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  1. Article ; Online: Author Correction

    Rebecka Svanberg / Cameron MacPherson / Adrian Zucco / Rudi Agius / Tereza Faitova / Michael Asger Andersen / Caspar da Cunha-Bang / Lars Klingen Gjærde / Maria Elizabeth Engel Møller / Patrick Terrence Brooks / Birgitte Lindegaard / Adin Sejdic / Zitta Barrella Harboe / Anne Ortved Gang / Ditte Stampe Hersby / Christian Brieghel / Susanne Dam Nielsen / Daria Podlekareva / Annemette Hald /
    Jakob Thaning Bay / Hanne Marquart / Jens Lundgren / Anne-Mette Lebech / Marie Helleberg / Carsten Utoft Niemann / Sisse Rye Ostrowski

    Communications Medicine, Vol 3, Iss 1, Pp 1-

    Early stimulated immune responses predict clinical disease severity in hospitalized COVID-19 patients

    2023  Volume 2

    Keywords Medicine ; R
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Real world data on young patients with high-risk diffuse large B-cell lymphoma treated with R-CHOP or R-CHOEP - MYC, BCL2 and BCL6 as prognostic biomarkers.

    Mette Ølgod Pedersen / Anne Ortved Gang / Peter Brown / Michael Pedersen / Helle Knudsen / Signe Ledou Nielsen / Tim Poulsen / Tobias Wirenfeldt Klausen / Estrid Høgdall / Peter Nørgaard

    PLoS ONE, Vol 12, Iss 10, p e

    2017  Volume 0186983

    Abstract: Double expression of MYC and BCL2 proteins (DE) and double-hit MYC+BCL2/BCL6 translocations (DH) were established as important biomarkers in patients with diffuse large B-cell lymphoma (DLBCL) by the 2016 revision of the World Health Organization ... ...

    Abstract Double expression of MYC and BCL2 proteins (DE) and double-hit MYC+BCL2/BCL6 translocations (DH) were established as important biomarkers in patients with diffuse large B-cell lymphoma (DLBCL) by the 2016 revision of the World Health Organization classification of lymphoid neoplasms. Whether this applies to the subgroup of young patients with high risk DLBCL is not known. We previously found that in a uniform retrospective population-based cohort of patients aged 18-60 years with high-risk DLBCL, the addition of etoposide to R-CHOP chemotherapy (R-CHOEP) resulted in improved survival mainly in patients with germinal center B-cell like (GCB) immunophenotype. The aim of this study was to investigate the prognostic and predictive value of DE and DH in this patient cohort.Data on all young Danish patients diagnosed with de novo high-risk DLBCL 2004-2008 and treated with R-CHOP or R-CHOEP were obtained from the Danish Lymphoma database (n = 159). Tumor samples were available from 103 patients. MYC and BCL2 proteins were analyzed with quantitative immunohistochemistry (IHC) using different cut off values. MYC-, BCL2- and BCL6-translocations were examined with fluorescent in situ hybridization (FISH).DE with MYC>75% and BCL2>85% was an independent negative prognostic marker of progression free survival (PFS) in patients treated with R-CHOP but not R-CHOEP (p<0.001), also after exclusion of patients with DH. A predictive effect of DE for response (PFS) to R-CHOEP vs. R-CHOP was almost significant (p = 0.07). DH was not prognostic in this patient cohort.In young patients with high-risk DLBCL, treatment with R-CHOEP may overcome the negative prognostic impact of DE observed in patients treated with R-CHOP.
    Keywords Medicine ; R ; Science ; Q
    Subject code 616
    Language English
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Human endogenous retroviruses form a reservoir of T cell targets in hematological cancers

    Sunil Kumar Saini / Andreas Due Ørskov / Anne-Mette Bjerregaard / Ashwin Unnikrishnan / Staffan Holmberg-Thydén / Annie Borch / Kathrine Valentini Jensen / Govardhan Anande / Amalie Kai Bentzen / Andrea Marion Marquard / Tripti Tamhane / Marianne Bach Treppendahl / Anne Ortved Gang / Inge Høgh Dufva / Zoltan Szallasi / Nicola Ternette / Anders Gorm Pedersen / Aron Charles Eklund / John Pimanda /
    Kirsten Grønbæk / Sine Reker Hadrup

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 14

    Abstract: Human endogenous retroviruses (HERV) normally remain quiescent, but can be reactivated by malignant transformation. Here the authors find, via HERV peptide library testing and tetramer validation, more profound HERV transcription and associated T cell ... ...

    Abstract Human endogenous retroviruses (HERV) normally remain quiescent, but can be reactivated by malignant transformation. Here the authors find, via HERV peptide library testing and tetramer validation, more profound HERV transcription and associated T cell recognition in myeloid cancer patients to implicate HERVs as potential therapeutic targets.
    Keywords Science ; Q
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Human endogenous retroviruses form a reservoir of T cell targets in hematological cancers

    Sunil Kumar Saini / Andreas Due Ørskov / Anne-Mette Bjerregaard / Ashwin Unnikrishnan / Staffan Holmberg-Thydén / Annie Borch / Kathrine Valentini Jensen / Govardhan Anande / Amalie Kai Bentzen / Andrea Marion Marquard / Tripti Tamhane / Marianne Bach Treppendahl / Anne Ortved Gang / Inge Høgh Dufva / Zoltan Szallasi / Nicola Ternette / Anders Gorm Pedersen / Aron Charles Eklund / John Pimanda /
    Kirsten Grønbæk / Sine Reker Hadrup

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 14

    Abstract: Human endogenous retroviruses (HERV) normally remain quiescent, but can be reactivated by malignant transformation. Here the authors find, via HERV peptide library testing and tetramer validation, more profound HERV transcription and associated T cell ... ...

    Abstract Human endogenous retroviruses (HERV) normally remain quiescent, but can be reactivated by malignant transformation. Here the authors find, via HERV peptide library testing and tetramer validation, more profound HERV transcription and associated T cell recognition in myeloid cancer patients to implicate HERVs as potential therapeutic targets.
    Keywords Science ; Q
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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