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  1. Article ; Online: Hypercontractile esophagus resolved after radiofrequency catheter ablation for atrial fibrillation: About a case.

    Anon, Benjamin / Aubourg, Alexandre / Moussata, Driffa / Babuty, Dominique / Picon, Laurence

    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society

    2020  Volume 32, Issue 11, Page(s) e13886

    Abstract: The pathophysiology of jackhammer esophagus is complex and remains unclear. Radiofrequency catheter ablation is indicated for highly symptomatic and drug-refractory atrial fibrillation. This technique can induce esophageal and nerve lesions, due to ... ...

    Abstract The pathophysiology of jackhammer esophagus is complex and remains unclear. Radiofrequency catheter ablation is indicated for highly symptomatic and drug-refractory atrial fibrillation. This technique can induce esophageal and nerve lesions, due to thermal injury. In this report, we describe a case of hypercontractile esophagus diagnosed by HRM (high-resolution manometry). Esophageal symptoms and HRM normalized immediately after RFCA, and we discuss the pathophysiology of hypercontractile esophagus.
    MeSH term(s) Aged ; Atrial Fibrillation/complications ; Atrial Fibrillation/surgery ; Catheter Ablation/methods ; Deglutition Disorders/physiopathology ; Esophageal Motility Disorders/complications ; Esophageal Motility Disorders/physiopathology ; Humans ; Male ; Manometry ; Muscle Contraction/physiology ; Myenteric Plexus/physiopathology ; Stomach Ulcer/surgery ; Treatment Outcome ; Vagotomy
    Language English
    Publishing date 2020-06-01
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1186328-6
    ISSN 1365-2982 ; 1350-1925
    ISSN (online) 1365-2982
    ISSN 1350-1925
    DOI 10.1111/nmo.13886
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2979: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Acute fatty liver of pregnancy simulating liver tumor.

    Anon, Benjamin / Scotto, Béatrice / Bacq, Yannick

    Clinical case reports

    2017  Volume 6, Issue 1, Page(s) 230–231

    Abstract: Acute fatty liver of pregnancy (AFLP) is a rare liver disease unique to pregnancy that can lead to acute liver failure. Clinicians must have a high index of suspicion for AFLP because only early diagnosis and prompt delivery improve maternal and fetal ... ...

    Abstract Acute fatty liver of pregnancy (AFLP) is a rare liver disease unique to pregnancy that can lead to acute liver failure. Clinicians must have a high index of suspicion for AFLP because only early diagnosis and prompt delivery improve maternal and fetal prognosis.
    Language English
    Publishing date 2017-11-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.1293
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  3. Article ; Online: Pectoralis major muscle atrophy is associated with mitochondrial energy wasting in cachectic patients with gastrointestinal cancer.

    Dolly, Adeline / Lecomte, Thierry / Tabchouri, Nicolas / Caulet, Morgane / Michot, Nicolas / Anon, Benjamin / Chautard, Romain / Desvignes, Yoann / Ouaissi, Mehdi / Fromont-Hankard, Gaëlle / Dumas, Jean-François / Servais, Stéphane

    Journal of cachexia, sarcopenia and muscle

    2022  Volume 13, Issue 3, Page(s) 1837–1849

    Abstract: Background: Cancer cachexia is a multifactorial syndrome characterized by involuntary and pathological weight loss, mainly due to skeletal muscle wasting, resulting in a decrease in patients' quality of life, response to cancer treatments, and survival. ...

    Abstract Background: Cancer cachexia is a multifactorial syndrome characterized by involuntary and pathological weight loss, mainly due to skeletal muscle wasting, resulting in a decrease in patients' quality of life, response to cancer treatments, and survival. Our objective was to investigate skeletal muscle alterations in cachectic cancer patients.
    Methods: This is a prospective study of patients managed for pancreatic or colorectal cancer with an indication for systemic chemotherapy (METERMUCADIG - NCT02573974). One lumbar CT image was used to determine body composition. Patients were divided into three groups [8 noncachectic (NC), 18 with mild cachexia (MC), and 19 with severe cachexia (SC)] based on the severity of weight loss and muscle mass. For each patient, a pectoralis major muscle biopsy was collected at the time of implantable chamber placement. We used high-resolution oxygraphy to measure mitochondrial muscle oxygen consumption on permeabilized muscle fibres. We also performed optical and electron microscopy analyses, as well as gene and protein expression analyses.
    Results: Forty-five patients were included. Patients were 67% male, aged 67 years (interquartile range, 59-77). Twenty-three (51%) and 22 (49%) patients were managed for pancreatic and colorectal cancer, respectively. Our results show a positive correlation between median myofibres area and skeletal muscle index (P = 0.0007). Cancer cachexia was associated with a decrease in MAFbx protein expression (P < 0.01), a marker of proteolysis through the ubiquitin-proteasome pathway. Mitochondrial oxygen consumption related to energy wasting was significantly increased (SC vs. NC, P = 0.028) and mitochondrial area tended to increase (SC vs. MC, P = 0.056) in SC patients. On the contrary, mitochondria content and networks remain unaltered in cachectic cancer patients. Finally, our results show no dysfunction in lipid storage and endoplasmic reticulum homeostasis.
    Conclusions: This clinical protocol brings unique data that provide new insight to mechanisms underlying muscle wasting in cancer cachexia. We report for the first time an increase in mitochondrial energy wasting in the skeletal muscle of severe cachectic cancer patients. Additional clinical studies are essential to further the exploring and understanding of these alterations.
    MeSH term(s) Aged ; Cachexia/pathology ; Colorectal Neoplasms/pathology ; Female ; Gastrointestinal Neoplasms/complications ; Humans ; Male ; Middle Aged ; Mitochondria/metabolism ; Muscular Atrophy/metabolism ; Pectoralis Muscles/metabolism ; Pectoralis Muscles/pathology ; Prospective Studies ; Quality of Life ; Weight Loss
    Language English
    Publishing date 2022-03-22
    Publishing country Germany
    Document type Clinical Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2586864-0
    ISSN 2190-6009 ; 2190-5991
    ISSN (online) 2190-6009
    ISSN 2190-5991
    DOI 10.1002/jcsm.12984
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  4. Article ; Online: One parasite may be hiding another...

    Broutin, Lauranne / Auzoux, Julie / Anon, Benjamin / Caulet, Morgane / Aubourg, Alexandre / Lecomte, Thierry / Chandenier, Jacques / Desoubeaux, Guillaume

    Annales de biologie clinique

    2017  Volume 75, Issue 2, Page(s) 231–232

    MeSH term(s) Animals ; Clonorchiasis/complications ; Clonorchiasis/diagnosis ; Clonorchiasis/drug therapy ; Clonorchis sinensis/isolation & purification ; Coinfection/diagnosis ; Coinfection/drug therapy ; Coinfection/parasitology ; Entamoeba histolytica/isolation & purification ; Entamoebiasis/complications ; Entamoebiasis/diagnosis ; Entamoebiasis/drug therapy ; Humans ; Liver Abscess, Amebic/complications ; Liver Abscess, Amebic/diagnosis ; Liver Abscess, Amebic/parasitology ; Male ; Middle Aged ; Praziquantel/therapeutic use ; Transients and Migrants
    Chemical Substances Praziquantel (6490C9U457)
    Language English
    Publishing date 2017-04-01
    Publishing country France
    Document type Case Reports ; Letter
    ZDB-ID 2023584-7
    ISSN 1950-6112 ; 0003-3898
    ISSN (online) 1950-6112
    ISSN 0003-3898
    DOI 10.1684/abc.2017.1220
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  5. Article ; Online: Usefulness of confocal laser endomicroscopy for predicting postoperative recurrence in patients with Crohn's disease: a pilot study.

    Auzoux, Julie / Boschetti, Gilles / Anon, Benjamin / Aubourg, Alexandre / Caulet, Morgane / Poisson, Lucile / Besson, Pierre / Lecomte, Thierry / Roger, Sebastien / Picon, Laurence / Nancey, Stephane / Moussata, Driffa / Flourie, Bernard

    Gastrointestinal endoscopy

    2019  Volume 90, Issue 1, Page(s) 151–157

    Abstract: Background and aims: Confocal laser endomicroscopy (CLE) has been shown to predict relapse in inflammatory bowel disease, but its value in the detection of postoperative recurrence in Crohn's disease (CD) is unknown. The aims of this pilot study ... ...

    Abstract Background and aims: Confocal laser endomicroscopy (CLE) has been shown to predict relapse in inflammatory bowel disease, but its value in the detection of postoperative recurrence in Crohn's disease (CD) is unknown. The aims of this pilot study performed in patients with CD after ileocolonic resection were to compare the macroscopic appearance of the neoterminal ileum, according to the endoscopic Rutgeerts score, with the microscopic findings provided by CLE 6 to 12 months after surgery and to assess the predictive values of CLE-generated parameters for predicting further recurrence in patients with postoperative endoscopic remission.
    Methods: In 25 consecutive patients with CD within 6 to 12 months of surgery, the neoterminal ileum was examined by standard white-light endoscopy (Rutgeerts scale) followed by CLE (Watson grade). Only patients without endoscopic recurrence (Rutgeerts i0 and i1) were then followed endoscopically and clinically (median follow-up 38 months).
    Results: At the time of the first postoperative colonoscopy, 18 patients (72%) were in endoscopic remission, and 7 (28%) experienced an endoscopic recurrence (Rutgeerts ≥i2). The Rutgeerts score was significantly correlated with the Watson score (ρ = 0 .73; P < .0001). The Watson scores at baseline were significantly higher in patients with further endoscopic recurrence (median 2.0; interquartile range [IQR] 1.5-2.0) than in those with endoscopic remission (median 1.0; IQR 1.0-1.0; P = .032) and were significantly higher in patients with clinical relapse (medium 2.0, IQR 2.0-2.0) compared with those in clinical remission (median 1.0; IQR 1.0-1.0; P = .036).
    Conclusions: CLE could be useful in monitoring patients with CD after intestinal resection. Further studies with a larger population are necessary to confirm these preliminary results.
    MeSH term(s) Adult ; Colectomy ; Colon/pathology ; Colon/surgery ; Colonoscopy ; Crohn Disease/pathology ; Crohn Disease/surgery ; Female ; Humans ; Ileum/pathology ; Ileum/surgery ; Male ; Microscopy, Confocal ; Middle Aged ; Pilot Projects ; Prognosis ; Recurrence ; Risk Assessment ; Young Adult
    Language English
    Publishing date 2019-03-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2019.02.030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 283: Show issues Location:
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    Zs.MO 519: Show issues

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  6. Article ; Online: Possible association of CAG repeat polymorphism in KCNN3 encoding the potassium channel SK3 with oxaliplatin-induced neurotoxicity.

    Anon, Benjamin / Largeau, Bérenger / Girault, Alban / Chantome, Aurélie / Caulet, Morgane / Perray, Clémence / Moussata, Driffa / Vandier, Christophe / Barin-Le Guellec, Chantal / Lecomte, Thierry

    Cancer chemotherapy and pharmacology

    2018  Volume 82, Issue 1, Page(s) 149–157

    Abstract: Introduction: Data suggest a role of the potassium channel SK3 (KCNN3 gene) in oxaliplatin-induced neurotoxicity (OIN). Length variations in the polymorphic CAG repeat of the KCNN3 gene may be associated with the risk of OIN.: Materials and methods: ... ...

    Abstract Introduction: Data suggest a role of the potassium channel SK3 (KCNN3 gene) in oxaliplatin-induced neurotoxicity (OIN). Length variations in the polymorphic CAG repeat of the KCNN3 gene may be associated with the risk of OIN.
    Materials and methods: We performed patch-clamp experiments on HEK293 cell lines, expressing SK3 channel isoforms with short (11) or long (24) CAG repetitions, to measure intracellular calcium concentrations to test the effects of oxaliplatin on current density. A retrospective study was carried out on patients with colorectal cancer who had received oxaliplatin-based chemotherapy. DNA for KCNN3 genotyping was extracted from leukocytes. The region containing the CAG repeats was amplified by PCR and the products separated by capillary electrophoresis for length analysis. The patients were divided into three groups depending on whether they carried two short alleles, one short allele and one long allele, or two long alleles. The primary endpoint was the onset of grade 2 or 3 neuropathy to oxaliplatin.
    Results: There was no difference in current density, but oxaliplatin induced a differential effect on apamin-sensitive current density between the two isoforms expressed in the HEK cell lines. There was a significant reduction of store-operated calcium entry into cells expressing the short and more active isoform only after high concentration of oxaliplatin exposition. Eighty-six patients were included in the clinical study. There was no significant association between OIN and KCNN3 polymorphism for the three groups.
    Conclusion: We observed a slight association between OIN and CAG repeat polymorphisms of the KCNN3 gene in a preclinical model, but not a clinical study.
    MeSH term(s) Adult ; Aged ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Female ; Fluorouracil/administration & dosage ; HEK293 Cells ; Humans ; Leucovorin/administration & dosage ; Male ; Middle Aged ; Neurotoxicity Syndromes/blood ; Neurotoxicity Syndromes/etiology ; Neurotoxicity Syndromes/genetics ; Organoplatinum Compounds/administration & dosage ; Oxaliplatin/administration & dosage ; Oxaliplatin/adverse effects ; Patch-Clamp Techniques ; Polymorphism, Genetic ; Small-Conductance Calcium-Activated Potassium Channels/genetics ; Trinucleotide Repeats
    Chemical Substances Antineoplastic Agents ; KCNN3 protein, human ; Organoplatinum Compounds ; Small-Conductance Calcium-Activated Potassium Channels ; Oxaliplatin (04ZR38536J) ; Leucovorin (Q573I9DVLP) ; Fluorouracil (U3P01618RT)
    Language English
    Publishing date 2018-05-17
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 6820-2
    ISSN 1432-0843 ; 0344-5704 ; 0943-9404
    ISSN (online) 1432-0843
    ISSN 0344-5704 ; 0943-9404
    DOI 10.1007/s00280-018-3600-1
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    Zs.A 1420: Show issues Location:
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  7. Article ; Online: A study of the association between UGT1A1*28 variant allele of UGT1A1 gene and colonic phenotype of sporadic colorectal cancer.

    Anon, Benjamin / Perray, Clémence / Regnault, David / Caulet, Morgane / Orain, Isabelle / Godart, Bruno / Pages, Jean-Christophe / Tallet, Anne / Ouaissi, Mehdi / Guyetant, Serge / Barin-le Guellec, Chantal / Lecomte, Thierry

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2018  Volume 51, Issue 4, Page(s) 579–583

    Abstract: Introduction: The transcriptional activity of the UGT1A1 gene is modulated by a variable number of repetitions of the dinucleotide (TA) within its promoter region. By comparison to the most common allele (TA): Material and methods: All patients ... ...

    Abstract Introduction: The transcriptional activity of the UGT1A1 gene is modulated by a variable number of repetitions of the dinucleotide (TA) within its promoter region. By comparison to the most common allele (TA)
    Material and methods: All patients treated for colorectal cancer in a tertiary care centre, between January 2009 and December 2013, who had routine UGT1A1 genotyping for irinotecan dose-adjustment were included. Data were retrospectively collected.
    Results: 292 patients were enrolled, including 23 UGT1A1*28/*28 homozygous (7.9%), 137 wild type homozygous (46.9%) and 132 heterozygous (45.2%). There were no significant differences in phenotypic colonic characteristics between homozygous and heterozygous patients carrying the UGT1A1*28 allele as compared to *1/*1 homozygous. Patients treated with aspirin were significantly more common in the UGT1A1*28/*28 homozygous group than in the other groups (7/23 (30.4%) compared to 22/269 (8.2%), p = 0.001).
    Conclusion: Dinucleotide polymorphism in the promoter region of the UGT1A1 gene is not associated with a specific colonic phenotype in patients with sporadic colorectal cancer.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Alleles ; Colorectal Neoplasms/genetics ; Female ; France ; Genetic Predisposition to Disease ; Glucuronosyltransferase/genetics ; Heterozygote ; Homozygote ; Humans ; Irinotecan ; Male ; Middle Aged ; Phenotype ; Polymorphism, Genetic ; Promoter Regions, Genetic ; Retrospective Studies ; Tertiary Care Centers
    Chemical Substances Irinotecan (7673326042) ; UGT1A1 enzyme (EC 2.4.1.-) ; Glucuronosyltransferase (EC 2.4.1.17)
    Language English
    Publishing date 2018-12-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2018.11.032
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    Zs.A 1134: Show issues Location:
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