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  1. AU="Annette M. Jackson"
  2. AU="Maeshibu, Takako"
  3. AU=Soresina Annarosa AU=Soresina Annarosa
  4. AU=Torke Alexia M
  5. AU=Sun Chuan-Bin
  6. AU="Krystal, Mark R"
  7. AU="Jiang, Yuandong"
  8. AU=Daly Roger J
  9. AU="Sorenson, Michael D"
  10. AU="Ruiqiang Li"
  11. AU="Marini, Davide"
  12. AU="Tirabassi, Jill N"
  13. AU="Song, Seok-Hwan"
  14. AU="A. Hakeem Anwer"
  15. AU="O'Connell, Jeff R"
  16. AU="Elizabeth C. Saunders"
  17. AU="Pratima Verma"
  18. AU="Nomaguchi, Masako"
  19. AU="Hutson, Alan D"
  20. AU="Jarvis, Deborah"
  21. AU="Yilmaz, Sevdican Ustun"
  22. AU="Kreisel, Wolfgang"
  23. AU="Tracy R. Nichols, Ph.D."
  24. AU="Hellal, Faycel"
  25. AU="Steffen Koschmieder"
  26. AU="Hsin-Hui Yu"
  27. AU="Watanabe, Sadanori"
  28. AU="Swarts, Benjamin M"
  29. AU="Zang, Trinity"
  30. AU="Almayahi, Basim A"
  31. AU="Lupke, Madeleine"
  32. AU="Tweed, Conor"

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  1. Artikel ; Online: A cell-based multiplex immunoassay platform using fluorescent protein-barcoded reporter cell lines

    Shengli Song / Miriam Manook / Jean Kwun / Annette M. Jackson / Stuart J. Knechtle / Garnett Kelsoe

    Communications Biology, Vol 4, Iss 1, Pp 1-

    2021  Band 9

    Abstract: Song et al. describe an immunoassay method, which is a multiplex, fluorescence-barcoded cell lines system that enables high-throughput screening of antibodies binding to large number of protein variants in a single-tube manner. They demonstrate the ... ...

    Abstract Song et al. describe an immunoassay method, which is a multiplex, fluorescence-barcoded cell lines system that enables high-throughput screening of antibodies binding to large number of protein variants in a single-tube manner. They demonstrate the utility of this tool by assessing binding of different antibodies to a panel of influenza hemagglutinin antigens and to epitope/domain map CCR2 and CCR5 antibodies.
    Schlagwörter Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2021-11-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Transcriptional responses define dysregulated immune activation in Hepatitis C (HCV)-naïve recipients of HCV-infected donor kidneys

    Julie M. Steinbrink / Cameron Miller / Rachel A. Myers / Scott Sanoff / Anna Mazur / Thomas W. Burke / Jennifer Byrns / Annette M. Jackson / Xunrong Luo / Micah T. McClain

    PLoS ONE, Vol 18, Iss

    2023  Band 1

    Abstract: Renal transplantation from hepatitis C (HCV) nucleic acid amplification test-positive (NAAT-positive) donors to uninfected recipients has greatly increased the organ donation pool. However, there is concern for adverse outcomes in these recipients due to ...

    Abstract Renal transplantation from hepatitis C (HCV) nucleic acid amplification test-positive (NAAT-positive) donors to uninfected recipients has greatly increased the organ donation pool. However, there is concern for adverse outcomes in these recipients due to dysregulated immunologic activation secondary to active inflammation from acute viremia at the time of transplantation. This includes increased rates of cytomegalovirus (CMV) DNAemia and allograft rejection. In this study, we evaluate transcriptional responses in circulating leukocytes to define the character, timing, and resolution of this immune dysregulation and assess for biomarkers of adverse outcomes in transplant patients. We enrolled 67 renal transplant recipients (30 controls, 37 HCV recipients) and performed RNA sequencing on serial samples from one, 3-, and 6-months post-transplant. CMV DNAemia and allograft rejection outcomes were measured. Least absolute shrinkage and selection operator was utilized to develop gene expression classifiers predictive of clinical outcomes. Acute HCV incited a marked transcriptomic response in circulating leukocytes of renal transplant recipients in the acute post-transplant setting, despite the presence of immunosuppression, with 109 genes significantly differentially expressed compared to controls. These HCV infection-associated genes were reflective of antiviral immune pathways and generally resolved by the 3-month timepoint after sustained viral response (SVR) for HCV. Differential gene expression was also noted from patients who developed CMV DNAemia or allograft rejection compared to those who did not, although transcriptomic classifiers could not accurately predict these outcomes, likely due to sample size and variable time-to-event. Acute HCV infection incites evidence of immune activation and canonical antiviral responses in the human host even in the presence of systemic immunosuppression. After treatment of HCV with antiviral therapy and subsequent aviremia, this immune activation resolves. Changes in gene ...
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Transcriptional responses define dysregulated immune activation in Hepatitis C (HCV)-naïve recipients of HCV-infected donor kidneys.

    Julie M Steinbrink / Cameron Miller / Rachel A Myers / Scott Sanoff / Anna Mazur / Thomas W Burke / Jennifer Byrns / Annette M Jackson / Xunrong Luo / Micah T McClain

    PLoS ONE, Vol 18, Iss 1, p e

    2023  Band 0280602

    Abstract: Renal transplantation from hepatitis C (HCV) nucleic acid amplification test-positive (NAAT-positive) donors to uninfected recipients has greatly increased the organ donation pool. However, there is concern for adverse outcomes in these recipients due to ...

    Abstract Renal transplantation from hepatitis C (HCV) nucleic acid amplification test-positive (NAAT-positive) donors to uninfected recipients has greatly increased the organ donation pool. However, there is concern for adverse outcomes in these recipients due to dysregulated immunologic activation secondary to active inflammation from acute viremia at the time of transplantation. This includes increased rates of cytomegalovirus (CMV) DNAemia and allograft rejection. In this study, we evaluate transcriptional responses in circulating leukocytes to define the character, timing, and resolution of this immune dysregulation and assess for biomarkers of adverse outcomes in transplant patients. We enrolled 67 renal transplant recipients (30 controls, 37 HCV recipients) and performed RNA sequencing on serial samples from one, 3-, and 6-months post-transplant. CMV DNAemia and allograft rejection outcomes were measured. Least absolute shrinkage and selection operator was utilized to develop gene expression classifiers predictive of clinical outcomes. Acute HCV incited a marked transcriptomic response in circulating leukocytes of renal transplant recipients in the acute post-transplant setting, despite the presence of immunosuppression, with 109 genes significantly differentially expressed compared to controls. These HCV infection-associated genes were reflective of antiviral immune pathways and generally resolved by the 3-month timepoint after sustained viral response (SVR) for HCV. Differential gene expression was also noted from patients who developed CMV DNAemia or allograft rejection compared to those who did not, although transcriptomic classifiers could not accurately predict these outcomes, likely due to sample size and variable time-to-event. Acute HCV infection incites evidence of immune activation and canonical antiviral responses in the human host even in the presence of systemic immunosuppression. After treatment of HCV with antiviral therapy and subsequent aviremia, this immune activation resolves. Changes in gene ...
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Complement-activating donor-specific anti-HLA antibodies and solid organ transplant survival

    Antoine Bouquegneau / Charlotte Loheac / Olivier Aubert / Yassine Bouatou / Denis Viglietti / Jean-Philippe Empana / Camilo Ulloa / Mohammad Hassan Murad / Christophe Legendre / Denis Glotz / Annette M Jackson / Adriana Zeevi / Stephan Schaub / Jean-Luc Taupin / Elaine F Reed / John J Friedewald / Dolly B Tyan / Caner Süsal / Ron Shapiro /
    E Steve Woodle / Luis G Hidalgo / Jacqueline O'Leary / Robert A Montgomery / Jon Kobashigawa / Xavier Jouven / Patricia Jabre / Carmen Lefaucheur / Alexandre Loupy

    PLoS Medicine, Vol 15, Iss 5, p e

    A systematic review and meta-analysis.

    2018  Band 1002572

    Abstract: BACKGROUND:Anti-human leukocyte antigen donor-specific antibodies (anti-HLA DSAs) are recognized as a major barrier to patients' access to organ transplantation and the major cause of graft failure. The capacity of circulating anti-HLA DSAs to activate ... ...

    Abstract BACKGROUND:Anti-human leukocyte antigen donor-specific antibodies (anti-HLA DSAs) are recognized as a major barrier to patients' access to organ transplantation and the major cause of graft failure. The capacity of circulating anti-HLA DSAs to activate complement has been suggested as a potential biomarker for optimizing graft allocation and improving the rate of successful transplantations. METHODS AND FINDINGS:To address the clinical relevance of complement-activating anti-HLA DSAs across all solid organ transplant patients, we performed a meta-analysis of their association with transplant outcome through a systematic review, from inception to January 31, 2018. The primary outcome was allograft loss, and the secondary outcome was allograft rejection. A comprehensive search strategy was conducted through several databases (Medline, Embase, Cochrane, and Scopus). A total of 5,861 eligible citations were identified. A total of 37 studies were included in the meta-analysis. Studies reported on 7,936 patients, including kidney (n = 5,991), liver (n = 1,459), heart (n = 370), and lung recipients (n = 116). Solid organ transplant recipients with circulating complement-activating anti-HLA DSAs experienced an increased risk of allograft loss (pooled HR 3.09; 95% CI 2.55-3.74, P = 0.001; I2 = 29.3%), and allograft rejection (pooled HR 3.75; 95% CI: 2.05-6.87, P = 0.001; I2 = 69.8%) compared to patients without complement-activating anti-HLA DSAs. The association between circulating complement-activating anti-HLA DSAs and allograft failure was consistent across all subgroups and sensitivity analyses. Limitations of the study are the observational and retrospective design of almost all included studies, the higher proportion of kidney recipients compared to other solid organ transplant recipients, and the inclusion of fewer studies investigating allograft rejection. CONCLUSIONS:In this study, we found that circulating complement-activating anti-HLA DSAs had a significant deleterious impact on solid organ transplant ...
    Schlagwörter Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2018-05-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Correction

    Antoine Bouquegneau / Charlotte Loheac / Olivier Aubert / Yassine Bouatou / Denis Viglietti / Jean-Philippe Empana / Camilo Ulloa / Mohammad Hassan Murad / Christophe Legendre / Denis Glotz / Annette M Jackson / Adriana Zeevi / Stephan Schaub / Jean-Luc Taupin / Elaine F Reed / John J Friedewald / Dolly B Tyan / Caner Süsal / Ron Shapiro /
    E Steve Woodle / Luis G Hidalgo / Jacqueline O'Leary / Robert A Montgomery / Jon Kobashigawa / Xavier Jouven / Patricia Jabre / Carmen Lefaucheur / Alexandre Loupy

    PLoS Medicine, Vol 15, Iss 7, p e

    Complement-activating donor-specific anti-HLA antibodies and solid organ transplant survival: A systematic review and meta-analysis.

    2018  Band 1002637

    Abstract: This corrects the article DOI:10.1371/journal.pmed.1002572.]. ...

    Abstract [This corrects the article DOI:10.1371/journal.pmed.1002572.].
    Schlagwörter Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2018-07-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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