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  1. Article ; Online: A subpopulation of cortical VIP-expressing interneurons with highly dynamic spines

    Christina Georgiou / Vassilis Kehayas / Kok Sin Lee / Federico Brandalise / Daniela A. Sahlender / Jerome Blanc / Graham Knott / Anthony Holtmaat

    Communications Biology, Vol 5, Iss 1, Pp 1-

    2022  Volume 15

    Abstract: Advanced light and electron microscopy identify a subset of cortical multipolar vasoactive intestinal peptide interneurons with high spine dynamics and characteristics that are greatly different from pyramidal neurons. ...

    Abstract Advanced light and electron microscopy identify a subset of cortical multipolar vasoactive intestinal peptide interneurons with high spine dynamics and characteristics that are greatly different from pyramidal neurons.
    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Dynamic perceptual feature selectivity in primary somatosensory cortex upon reversal learning

    Ronan Chéreau / Tanika Bawa / Leon Fodoulian / Alan Carleton / Stéphane Pagès / Anthony Holtmaat

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 14

    Abstract: Do cortical neurons stably represent stimulus features in different contexts? Here, using calcium imaging, the authors show that texture selectivity of individual neurons is dynamic during reversal learning. For a subclass this is contingent on the ... ...

    Abstract Do cortical neurons stably represent stimulus features in different contexts? Here, using calcium imaging, the authors show that texture selectivity of individual neurons is dynamic during reversal learning. For a subclass this is contingent on the associated reward and forecasts the onset of learning.
    Keywords Science ; Q
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Dynamic perceptual feature selectivity in primary somatosensory cortex upon reversal learning

    Ronan Chéreau / Tanika Bawa / Leon Fodoulian / Alan Carleton / Stéphane Pagès / Anthony Holtmaat

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 14

    Abstract: Do cortical neurons stably represent stimulus features in different contexts? Here, using calcium imaging, the authors show that texture selectivity of individual neurons is dynamic during reversal learning. For a subclass this is contingent on the ... ...

    Abstract Do cortical neurons stably represent stimulus features in different contexts? Here, using calcium imaging, the authors show that texture selectivity of individual neurons is dynamic during reversal learning. For a subclass this is contingent on the associated reward and forecasts the onset of learning.
    Keywords Science ; Q
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Neurogliaform cortical interneurons derive from cells in the preoptic area

    Mathieu Niquille / Greta Limoni / Foivos Markopoulos / Christelle Cadilhac / Julien Prados / Anthony Holtmaat / Alexandre Dayer

    eLife, Vol

    2018  Volume 7

    Abstract: Delineating the basic cellular components of cortical inhibitory circuits remains a fundamental issue in order to understand their specific contributions to microcircuit function. It is still unclear how current classifications of cortical interneuron ... ...

    Abstract Delineating the basic cellular components of cortical inhibitory circuits remains a fundamental issue in order to understand their specific contributions to microcircuit function. It is still unclear how current classifications of cortical interneuron subtypes relate to biological processes such as their developmental specification. Here we identified the developmental trajectory of neurogliaform cells (NGCs), the main effectors of a powerful inhibitory motif recruited by long-range connections. Using in vivo genetic lineage-tracing in mice, we report that NGCs originate from a specific pool of 5-HT3AR-expressing Hmx3+ cells located in the preoptic area (POA). Hmx3-derived 5-HT3AR+ cortical interneurons (INs) expressed the transcription factors PROX1, NR2F2, the marker reelin but not VIP and exhibited the molecular, morphological and electrophysiological profile of NGCs. Overall, these results indicate that NGCs are a distinct class of INs with a unique developmental trajectory and open the possibility to study their specific functional contribution to cortical inhibitory microcircuit motifs.
    Keywords Cortex ; development ; interneurons ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2018-03-01T00:00:00Z
    Publisher eLife Sciences Publications Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Computer assisted detection of axonal bouton structural plasticity in in vivo time-lapse images

    Rohan Gala / Daniel Lebrecht / Daniela A Sahlender / Anne Jorstad / Graham Knott / Anthony Holtmaat / Armen Stepanyants

    eLife, Vol

    2017  Volume 6

    Abstract: The ability to measure minute structural changes in neural circuits is essential for long-term in vivo imaging studies. Here, we propose a methodology for detection and measurement of structural changes in axonal boutons imaged with time-lapse two-photon ...

    Abstract The ability to measure minute structural changes in neural circuits is essential for long-term in vivo imaging studies. Here, we propose a methodology for detection and measurement of structural changes in axonal boutons imaged with time-lapse two-photon laser scanning microscopy (2PLSM). Correlative 2PLSM and 3D electron microscopy (EM) analysis, performed in mouse barrel cortex, showed that the proposed method has low fractions of false positive/negative bouton detections (2/0 out of 18), and that 2PLSM-based bouton weights are correlated with their volumes measured in EM (r = 0.93). Next, the method was applied to a set of axons imaged in quick succession to characterize measurement uncertainty. The results were used to construct a statistical model in which bouton addition, elimination, and size changes are described probabilistically, rather than being treated as deterministic events. Finally, we demonstrate that the model can be used to quantify significant structural changes in boutons in long-term imaging experiments.
    Keywords bouton detection ; bouton volume ; structural plasticity ; time-lapse imaging ; synaptic strength ; CLEM ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2017-10-01T00:00:00Z
    Publisher eLife Sciences Publications Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Transcriptomic and anatomic parcellation of 5-HT3AR expressing cortical interneuron subtypes revealed by single-cell RNA sequencing

    Sarah Frazer / Julien Prados / Mathieu Niquille / Christelle Cadilhac / Foivos Markopoulos / Lucia Gomez / Ugo Tomasello / Ludovic Telley / Anthony Holtmaat / Denis Jabaudon / Alexandre Dayer

    Nature Communications, Vol 8, Iss 1, Pp 1-

    2017  Volume 12

    Abstract: Cortical GABAergic interneurons are highly diverse in their gene expression, electrophysiological properties, and connectivity. Here the authors reveal three distinct subtypes of Htr3a-GFP+ interneurons using the single-cell RNA-seq approach, and ... ...

    Abstract Cortical GABAergic interneurons are highly diverse in their gene expression, electrophysiological properties, and connectivity. Here the authors reveal three distinct subtypes of Htr3a-GFP+ interneurons using the single-cell RNA-seq approach, and identify MEIS2 as a marker for one such subtype.
    Keywords Science ; Q
    Language English
    Publishing date 2017-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  7. Article ; Online: Input-dependent regulation of excitability controls dendritic maturation in somatosensory thalamocortical neurons

    Laura Frangeul / Vassilis Kehayas / Jose V. Sanchez-Mut / Sabine Fièvre / K. Krishna-K / Gabrielle Pouchelon / Ludovic Telley / Camilla Bellone / Anthony Holtmaat / Johannes Gräff / Jeffrey D. Macklis / Denis Jabaudon

    Nature Communications, Vol 8, Iss 1, Pp 1-

    2017  Volume 10

    Abstract: Sensory input and neuronal activity are crucial for proper morphological development of neurons. Here, Frangeul and colleagues show that membrane excitability is a critical component of dendritic development in mouse somatosensory thalamocortical neurons. ...

    Abstract Sensory input and neuronal activity are crucial for proper morphological development of neurons. Here, Frangeul and colleagues show that membrane excitability is a critical component of dendritic development in mouse somatosensory thalamocortical neurons.
    Keywords Science ; Q
    Language English
    Publishing date 2017-12-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  8. Article ; Online: Input-dependent regulation of excitability controls dendritic maturation in somatosensory thalamocortical neurons

    Laura Frangeul / Vassilis Kehayas / Jose V. Sanchez-Mut / Sabine Fièvre / K. Krishna-K / Gabrielle Pouchelon / Ludovic Telley / Camilla Bellone / Anthony Holtmaat / Johannes Gräff / Jeffrey D. Macklis / Denis Jabaudon

    Nature Communications, Vol 8, Iss 1, Pp 1-

    2017  Volume 10

    Abstract: Sensory input and neuronal activity are crucial for proper morphological development of neurons. Here, Frangeul and colleagues show that membrane excitability is a critical component of dendritic development in mouse somatosensory thalamocortical neurons. ...

    Abstract Sensory input and neuronal activity are crucial for proper morphological development of neurons. Here, Frangeul and colleagues show that membrane excitability is a critical component of dendritic development in mouse somatosensory thalamocortical neurons.
    Keywords Science ; Q
    Language English
    Publishing date 2017-12-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  9. Article ; Online: Correlative in vivo 2 photon and focused ion beam scanning electron microscopy of cortical neurons.

    Bohumil Maco / Anthony Holtmaat / Marco Cantoni / Anna Kreshuk / Christoph N Straehle / Fred A Hamprecht / Graham W Knott

    PLoS ONE, Vol 8, Iss 2, p e

    2013  Volume 57405

    Abstract: Correlating in vivo imaging of neurons and their synaptic connections with electron microscopy combines dynamic and ultrastructural information. Here we describe a semi-automated technique whereby volumes of brain tissue containing axons and dendrites, ... ...

    Abstract Correlating in vivo imaging of neurons and their synaptic connections with electron microscopy combines dynamic and ultrastructural information. Here we describe a semi-automated technique whereby volumes of brain tissue containing axons and dendrites, previously studied in vivo, are subsequently imaged in three dimensions with focused ion beam scanning electron microcopy. These neurites are then identified and reconstructed automatically from the image series using the latest segmentation algorithms. The fast and reliable imaging and reconstruction technique avoids any specific labeling to identify the features of interest in the electron microscope, and optimises their preservation and staining for 3D analysis.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2013-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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