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Article ; Online: Surgical management of head and neck tumours during the SARS-CoV (COVID-19) pandemic.

Ansarin, Mohssen

Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale

2020 Volume 40, Issue 2, Page(s) 87–89

MeSH term(s)	Appointments and Schedules ; Betacoronavirus/isolation & purification ; COVID-19 ; Clinical Decision-Making ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Head and Neck Neoplasms/surgery ; Hospitals/standards ; Humans ; Infection Control/methods ; Infection Control/standards ; Italy/epidemiology ; Pandemics/prevention & control ; Personal Protective Equipment/standards ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-04-10
Publishing country	Italy
Document type	Editorial
ZDB-ID	604898-5
ISSN	1827-675X ; 0392-100X
ISSN (online)	1827-675X
ISSN	0392-100X
DOI	10.14639/0392-100X-N0783
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Article: Surgical management of head and neck tumours during the SARS-CoV (COVID-19) pandemic

Ansarin, Mohssen

Acta Otorhinolaryngol Ital

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #47932
Database	COVID19

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Article ; Online: Step-by-step illustrated guide to central neck dissection.

Chu, F / De Berardinis, R / Pietrobon, G / Tagliabue, M / Giugliano, G / Ansarin, M

The Journal of laryngology and otology

2021 , Page(s) 1–6

Abstract: Background: The incidence of thyroid carcinoma has been increasing worldwide and surgery is the primary treatment. Central compartment dissection of the neck is a very delicate procedure given the risks of recurrent laryngeal nerve injury and ... ...

Abstract	Background: The incidence of thyroid carcinoma has been increasing worldwide and surgery is the primary treatment. Central compartment dissection of the neck is a very delicate procedure given the risks of recurrent laryngeal nerve injury and hypoparathyroidism. Methods: This paper gives a detailed description of this surgical technique in a patient affected by papillary carcinoma of the thyroid gland, supported by highly representative iconographic materials from a tertiary department. Results: A stepwise description is provided, along with high-quality pictures and specific tips and tricks. Although neck dissection is a well-codified procedure, the fine details of this surgical technique are not currently available and are still the prerogative of the expert surgeon. Conclusion: The central neck compartment contains several vulnerable structures; damage to these structures would affect patients' lives, possibly permanently. Anatomical knowledge and standardisation are needed for all surgeons, particularly new surgeons (such as residents) who cannot rely simply on experience.
Language	English
Publishing date	2021-10-01
Publishing country	England
Document type	Journal Article
ZDB-ID	218299-3
ISSN	1748-5460 ; 0022-2151
ISSN (online)	1748-5460
ISSN	0022-2151
DOI	10.1017/S002221512100270X
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Article ; Online: Small tongue squamous cell carcinoma with neck metastasis at diagnosis: operative insights and surgical technique.

Bruschini, Roberto / Chu, Francesco / Tagliabue, Marta / Giugliano, Gioacchino / Ansarin, Mohssen

Tumori

2022 Volume 109, Issue 1, Page(s) 138–140

Abstract: Background: The treatment of tongue tumors includes different surgical procedures ranging from a simple mucosal resection to complex combined resection depending on the tumor stage and size. In 2019 we reported an international glossectomy ... ...

Abstract	Background: The treatment of tongue tumors includes different surgical procedures ranging from a simple mucosal resection to complex combined resection depending on the tumor stage and size. In 2019 we reported an international glossectomy classification with the purpose of standardizing all the different types of surgical procedures adopted for tongue cancer. Methods: The present communication aims at providing further insight into the glossectomy classification. More specifically, it is intended to better specify the indications to glossectomy type IIIA and B in selected tongue cancers, with positive cervical lymph nodes at the diagnosis. Results and conclusions: Type IIIA glossectomy permits a high function sparing surgery in selected cases, with better postoperative functional outcomes. From an oncological perspective, it permits a radical surgery, avoiding postoperative radiation in the absence of extracapsular spread, multiple nodal metastases or T-N tract involvement.
MeSH term(s)	Humans ; Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/surgery ; Carcinoma, Squamous Cell/pathology ; Tongue Neoplasms/diagnosis ; Tongue Neoplasms/surgery ; Tongue Neoplasms/pathology ; Lymph Nodes/surgery ; Lymph Nodes/pathology ; Neck Dissection ; Neoplasm Staging ; Tongue/pathology ; Retrospective Studies
Language	English
Publishing date	2022-03-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	280962-x
ISSN	2038-2529 ; 0300-8916
ISSN (online)	2038-2529
ISSN	0300-8916
DOI	10.1177/03008916221082703
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Article ; Online: Unlocking tracheoesophageal speech from pharyngoesophageal spasm: preliminary results of a videofluoroscopic-guided botulinum toxin A injection technique.

Bandi, Francesco / Chu, Francesco / Zurlo, Valeria / Di Natale, Valentina / Zorzi, Stefano / Pietrobon, Giacomo / De Berardinis, Rita / Tagliabue, Marta / Ansarin, Mohssen

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

2024 Volume 281, Issue 4, Page(s) 1885–1893

Abstract: Purpose: The tracheoesophageal puncture for the voice prosthesis (VP) placement is the recognized gold standard in post-laryngectomy voice rehabilitation. Despite the development of specific intraoperative techniques, a subset of patients will suffer ... ...

Abstract	Purpose: The tracheoesophageal puncture for the voice prosthesis (VP) placement is the recognized gold standard in post-laryngectomy voice rehabilitation. Despite the development of specific intraoperative techniques, a subset of patients will suffer from poor functional outcomes due to pharyngoesophageal spasms (PES). This paper evaluates the functional outcomes after transcutaneous botulinum toxin type A (BTX-A) infiltration for PES with a videofluoroscopy-guided technique. Methods: Since 2022, eight consecutive patients with VP and affected by PES were treated with BTX-A injection by a standard videofluoroscopic guided technique at the European Institute of Oncology, IRCCS (IEO) in Milan. A lidocaine test was performed pre-operatively to evaluate the potential effect of chemical neurectomy. All patients with positive lidocaine tests were injected with 50 IU of BTX-A (Allergan, Irvine, CA) according to the sites marked during the videofluoroscopy. Reported symptoms (VHI, SECEL), perceptual (INFVo), aerodynamic (MPT) and manometric parameters were collected before and after treatment. Results: In all cases, BTX-A was performed as an outpatient procedure without complications. For seven patients, only one BTX-A injection was needed, while one patient required a re-injection. Subjective and perceptive improvement after BTX-A was significant for VHI, SECEL and INFVo. MPT showed significant improvement after a chemical neurectomy. After a mean follow-up of 6 months, all patients maintained a good TES quality. Conclusion: The videofluoroscopic guided BTX-A injection of the pharyngoesophageal tract showed to be a feasible and reproducible technique in all cases. The pharyngoesophageal videofluoroscopy allows defining of patients' anatomical landmarks that help the surgeon to perform a homogeneous injection, empowered by post-injection massage.
MeSH term(s)	Humans ; Botulinum Toxins, Type A ; Speech ; Laryngectomy/adverse effects ; Speech, Esophageal ; Spasm/etiology ; Lidocaine ; Treatment Outcome
Chemical Substances	Botulinum Toxins, Type A (EC 3.4.24.69) ; Lidocaine (98PI200987)
Language	English
Publishing date	2024-01-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1017359-6
ISSN	1434-4726 ; 0937-4477
ISSN (online)	1434-4726
ISSN	0937-4477
DOI	10.1007/s00405-024-08448-9
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Book ; Online: Study on Regulatory Sandboxes in the Energy Sector. Final report ; EnTEC – Regulatory Sandboxes in the Energy Sector

Gorenstein Dedecca, João / Ansarin, Mohammad / Afrodit Adsal, Kardelen / Blind, Knut

2023

Abstract: Regulatory sandboxes aim to support innovative solutions and promote regulatory learning, often by giving derogations from certain regulatory provisions to participants for a limited amount of time. Other forms of experimentation (regulatory or otherwise) ...

Abstract	Regulatory sandboxes aim to support innovative solutions and promote regulatory learning, often by giving derogations from certain regulatory provisions to participants for a limited amount of time. Other forms of experimentation (regulatory or otherwise) exist, such as regulatory pilot projects, pilot regulations, living labs and test beds. Several Member States have already adopted or are considering adopting frameworks for regulatory experimentation in the energy sector, including regulatory sandboxes. A few reports have compared existing regulatory sandboxes in the EU and globally. However, there is limited information on the concrete implementation of these sandboxes, barriers for implementation and best practices, and the concrete impacts. A recent notable exception is the report by the Joint Research Centre (JRC), which represents the first EU-wide overview of regulatory experimentation frameworks for the energy sector. The main objective of this report is to analyse existing regulatory sandbox schemes for the energy sector with a focus on the EU Member States regarding their purpose, regulatory/legal basis, format, implementation barriers and best practices, and impacts in fostering regulatory learning and new business cases. Our analysis indicates that regulatory sandboxes are useful policy tools to develop regulations and enable the creation of new products and services, even if not all examples have a clear positive impact and many projects awarded under regulatory sandboxes are still ongoing. However, regulatory sandboxes are warranted only in the case where a regulatory exemption is strictly necessary for the innovation to take place. In other cases, different instruments (such as the ones where regulators/authorities supervise and guide the innovative projects) may be more adequate while avoiding the risk of distorting the level-playing field.
Keywords	Electrical energy ; Energy grid ; Energy market ; Energy technology ; Energy transition ; Environmental impact ; Environmental law ; EU energy policy ; Innovation ; Regulatory policy ; Renewable energy
Subject code	303
Language	English
Publisher	Publications Office of the European Union
Publishing country	de
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Economic inefficiencies of pricing distributed generation under novel tariff designs

Ansarin, Mohammad / Ghiassi-Farrokhfal, Yashar / Ketter, Wolfgang / Collins, John

Applied energy. 2022 May 01, v. 313

2022

Abstract: A common principle of electricity pricing is ensuring that costs and benefits are aligned such that economic efficiency is optimized. Deviations from this principle are commonplace in residential pricing, especially for distributed generation (DG). Here, ...

Abstract	A common principle of electricity pricing is ensuring that costs and benefits are aligned such that economic efficiency is optimized. Deviations from this principle are commonplace in residential pricing, especially for distributed generation (DG). Here, subsidizing renewable energy sources can sometimes precede economic considerations, causing a divergence between the real value of a household’s DG electricity and the credits a household receives. Hence, many households install DG larger or smaller than optimal. Few studies have investigated the impact of various electricity tariffs on efficiency and welfare consequences of mis-pricing DG. We study this matter for multiple tariffs, including flat-rate feed-in pricing, net metering, and net metering with different time windows for volumetric accumulation. We use a unique set of 2016 DG generation, installation costs, and value data that allows us to calculate DG installation size changes without making ex ante assumptions regarding household discount rates and with consideration of the entire value chain of DG electricity. We find that using a flat-rate (per-kWh) tariff creates some efficiency losses comparable to that of a net metering setup with yearly accumulation. Lower accumulation windows show drastically lower rates of DG installation and higher welfare losses. Sensitivity analyses show that these results are somewhat agnostic to DG system size and the benefit of DG systems for distribution grid support costs. These results provide a crucial measure of the social ramifications of DG installations, particularly solar panels.
Keywords	electricity ; energy ; supply chain ; tariffs
Language	English
Dates of publication	2022-0501
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2000772-3
ISSN	0306-2619
ISSN	0306-2619
DOI	10.1016/j.apenergy.2022.118839
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: HPV-mediated regulation of SMAD4 modulates the DNA damage response in head and neck cancer.

Citro, Simona / Miccolo, Claudia / Medda, Alessandro / Ghiani, Lavinia / Tagliabue, Marta / Ansarin, Mohssen / Chiocca, Susanna

Journal of experimental & clinical cancer research : CR

2022 Volume 41, Issue 1, Page(s) 59

Abstract: Background: Head and Neck cancer (HNC) is a fatal malignancy with poor prognosis. Human Papillomavirus (HPV) infection is becoming the prominent cause of HNC in the western world, and studying the molecular mechanisms underlying its action in cancers is ...

Abstract	Background: Head and Neck cancer (HNC) is a fatal malignancy with poor prognosis. Human Papillomavirus (HPV) infection is becoming the prominent cause of HNC in the western world, and studying the molecular mechanisms underlying its action in cancers is key towards targeted therapy. To replicate, HPV regulates the host DNA damage repair (DDR) pathway. SMAD4 is also involved in the regulation of the DDR machinery and likely plays important role in maintaining cell viability upon genotoxic stress. In this study, we investigated the role of HPV in the upregulation of SMAD4 to control the DDR response and facilitate its lifecycle. Methods: SMAD4, Rad51 and CHK1 expression was assessed in HPV-positive and HPV-negative HNC using TCGA data, a panel of 14 HNC cell lines and 8 fresh tumour tissue samples from HNC patients. HPV16 expression was modulated by E6/E7 siRNA knock-down or transduction in HPV-positive HNC cell lines and Human Primary keratinocytes respectively. SMAD4 half-life was assessed by cycloheximide treatment in HNC cell lines, together with βTRCP1-dependent SMAD4 ubiquitination. SMAD4 siRNA knock-down was used to determine its role in HPV-mediated regulation of DDR machinery and to assess cisplatin sensitivity in HPV-positive HNC cell lines. Results: We found that HPV increases SMAD4 expression is both HPV-positive HNC tumours and cell lines, impairing its degradation which is mediated by the E3 ubiquitin ligase βTRCP1. SMAD4 expression highly correlates with the expression of two main players of the DDR pathway, CHK1 and Rad51, which expression is also upregulated by the presence of HPV. In particular, we demonstrate that HPV stabilizes SMAD4 to increase CHK1 and Rad51 expression. In addition, SMAD4-deficient HPV-positive cells have increased sensitivity to cisplatin treatment. Conclusions: Our results give a clear molecular mechanism at the basis of HPV regulation of the DDR pathway. In particular, we show how HPV stabilizes SMAD4 to promote DDR protein expression, which may be used to facilitate viral replication and HNC onset. Moreover, we found that SMAD4 silencing in HPV-positive HNC cell lines increases sensitivity to cisplatin treatment, suggesting that HPV-positive HNC with low SMAD4 expression may be preferentially susceptible to similar treatments.
MeSH term(s)	DNA Damage/genetics ; Head and Neck Neoplasms/genetics ; Humans ; Papillomavirus Infections/genetics ; Prognosis ; Smad4 Protein/metabolism ; Transfection
Chemical Substances	SMAD4 protein, human ; Smad4 Protein
Language	English
Publishing date	2022-02-10
Publishing country	England
Document type	Journal Article
ZDB-ID	803138-1
ISSN	1756-9966 ; 0392-9078
ISSN (online)	1756-9966
ISSN	0392-9078
DOI	10.1186/s13046-022-02258-9
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Article ; Online: Superior temporo-auricular perforator flap for reconstruction of extensive conchal defects.

Parisi, Paola / Ansarin, Mohssen / Pennacchioli, Elisabetta / Di Meglio, Filippo / Ribuffo, Diego / Navach, Valeria

Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale

2022 Volume 42, Issue 4, Page(s) 395–399

MeSH term(s)	Ear Auricle/surgery ; Humans ; Perforator Flap/surgery ; Reconstructive Surgical Procedures
Language	English
Publishing date	2022-10-18
Publishing country	Italy
Document type	Journal Article
ZDB-ID	604898-5
ISSN	1827-675X ; 0392-100X
ISSN (online)	1827-675X
ISSN	0392-100X
DOI	10.14639/0392-100X-N2036
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Article ; Online: c-MYC-dependent transcriptional inhibition of autophagy is implicated in cisplatin sensitivity in HPV-positive head and neck cancer.

Medda, Alessandro / Compagnoni, Micaela / Spini, Giorgio / Citro, Simona / Croci, Ottavio / Campaner, Stefano / Tagliabue, Marta / Ansarin, Mohssen / Chiocca, Susanna

Cell death & disease

2023 Volume 14, Issue 11, Page(s) 719

Abstract: Autophagy is important for the removal, degradation and recycling of damaged organelles, proteins, and lipids through the degradative action of lysosomes. In addition to its catabolic function, autophagy is important in cancer and viral-mediated ... ...

Abstract	Autophagy is important for the removal, degradation and recycling of damaged organelles, proteins, and lipids through the degradative action of lysosomes. In addition to its catabolic function, autophagy is important in cancer and viral-mediated tumorigenesis, including Human Papillomavirus (HPV) positive cancers. HPV infection is a major risk factor in a subset of head and neck cancer (HNC), for which no targeted therapies are currently available. Herein, we assessed autophagy function in HPV-positive HNC. We showed that HPV-positive HNC cells presented a transcriptional and functional impairment of the autophagic process compared to HPV-negative cells, which were reactivated by knocking down HPV E6/E7 oncoproteins, the drivers of cellular transformation. We found that the oncoprotein c-MYC was stabilized and triggered in HPV-positive cell lines. This resulted in the reduced binding of the MiT/TFE transcription factors to their autophagy targets due to c-MYC competition. Thus, the knock-down of c-MYC induced the upregulation of autophagic and lysosomal genes in HPV-positive HNC cells, as well as the increase of autophagic markers at the protein level. Moreover, HPV oncoprotein E7 upregulated the expression of the phosphatase inhibitor CIP2A, accounting for c-MYC upregulation and stability in HPV+ HNC cells. CIP2A mRNA expression negatively correlated with autophagy gene expression in tumor tissues from HNC patients, showing, for the first time, its implication in a transcriptional autophagic context. Both CIP2A and c-MYC knock-down, as well as pharmacological downregulation of c-MYC, resulted in increased resistance to cisplatin treatment. Our results not only show a novel way by which HPV oncoproteins manipulate the host machinery but also provide more insights into the role of autophagy in chemoresistance, with possible implications for targeted HPV-positive HNC therapy.
MeSH term(s)	Humans ; Autophagy ; Cisplatin/pharmacology ; Cisplatin/therapeutic use ; Head and Neck Neoplasms/drug therapy ; Head and Neck Neoplasms/genetics ; Head and Neck Neoplasms/virology ; Papillomavirus E7 Proteins/genetics ; Papillomavirus E7 Proteins/metabolism ; Papillomavirus Infections/drug therapy ; Papillomavirus Infections/genetics ; Proto-Oncogene Proteins c-myc/genetics ; Proto-Oncogene Proteins c-myc/metabolism
Chemical Substances	Cisplatin (Q20Q21Q62J) ; Papillomavirus E7 Proteins ; Proto-Oncogene Proteins c-myc
Language	English
Publishing date	2023-11-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2541626-1
ISSN	2041-4889 ; 2041-4889
ISSN (online)	2041-4889
ISSN	2041-4889
DOI	10.1038/s41419-023-06248-3
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