LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 2 of total 2

Search options

  1. Article ; Online: Hitting the Road towards a Greater Digital Destination

    Annie Wu / Santi Thompson / Rachel Vacek / Sean Watkins / Andy Weidner

    Information Technology and Libraries, Vol 35, Iss 2, Pp 5-

    Evaluating and Testing DAMS at the University of Houston Libraries

    2016  Volume 18

    Abstract: Since 2009, tens of thousands of rare and unique items have been made available online for research through the University of Houston Digital Library. Six years later, the Libraries' new digital initiatives call for a more dynamic digital repository ... ...

    Abstract Since 2009, tens of thousands of rare and unique items have been made available online for research through the University of Houston Digital Library. Six years later, the Libraries' new digital initiatives call for a more dynamic digital repository infrastructure that is extensible, scalable, and interoperable. The Libraries’ mission and the mandate of its strategic directions drives the pursuit of seamless access and expanded digital collections. To answer the calls for technological change, the Libraries Administration appointed a Digital Asset Management System (DAMS) Implementation Task Force to explore, evaluate, test, recommend, and implement a more robust digital asset management system. This article focuses on the task force’s DAMS selection activities: needs assessment, systems evaluation, and systems testing. The authors also describe the task force’s DAMS recommendation based on the evaluation and testing data analysis, a comparison of the advantages and disadvantages of each system, and system cost. Finally, the authors outline their DAMS implementation strategy comprised of a phased rollout with the following stages: system installation, data migration, and interface development.
    Keywords Bibliography. Library science. Information resources ; Z
    Subject code 028
    Language English
    Publishing date 2016-06-01T00:00:00Z
    Publisher American Library Association
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Secreted ORF8 induces monocytic pro-inflammatory cytokines through NLRP3 pathways in patients with severe COVID-19

    Xiaosheng Wu / Michelle K. Manske / Gordon J. Ruan / Taylor L. Witter / Kevin E. Nowakowski / Jithma P. Abeykoon / Xinyi Tang / Yue Yu / Kimberly A. Gwin / Annie Wu / Vanessa Taupin / Vaishali Bhardwaj / Jonas Paludo / Surendra Dasari / Haidong Dong / Stephen M. Ansell / Andrew D. Badley / Matthew J. Schellenberg / Thomas E. Witzig

    iScience, Vol 26, Iss 6, Pp 106929- (2023)

    2023  

    Abstract: Summary: Despite extensive research, the specific factor associated with SARS-CoV-2 infection that mediates the life-threatening inflammatory cytokine response in patients with severe COVID-19 remains unidentified. Herein we demonstrate that the virus- ... ...

    Abstract Summary: Despite extensive research, the specific factor associated with SARS-CoV-2 infection that mediates the life-threatening inflammatory cytokine response in patients with severe COVID-19 remains unidentified. Herein we demonstrate that the virus-encoded Open Reading Frame 8 (ORF8) protein is abundantly secreted as a glycoprotein in vitro and in symptomatic patients with COVID-19. ORF8 specifically binds to the NOD-like receptor family pyrin domain-containing 3 (NLRP3) in CD14+ monocytes to induce inflammasomal cytokine/chemokine responses including IL1β, IL8, and CCL2. Levels of ORF8 protein in the blood correlate with severity and disease-specific mortality in patients with acute SARS-CoV-2 infection. Furthermore, the ORF8-induced inflammasome response was readily inhibited by the NLRP3 inhibitor MCC950 in vitro. Our study identifies a dominant cause of pathogenesis, its underlying mechanism, and a potential new treatment strategy for severe COVID-19.
    Keywords Immunity ; Virology ; Science ; Q
    Subject code 616 ; 610
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top