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  1. Article ; Online: Developmental Timing: Honey, I Reprogrammed the Kids.

    Antebi, Adam

    Current biology : CB

    2019  Volume 29, Issue 11, Page(s) R420–R422

    Abstract: A new study finds that signaling pathways promoting developmental quiescence can reprogram developmental time. ...

    Abstract A new study finds that signaling pathways promoting developmental quiescence can reprogram developmental time.
    MeSH term(s) Animals ; Caenorhabditis elegans ; Gene Expression Regulation, Developmental ; Honey ; MicroRNAs ; Pheromones
    Chemical Substances MicroRNAs ; Pheromones
    Language English
    Publishing date 2019-06-04
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2019.04.054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: BLMP-1 is a critical temporal regulator of dietary-restriction-induced response in Caenorhabditis elegans.

    Hu, Qingyuan / Xu, Yunpeng / Song, Mengjiao / Dai, Yumin / Antebi, Adam / Shen, Yidong

    Cell reports

    2024  Volume 43, Issue 3, Page(s) 113959

    Abstract: The extrinsic diet and the intrinsic developmental programs are intertwined. Although extensive research has been conducted on how nutrition regulates development, whether and how developmental programs control the timing of nutritional responses remain ... ...

    Abstract The extrinsic diet and the intrinsic developmental programs are intertwined. Although extensive research has been conducted on how nutrition regulates development, whether and how developmental programs control the timing of nutritional responses remain barely known. Here, we report that a developmental timing regulator, BLMP-1/BLIMP1, governs the temporal response to dietary restriction (DR). At the end of larval development, BLMP-1 is induced and interacts with DR-activated PHA-4/FOXA, a key transcription factor responding to the reduced nutrition. By integrating temporal and nutritional signaling, the DR response regulates many development-related genes, including gska-3/GSK3β, through BLMP-1-PHA-4 at the onset of adulthood. Upon DR, a precocious activation of BLMP-1 in early larval stages impairs neuronal development through gska-3, whereas the increase of gska-3 by BLMP-1-PHA-4 at the last larval stage suppresses WNT signaling in adulthood for DR-induced longevity. Our findings reveal a temporal checkpoint of the DR response that protects larval development and promotes adult health.
    MeSH term(s) Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Caloric Restriction ; Gene Expression Regulation ; Longevity/genetics ; Transcription Factors/metabolism ; Wnt Signaling Pathway
    Chemical Substances Caenorhabditis elegans Proteins ; Transcription Factors ; blmp-1 protein, C elegans
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2024.113959
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Novel Genetic and Phenotypic Expansion in Ameliorated

    Baum, Emily / Huang, Wenming / Vincent-Delorme, Catherine / Brunelle, Perrine / Antebi, Adam / Dafsari, Hormos Salimi

    International journal of molecular sciences

    2024  Volume 25, Issue 4

    Abstract: Heterozygous variants in the Poly(U) Binding Splicing Factor 60kDa gene ( ...

    Abstract Heterozygous variants in the Poly(U) Binding Splicing Factor 60kDa gene (
    MeSH term(s) Humans ; Coloboma ; Mutation, Missense ; Neurodevelopmental Disorders/genetics ; Phenotype ; RNA Splicing Factors/genetics
    Chemical Substances RNA Splicing Factors ; poly-U binding splicing factor 60KDa
    Language English
    Publishing date 2024-02-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25042053
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  4. Article ; Online: Nuclear receptor signal transduction in C. elegans.

    Antebi, Adam

    WormBook : the online review of C. elegans biology

    2015  , Page(s) 1–49

    Abstract: Nuclear receptors are transcription factors that often respond to small molecule metabolites and fat-soluble compounds to regulate gene expression. They broadly govern development, reproduction, metabolism, and homeostasis in diverse metazoan species and ...

    Abstract Nuclear receptors are transcription factors that often respond to small molecule metabolites and fat-soluble compounds to regulate gene expression. They broadly govern development, reproduction, metabolism, and homeostasis in diverse metazoan species and their dysregulation is associated with numerous diseases. Work in C. elegans has shed light on the seminal role of nuclear receptors in life history regulation, stem cell progression, developmental timing, cell fate specification, nutrient sensing, metabolism, and longevity. Here we highlight recent advances on the best-studied nuclear receptors in the worm, and how they illuminate metazoan biology.
    MeSH term(s) Animals ; Caenorhabditis elegans/metabolism ; Receptors, Cytoplasmic and Nuclear/metabolism ; Signal Transduction
    Chemical Substances Receptors, Cytoplasmic and Nuclear
    Language English
    Publishing date 2015-06-09
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1551-8507
    ISSN (online) 1551-8507
    DOI 10.1895/wormbook.1.64.2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Steroid regulation of C. elegans diapause, developmental timing, and longevity.

    Antebi, Adam

    Current topics in developmental biology

    2013  Volume 105, Page(s) 181–212

    Abstract: Hormones play a critical role in driving major stage transitions and developmental timing events in many species. In the nematode C. elegans the steroid hormone receptor, DAF-12, works at the confluence of pathways regulating developmental timing, stage ... ...

    Abstract Hormones play a critical role in driving major stage transitions and developmental timing events in many species. In the nematode C. elegans the steroid hormone receptor, DAF-12, works at the confluence of pathways regulating developmental timing, stage specification, and longevity. DAF-12 couples environmental and physiologic signals to life history regulation, and it is embedded in a rich architecture governing diverse processes. Here, we highlight the molecular insights, extraordinary circuitry, and signaling pathways governing life stage transitions in the worm and how they have yielded fundamental insights into steroid regulation of biological time.
    MeSH term(s) Acclimatization/physiology ; Animals ; Caenorhabditis elegans/growth & development ; Caenorhabditis elegans Proteins/biosynthesis ; Caenorhabditis elegans Proteins/chemistry ; Caenorhabditis elegans Proteins/metabolism ; Gonadal Steroid Hormones/metabolism ; Life Cycle Stages/physiology ; Longevity/physiology ; Models, Biological ; Molecular Structure ; Receptors, Cytoplasmic and Nuclear/biosynthesis ; Receptors, Cytoplasmic and Nuclear/chemistry ; Receptors, Cytoplasmic and Nuclear/metabolism ; Signal Transduction/physiology ; Species Specificity ; Time Factors
    Chemical Substances Caenorhabditis elegans Proteins ; DAF-12 protein, C elegans ; Gonadal Steroid Hormones ; Receptors, Cytoplasmic and Nuclear
    Language English
    Publishing date 2013
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1557-8933 ; 0070-2153
    ISSN (online) 1557-8933
    ISSN 0070-2153
    DOI 10.1016/B978-0-12-396968-2.00007-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: In Vitro Fertilization of the African Turquoise Killifish

    Dolfi, Luca / Suen, Tsz Kin / Medelbekova, Danel / Ripa, Roberto / Symmons, Orsolya / Antebi, Adam

    Cold Spring Harbor protocols

    2023  Volume 2023, Issue 11, Page(s) pdb.prot107886

    Abstract: The ability to perform in vitro fertilization, together with sperm cryopreservation, greatly facilitates the long-term laboratory maintenance of wild-type and transgenic model organisms and helps prevent genetic drift. It is also useful in cases where ... ...

    Abstract The ability to perform in vitro fertilization, together with sperm cryopreservation, greatly facilitates the long-term laboratory maintenance of wild-type and transgenic model organisms and helps prevent genetic drift. It is also useful in cases where reproduction may be compromised. In this protocol, we present a method for in vitro fertilization of the African Turquoise killifish
    MeSH term(s) Animals ; Male ; Fundulidae ; Semen ; Laboratories ; Fertilization in Vitro ; Aging
    Language English
    Publishing date 2023-11-01
    Publishing country United States
    Document type Journal Article
    ISSN 1559-6095
    ISSN (online) 1559-6095
    DOI 10.1101/pdb.prot107886
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Micro-CT Analysis of Fat in the Killifish

    Ripa, Roberto / Mesaros, Andrea / Symmons, Orsolya / Ballhysa, Eugen / Dolfi, Luca / Antebi, Adam

    Cold Spring Harbor protocols

    2023  Volume 2023, Issue 8, Page(s) 107884

    Abstract: Aging is associated with an increase in body fat mass and a concomitant decrease in lean mass and bone density in mammals. Body adiposity can also be redistributed with age, resulting in abdominal fat accumulation and subcutaneous fat reduction. In ... ...

    Abstract Aging is associated with an increase in body fat mass and a concomitant decrease in lean mass and bone density in mammals. Body adiposity can also be redistributed with age, resulting in abdominal fat accumulation and subcutaneous fat reduction. In addition, specific variation in fat distribution is considered to be a risk factor for a number of age-related metabolic disorders. Micro computed tomography (micro-CT) is a nondestructive high-resolution imaging method that uses planar X-ray images captured at various angles around a sample of interest to yield a three-dimensional array of radiodensity values, which can then be used to computationally extract the adipose volume in situ using its innate contrast properties. This method was successfully used to study adipose tissue dynamics in rodents and more recently in zebrafish. The naturally short-lived African turquoise killifish is an emerging model organism to study the biology of aging. Like mammals, killifish also have different fat deposits (visceral and subcutaneous), making them a suitable model to study age-related changes in fat mass and distribution. However, procedures allowing precise quantification of fat content and distribution are missing in this species. Here, we provide an optimized protocol to measure and quantify fat distribution in turquoise killifish by micro-CT scan analysis and show the applicability of the method in young and old animals of both sexes.
    MeSH term(s) Male ; Animals ; Female ; X-Ray Microtomography/methods ; Fundulidae ; Zebrafish ; Adipose Tissue/diagnostic imaging ; Mammals
    Language English
    Publishing date 2023-08-01
    Publishing country United States
    Document type Journal Article
    ISSN 1559-6095
    ISSN (online) 1559-6095
    DOI 10.1101/pdb.prot107884
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Nonlethal Blood Sampling from the Killifish

    Dolfi, Luca / Ripa, Roberto / Medelbekova, Danel / Ballhysa, Eugen / Symmons, Orsolya / Antebi, Adam

    Cold Spring Harbor protocols

    2023  Volume 2023, Issue 8, Page(s) 107745

    Abstract: Blood withdrawal is a common procedure performed on laboratory animals to monitor key processes and indicators of fish health and physiology, such as hematopoiesis, hemostasis, and lipid and glucose metabolism. Moreover, the ability to extract blood with ...

    Abstract Blood withdrawal is a common procedure performed on laboratory animals to monitor key processes and indicators of fish health and physiology, such as hematopoiesis, hemostasis, and lipid and glucose metabolism. Moreover, the ability to extract blood with minimal invasiveness and without sacrificing animals enables repeated sampling, allowing both longitudinal studies of individual animals, as well as reducing the number of experimental animals needed in a study. The African turquoise killifish is an emerging animal model that is progressively being adopted worldwide for aging studies because of its naturally short life span. However, because of the small body size of this species, nonlethal blood collection is a challenging procedure. Here we present a detailed protocol enabling repeated blood sampling from the same individual fish. This method, if correctly executed, is minimally invasive and does not cause any lasting damage. The protocol has been tested on animals spanning from 6 to 24 wk of age and the amount of blood that could be extracted varied from 0.5 to 8 µL, greatly depending on specimen age, sex, and size. This volume is sufficient to perform analyses such as blood glucose measurement, blood cell counts, or histological stains on blood smears.
    MeSH term(s) Animals ; Fundulidae/physiology ; Cyprinodontiformes/physiology ; Aging ; Longevity
    Language English
    Publishing date 2023-08-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1559-6095
    ISSN (online) 1559-6095
    DOI 10.1101/pdb.prot107745
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Sperm Cryopreservation of the African Turquoise Killifish

    Dolfi, Luca / Suen, Tsz Kin / Medelbekova, Danel / Ripa, Roberto / Symmons, Orsolya / Antebi, Adam

    Cold Spring Harbor protocols

    2023  Volume 2023, Issue 11, Page(s) pdb.prot107885

    Abstract: Sperm cryopreservation is an essential method for the genetic preservation and long-term storage of wild-type and transgenic animal stocks. In addition, it allows for the synchronization of gamete availability and the transport and sharing of lines ... ...

    Abstract Sperm cryopreservation is an essential method for the genetic preservation and long-term storage of wild-type and transgenic animal stocks. In addition, it allows for the synchronization of gamete availability and the transport and sharing of lines between different laboratories. Here, we describe a protocol developed in our laboratory for the extraction and cryopreservation of killifish (
    MeSH term(s) Male ; Animals ; Fundulidae ; Semen ; Animals, Genetically Modified ; Cryopreservation ; Aging
    Language English
    Publishing date 2023-11-01
    Publishing country United States
    Document type Journal Article
    ISSN 1559-6095
    ISSN (online) 1559-6095
    DOI 10.1101/pdb.prot107885
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Regulation of longevity by the reproductive system.

    Antebi, Adam

    Experimental gerontology

    2012  Volume 48, Issue 7, Page(s) 596–602

    Abstract: Pioneering work in model organisms reveals that the reproductive system is involved not only in propagation of the species but also regulates organismal metabolism and longevity. In C. elegans, prevention of germline stem cell proliferation results in a ... ...

    Abstract Pioneering work in model organisms reveals that the reproductive system is involved not only in propagation of the species but also regulates organismal metabolism and longevity. In C. elegans, prevention of germline stem cell proliferation results in a 60% extension of lifespan, termed gonadal longevity. Gonadal longevity relies on the transcriptional activities of steroid nuclear receptor DAF-12, the FOXO transcription factor homolog DAF-16, the FOXA transcription factor homolog PHA-4, and the HNF-4-like nuclear receptor NHR-80. These transcription factors work in an integrated transcriptional network to regulate fatty acid lipolysis, autophagy, stress resistance and other processes, which altogether enhance homeostasis and extend life. Because the reproductive system also regulates longevity in other species, studies in C. elegans may shed light on ancient mechanisms governing reproduction and survival.
    MeSH term(s) Age Factors ; Aging/genetics ; Aging/metabolism ; Aging/physiology ; Animals ; Autophagy ; Cell Proliferation ; Cellular Senescence ; Energy Metabolism ; Gene Expression Regulation ; Gonadal Steroid Hormones/metabolism ; Gonads/metabolism ; Gonads/physiology ; Homeostasis ; Humans ; Longevity ; Models, Biological ; Reproduction/genetics ; Signal Transduction ; Transcription Factors/metabolism
    Chemical Substances Gonadal Steroid Hormones ; Transcription Factors
    Language English
    Publishing date 2012-10-11
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 390992-x
    ISSN 1873-6815 ; 0531-5565
    ISSN (online) 1873-6815
    ISSN 0531-5565
    DOI 10.1016/j.exger.2012.09.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 579: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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