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  1. Article: All the Routes for Laparoscopic Liver Segment VIII Resection: A Comprehensive Review of Surgical Techniques.

    Anselmo, Alessandro / Sensi, Bruno / Bacchiocchi, Giulia / Siragusa, Leandro / Tisone, Giuseppe

    Frontiers in oncology

    2022  Volume 12, Page(s) 864867

    Abstract: Liver surgery is highly demanding for anatomical, physiological and technical reasons, and minimally invasive approaches have been implemented at a slower rate. Today, laparoscopic liver resection is a standard of care in many occasions, yet specific ... ...

    Abstract Liver surgery is highly demanding for anatomical, physiological and technical reasons, and minimally invasive approaches have been implemented at a slower rate. Today, laparoscopic liver resection is a standard of care in many occasions, yet specific operations remain particularly challenging and generally performed in open surgery. In particular, SVIII resection may be considered one of the most difficult due to anatomical characteristics including its sub-diaphragmatic position, the deep-lying Glissonean pedicle and the close contact with the inferior vena cava and right and middle hepatic veins. Many techniques have risen to overcome technical difficulties, and today laparoscopic SVIII resection has been demonstrated to be feasible. This review provides a complete picture of current approaches, focusing on all techniques reported so far with critical appraisal of each, discussing and explaining benefits and pitfalls.
    Language English
    Publishing date 2022-04-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.864867
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  2. Article: Primary versus Salvage Liver Transplantation after Curative-Intent Resection or Radiofrequency Ablation for Hepatocellular Carcinoma: Long-Term Oncological Outcomes.

    Anselmo, Alessandro / Siragusa, Leandro / Brigato, Paolo / Riccetti, Camilla / Collini, Andrea / Sensi, Bruno / Tisone, Giuseppe

    Cancers

    2023  Volume 15, Issue 20

    Abstract: Liver transplantation for hepatocellular carcinoma (HCC) may be performed ab initio, primary liver transplantation (PLT), or for HCC recurrence after previous treatments such as liver resection (LR) or radiofrequency ablation (RFA), salvage liver ... ...

    Abstract Liver transplantation for hepatocellular carcinoma (HCC) may be performed ab initio, primary liver transplantation (PLT), or for HCC recurrence after previous treatments such as liver resection (LR) or radiofrequency ablation (RFA), salvage liver transplantation (SLT). The aim of this study was to evaluate the oncological outcomes of SLT vs. PLT. For this, a retrospective study was carried out on patients undergoing liver transplantation for HCC. The outcomes of PLT were compared with those of SLT. The primary outcome was disease-free survival (DFS). The secondary outcomes included overall survival (OS), cancer-specific survival (CSS), and major postoperative complications. A sub-analysis of SLT-LR and SLT-RFA was also performed. In total, 141 patients were included: 96 underwent PLT and 45 SLT. Among the SLT group, 25 patients had undergone previous LR while 20 had had RFA. There were no differences in the major postoperative complications. Unadjusted DFS was significantly longer in the PLT group (
    Language English
    Publishing date 2023-10-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15205030
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  3. Article ; Online: Laparoscopic Left Hemihepatectomy for Intrahepatic Cholangiocellular Carcinoma: An Adequate Lymphadenectomy is Also Possible in Artery Variation.

    Anselmo, Alessandro / Siragusa, Leandro / Pisani, Gennaro / Materazzo, Marco / Pirozzi, Brunella / Tisone, Giuseppe

    Annals of surgical oncology

    2022  

    Abstract: Background: Laparoscopic liver resection (LLR) is becoming essential in the treatment of malignant liver tumors but only a few reports exist about LLR for intrahepatic cholangiocarcinoma (IHCC).: Methods: We present a video of a laparoscopic left ... ...

    Abstract Background: Laparoscopic liver resection (LLR) is becoming essential in the treatment of malignant liver tumors but only a few reports exist about LLR for intrahepatic cholangiocarcinoma (IHCC).
    Methods: We present a video of a laparoscopic left hemihepatectomy with lymphadenectomy for IHCC.
    Case presentation: A 67-year-old asymptomatic male underwent a routine abdominal ultrasound, revealing a 15 × 9 mm solid nodular iso-hyperechoic lesion, located in SIII, with SII/III biliary duct dilation. Magnetic resonance imaging confirmed a 32 × 22 mm lesion in SII/III, with mild hyper-intensity on T2-weighted images and strong hypo-intensity on T1-weighted images. After administration of contrast medium, the lesion showed light peripheral enhancement on the portal and delayed phases, and hypo-intensity on the hepatospecific phase. No relevant comorbidities were reported (KPS 100). Laboratory tests showed normal liver function and normal CA19-9 levels. A laparoscopic left hemihepatectomy was indicated.
    Results: Operative time was 330 min. Four intermittent Pringle maneuver cycles were applied and no blood transfusions were administered. Intraoperative ultrasound confirmed preoperative findings and additionally highlighted involvement of the SIV duct. A full replacing right hepatic artery arising from the superior mesenteric artery was identified and was preserved during hilar dissection. Postoperative course was uneventful and the patient was discharged on postoperative day 3. The pathology report indicated cholangiocellular carcinoma pT1bN0. Twelve lymph nodes were retrieved.
    Conclusions: According to recent literature reports and our experience, laparoscopic surgery for intrahepatic cholangiocellular carcinoma should be considered feasible and safe in selected patients. Hepatic artery variations allow for adequate lymphadenectomy. Oncological long-term results require multicenter randomized studies in order to be validated.
    Language English
    Publishing date 2022-03-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-022-11549-6
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: ASO Author Reflections: Can Indocyanine Green Increase the Safety of Bile Duct Dissection and Thus Improve Regional Lymphadenectomy in Re-Do Surgery for Incidental Gallbladder Cancer?

    Anselmo, Alessandro / Siragusa, Leandro / Materazzo, Marco / Sforza, Daniele / Bacchiocchi, Giulia / Sensi, Bruno / Tisone, Giuseppe

    Annals of surgical oncology

    2022  Volume 29, Issue 9, Page(s) 5554

    MeSH term(s) Bile Duct Neoplasms/surgery ; Bile Ducts ; Dissection ; Gallbladder Neoplasms/surgery ; Humans ; Indocyanine Green ; Lymph Node Excision
    Chemical Substances Indocyanine Green (IX6J1063HV)
    Language English
    Publishing date 2022-06-23
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-022-12045-7
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    Zs.A 4042: Show issues Location:
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  5. Article ; Online: Indocyanine Green-Guided Laparoscopic Redo Surgery for Incidental T2a Gallbladder Cancer.

    Anselmo, Alessandro / Siragusa, Leandro / Materazzo, Marco / Sforza, Daniele / Bacchiocchi, Giulia / Sensi, Bruno / Tisone, Giuseppe

    Annals of surgical oncology

    2022  Volume 29, Issue 9, Page(s) 5552–5553

    MeSH term(s) Cholecystectomy, Laparoscopic ; Gallbladder Neoplasms/surgery ; Humans ; Incidental Findings ; Indocyanine Green ; Laparoscopy
    Chemical Substances Indocyanine Green (IX6J1063HV)
    Language English
    Publishing date 2022-06-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-022-11918-1
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article ; Online: Percutaneous Tibial Nerve Stimulation Improves Lower Urinary Tract Dysfunction and Infection Rate in a Kidney Transplant Recipient With Augmentation Cystoplasty: A Case Report and Literature Review.

    Orecchia, Luca / Rosato, Eleonora / Siragusa, Leandro / Tisone, Giuseppe / Finazzi Agrò, Enrico / Anselmo, Alessandro

    Transplantation proceedings

    2022  

    Abstract: Almost 20% of patients with congenital posterior urethral valves (PUV) reach end-stage kidney disease requiring kidney transplantation (KT). An augmentation cystoplasty (AC) is performed to treat significant lower urinary tract dysfunction (LUTD) which ... ...

    Abstract Almost 20% of patients with congenital posterior urethral valves (PUV) reach end-stage kidney disease requiring kidney transplantation (KT). An augmentation cystoplasty (AC) is performed to treat significant lower urinary tract dysfunction (LUTD) which can persist afterwards due to residual valve bladder and lead to recurrent urinary tract infections (UTIs) and a worse graft survival. Percutaneous tibial nerve stimulation (PTNS) is a minimally invasive second-line neuromodulation therapy approved for the treatment of non-neurogenic LUTD performed in the outpatient setting. Herein, we reported the case of significant improvement of bladder voiding pattern and yearly UTI rates through PTNS in a 32-year-old male KT recipient with a history of congenital PUV and AC. The patient was referred to our institution at the beginning of 2019 for urgency, high post-void residual volume (PVR) and recurrent clinically significant UTIs (3 to 4/y). After assessment, the patient attended once-weekly 30-minute sessions of PTNS for 12 consecutive weeks. A significant improvement of urodynamic and infectious outcomes was observed through 3-day bladder diaries, questionnaires, and laboratory exams during the subsequent 3 years of regular follow-up. The present results might be significant for the prevention of antibiotic resistance and for better graft survival in KT recipients. We successfully treated a patient with AC, implying that the technique may be appliable also in this case. Neuromodulation in KT is still an unexplored field of research, we advocate for prospective assessment of the efficacy of PTNS in these patients, as reproducible results might lead to life-changing improvements.
    Language English
    Publishing date 2022-10-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2022.08.049
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    Zs.A 835: Show issues Location:
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  7. Article ; Online: Genomic and transcriptomic profiling of hepatocellular carcinoma reveals a rare molecular subtype.

    Zhu, Mengting / Rovella, Valentina / Scimeca, Manuel / Mauriello, Alessandro / Shi, Yufang / Bischof, Julia / Woodsmith, Jonathan / Anselmo, Alessandro / Melino, Gerry / Tisone, Giuseppe / Agostini, Massimiliano

    Discover. Oncology

    2024  Volume 15, Issue 1, Page(s) 10

    Abstract: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide, occurring predominantly in patients with underlying chronic liver disease and cirrhosis. Here, we describe a case of a 62-year-old man that was admitted to our ... ...

    Abstract Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide, occurring predominantly in patients with underlying chronic liver disease and cirrhosis. Here, we describe a case of a 62-year-old man that was admitted to our hospital and diagnosed with HCC where the cancer has already metastasized to the retroperitoneum and peritoneum. In order to better characterize the HCC, both the cancerous liver tissue and the adjacent normal liver tissue of the patient were collected and subjected to a genomic, transcriptomic and proteomic analysis. Our patient carries a highly mutated HCC, which is characterized by both somatic mutation in the following genes ALK, CDK6, TP53, PGR. In addition, we observe several molecular alterations that are associated with potential therapy resistance, for example the expression of the organic-anion-transporting polypeptide (OATP) family members B1 and B3, that mediate the transport of the anticancer drugs, has been found decreased. Overall, our molecular profiling potentially classify the patient with poor prognosis and possibly displaying resistance to pharmacological therapy.
    Language English
    Publishing date 2024-01-16
    Publishing country United States
    Document type Journal Article
    ISSN 2730-6011
    ISSN (online) 2730-6011
    DOI 10.1007/s12672-023-00850-9
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  8. Article: Disappearing Colorectal Liver Metastases: Do We Really Need a Ghostbuster?

    Anselmo, Alessandro / Cascone, Chiara / Siragusa, Leandro / Sensi, Bruno / Materazzo, Marco / Riccetti, Camilla / Bacchiocchi, Giulia / Ielpo, Benedetto / Rosso, Edoardo / Tisone, Giuseppe

    Healthcare (Basel, Switzerland)

    2022  Volume 10, Issue 10

    Abstract: The development of new systemic treatment strategies has resulted in a significant increase in the response rates of colorectal liver metastases (CRLM) in the last few years. Although the radiological response is a favorable prognostic factor, complete ... ...

    Abstract The development of new systemic treatment strategies has resulted in a significant increase in the response rates of colorectal liver metastases (CRLM) in the last few years. Although the radiological response is a favorable prognostic factor, complete shrinkage of CRLM, known as disappearing liver metastases (DLM), presents a therapeutic dilemma, and proper management is still debated in the literature. In fact, DLM is not necessarily equal to cure, and when resected, pathological examination reveals in more than 80% of patients a variable percentage of the tumor as residual disease or early recurrence in situ. Moreover, while a higher incidence of intrahepatic recurrence is documented in small series when surgery is avoided, its clinical significance for long-term OS is still under investigation. In light of this, a multidisciplinary approach and, in particular, radiologists' role is needed to assist the surgeon in the management of DLM, thanks to emerging technology and strategy. Therefore, the aim of this review is to provide an overview of the DLM phenomenon and current management.
    Language English
    Publishing date 2022-09-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare10101898
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  9. Article: KRAS

    Morató, Olga / Villamonte, Maria / Sánchez-Velázquez, Patricia / Pueyo-Périz, Eva / Grande, Luís / Ielpo, Benedetto / Rosso, Edoardo / Anselmo, Alessandro / Burdío, Fernando

    Healthcare (Basel, Switzerland)

    2022  Volume 10, Issue 3

    Abstract: Background: Genetic evaluation is essential in assessing colorectal cancer (CRC) and colorectal liver metastasis (CRLM). The aim of this study was to determine the pragmatic value of : Methods: A retrospective cohort of 126 patients who underwent ... ...

    Abstract Background: Genetic evaluation is essential in assessing colorectal cancer (CRC) and colorectal liver metastasis (CRLM). The aim of this study was to determine the pragmatic value of
    Methods: A retrospective cohort of 126 patients who underwent surgery for hepatic resection for CRLM between 2009 and 2020 were reviewed. The patients were divided into three categories: wild-type
    Results: Of the 108 patients identified, 35 cases had
    Conclusion: Our study considers the possibility of unnecessary
    Language English
    Publishing date 2022-03-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare10030472
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  10. Article ; Online: Attenuation of peri-vascular fat at computed tomography to measure inflammation in ascending aorta aneurysms.

    Gaibazzi, Nicola / Sartorio, Daniele / Tuttolomondo, Domenico / Napolitano, Fiorenza / Siniscalchi, Carmine / Borrello, Bruno / Palumbo, Anselmo Alessandro / Nicolini, Francesco

    European journal of preventive cardiology

    2022  Volume 28, Issue 8, Page(s) e23–e25

    MeSH term(s) Aneurysm, Dissecting ; Aorta/diagnostic imaging ; Aortic Aneurysm/diagnostic imaging ; Humans ; Inflammation/diagnostic imaging ; Tomography, X-Ray Computed
    Language English
    Publishing date 2022-07-01
    Publishing country England
    Document type Letter
    ZDB-ID 2626011-6
    ISSN 2047-4881 ; 2047-4873
    ISSN (online) 2047-4881
    ISSN 2047-4873
    DOI 10.1177/2047487320911846
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