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  1. AU="Anne K. McGavigan"
  2. AU="Martín-Francés, Laura"
  3. AU="Roy Remmen"
  4. AU="Perlee, Sarah"
  5. AU="Atamanalp, Refik Selim"
  6. AU="Costa, Bruno Buranello"
  7. AU="Kohler, Beatriz"
  8. AU="Tabata, Toshinori"
  9. AU="Sun, Shijing"
  10. AU="Kufeji D."
  11. AU="Kohani, Sayeh"
  12. AU="Wong, John Cm"
  13. AU="Hua LI"
  14. AU="Özkan, Yasemin"
  15. AU=Quirmbach Diana
  16. AU="Corpstein, Clairissa D"
  17. AU="Motel-Klingebiel, Andreas"
  18. AU="Brown, Randy A"
  19. AU="Feng, Yaying"
  20. AU="Lussi, A"
  21. AU="Yeon Susan B"
  22. AU="Abaci, Irem"
  23. AU="Lin, Xiaode"
  24. AU="Mendez, Luis"
  25. AU=Alzahrani Faisal A AU=Alzahrani Faisal A
  26. AU="Heidi G Standke"
  27. AU="Banville, Isabelle"
  28. AU=Morrow Lee E
  29. AU="Cuss, Chad W."
  30. AU="Carter, Paul (Interviewpartner)"
  31. AU=Lubozynski M F
  32. AU="Yves, Ville"
  33. AU="Bayer, Emily A"
  34. AU=Roesch Saskia
  35. AU="Tam, Benjamin"
  36. AU="Mori, Kousuke"
  37. AU="Steuer, Melanie"
  38. AU="Sood Hemant"
  39. AU="Jennifer Schaff"
  40. AU="Maji, Manideepa"
  41. AU=Evans Heather L
  42. AU="Cheng, Shuai"
  43. AU="Zalis, Joshua"

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  1. Artikel ; Online: Publisher Correction

    Caroline Araiz / Anqi Yan / Lucia Bettedi / Isabella Samuelson / Sam Virtue / Anne K. McGavigan / Christian Dani / Antonio Vidal-Puig / Lazaros C. Foukas

    Nature Communications, Vol 11, Iss 1, Pp 1-

    Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue

    2020  Band 1

    Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2020-02-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Publisher Correction

    Caroline Araiz / Anqi Yan / Lucia Bettedi / Isabella Samuelson / Sam Virtue / Anne K. McGavigan / Christian Dani / Antonio Vidal-Puig / Lazaros C. Foukas

    Nature Communications, Vol 11, Iss 1, Pp 1-

    Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue

    2020  Band 1

    Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2020-02-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue

    Caroline Araiz / Anqi Yan / Lucia Bettedi / Isabella Samuelson / Sam Virtue / Anne K. McGavigan / Christian Dani / Antonio Vidal-Puig / Lazaros C. Foukas

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Band 14

    Abstract: Insulin/IGF-1 signalling plays an important role in the regulation of metabolism and ageing. Here the authors show that inactivation of the pathway component PI3K p110α in the adipose tissue of mice produces a beneficial metabolic effect by enhancing β- ... ...

    Abstract Insulin/IGF-1 signalling plays an important role in the regulation of metabolism and ageing. Here the authors show that inactivation of the pathway component PI3K p110α in the adipose tissue of mice produces a beneficial metabolic effect by enhancing β-adrenergic signalling thus energy expenditure.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2019-04-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue

    Caroline Araiz / Anqi Yan / Lucia Bettedi / Isabella Samuelson / Sam Virtue / Anne K. McGavigan / Christian Dani / Antonio Vidal-Puig / Lazaros C. Foukas

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Band 14

    Abstract: Insulin/IGF-1 signalling plays an important role in the regulation of metabolism and ageing. Here the authors show that inactivation of the pathway component PI3K p110α in the adipose tissue of mice produces a beneficial metabolic effect by enhancing β- ... ...

    Abstract Insulin/IGF-1 signalling plays an important role in the regulation of metabolism and ageing. Here the authors show that inactivation of the pathway component PI3K p110α in the adipose tissue of mice produces a beneficial metabolic effect by enhancing β-adrenergic signalling thus energy expenditure.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2019-04-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

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  5. Artikel ; Online: Important Role of the GLP-1 Axis for Glucose Homeostasis after Bariatric Surgery

    Pierre Larraufie / Geoffrey P. Roberts / Anne K. McGavigan / Richard G. Kay / Joyce Li / Andrew Leiter / Audrey Melvin / Emma K. Biggs / Peter Ravn / Kathleen Davy / David C. Hornigold / Giles S.H. Yeo / Richard H. Hardwick / Frank Reimann / Fiona M. Gribble

    Cell Reports, Vol 26, Iss 6, Pp 1399-1408.e

    2019  Band 6

    Abstract: Summary: Bariatric surgery is widely used to treat obesity and improves type 2 diabetes beyond expectations from the degree of weight loss. Elevated post-prandial concentrations of glucagon-like peptide 1 (GLP-1), peptide YY (PYY), and insulin are widely ...

    Abstract Summary: Bariatric surgery is widely used to treat obesity and improves type 2 diabetes beyond expectations from the degree of weight loss. Elevated post-prandial concentrations of glucagon-like peptide 1 (GLP-1), peptide YY (PYY), and insulin are widely reported, but the importance of GLP-1 in post-bariatric physiology remains debated. Here, we show that GLP-1 is a major driver of insulin secretion after bariatric surgery, as demonstrated by blocking GLP-1 receptors (GLP1Rs) post-gastrectomy in lean humans using Exendin-9 or in mice using an anti-GLP1R antibody. Transcriptomics and peptidomics analyses revealed that human and mouse enteroendocrine cells were unaltered post-surgery; instead, we found that elevated plasma GLP-1 and PYY correlated with increased nutrient delivery to the distal gut in mice. We conclude that increased GLP-1 secretion after bariatric surgery arises from rapid nutrient delivery to the distal gut and is a key driver of enhanced insulin secretion. : Bariatric surgery is associated with enhanced postprandial gut hormone release, particularly of GLP-1, which increases insulin secretion and glucose clearance. Larraufie et al. show that higher gut hormone levels are due not to changes in enteroendocrine cell characteristics or tissue hormone content but to altered flow of nutrients that stimulates more distal enteroendocrine cells. Keywords: bariatric surgery, GLP-1, enteroendocrine cells, peptidomics, mass spectrometry, transcriptomics, intestinal transit, gut hormones
    Schlagwörter Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2019-02-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Vertical sleeve gastrectomy reduces blood pressure and hypothalamic endoplasmic reticulum stress in mice

    Anne K. McGavigan / Zachariah M. Henseler / Darline Garibay / Scott D. Butler / Sisitha Jayasinghe / Ruth E. Ley / Robin L. Davisson / Bethany P. Cummings

    Disease Models & Mechanisms, Vol 10, Iss 3, Pp 235-

    2017  Band 243

    Abstract: Bariatric surgery, such as vertical sleeve gastrectomy (VSG), causes remarkable improvements in cardiometabolic health, including hypertension remission. However, the mechanisms responsible remain undefined and poorly studied. Therefore, we developed and ...

    Abstract Bariatric surgery, such as vertical sleeve gastrectomy (VSG), causes remarkable improvements in cardiometabolic health, including hypertension remission. However, the mechanisms responsible remain undefined and poorly studied. Therefore, we developed and validated the first murine model of VSG that recapitulates the blood pressure-lowering effect of VSG using gold-standard radiotelemetry technology. We used this model to investigate several potential mechanisms, including body mass, brain endoplasmic reticulum (ER) stress signaling and brain inflammatory signaling, which are all critical contributors to the pathogenesis of obesity-associated hypertension. Mice fed on a high-fat diet underwent sham or VSG surgery and radiotelemeter implantation. Sham mice were fed ad libitum or were food restricted to match their body mass to VSG-operated mice to determine the role of body mass in the ability of VSG to lower blood pressure. Blood pressure was then measured in freely moving unstressed mice by radiotelemetry. VSG decreased energy intake, body mass and fat mass. Mean arterial blood pressure (MAP) was reduced in VSG-operated mice compared with both sham-operated groups. VSG-induced reductions in MAP were accompanied by a body mass-independent decrease in hypothalamic ER stress, hypothalamic inflammation and sympathetic nervous system tone. Assessment of gut microbial populations revealed VSG-induced increases in the relative abundance of Gammaproteobacteria and Enterococcus, and decreases in Adlercreutzia. These results suggest that VSG reduces blood pressure, but this is only partly due to the reduction in body weight. VSG-induced reductions in blood pressure may be driven by a decrease in hypothalamic ER stress and inflammatory signaling, and shifts in gut microbial populations.
    Schlagwörter Vertical sleeve gastrectomy ; Hypertension ; ER stress ; Mouse model ; Medicine ; R ; Pathology ; RB1-214
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsdatum 2017-03-01T00:00:00Z
    Verlag The Company of Biologists
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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