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  1. Article ; Online: Job Insecurity and Employees’ Taking Charge Behaviors

    Fang Sun / Anqi Zheng / Junbang Lan

    International Journal of Environmental Research and Public Health, Vol 19, Iss 696, p

    Testing a Moderated Mediation Model

    2022  Volume 696

    Abstract: Given the rapid changes in current technologies, business models, and work environments, organizations and managers increasingly rely on their employees’ proactive behaviors, such as taking charge, to gain competitive advantages. Taking charge involves a ...

    Abstract Given the rapid changes in current technologies, business models, and work environments, organizations and managers increasingly rely on their employees’ proactive behaviors, such as taking charge, to gain competitive advantages. Taking charge involves a range of risky and future-oriented behaviors, and it requires employees to work hard to achieve them in the future. For employees with high job-insecurity, their job continuity in the future is threatened. Thus, they may not be willing to take risks to do additional work that is “future-oriented”. To our knowledge, the effect of job insecurity on employees’ taking charge has rarely been studied. As a result, the purpose of our study is to investigate whether, how, and when job insecurity will influence taking charge. Drawing on the conservation of resources theory and proactive motivation model, we develop a theoretical model. Moreover, we employed a multi-wave and multi-source survey to test our predictions. Based on the data from 194 full-time employees paired with their direct supervisors, the results provided consistent support for the proposed hypotheses. Specifically, the results indicate that job insecurity prohibits employees’ taking charge behaviors through deteriorating their work engagement. Furthermore, employees’ perception of interactional justice moderates the negative influence of job insecurity on their work engagement and, consequently, their taking charge behaviors. Theoretical and practical implications are discussed.
    Keywords job insecurity ; work engagement ; taking charge ; interactional justice ; proactive behavior ; Medicine ; R
    Subject code 650
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Evaluating the value of 18F-PSMA-1007 PET/CT in the detection and identification of prostate cancer using histopathology as the standard

    Liang Luo / Anqi Zheng / Ruxi Chang / Yunxuan Li / Jungang Gao / Zhuonan Wang / Xiaoyi Duan

    Cancer Imaging, Vol 23, Iss 1, Pp 1-

    2023  Volume 8

    Abstract: Abstract Background Prostate-specific membrane antigen (PSMA) PET/CT is a highly regarded radionuclide imaging modality for prostate cancer (PCa). This study aimed to evaluate the diagnostic performance of 18F-PSMA-1007 PET/CT in detecting intraprostatic ...

    Abstract Abstract Background Prostate-specific membrane antigen (PSMA) PET/CT is a highly regarded radionuclide imaging modality for prostate cancer (PCa). This study aimed to evaluate the diagnostic performance of 18F-PSMA-1007 PET/CT in detecting intraprostatic lesions of PCa using radical prostatectomy (RP) specimens as a reference standard and to establish an optimal maximum standardized uptake value (SUVmax) cutoff for distinguishing between PCa and non-PCa lesions. Methods We retrospectively collected 117 patients who underwent 18F-PSMA-1007 PET/CT before RP. The uptake of the index tumor and contralateral non-PCa lesion was assessed. Histopathology of RP specimens was used as the gold standard. Kappa test was used to evaluate the consistency of preoperative PSMA PET/CT staging and postoperative pathological staging. Finally, an SUVmax cutoff value was identified by receiver operating characteristic (ROC) curve analysis to distinguish PCa lesions from non-PCa lesions. A prospective cohort including 76 patients was used to validate the results. Results The detection rate of 18F-PSMA-1007 PET/CT for prostate cancer was 96.6% (113/117). 18F-PSMA-1007 had a sensitivity of 91.2% and a positive predictive value (PPV) of 89.8% for the identification of intraprostatic lesions. The consistency test (Kappa = 0.305) indicated poor agreement between the pathologic T-stage and PSMA PET/CT T-stage. Based on ROC curve analysis, the appropriate SUVmax to diagnose PCa lesions was 8.3 (sensitivity of 71.3% and specificity 96.8%) with an area under the curve (AUC) of 0.93 (P < 0.001). This SUVmax cutoff discriminated PCa lesions from non-PCa lesions with a sensitivity of 74.4%, a specificity of 95.8% in the prospective validation group. Conclusions 18F-PSMA-1007 PET/CT demonstrated excellent performance in detecting PCa. An optimal SUVmax threshold (8.3) could be utilized to identify lesions of PCa by 18F-PSMA-1007 PET/CT. Trial registration ClinicalTrials.gov Identifier: NCT04521894, Registered: August 17, 2020.
    Keywords Prostate cancer ; Prostate-specific membrane antigen ; PET/CT ; SUVmax cutoff ; Medical physics. Medical radiology. Nuclear medicine ; R895-920 ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
    Subject code 610
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Research Progress on Metal–Organic Frameworks by Advanced Transmission Electron Microscopy

    Anqi Zheng / Kuibo Yin / Rui Pan / Mingyun Zhu / Yuwei Xiong / Litao Sun

    Nanomaterials, Vol 13, Iss 1742, p

    2023  Volume 1742

    Abstract: Metal–organic frameworks (MOFs), composed of metal nodes and inorganic linkers, are promising for a wide range of applications due to their unique periodic frameworks. Understanding structure–activity relationships can facilitate the development of new ... ...

    Abstract Metal–organic frameworks (MOFs), composed of metal nodes and inorganic linkers, are promising for a wide range of applications due to their unique periodic frameworks. Understanding structure–activity relationships can facilitate the development of new MOFs. Transmission electron microscopy (TEM) is a powerful technique to characterize the microstructures of MOFs at the atomic scale. In addition, it is possible to directly visualize the microstructural evolution of MOFs in real time under working conditions via in situ TEM setups. Although MOFs are sensitive to high-energy electron beams, much progress has been made due to the development of advanced TEM. In this review, we first introduce the main damage mechanisms for MOFs under electron-beam irradiation and two strategies to minimize these damages: low-dose TEM and cryo-TEM. Then we discuss three typical techniques to analyze the microstructure of MOFs, including three-dimensional electron diffraction, imaging using direct-detection electron-counting cameras, and iDPC-STEM. Groundbreaking milestones and research advances of MOFs structures obtained with these techniques are highlighted. In situ TEM studies are reviewed to provide insights into the dynamics of MOFs induced by various stimuli. Additionally, perspectives are analyzed for promising TEM techniques in the research of MOFs’ structures.
    Keywords metal–organic frameworks ; transmission electron microscopy ; in situ TEM ; structural characterization ; structure–activity ; dynamics visualization ; Chemistry ; QD1-999
    Subject code 669
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Facile Synthesis of Sponge-Like Porous Nano Carbon-Coated Silicon Anode with Tunable Pore Structure for High-Stability Lithium-Ion Batteries

    Shugui Song / Jingcang Li / Anqi Zheng / Yongqiang Yang / Kuibo Yin

    Molecules, Vol 26, Iss 3211, p

    2021  Volume 3211

    Abstract: To address the challenge of the huge volume expansion of silicon anode, carbon-coated silicon has been developed as an effective design strategy due to the improved conductivity and stable electrochemical interface. However, although carbon-coated ... ...

    Abstract To address the challenge of the huge volume expansion of silicon anode, carbon-coated silicon has been developed as an effective design strategy due to the improved conductivity and stable electrochemical interface. However, although carbon-coated silicon anodes exhibit improved cycling stability, the complex synthesis methods and uncontrollable structure adjustment still make the carbon-coated silicon anodes hard to popularize in practical application. Herein, we propose a facile method to fabricate sponge-like porous nano carbon-coated silicon (sCCSi) with a tunable pore structure. Through the strategy of adding water into precursor solution combined with a slow heating rate of pre-oxidation, a sponge-like porous structure can be formed. Furthermore, the porous structure can be controlled through stirring temperature and oscillation methods. Owing to the inherent material properties and the sponge-like porous structure, sCCSi shows high conductivity, high specific surface area, and stable chemical bonding. As a result, the sCCSi with normal and excessive silicon-to-carbon ratios all exhibit excellent cycling stability, with 70.6% and 70.2% capacity retentions after 300 cycles at 500 mA g −1 , respectively. Furthermore, the enhanced buffering effect on pressure between silicon nanoparticles and carbon material due to the sponge-like porous structure in sCCSi is further revealed through mechanical simulation. Considering the facile synthesis method, flexible regulation of porous structure, and high cycling stability, the design of the sCCSi paves a way for the synthesis of high-stability carbon-coated silicon anodes.
    Keywords carbon-coated silicon ; porous structure ; mechanical simulation ; lithium-ion battery ; Organic chemistry ; QD241-441
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Highly stable and antifungal properties on the oilseed rape of Cu

    Xu, Zhao / Lisha, Xu / Yi, Liu / Yunjun, Mei / Luocheng, Chen / Anqi, Zheng / Kuibo, Yin / Xiaolu, Xiao / Shaozhen, Li / Xuecheng, Sun / Yifu, Zhang

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 5235

    Abstract: In the last few decades, nanoparticles have been a prominent topic in various fields, particularly in agriculture, due to their unique physicochemical properties. Herein, molybdenum copper lindgrenite ... ...

    Abstract In the last few decades, nanoparticles have been a prominent topic in various fields, particularly in agriculture, due to their unique physicochemical properties. Herein, molybdenum copper lindgrenite Cu
    MeSH term(s) Antifungal Agents/pharmacology ; Copper ; Agriculture ; Bone Plates ; Brassica rapa
    Chemical Substances Antifungal Agents ; Copper (789U1901C5)
    Language English
    Publishing date 2024-03-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-53612-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Exploring the Interconnection of Greenhouse Gas Emission and Socio-economic Factors

    Weiheng Fu / Weirong Han / Tianze Xu / Yerin Kim / Chengda Lyu / Anqi Zheng

    SAR Journal, Vol 2, Iss 3, Pp 115-

    2019  Volume 120

    Abstract: This paper examines the dependence of the emission of greenhouse gases including CO2, N2O and CH4 on social, economic and demographic factors. Feature selection is used to identify the most influential parameters, and emissions are modeled using three ... ...

    Abstract This paper examines the dependence of the emission of greenhouse gases including CO2, N2O and CH4 on social, economic and demographic factors. Feature selection is used to identify the most influential parameters, and emissions are modeled using three regression techniques, including linear regression, principal component regression and partial least square regression. The models are evaluated for key implications.
    Keywords greenhouse gas ; socio-economic factors ; feature selection ; principal component ; regression ; Science ; Q
    Language English
    Publishing date 2019-09-01T00:00:00Z
    Publisher UIKTEN
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Binding and structural basis of equine ACE2 to RBDs from SARS-CoV, SARS-CoV-2 and related coronaviruses

    Zepeng Xu / Xinrui Kang / Pu Han / Pei Du / Linjie Li / Anqi Zheng / Chuxia Deng / Jianxun Qi / Xin Zhao / Qihui Wang / Kefang Liu / George Fu Gao

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 11

    Abstract: This study documents equine ACE2 (eqACE2) binding to the RBDs of SARS-CoV-2 and related CoVs, revealing a mechanism of eqACE2 binding with RaTG13-RBD, SARS-CoV-2 prototype-RBD and Omicron BA.1-RBD. ...

    Abstract This study documents equine ACE2 (eqACE2) binding to the RBDs of SARS-CoV-2 and related CoVs, revealing a mechanism of eqACE2 binding with RaTG13-RBD, SARS-CoV-2 prototype-RBD and Omicron BA.1-RBD.
    Keywords Science ; Q
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: A binding-enhanced but enzymatic activity-eliminated human ACE2 efficiently neutralizes SARS-CoV-2 variants

    Anqi Zheng / Lili Wu / Renyi Ma / Pu Han / Baoying Huang / Chengpeng Qiao / Qihui Wang / Wenjie Tan / George F. Gao / Pengcheng Han

    Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-

    2022  Volume 4

    Keywords Medicine ; R ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Thermo/pH dual-stimuli-responsive drug delivery for chemo-/photothermal therapy monitored by cell imaging

    Shu, Yang / Rusheng Song / Anqi Zheng / Jingli Huang / Mingli Chen / Jianhua Wang

    Talanta. 2018 May 01, v. 181

    2018  

    Abstract: A thermo/pH dual-stimuli-responsive drug delivery system (DDS) based on polymer coated mesoporous silica nanostructures (MSNs) is developed for facilitating chemotherapy and photothermal therapy. Thermo/pH-responsive polymer, poly((N-isopropylacrylamide, ...

    Abstract A thermo/pH dual-stimuli-responsive drug delivery system (DDS) based on polymer coated mesoporous silica nanostructures (MSNs) is developed for facilitating chemotherapy and photothermal therapy. Thermo/pH-responsive polymer, poly((N-isopropylacrylamide, NIPAM)-co-methacrylic acid, MA), is grafted onto MSNs by in situ polymerization, followed by loading a chemotherapeutic drug (doxorubicin hydrochloride, DOX) and a near-infrared-absorbing phototherapeutic agent (indocyanine green, ICG) to construct the intelligent drug delivery system, shortly as DOX-ICG-MSN@p(NIPAM-co-MA). At NIR irradiation, the photothermal conversion capability of ICG raises the temperature of the DDS and opens the gatekeeper by shrinkage of the copolymer p(NIPAM-co-MA), which triggers controlled release of DOX at an elevated temperature. On the other hand, drug release is also realized at pH 5.3, a characteristic pH value in cancer cell microenvironment, at which it not only causes the shrinkage of the pH-sensitive polymeric moiety of methacrylic acid in MSN@p(NIPAM-co-MA) but also deteriorates electrostatic interaction of DOX molecules in the mesoporous channel by protonation of silanols. In addition, ICG further ensures photothermal therapy (PTT) and photodynamic therapy (PDT). The cytotoxicity assay of HeLa cells shows obvious synergistic effect by demonstrating that the combined use of DOX and ICG is more effective in killing HeLa cells than free DOX and ICG. The endocytosis of the drug is monitored by cell imaging.
    Keywords cellular microenvironment ; composite polymers ; doxorubicin ; drug delivery systems ; electrostatic interactions ; endocytosis ; human cell lines ; image analysis ; irradiation ; moieties ; nanomaterials ; neoplasms ; pH ; photochemotherapy ; polymerization ; porous media ; shrinkage ; silica ; synergism ; temperature ; toxicity testing
    Language English
    Dates of publication 2018-0501
    Size p. 278-285.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/j.talanta.2018.01.018
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape

    Zhennan Zhao / Jingya Zhou / Mingxiong Tian / Min Huang / Sheng Liu / Yufeng Xie / Pu Han / Chongzhi Bai / Pengcheng Han / Anqi Zheng / Lutang Fu / Yuanzhu Gao / Qi Peng / Ying Li / Yan Chai / Zengyuan Zhang / Xin Zhao / Hao Song / Jianxun Qi /
    Qihui Wang / Peiyi Wang / George F. Gao

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 12

    Abstract: The SARS-CoV-2 Omicron variant spreads rapidly. Here the authors show that Omicron S preferentially adopts the one-RBD-up conformation, which leads to a non-RBM-binding monoclonal antibody escape. Mutagenesis reveals that S371L, S373P and S375F ... ...

    Abstract The SARS-CoV-2 Omicron variant spreads rapidly. Here the authors show that Omicron S preferentially adopts the one-RBD-up conformation, which leads to a non-RBM-binding monoclonal antibody escape. Mutagenesis reveals that S371L, S373P and S375F substitutions enhance the conformational stability.
    Keywords Science ; Q
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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