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  1. AU="Antoine Fakhry Abdelmassih"
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  1. Article ; Online: Low iron mitigates viral survival

    Rahma Menshawey / Esraa Menshawey / Ayman H. K. Alserr / Antoine Fakhry Abdelmassih

    Egyptian Journal of Medical Human Genetics, Vol 21, Iss 1, Pp 1-

    insights from evolution, genetics, and pandemics—a review of current hypothesis

    2020  Volume 14

    Abstract: Abstract Background Upon re-examination of our human history, evolutionary perspectives, and genetics, a prevailing iron deficiency phenotype appears to have evolved to protect the human race from extinction. Body In this review, we summarize the ... ...

    Abstract Abstract Background Upon re-examination of our human history, evolutionary perspectives, and genetics, a prevailing iron deficiency phenotype appears to have evolved to protect the human race from extinction. Body In this review, we summarize the evolutionary and genetic perspectives pointing towards the hypothesis that low iron mitigates infection. The presence of infection promotes the generation of resistance alleles, and there are some evolutionary and genetic clues that suggest the presence of an iron deficiency phenotype that may have developed to protect against infection. Examples include the relative paucity of iron overload genes given the essential role of iron, as well as the persistence of iron deficiency among populations in spite of public health efforts to treat it. Additional examination of geographic areas with severe iron deficiency in the setting of pandemics including H1N1, SARS, and COVID-19 reveals that areas with higher prevalence of iron deficiency are less affected. RNA viruses have several evolutionary adaptations which suggest their absolute need for iron, and this dependency may be exploited during treatment. Conclusion RNA viruses pose a unique challenge to modern healthcare, with an average of 2–3 new pathogens being discovered yearly. Their overarching requirements for iron, along with human evolutionary and genetic adaptations which favored an iron deficiency phenotype, ultimately suggest the potential need for iron control in these infections.
    Keywords Iron deficiency anemia ; RNA viruses ; COVID-19 ; Hyperferritinemia ; Hepcidin ; Ferroptosis ; Medicine (General) ; R5-920 ; Genetics ; QH426-470
    Subject code 570
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher SpringerOpen
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Intensity of inflammation as the most important predictor of myocardial involvement in JIA. A 3D echocardiographic study.

    Antoine Fakhry AbdelMassih / Amr Salem / Salma Arabi / Lauris Malak / Huda Marzouk

    Acta Reumatológica Portuguesa, Vol 2019, Iss 4, Pp 296-

    2019  Volume 302

    Abstract: Introduction: Myocardial dysfunction is an important complication in the context of juvenile idiopathic arthritis (JIA). Several mechanisms might be involved in the induction of myocardial injury in such a disabling disease. Among several factors ... ...

    Abstract Introduction: Myocardial dysfunction is an important complication in the context of juvenile idiopathic arthritis (JIA). Several mechanisms might be involved in the induction of myocardial injury in such a disabling disease. Among several factors involved, myocardial inflammation and cardiotoxic drugs were thought to be the most incriminated factors. The aim of this paper was to determine the most important factors that implicated myocardial injury in JIA and to weigh whether the severity of inflammation varies significantly among the several subtypes or not. Methods: Sixty JIA patients as well as sixty, age and surface area, matched controls were subjected to conventional Echocardiography, 3D Speckle tracking and the disease activity was measured as by Juvenile Arthritis Disease Score 27 (JADAS 27). Results: JIA cases showed statistically significant systolic and diastolic dysfunction when compared to controls. Global longitudinal strain (GLS) (index of systolic function) was lower in cases compared to controls (JIA: 16.1±6.7 vs Controls: 23.9±1.4, P < 0.0001), Left Ventricular ratio of early diastolic mitral inflow velocity to average of early diastolic velocities of the mitral annulus and basal septum (LV E/E’) (index of diastolic function) was higher in cases compared to controls (JIA: 14.8±7 vs. Controls: 5.9±1.3). There was no statistically significant difference in echocardiographic parameters as well as JADAS 27 between subtypes of JIA patients. Multivariate analysis showed that the best predictor of both systolic and diastolic involvement of the myocardium in JIA patients was the severity of inflammation rather than the duration or the type of medications used. Conclusion: This study points out the potential of inflammation as an important inducer of myocardial injury in JIA. It also underlines the fact that this inflammation does not differ significantly according to the disease subtype.
    Keywords echocardiography ; juvenile idiopathic arthritis ; Internal medicine ; RC31-1245 ; Immunologic diseases. Allergy ; RC581-607
    Subject code 610
    Language English
    Publishing date 2019-10-01T00:00:00Z
    Publisher Sociedade Portuguesa de Reumatologia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Effect of pioglitazone, as antidiabetic agent, on atheroma regression in type 2 diabetic patients

    Antoine Fakhry AbdelMassih / Ahmed Ashraf / Habiba-Allah Ismail / Bassant AbdelAzeim / Ihab Hany Barsoum / Shady Girgis / George Afdal / Nesrine AbdelAzeim / Peter Afdal / Esraa Menshawey / Rahma Menshawey / Kirollos Badr / Mariem Arsanyous

    Beni-Suef University Journal of Basic and Applied Sciences, Vol 10, Iss 1, Pp 1-

    a systematic review and meta-analysis

    2021  Volume 6

    Abstract: Abstract Background Pioglitazone’s role in the induction of atheroma regression in diabetics was suggested by several RCT. The aim of our study was to evaluate this role through a systematic review of all RCT conducted on this subject. Methods Literature ...

    Abstract Abstract Background Pioglitazone’s role in the induction of atheroma regression in diabetics was suggested by several RCT. The aim of our study was to evaluate this role through a systematic review of all RCT conducted on this subject. Methods Literature was searched for relevant studies. We included all RCT that compared pioglitazone versus other antidiabetic agents. Mean differences of either AV or CIMT, HbA1C, HDL, and LDL between the two groups were used to assess the effect of pioglitazone versus alternative therapies. Results Six RCT were included with a total of 1180 patients. Pioglitazone was significantly superior to glimepiride and gliclazide in improving IMT. No significant difference was observed in overall AV, HbA1C, and LDL. Conclusion The latter findings confirm that anti-atheroma action of pioglitazone is not achieved through its antiglycemic or antidyslipidemia effects, but probably through a DNA-mediated effect, and may lead to its repurposing for reversal of organ fibrosis.
    Keywords Pioglitazone ; Antiatherogenic effect ; Regenerative medicine ; Metabolic syndrome ; Type 2 diabetes mellitus ; Medicine (General) ; R5-920 ; Science ; Q
    Subject code 150
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher SpringerOpen
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Unleashing the mysterious link between COVID-19 and a famous childhood vasculitis

    Antoine Fakhry AbdelMassih / Aisha Said AbdelAzeam / Aya Ayad / Aya Yasser Kamel / Ayah Khalil / Basma Kotb / Dina Waheed / Esraa Menshawey / Fady Sefein / Farah Taha / Habiba-Allah Ismail / Ibrahim Osman / John Iskander / Lama El Wakil / Lara Rashad / Mariem Badr Arsanyous / Meryam El Shershaby / Mina Mansour / Mirette Ashraf /
    Nada Hafez / Nadeen Mohamed Abuzeid / Noheir Mahmoud-Nashaat AbdElSalam / Nouran Gamal Hafez / Nourhan Youssef / Rafeef Hozaien / Rana Saeed / Dina Kamel / Manal Ahmed AbdelHameed / Salma Ali

    Egyptian Pediatric Association Gazette, Vol 68, Iss 1, Pp 1-

    Kawasaki disease

    2020  Volume 7

    Abstract: Abstract Background Coronavirus disease 2019 (COVID-19) emerged as a small outbreak in Wuhan rapidly progressing into the deadliest pandemic since the Spanish flu of 1918. The disease was deemed trivial in children, until the reporting, few days ago, of ... ...

    Abstract Abstract Background Coronavirus disease 2019 (COVID-19) emerged as a small outbreak in Wuhan rapidly progressing into the deadliest pandemic since the Spanish flu of 1918. The disease was deemed trivial in children, until the reporting, few days ago, of an emerging pediatric multi-inflammatory syndrome mimicking Kawasaki disease (KD). Main body This report reveals that coronaviridae were implicated in induction of several post-infectious vasculitides, namely, KD, AHEI, and HSP. This occurs in genetically susceptible individuals to vascular inflammation. Shared genetic susceptibilities between KD and CoV include genes encoding for CD 40, HLAB-15:03, and ACE. This leads to augmented inflammation with hypersecretion of cytokines especially IL-6. Conclusion The revealed relationships between KD and CoV can help to predict the risk of KD in COVID-19 patients through screening levels of upregulated cytokines. It might also signify that classic treatment of KD with IVIG might need to be replaced with anti-cytokine therapy in COVID-19 patients.
    Keywords COVID-19 ; Kawasaki disease ; Shared genetic and inflammatory pathways ; Upregulated inflammation ; Pediatrics ; RJ1-570 ; covid19
    Subject code 610
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher SpringerOpen
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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