women, it can bring about significant emotional distress and feelings of vulnerability. The physiological changes that occur during pregnancy, including hormonal ... ...

Abstract	Pregnancy is often thought of as a time of happiness and anticipation, however, for some women, it can bring about significant emotional distress and feelings of vulnerability. The physiological changes that occur during pregnancy, including hormonal fluctuations and alterations to the immune and physical systems, can affect various parts of the body, including the central nervous system (CNS). As a result, existing conditions may be intensified or new ones, such as neurologic or psychiatric disorders, may arise, exposing women to increased risk of life-threatening conditions or suicide, in the worst-case scenarios. Given the impact of pregnancy on CNS diseases, it is crucial for healthcare providers and patients alike to be aware of these potential effects. By understanding how pregnancy may affect the CNS, clinicians can take appropriate steps to ensure that women receive the care and support they need to minimize any negative outcomes for both the mother and the baby. This paper aims to review the available evidence on the impact of pregnancy on CNS diseases, including mental health conditions, from both the clinical and biomolecular perspectives. By illuminating this crucial subject, this study fosters a delicate understanding within both patients and healthcare providers, thereby paving the way for enhanced outcomes for women throughout their pregnancy journey and beyond.
MeSH term(s)	Pregnancy ; Infant ; Humans ; Female ; Central Nervous System ; Immunity ; Central Nervous System Diseases
Language	English
Publishing date	2023-09-15
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2415544-5
ISSN	1944-7930 ; 1944-7930
ISSN (online)	1944-7930
ISSN	1944-7930
DOI	10.24976/Discov.Med.202335178.66
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Book: The common agricultural policy, new challenges

Eckstein, Anne Michèle / Ellerton, Amanda

(Europe in 1983 ; 3)

1983

Author's details	survey prepared by Anne Michèle Eckstein ; Amanda Ellerton
Series title	Europe in 1983 ; 3 Europe in 1983 Europe in 1983
Collection	Europe in 1983 Europe in 1983
Language	English
Size	V, 409 S. : graph. Darst.
Publisher	Agence Européenne d'Informations
Publishing place	Bruxelles
Publishing country	Belgium
Document type	Book
HBZ-ID	HT015308244
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

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884/171	order for loan	Geschlossenes Magazin (U2)

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Article ; Online: Validation of ELISA assays for the calculation of FLC indices for the diagnosis of intrathecal immunoglobulin synthesis.

Heim, Xavier / Hubert, Anne Michele / Raouak, Issam / Nzepa, Anthony Charles / Mege, Jean-Louis / Delmont, Emilien / Attarian, Shahram / Koric, Lejla / Pelletier, Jean / Brodovitch, Alexandre / Boucraut, José

Clinical chemistry and laboratory medicine

2023 Volume 61, Issue 9, Page(s) 1623–1629

Abstract: Objectives: Define the cutoff thresholds of the Kappa (K) and Lambda (L) free light chains (FLC) indices for the detection of intrathecal immunoglobulin synthesis (IIS) using the new K and L FLC ELISA from SEBIA. The reference technique, which is not ... ...

Abstract	Objectives: Define the cutoff thresholds of the Kappa (K) and Lambda (L) free light chains (FLC) indices for the detection of intrathecal immunoglobulin synthesis (IIS) using the new K and L FLC ELISA from SEBIA. The reference technique, which is not readily standardized between laboratories, is based on the demonstration of oligoclonal banding (OCB) in cerebrospinal fluid (CSF) which is absent in serum. For the past 6 years, we have also routinely calculated the K FLC index using The Binding Site (TBS) reagents on an Optilite instrument, an approach increasingly used as an alternative and/or a complement to electrophoretic analysis. Methods: We analyzed 391 serum/CSF pairs divided into three groups. The first group were cases without OCB and with normal albumin CSF/serum ratio (n=174). The second group were cases with specific OCB (n=73). The last group included patients with increased albumin CSF/sera ratio without OCB (n=142). Results: Analysis of the first group determined that the cutoffs for detection of IIS are respectively 2.55 and 1.02 for the K FLC and L FLC indices. Of the 73 cases with IIS, only 2 had a K FLC index below this threshold (sensitivity of 97.26%), while 16 out of 73 cases (78.08%) and 13 out of 72 cases (81.94%) had an IgG and L FLC index below the cutoffs, respectively. Additionally, we illustrate equivalent performances for prediction of the presence of OCB between SEBIA and TBS methods. Conclusions: Sebia K FLC and L FLC assays are adequate alternative methods for the diagnosis of IIS.
MeSH term(s)	Humans ; Immunoglobulin kappa-Chains ; Immunoglobulin lambda-Chains ; Multiple Sclerosis/diagnosis ; Immunoglobulin Light Chains ; Enzyme-Linked Immunosorbent Assay ; Albumins
Chemical Substances	Immunoglobulin kappa-Chains ; Immunoglobulin lambda-Chains ; Immunoglobulin Light Chains ; Albumins
Language	English
Publishing date	2023-04-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1418007-8
ISSN	1437-4331 ; 1434-6621 ; 1437-8523
ISSN (online)	1437-4331
ISSN	1434-6621 ; 1437-8523
DOI	10.1515/cclm-2022-0602
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Article: Diagnostik : Was für eine Gesellschaft wollen wir?

Keller, Jennifer / Stupf, Anne-Michèle

Insieme : Zeitschrift über Fragen der geistigen Behinderung

2014 , Issue 1, Page(s) 16–19

Abstract: Die Präimplantationsdiagnostik (PID), die in der Schweiz vor der Zulassung steht, stellt die heikle Frage nach der Selektion. Wer verdient es zu leben? Wer bestimmt die Kriterien der Selektion? Welche Auswirkungen hat die Möglichkeit von flächendeckenden ...

Abstract	Die Präimplantationsdiagnostik (PID), die in der Schweiz vor der Zulassung steht, stellt die heikle Frage nach der Selektion. Wer verdient es zu leben? Wer bestimmt die Kriterien der Selektion? Welche Auswirkungen hat die Möglichkeit von flächendeckenden Embryonentests auf Menschen mit Behinderung und deren Angehörige? Ein Gespräch mit Anne-Michèle Stupf von insieme Genève.
Keywords	Behinderte ; Ethik ; Präimplantationsdiagnostik
Language	German
Document type	Article
ZDB-ID	1201673-1
Database	bibnet.org

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Article ; Online: Targeting the Complement-Sphingolipid System in COVID-19 and Gaucher Diseases: Evidence for a New Treatment Strategy.

Trivedi, Vyoma Snehal / Magnusen, Albert Frank / Rani, Reena / Marsili, Luca / Slavotinek, Anne Michele / Prows, Daniel Ray / Hopkin, Robert James / McKay, Mary Ashley / Pandey, Manoj Kumar

International journal of molecular sciences

2022 Volume 23, Issue 22

Abstract: Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)-induced disease (COVID-19) and Gaucher disease (GD) exhibit upregulation of complement 5a (C5a) and its C5aR1 receptor, and excess synthesis of glycosphingolipids that lead to increased ... ...

Abstract	Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)-induced disease (COVID-19) and Gaucher disease (GD) exhibit upregulation of complement 5a (C5a) and its C5aR1 receptor, and excess synthesis of glycosphingolipids that lead to increased infiltration and activation of innate and adaptive immune cells, resulting in massive generation of pro-inflammatory cytokines, chemokines and growth factors. This C5a-C5aR1-glycosphingolipid pathway- induced pro-inflammatory environment causes the tissue damage in COVID-19 and GD. Strikingly, pharmaceutically targeting the C5a-C5aR1 axis or the glycosphingolipid synthesis pathway led to a reduction in glycosphingolipid synthesis and innate and adaptive immune inflammation, and protection from the tissue destruction in both COVID-19 and GD. These results reveal a common involvement of the complement and glycosphingolipid systems driving immune inflammation and tissue damage in COVID-19 and GD, respectively. It is therefore expected that combined targeting of the complement and sphingolipid pathways could ameliorate the tissue destruction, organ failure, and death in patients at high-risk of developing severe cases of COVID-19.
MeSH term(s)	Humans ; Gaucher Disease/drug therapy ; Sphingolipids ; COVID-19/drug therapy ; SARS-CoV-2 ; Complement System Proteins ; Complement C5a/metabolism ; Inflammation ; Glycosphingolipids
Chemical Substances	Sphingolipids ; Complement System Proteins (9007-36-7) ; Complement C5a (80295-54-1) ; Glycosphingolipids
Language	English
Publishing date	2022-11-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms232214340
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Article: Asparagine 42 of the conserved endo-inulinase INU2 motif WMNDPN from Aspergillus ficuum plays a role in activity specificity.

Vandamme, Anne-Michèle / Michaux, Catherine / Mayard, Aurélie / Housen, Isabelle

FEBS open bio

2013 Volume 3, Page(s) 467–472

Abstract: Endo-inulinase INU2 from Aspergillus ficuum belongs to glycosidase hydrolase family 32 (GH32) that degrades inulin into fructo oligosaccharides consisting mainly of inulotriose and inulotetraose. The 3D structure of INU2 was recently obtained (Pouyez et ... ...

Abstract	Endo-inulinase INU2 from Aspergillus ficuum belongs to glycosidase hydrolase family 32 (GH32) that degrades inulin into fructo oligosaccharides consisting mainly of inulotriose and inulotetraose. The 3D structure of INU2 was recently obtained (Pouyez et al., 2012, Biochimie, 94, 2423-2430). An enlarged cavity compared to exo-inulinase formed by the conserved motif W-M(I)-N-D(E)-P-N-G, the so-called loop 1 and the loop 4, was identified. In the present study we have characterized the importance of 12 residues situated around the enlarged cavity. These residues were mutated by site-directed mutagenesis. Comparative activity analysis was done by plate, spectrophotometric and thin-layer chromatography assay. Most of the mutants were less active than the wild-type enzyme. Most interestingly, mutant N42G differed in the size distribution of the FOS synthesized.
Language	English
Publishing date	2013-11-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2651702-4
ISSN	2211-5463
ISSN	2211-5463
DOI	10.1016/j.fob.2013.10.009
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