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Article ; Online: Response to: 'Autoinflammatory disease damage index (ADDI): a possible newborn also in hidradenitis suppurativa daily practice' by Damiani

Annink, Kim V / Ter Haar, Nienke M / Frenkel, Joost

2017 Volume 76, Issue 8, Page(s) e26

MeSH term(s)	Hidradenitis Suppurativa ; Humans
Language	English
Publishing date	2017-01-02
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	7090-7
ISSN	1468-2060 ; 0003-4967
ISSN (online)	1468-2060
ISSN	0003-4967
DOI	10.1136/annrheumdis-2016-210918
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Zs.MO 167: Show issues

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Article: Pathophysiology of Cerebral Hyperperfusion in Term Neonates With Hypoxic-Ischemic Encephalopathy: A Systematic Review for Future Research.

Kleuskens, Dianne G / Gonçalves Costa, Filipe / Annink, Kim V / van den Hoogen, Agnes / Alderliesten, Thomas / Groenendaal, Floris / Benders, Manon J N / Dudink, Jeroen

Frontiers in pediatrics

2021 Volume 9, Page(s) 631258

Abstract: Worldwide neonatal hypoxic-ischemic encephalopathy (HIE) is a common cause of mortality and neurologic disability, despite the implementation of therapeutic hypothermia treatment. Advances toward new neuroprotective interventions have been limited by ... ...

Abstract	Worldwide neonatal hypoxic-ischemic encephalopathy (HIE) is a common cause of mortality and neurologic disability, despite the implementation of therapeutic hypothermia treatment. Advances toward new neuroprotective interventions have been limited by incomplete knowledge about secondary injurious processes such as cerebral hyperperfusion commonly observed during the first 1-5 days after asphyxia. Cerebral hyperperfusion is correlated with adverse neurodevelopmental outcome and it is a process that remains poorly understood. In order to provide an overview of the existing knowledge on the pathophysiology and highlight the gaps in current understanding of cerebral hyperperfusion in term animals and neonates with HIE, we performed a systematic research. We included papers scoping for study design, population, number of participants, study technique and relevant findings. Methodological quality was assessed using the checklist for cohort studies from The Joanna Briggs Institute. Out of 2,690 results, 34 studies were included in the final review-all prospective cohort studies. There were 14 studies of high, 17 moderate and 3 of low methodological quality. Data from the literature were analyzed in two main subjects: (1) Hemodynamic Changes subdivided into macro- and microscopic hemodynamic changes, and (2) Endogenous Pathways which was subdivided into N-methyl-D-aspartate/Mitogen activated protein kinase (NDMA/MAPK), Nitric Oxide (NO), prostanoids and other endogenous studies. Cerebral hyperperfusion in term neonates with HIE was found to be present 10-30 min after the hypoxic-ischemic event and was still present around day 10 and up to 1 month after birth. Cerebral hyperperfusion was also characterized by angiogenesis and cerebral vasodilation. Additionally, cerebral vasodilation was mediated by endogenous pathways such as MAPK through urokinase Plasminogen Activator (uPA), by neuronal NO synthase following NMDA and by prostanoid synthesis. Future research should elucidate the precise role of NMDA, MAPK and prostanoids in cerebral hyperperfusion. Moreover, research should focus on possible interventions and the effect of hypothermia on hyperperfusion. These findings should be taken into account simultaneously with brain imagining techniques, becoming a valuable asset in assessing the impact in neurodevelopmental outcome.
Language	English
Publishing date	2021-02-02
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2021.631258
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Article ; Online: The development and validation of a cerebral ultrasound scoring system for infants with hypoxic-ischaemic encephalopathy.

Annink, Kim V / de Vries, Linda S / Groenendaal, Floris / Vijlbrief, Daniel C / Weeke, Lauren C / Roehr, Charles C / Lequin, Maarten / Reiss, Irwin / Govaert, Paul / Benders, Manon J N L / Dudink, Jeroen

Pediatric research

2020 Volume 87, Issue Suppl 1, Page(s) 59–66

Abstract: Background: Hypoxic-ischaemic encephalopathy (HIE) is an important cause of morbidity and mortality in neonates. When the gold standard MRI is not feasible, cerebral ultrasound (CUS) might offer an alternative. In this study, the association between a ... ...

Abstract	Background: Hypoxic-ischaemic encephalopathy (HIE) is an important cause of morbidity and mortality in neonates. When the gold standard MRI is not feasible, cerebral ultrasound (CUS) might offer an alternative. In this study, the association between a novel CUS scoring system and neurodevelopmental outcome in neonates with HIE was assessed. Methods: (Near-)term infants with HIE and therapeutic hypothermia, a CUS on day 1 and day 3-7 after birth and available outcome data were retrospectively included in cohort I. CUS findings on day 1 and day 3-7 were related to adverse outcome in univariate and the CUS of day 3-7 also in multivariable logistic regression analyses. The resistance index, the sum of deep grey matter and of white matter involvement were included in multivariable logistic regression analyses. A comparable cohort from another hospital was used for validation (cohort II). Results: Eighty-three infants were included in cohort I and 35 in cohort II. The final CUS scoring system contained the sum of white matter (OR = 2.6, 95% CI 1.5-4.7) and deep grey matter involvement (OR = 2.7, 95% CI 1.7-4.4). The CUS scoring system performed well in cohort I (AUC = 0.90) and II (AUC = 0.89). Conclusion: This validated CUS scoring system is associated with neurodevelopmental outcome in neonates with HIE.
MeSH term(s)	Area Under Curve ; Brain/diagnostic imaging ; Echoencephalography/methods ; Female ; Humans ; Hypothermia, Induced/methods ; Hypoxia-Ischemia, Brain/diagnostic imaging ; Infant, Newborn ; Infant, Premature ; Magnetic Resonance Imaging ; Male ; Multivariate Analysis ; Neonatology/methods ; Neonatology/standards ; Reproducibility of Results ; Retrospective Studies ; Severity of Illness Index
Language	English
Publishing date	2020-03-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	4411-8
ISSN	1530-0447 ; 0031-3998
ISSN (online)	1530-0447
ISSN	0031-3998
DOI	10.1038/s41390-020-0782-0
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Zs.A 564: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Cerebellar injury in term neonates with hypoxic-ischemic encephalopathy is underestimated.

Annink, Kim V / Meerts, Lilly / van der Aa, Niek E / Alderliesten, Thomas / Nikkels, Peter G J / Nijboer, Cora H A / Groenendaal, Floris / de Vries, Linda S / Benders, Manon J N L / Hoebeek, Freek E / Dudink, Jeroen

Pediatric research

2020 Volume 89, Issue 5, Page(s) 1171–1178

Abstract: Background: Postmortem examinations frequently show cerebellar injury in infants with severe hypoxic-ischemic encephalopathy (HIE), while it is less well visible on MRI. The primary aim was to investigate the correlation between cerebellar apparent ... ...

Abstract	Background: Postmortem examinations frequently show cerebellar injury in infants with severe hypoxic-ischemic encephalopathy (HIE), while it is less well visible on MRI. The primary aim was to investigate the correlation between cerebellar apparent diffusion coefficient (ADC) values and histopathology in infants with HIE. The secondary aim was to compare ADC values in the cerebellum of infants with HIE and infants without brain injury. Methods: ADC values in the cerebellar vermis, hemispheres and dentate nucleus (DN) of (near-)term infants with HIE (n = 33) within the first week after birth were compared with neonates with congenital non-cardiac anomalies, normal postoperative MRIs and normal outcome (n = 22). Microglia/macrophage activation was assessed using CD68 and/or HLA-DR staining and Purkinje cell (PC) injury using H&E-stained slices. The correlation between ADC values and the histopathological measures was analyzed. Results: ADC values in the vermis (p = 0.021) and DN (p < 0.001) were significantly lower in infants with HIE compared to controls. ADC values in the cerebellar hemispheres were comparable. ADC values in the vermis were correlated with the number and percentage of normal PCs; otherwise ADC values and histology were not correlated. Conclusion: Histopathological injury in the cerebellum is common in infants with HIE. ADC values underestimate histopathological injury. Impact: ADC values might underestimate cerebellar injury in neonates with HIE. ADC values in the vermis and dentate nucleus of infants with HIE are lower compared to controls, but not in the cerebellar hemispheres. Abnormal ADC values are only found when cytotoxic edema is very severe. ADC values in the vermis are correlated with Purkinje cell injury in the vermis; furthermore, there were no correlations between ADC values and histopathological measures.
MeSH term(s)	Cerebellum/pathology ; Female ; Humans ; Hypoxia-Ischemia, Brain/diagnostic imaging ; Hypoxia-Ischemia, Brain/pathology ; Infant, Newborn ; Infant, Newborn, Diseases/diagnostic imaging ; Infant, Newborn, Diseases/pathology ; Magnetic Resonance Imaging ; Male ; Retrospective Studies
Language	English
Publishing date	2020-09-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	4411-8
ISSN	1530-0447 ; 0031-3998
ISSN (online)	1530-0447
ISSN	0031-3998
DOI	10.1038/s41390-020-01173-z
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Zs.A 564: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 373: Show issues

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Article ; Online: Brain temperature of infants with neonatal encephalopathy following perinatal asphyxia calculated using magnetic resonance spectroscopy.

Annink, Kim V / Groenendaal, Floris / Cohen, Daan / van der Aa, Niek E / Alderliesten, Thomas / Dudink, Jeroen / Benders, Manon J N L / Wijnen, Jannie P

Pediatric research

2020 Volume 88, Issue 2, Page(s) 279–284

Abstract: Background: Little is known about brain temperature of neonates during MRI. Brain temperature can be estimated non-invasively with proton Magnetic Resonance Spectroscopy (: Methods: In this retrospective study, brain temperature in 36 (near-)term ... ...

Abstract	Background: Little is known about brain temperature of neonates during MRI. Brain temperature can be estimated non-invasively with proton Magnetic Resonance Spectroscopy ( Methods: In this retrospective study, brain temperature in 36 (near-)term infants with NE was estimated using short (36 ms) and long (288 ms) echo time (TE) Results: Brain temperatures calculated with the formula of Wu et al. and the calibrated formula were similar as well as brain temperatures derived from short and long TE Conclusions: Brain temperature can be measured using
MeSH term(s)	Asphyxia Neonatorum/complications ; Asphyxia Neonatorum/pathology ; Body Temperature ; Brain/pathology ; Brain Diseases/complications ; Brain Diseases/pathology ; Calibration ; Electronic Health Records ; Female ; Humans ; Hypoxia-Ischemia, Brain/pathology ; Infant, Newborn ; Intensive Care Units, Neonatal ; Intensive Care, Neonatal ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy/methods ; Male ; Phantoms, Imaging ; Proton Magnetic Resonance Spectroscopy ; Rectum ; Retrospective Studies ; Risk Factors ; Temperature
Language	English
Publishing date	2020-01-02
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	4411-8
ISSN	1530-0447 ; 0031-3998
ISSN (online)	1530-0447
ISSN	0031-3998
DOI	10.1038/s41390-019-0739-3
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Zs.A 564: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Mammillary body atrophy and other MRI correlates of school-age outcome following neonatal hypoxic-ischemic encephalopathy.

Annink, Kim V / de Vries, Linda S / Groenendaal, Floris / Eijsermans, Rian M J C / Mocking, Manouk / van Schooneveld, Monique M J / Dudink, Jeroen / van Straaten, Henrica L M / Benders, Manon J N L / Lequin, Maarten / van der Aa, Niek E

Scientific reports

2021 Volume 11, Issue 1, Page(s) 5017

Abstract: The mammillary bodies (MB) and hippocampi are important for memory function and are often affected following neonatal hypoxic ischemic encephalopathy (HIE). The aim of this study was to assess neurodevelopmental outcome in 10-year-old children with HIE ... ...

Abstract	The mammillary bodies (MB) and hippocampi are important for memory function and are often affected following neonatal hypoxic ischemic encephalopathy (HIE). The aim of this study was to assess neurodevelopmental outcome in 10-year-old children with HIE with and without therapeutic hypothermia. Additional aims were to assess the associations between MB atrophy, brain volumes (including the hippocampi), white matter microstructure and neurodevelopmental outcome at school-age. Ten-year-old children with HIE were included, who were treated with therapeutic hypothermia (n = 22) or would have qualified but were born before this became standard of care (n = 28). Children completed a neuropsychological and motor assessment and MRI. Mammillary bodies were scored as normal or atrophic at 10 years. Brain volumes were segmented on childhood MRI and DTI scans were analysed using tract-based spatial statistics. Children with HIE suffered from neurocognitive and memory problems at school-age, irrespective of hypothermia. Hippocampal volumes and MB atrophy were associated with total and performance IQ, processing speed and episodic memory in both groups. Normal MB and larger hippocampi were positively associated with global fractional anisotropy. In conclusion, injury to the MB and hippocampi was associated with neurocognition and memory at school-age in HIE and might be an early biomarker for neurocognitive and memory problems.
MeSH term(s)	Anisotropy ; Atrophy/diagnostic imaging ; Atrophy/pathology ; Atrophy/physiopathology ; Atrophy/prevention & control ; Child ; Diffusion Tensor Imaging ; Female ; Hippocampus/diagnostic imaging ; Hippocampus/pathology ; Hippocampus/physiopathology ; Humans ; Hypothermia, Induced/methods ; Hypoxia-Ischemia, Brain/diagnostic imaging ; Hypoxia-Ischemia, Brain/pathology ; Hypoxia-Ischemia, Brain/physiopathology ; Hypoxia-Ischemia, Brain/therapy ; Infant, Newborn ; Male ; Mammillary Bodies/diagnostic imaging ; Mammillary Bodies/pathology ; Mammillary Bodies/physiopathology ; Memory/physiology ; Netherlands ; Neuropsychological Tests ; Psychomotor Performance/physiology ; Retrospective Studies ; Schools ; Students ; White Matter/diagnostic imaging ; White Matter/pathology ; White Matter/physiopathology
Language	English
Publishing date	2021-03-03
Publishing country	England
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-83982-8
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Article ; Online: Glomerular Filtration Rate in Asphyxiated Neonates Under Therapeutic Whole-Body Hypothermia, Quantified by Mannitol Clearance.

Deferm, Neel / Annink, Kim V / Faelens, Ruben / Schroth, Michael / Maiwald, Christian A / Bakkali, Loubna El / van Bel, Frank / Benders, Manon J N L / van Weissenbruch, Mirjam M / Hagen, Anja / Smits, Anne / Annaert, Pieter / Franz, Axel R / Allegaert, Karel

Clinical pharmacokinetics

2021 Volume 60, Issue 7, Page(s) 897–906

Abstract: Background: Therapeutic hypothermia (TH) is an established intervention to improve the outcome of neonates with moderate-to-severe hypoxic-ischemic encephalopathy resulting from perinatal asphyxia. Despite this beneficial effect, TH may further affect ... ...

Abstract	Background: Therapeutic hypothermia (TH) is an established intervention to improve the outcome of neonates with moderate-to-severe hypoxic-ischemic encephalopathy resulting from perinatal asphyxia. Despite this beneficial effect, TH may further affect drug elimination pathways such as the glomerular filtration rate. Objectives: The objective of this study was to quantify the effect of TH in addition to asphyxia on mannitol clearance as a surrogate for the glomerular filtration rate. Methods: The effect of asphyxia and TH (mild vs moderate/severe) on mannitol clearance was assessed using a population approach, based on mannitol observations collected in the ALBINO (ALlopurinol in addition to TH for hypoxic-ischemic Brain Injury on Neurocognitive Outcome) trial, as some were exposed to a second dose of 10 mg/kg intravenous mannitol as placebo to ensure blinding. Pharmacokinetic analysis and model development were conducted using NONMEM version 7.4. Results: Based on 77 observations from 17 neonates (TH = 13), a one-compartment model with first-order linear elimination best described the observed data. To account for prenatal glomerular filtration rate maturation, both birthweight and gestational age were implemented as clearance covariates using an earlier published three-quarters power function and a sigmoid hyperbolic function. Our final model predicted a mannitol clearance of 0.15 L/h for a typical asphyxia neonate (39.5 weeks, birthweight 3.25 kg, no TH), lower than the reported value of 0.33 L/h for a healthy neonate of similar age and weight. By introducing TH as a binary covariate on clearance, the additional impact of TH on mannitol clearance was quantified (60% decrease). Conclusions: Mannitol clearance was decreased by approximately 60% in neonates undergoing TH, although this is likely confounded with asphyxia severity. Trial registration: ClinicalTrials.gov identifier NCT03162653.
MeSH term(s)	Asphyxia Neonatorum/therapy ; Female ; Glomerular Filtration Rate ; Humans ; Hypothermia ; Hypothermia, Induced ; Hypoxia-Ischemia, Brain/therapy ; Infant, Newborn ; Mannitol ; Pregnancy
Chemical Substances	Mannitol (3OWL53L36A)
Language	English
Publishing date	2021-02-21
Publishing country	Switzerland
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	197627-8
ISSN	1179-1926 ; 0312-5963
ISSN (online)	1179-1926
ISSN	0312-5963
DOI	10.1007/s40262-021-00991-6
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Article ; Online: Pharmacokinetic/Pharmacodynamic Modelling of Allopurinol, its Active Metabolite Oxypurinol, and Biomarkers Hypoxanthine, Xanthine and Uric Acid in Hypoxic-Ischemic Encephalopathy Neonates.

Chu, Wan-Yu / Annink, Kim V / Nijstad, A Laura / Maiwald, Christian A / Schroth, Michael / Bakkali, Loubna El / van Bel, Frank / Benders, Manon J N L / van Weissenbruch, Mirjam M / Hagen, Anja / Franz, Axel R / Dorlo, Thomas P C / Allegaert, Karel / Huitema, Alwin D R

Clinical pharmacokinetics

2021 Volume 61, Issue 2, Page(s) 321–333

Abstract: Background: Allopurinol, an xanthine oxidase (XO) inhibitor, is a promising intervention that may provide neuroprotection for neonates with hypoxic-ischemic encephalopathy (HIE). Currently, a double-blind, placebo-controlled study (ALBINO, NCT03162653) ... ...

Abstract	Background: Allopurinol, an xanthine oxidase (XO) inhibitor, is a promising intervention that may provide neuroprotection for neonates with hypoxic-ischemic encephalopathy (HIE). Currently, a double-blind, placebo-controlled study (ALBINO, NCT03162653) is investigating the neuroprotective effect of allopurinol in HIE neonates. Objective: The aim of the current study was to establish the pharmacokinetics (PK) of allopurinol and oxypurinol, and the pharmacodynamics (PD) of both compounds on hypoxanthine, xanthine, and uric acid in HIE neonates. The dosage used and the effect of allopurinol in this population, either or not undergoing therapeutic hypothermia (TH), were evaluated. Methods: Forty-six neonates from the ALBINO study and two historical clinical studies were included. All doses were administered on the first day of life. In the ALBINO study (n = 20), neonates received a first dose of allopurinol 20 mg/kg, and, in the case of TH (n = 13), a second dose of allopurinol 10 mg/kg. In the historical cohorts (n = 26), neonates (all without TH) received two doses of allopurinol 20 mg/kg in total. Allopurinol and oxypurinol population PK, and their effects on inhibiting conversions of hypoxanthine and xanthine to uric acid, were assessed using nonlinear mixed-effects modelling. Results: Allopurinol and oxypurinol PK were described by two sequential one-compartment models with an autoinhibition effect on allopurinol metabolism by oxypurinol. For allopurinol, clearance (CL) was 0.83 L/h (95% confidence interval [CI] 0.62-1.09) and volume of distribution (V Conclusion: The PK and PD of allopurinol, oxypurinol, hypoxanthine, xanthine, and uric acid in neonates with HIE were described. The dosing regimen applied in the ALBINO trial leads to the targeted XO inhibition in neonates treated with or without TH.
MeSH term(s)	Allopurinol/pharmacology ; Allopurinol/therapeutic use ; Biomarkers ; Enzyme Inhibitors ; Humans ; Hypoxanthine ; Hypoxia-Ischemia, Brain/drug therapy ; Infant, Newborn ; Oxypurinol/pharmacokinetics ; Uric Acid ; Xanthine ; Xanthine Oxidase
Chemical Substances	Biomarkers ; Enzyme Inhibitors ; Xanthine (1AVZ07U9S7) ; Uric Acid (268B43MJ25) ; Hypoxanthine (2TN51YD919) ; Allopurinol (63CZ7GJN5I) ; Xanthine Oxidase (EC 1.17.3.2) ; Oxypurinol (G97OZE5068)
Language	English
Publishing date	2021-10-07
Publishing country	Switzerland
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	197627-8
ISSN	1179-1926 ; 0312-5963
ISSN (online)	1179-1926
ISSN	0312-5963
DOI	10.1007/s40262-021-01068-0
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Article ; Online: Allopurinol: Old Drug, New Indication in Neonates?

Annink, Kim V / Franz, Axel R / Derks, Jan B / Rudiger, Mario / Bel, Frank van / Benders, Manon J N L

Current pharmaceutical design

2017 Volume 23, Issue 38, Page(s) 5935–5942

Abstract: Background: Hypoxic-ischemic encephalopathy (HIE) is an important cause of neonatal mortality and neurological morbidity, even despite hypothermia treatment. Neuronal damage in these infants is partly caused by the production of superoxides via the ... ...

Abstract	Background: Hypoxic-ischemic encephalopathy (HIE) is an important cause of neonatal mortality and neurological morbidity, even despite hypothermia treatment. Neuronal damage in these infants is partly caused by the production of superoxides via the xanthine-oxidase pathway and concomitant free radical formation. Allopurinol is a xanthine-oxidase inhibitor and can potentially reduce the formation of these superoxides that lead to brain damage in HIE. Methods: The aim of this review is to provide an overview of the animal and clinical data about the neuroprotective effect of allopurinol in HIE and the relevant mechanisms leading to brain injury in HIE. Results: A possible neuroprotective effect of allopurinol has been suggested based on several preclinical studies in rats, piglets and sheep. Allopurinol seemed to inhibit the formation of superoxide and to scavenge free radicals directly, but the effect on brain damage was inconclusive in these preclinical trials. The neuroprotective effect was also investigated in neonates with HIE. In three small studies, in which, allopurinol was administered postnatally and a pilot and one multi-center study, in which, allopurinol was administered antenatally, a possible beneficial effect was found. After combining the data of 2 postnatal allopurinol studies, long-term follow-up was only beneficial in infants with moderate HIE, therefore, large-scale studies are needed. Additionally, safety, pharmacokinetics and the neuroprotective effect of allopurinol in other neonatal populations are discussed in this review. Conclusion: The available literature is not conclusive whether allopurinol is a neuroprotective add-on therapy in infants with HIE. More research is needed to establish the neuroprotective effect of allopurinol especially in combination with hypothermia.
MeSH term(s)	Allopurinol/pharmacology ; Allopurinol/therapeutic use ; Animals ; Brain Injuries/diagnosis ; Brain Injuries/drug therapy ; Brain Injuries/metabolism ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/therapeutic use ; Free Radical Scavengers/pharmacology ; Free Radical Scavengers/therapeutic use ; Humans ; Hypoxia-Ischemia, Brain/diagnosis ; Hypoxia-Ischemia, Brain/drug therapy ; Hypoxia-Ischemia, Brain/metabolism ; Infant, Newborn ; Xanthine Oxidase/antagonists & inhibitors ; Xanthine Oxidase/metabolism
Chemical Substances	Enzyme Inhibitors ; Free Radical Scavengers ; Allopurinol (63CZ7GJN5I) ; Xanthine Oxidase (EC 1.17.3.2)
Language	English
Publishing date	2017-09-19
Publishing country	United Arab Emirates
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/1381612823666170918123307
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Article ; Online: The long-term effect of perinatal asphyxia on hippocampal volumes.

Annink, Kim V / de Vries, Linda S / Groenendaal, Floris / van den Heuvel, Martijn P / van Haren, Neeltje E M / Swaab, Hanna / van Handel, Mariëlle / Jongmans, Marian J / Benders, Manon J / van der Aa, Niek E

Pediatric research

2018 Volume 85, Issue 1, Page(s) 43–49

Abstract: Background: Hypoxic-ischemic encephalopathy (HIE) in term-born infants can lead to memory problems. The hippocampus is important for long-term episodic memory. The primary aim was to investigate the effect of HIE on hippocampal volumes in 9- to 10-year- ... ...

Abstract	Background: Hypoxic-ischemic encephalopathy (HIE) in term-born infants can lead to memory problems. The hippocampus is important for long-term episodic memory. The primary aim was to investigate the effect of HIE on hippocampal volumes in 9- to 10-year-old children. The secondary aim was to investigate the association between hippocampal volumes and previously found impaired memory and cognitive functions in the current cohort. Methods: In total 26 children with mild HIE, 26 with moderate HIE, and 37 controls were included. The intelligence quotient (IQ) and memory were tested. A 3D-volumetric MRI was obtained. Brain segmentation was performed for hippocampal volumes and intracranial volume. The differences in hippocampal volumes, memory, and IQ between the groups were determined. Multivariable linear regression analyses were performed, including hippocampal volume as a percentage of intracranial volume as a dependent variable. Results: Smaller hippocampal volumes were found in moderate HIE (p < 0.001), with a trend toward smaller volumes in mild HIE, compared to controls. In multivariable linear regression analysis, hippocampal volume as a percentage of intracranial volume was significantly associated with long-term visuospatial memory. Conclusion: Children with moderate HIE had smaller hippocampal volumes than controls, with a trend toward smaller volumes following mild HIE. Reduced hippocampal volumes were associated with poorer long-term visuospatial memory.
MeSH term(s)	Age Factors ; Case-Control Studies ; Child ; Child Behavior ; Child Development ; Cognition ; Female ; Hippocampus/diagnostic imaging ; Hippocampus/growth & development ; Humans ; Hypoxia-Ischemia, Brain/complications ; Hypoxia-Ischemia, Brain/diagnostic imaging ; Hypoxia-Ischemia, Brain/physiopathology ; Hypoxia-Ischemia, Brain/psychology ; Intelligence Tests ; Magnetic Resonance Imaging ; Male ; Memory ; Memory Disorders/diagnosis ; Memory Disorders/etiology ; Memory Disorders/psychology ; Predictive Value of Tests ; Time Factors
Language	English
Publishing date	2018-07-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	4411-8
ISSN	1530-0447 ; 0031-3998
ISSN (online)	1530-0447
ISSN	0031-3998
DOI	10.1038/s41390-018-0115-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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