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  1. Article ; Online: Therapy initiation and rapid start with Bictegravir/Emtricitabine/Tenofovir Alafenamide in PLWH.

    Antinori, Andrea

    Le infezioni in medicina

    2023  Volume 31, Issue 3, Page(s) 277–282

    Abstract: Advanced HIV naive represents an unfavorable prognostic condition due to a persistent high risk of death, increased probability of virological failure, immunologic impairment, clinical progression, and immune reconstitution inflammatory syndrome (IRIS), ... ...

    Abstract Advanced HIV naive represents an unfavorable prognostic condition due to a persistent high risk of death, increased probability of virological failure, immunologic impairment, clinical progression, and immune reconstitution inflammatory syndrome (IRIS), cumulative adverse drug events, drug-drug interactions and increased healthcare costs. Currently, all international guidelines recommend the rapid initiation of ART, especially in late-stage naive patients. Bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF), due to its efficacy high genetic barrier, good safety profile, and low DDI potential, is one of the regimens recommended for overall rapid initiation by international guidelines. B/F/TAF has been tested in observational or uncontrolled pilot studies (OPERA, RAINBOW), while a large randomized controlled trial is currently ongoing (LAPTOP). In conclusion, B/F/TAF is an ideal combination for the initiation of antiretroviral therapy, particularly in the HIV late presenter or advanced HIV disease patient, even in the context of rapid start or same-day treatment regimens, where the initiation of treatment usually occurs in the absence of information on viral load, CD4 count, biochemical profile and HIV transmitted resistance.
    Language English
    Publishing date 2023-09-01
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2041081-5
    ISSN 2532-8689 ; 1124-9390
    ISSN (online) 2532-8689
    ISSN 1124-9390
    DOI 10.53854/liim-3103-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5576: Show issues Location:
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  2. Book ; Conference proceedings: Proceedings of the 1st Workshop on HAART Adherence: State-of-the-Art

    Antinori, Andrea

    derived from a workshop held in Rome, June 25 - 26, 2001]

    (Journal of acquired immune deficiency syndromes ; 31, Suppl. 3)

    2002  

    Institution Workshop on HAART Adherence: State-of-the-Art
    Author's details guest ed. Andrea Antinori
    Series title Journal of acquired immune deficiency syndromes ; 31, Suppl. 3
    Collection
    Language English
    Size S. S95 - S169 : Ill., graph. Darst.
    Publisher Lippincott Williams & Wilkins
    Publishing place Hagerstown, MD
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT013577045
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 2442 -31,Suppl.3- not available for loan Zeitschriften-Lesesaal

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  3. Article ; Online: The Burden of COVID-19 in the Immunocompromised Patient: Implications for Vaccination and Needs for the Future.

    Antinori, Andrea / Bausch-Jurken, Mary

    The Journal of infectious diseases

    2023  Volume 228, Issue Suppl 1, Page(s) S4–S12

    Abstract: Approximately 3% of US adults are immunocompromised and less capable of fighting infections such as SARS-CoV-2 (the causative agent of COVID-19). Individuals may be immunocompromised for reasons related to an underlying medical condition or to ... ...

    Abstract Approximately 3% of US adults are immunocompromised and less capable of fighting infections such as SARS-CoV-2 (the causative agent of COVID-19). Individuals may be immunocompromised for reasons related to an underlying medical condition or to immunomodulatory therapies that alter the immune response. In general, vaccination with mRNA-based vaccines is effective at reducing COVID-19-associated hospitalization and death among immunocompromised populations, particularly after 3 or more doses. However, the immunocompromised population is heterogeneous, with COVID-19 vaccine-elicited immune responses and risk for severe COVID-19 existing on a continuum. Therefore, understanding the impact of vaccination and the complexity of immune responses across heterogeneous immunocompromised individuals is essential for guiding effective vaccination regimens including additional (booster) doses. In this article, we provide an overview of the immunocompromised population and the burden of disease attributable to COVID-19, while discussing key opportunities and challenges of vaccinating immunocompromised individuals.
    MeSH term(s) Adult ; Humans ; COVID-19/prevention & control ; COVID-19 Vaccines ; SARS-CoV-2 ; Hospitalization ; Vaccination ; mRNA Vaccines
    Chemical Substances COVID-19 Vaccines ; mRNA Vaccines
    Language English
    Publishing date 2023-08-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiad181
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    Zs.MO 445: Show issues

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  4. Article ; Online: Progress in the evaluation of modified vaccinia Ankara vaccine against mpox.

    Mazzotta, Valentina / Matusali, Giulia / Oliva, Alessandra / Maggi, Fabrizio / Antinori, Andrea

    The Lancet. Infectious diseases

    2023  Volume 23, Issue 11, Page(s) 1214–1215

    MeSH term(s) Humans ; Vaccinia/prevention & control ; Mpox (monkeypox) ; Vaccinia virus ; Viral Vaccines
    Chemical Substances Viral Vaccines
    Language English
    Publishing date 2023-07-17
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(23)00369-9
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    Zs.A 5743: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Long-term outcome of dolutegravir-containing regimens according to sex: data from the ICONA Study-authors' response.

    Monforte, Antonella d'Arminio / Tavelli, Alessandro / Antinori, Andrea / Cozzi-Lepri, Alessandro

    The Journal of antimicrobial chemotherapy

    2023  Volume 78, Issue 7, Page(s) 1809–1810

    MeSH term(s) Humans ; HIV Infections/drug therapy ; Anti-HIV Agents/therapeutic use ; Oxazines/therapeutic use ; Heterocyclic Compounds, 3-Ring/therapeutic use ; Pyridones/therapeutic use
    Chemical Substances dolutegravir (DKO1W9H7M1) ; Anti-HIV Agents ; Oxazines ; Heterocyclic Compounds, 3-Ring ; Pyridones
    Language English
    Publishing date 2023-05-25
    Publishing country England
    Document type Research Support, Non-U.S. Gov't ; Letter ; Comment
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkad152
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    Zs.A 1197: Show issues Location:
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    Zs.MO 124: Show issues

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  6. Article ; Online: Monkeypox Virus Infection across 16 Countries - April-June 2022. Reply.

    Thornhill, John P / Antinori, Andrea / Orkin, Chloe M

    The New England journal of medicine

    2021  Volume 387, Issue 25, Page(s) e69

    MeSH term(s) Humans ; Monkeypox virus ; Mpox (monkeypox)/epidemiology ; Mpox (monkeypox)/virology
    Language English
    Publishing date 2021-07-03
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2213969
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  7. Article ; Online: Lymphomas included in the AIDS case definition: an update 30 years later.

    Vaccher, Emanuela / Chadburn, Amy / Gloghini, Annunziata / Antinori, Andrea / Bower, Mark / Carbone, Antonino

    The lancet. HIV

    2023  Volume 10, Issue 10, Page(s) e635

    Language English
    Publishing date 2023-09-06
    Publishing country Netherlands
    Document type Letter
    ISSN 2352-3018
    ISSN (online) 2352-3018
    DOI 10.1016/S2352-3018(23)00199-6
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  8. Article ; Online: Evaluating the Dual-Target Aptima HIV-1 Quant Dx Assay: Comparison between Viral Loads Measured with

    Sberna, Giuseppe / Sarti, Silvia / Cicalini, Stefania / Antinori, Andrea / Garbuglia, Anna Rosa / Amendola, Alessandra

    Microbiology spectrum

    2022  Volume 10, Issue 5, Page(s) e0136122

    Abstract: For effective management of HIV-1 patients, accurate measurement of HIV-1-RNA viral load (VL) is fundamental. The latest generation molecular assays for monitoring VL perform simultaneous detection of two regions of the viral genome, but without ... ...

    Abstract For effective management of HIV-1 patients, accurate measurement of HIV-1-RNA viral load (VL) is fundamental. The latest generation molecular assays for monitoring VL perform simultaneous detection of two regions of the viral genome, but without specifying the target used for VL quantitation. By using the "open" software (research use only [RUO]) of Aptima HIV-1 Quant Dx Assay (Aptima) which provides both results obtained with the
    MeSH term(s) Humans ; Viral Load/methods ; HIV-1/genetics ; RNA, Viral/genetics ; RNA, Viral/analysis ; Reagent Kits, Diagnostic ; Molecular Diagnostic Techniques/methods ; Sensitivity and Specificity ; HIV Infections/diagnosis ; HIV Infections/drug therapy
    Chemical Substances RNA, Viral ; Reagent Kits, Diagnostic
    Language English
    Publishing date 2022-09-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.01361-22
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  9. Article ; Online: Monkeypox virus in human body sites and fluids: evidence for transmission.

    Colavita, Francesca / Antinori, Andrea / Nicastri, Emanuele / Focosi, Daniele / Girardi, Enrico / Vaia, Francesco / Maggi, Fabrizio

    The Lancet. Infectious diseases

    2022  Volume 23, Issue 1, Page(s) 6–8

    MeSH term(s) Humans ; Monkeypox virus ; Human Body ; Mpox (monkeypox)/epidemiology ; Disease Outbreaks ; Feces
    Language English
    Publishing date 2022-09-29
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(22)00639-9
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    Zs.A 5743: Show issues Location:
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  10. Article: Efficacy and Safety of Anticoagulant Therapy in COVID-19-Related Pulmonary Embolism with Different Extension.

    Gatto, Maria Chiara / Oliva, Alessandra / Palazzolo, Claudia / Picariello, Claudio / Garascia, Andrea / Nicastri, Emanuele / Girardi, Enrico / Antinori, Andrea

    Biomedicines

    2023  Volume 11, Issue 5

    Abstract: Pulmonary embolism (PE) has been associated with SARS-CoV-2 infection, and its incidence is highly variable. The aim of our study was to describe the radiological and clinical presentations, as well as the therapeutic management, of PEs that occurred ... ...

    Abstract Pulmonary embolism (PE) has been associated with SARS-CoV-2 infection, and its incidence is highly variable. The aim of our study was to describe the radiological and clinical presentations, as well as the therapeutic management, of PEs that occurred during SARS-CoV-2 infection in a cohort of hospitalized patients. In this observational study, we enrolled patients with moderate COVID-19 who developed PE during hospitalization. Clinical, laboratory, and radiological features were recorded. PE was diagnosed on clinical suspicion and/or CT angiography. According to CT angiography results, two groups of patients were further distinguished: those with proximal or central pulmonary embolism (cPE) and those with distal or micro-pulmonary embolism (mPE). A total of 56 patients with a mean age of 78 ± 15 years were included. Overall, PE occurred after a median of 2 days from hospitalization (range 0-47 days) and, interestingly, the majority of them (89%) within the first 10 days of hospitalization, without differences between the groups. Patients with cPE were younger (
    Language English
    Publishing date 2023-04-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11051282
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