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Article ; Online: Neuropsychiatric complications and associated management in adolescent and young adult cancer survivors: An All of Us study.

Agapito, Ivann / Ng, Ding Quan / Milam, Joel / Ziogas, Argyrios / Anton-Culver, Hoda / Chan, Alexandre

2023 Volume 12, Issue 22, Page(s) 20953–20963

Abstract: Background: About 4.5% of new cancer cases affect adolescent and young adult aged between 15 and 39 years in the United States (US). However, the effect of neuropsychiatric conditions on long-term adolescent and young adult cancer (AYAC) survivors has ... ...

Abstract	Background: About 4.5% of new cancer cases affect adolescent and young adult aged between 15 and 39 years in the United States (US). However, the effect of neuropsychiatric conditions on long-term adolescent and young adult cancer (AYAC) survivors has not been formally investigated. Thus, the impact and management of late neuropsychiatric complications in AYAC survivors compared to non-cancer-matched controls (NCMC) in the US were evaluated using the All of Us (AoU) Research Program. Methods: Participants in the AoU Controlled Tier Dataset (v6) diagnosed with cancer between ages 15 and 39 were identified from electronic health records and surveys. AYAC survivors were matched with NCMC using the optimal pair-matching algorithm at a 1:4 ratio. Data on past diagnoses, current follow-up care, and treatment patterns of neuropsychiatric complications were collected. Results: Analysis was performed on 788 AYAC survivors and 3152 NCMC. AYAC survivors, with an average of 8.8 years since their first cancer diagnosis, were more likely than NCMC to receive a diagnosis of neuropathy, memory loss and epilepsy (p < 0.001). Survivors also had a higher rate of follow-up care and treatment utilization for these neurological conditions compared to NCMC (p < 0.05). Treatment utilization was highest among survivors receiving care for epilepsy (88%), and lower for neuropathy (70%), memory loss (61%), and chronic fatigue (59%). Conclusions: This large study reveals that AYAC survivors, on average 9 years after their cancer diagnosis, require more frequent follow-up care for neurological complications compared to non-cancer individuals. However, the management of neuropathy, memory loss, and chronic fatigue is hindered by a lack of mechanism-based effective therapies.
MeSH term(s)	Humans ; Adolescent ; Young Adult ; United States ; Adult ; Cancer Survivors ; Fatigue Syndrome, Chronic ; Population Health ; Neoplasms/complications ; Neoplasms/epidemiology ; Neoplasms/therapy ; Memory Disorders ; Epilepsy
Language	English
Publishing date	2023-10-30
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.6641
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Article ; Online: Survival of Middle Eastern and North African Individuals Diagnosed with Colorectal Cancer: A Population-Based Study in California.

Zaki, Timothy A / Ziogas, Argyrios / Chang, Jenny / Murphy, Caitlin C / Anton-Culver, Hoda

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

2023 Volume 32, Issue 6, Page(s) 795–801

Abstract: Background: Literature on colorectal cancer outcomes in individuals of Middle Eastern and North African (MENA) descent is limited. To address this gap, we estimated five-year colorectal cancer-specific survival by race and ethnicity, including MENA ... ...

Abstract	Background: Literature on colorectal cancer outcomes in individuals of Middle Eastern and North African (MENA) descent is limited. To address this gap, we estimated five-year colorectal cancer-specific survival by race and ethnicity, including MENA individuals, in a diverse, population-based sample in California. Methods: We identified adults (ages 18-79 years) diagnosed with a first or only colorectal cancer in 2004 to 2017 using the California Cancer Registry (CCR), including non-Hispanic White, non-Hispanic Black, non-Hispanic Asian, Hispanic, and MENA individuals. For each racial/ethnic group, we calculated five-year colorectal cancer-specific survival and used Cox proportional hazards regression models to examine the association of race/ethnicity and survival, adjusting for clinical and socio demographic factors. Results: Of 110,192 persons diagnosed with colorectal cancer, five-year colorectal cancer-specific survival was lowest in Black (61.0%) and highest in MENA (73.2%) individuals. Asian (72.2%) individuals had higher survival than White (70.0%) and Hispanic (68.2%) individuals. In adjusted analysis, MENA [adjusted HR (aHR), 0.82; 95% confidence interval (CI), 0.76-0.89], Asian (aHR, 0.86; 95% CI, 0.83-0.90), and Hispanic (aHR, 0.94; 95% CI, 0.91-0.97) race/ethnicity were associated with higher, and Black (aHR, 1.13; 95% CI, 1.09-1.18) race/ethnicity was associated with lower survival compared with non-Hispanic White race/ethnicity. Conclusions: To our knowledge, this is the first study to report colorectal cancer survival in MENA individuals in the United States. We observed higher survival of MENA individuals compared with other racial/ethnic groups, adjusting for sociodemographic and clinical factors. Impact: Future studies are needed to identify factors contributing to cancer outcomes in this unique population.
MeSH term(s)	Adult ; Humans ; California/epidemiology ; Colorectal Neoplasms/ethnology ; North African People ; United States ; White ; Adolescent ; Young Adult ; Middle Aged ; Aged ; Middle Eastern People
Language	English
Publishing date	2023-04-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	1153420-5
ISSN	1538-7755 ; 1055-9965
ISSN (online)	1538-7755
ISSN	1055-9965
DOI	10.1158/1055-9965.EPI-22-1326
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Article ; Online: Relationship between BMI trajectories and cardiometabolic outcomes in postmenopausal women: a growth mixture modeling approach.

Banack, Hailey R / Chang, Jenny / Stefanick, Marcia L / Arnold, Melina / Anton-Culver, Hoda / Jiang, Luohua

Annals of epidemiology

2022 Volume 72, Page(s) 9–17

Abstract: Purpose: The objective of this manuscript is to identify longitudinal trajectories of change in body mass index (BMI) after menopause and investigate the association of BMI trajectories with risk of diabetes and cardiovascular disease (CVD) among ... ...

Abstract	Purpose: The objective of this manuscript is to identify longitudinal trajectories of change in body mass index (BMI) after menopause and investigate the association of BMI trajectories with risk of diabetes and cardiovascular disease (CVD) among postmenopausal women. Methods: Using data from 54,073 participants in the Women's Health Initiative (WHI) clinical trials, we used growth mixture modeling (GMM) to develop BMI trajectories. Cox proportional hazards models were used to examine the relationship between BMI trajectories with incident diabetes and CVD. Further, we stratified by hormone therapy trial arm and time since menopause. Results: Using GMM, we identified five BMI trajectories. We did not find evidence of substantial change in BMI over time; the trajectories were stable over the study follow-up period in this sample of postmenopausal women. Risk of diabetes and CVD increased by BMI trajectory; risk was greater for women in moderate-high, high, and very high BMI trajectories compared to those in the lowest trajectory group. Conclusions: Despite minimal change in BMI over the follow-up period, our results demonstrate a strong association of high BMI with diabetes and CVD. These results highlight the importance of further longitudinal research focused on adverse health effects of BMI in older women.
MeSH term(s)	Aged ; Body Mass Index ; Cardiovascular Diseases/epidemiology ; Female ; Humans ; Postmenopause ; Proportional Hazards Models ; Risk Factors
Language	English
Publishing date	2022-04-22
Publishing country	United States
Document type	Clinical Trial ; Journal Article
ZDB-ID	1074355-8
ISSN	1873-2585 ; 1047-2797
ISSN (online)	1873-2585
ISSN	1047-2797
DOI	10.1016/j.annepidem.2022.04.004
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Article ; Online: Impact of Lifetime Obesity on Urinary Incontinence in the Women's Health Initiative.

Choi, Judy M / Jiang, James / Chang, Jenny / Ziogas, Argyrios / Jiang, Luohua / Anton-Culver, Hoda

The Journal of urology

2021 Volume 207, Issue 5, Page(s) 1096–1104

Abstract: Purpose: We assessed the impact of lifetime obesity on the development of urinary incontinence (UI).: Materials and methods: Using data from the Women's Health Initiative, we evaluated the cumulative impact of obesity over a postmenopausal woman's ... ...

Abstract	Purpose: We assessed the impact of lifetime obesity on the development of urinary incontinence (UI). Materials and methods: Using data from the Women's Health Initiative, we evaluated the cumulative impact of obesity over a postmenopausal woman's lifetime on the development of UI. Analyses using logistic models assessed the relationship between overweight/obesity duration and the development of UI during the Women's Health Initiative study at year 3. Results: Of the 15,420 women aged 50-79 years, 4,568 (30.0%) developed UI by year 3. When controlling for covariates, the duration of overweight years (OWY) and obese years (OBY) was significantly associated with overall UI. The number of OWY was associated with an increased risk of developing UI postmenopausally (OR 1.17, 95% CI 1.13-1.22) compared to those with 0 OWY. The number of OBY was associated with a higher risk of developing UI postmenopausally (OR 1.28, 95% CI 1.18-1.39). Severity of UI was also associated with higher OWY/OBY. Compared to participants who maintained normal weight, those who gained weight from age 18 to 50 years were more likely to report increased UI (OR 1.26, 95% CI 1.16-1.37), as did those who remained overweight/obese (OR 1.27, 95% CI 1.04-1.55). Those who lost weight reported no difference in rates of any UI. Conclusions: Chronic, increased body mass index status is associated with an elevated risk of UI later in life. Symptom severity also appears to be worsened with duration of increased body mass index status. Weight management should be supported throughout one's lifetime, as it may impact UI in later stages of life.
MeSH term(s)	Body Mass Index ; Female ; Humans ; Obesity/complications ; Obesity/epidemiology ; Overweight ; Risk Factors ; Surveys and Questionnaires ; Urinary Incontinence/epidemiology ; Urinary Incontinence/etiology ; Women's Health
Language	English
Publishing date	2021-12-30
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	3176-8
ISSN	1527-3792 ; 0022-5347
ISSN (online)	1527-3792
ISSN	0022-5347
DOI	10.1097/JU.0000000000002380
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Article ; Online: Mammography screening and mortality by risk status in the California teachers study.

Park, Hannah Lui / Chang, Jenny / Haridass, Vikram / Wang, Sophia S / Ziogas, Argyrios / Anton-Culver, Hoda

BMC cancer

2021 Volume 21, Issue 1, Page(s) 1341

Abstract: Background: The debate continues among medical professionals regarding the frequency, starting age, and stopping age for mammography screening. Some experts suggest tailoring recommendations based on individuals' personal breast cancer risk. Previous ... ...

Abstract	Background: The debate continues among medical professionals regarding the frequency, starting age, and stopping age for mammography screening. Some experts suggest tailoring recommendations based on individuals' personal breast cancer risk. Previous studies have not compared the impact of annual versus biennial mammography stratified by age group and risk category. The purpose of this study was to examine the relationship between mammography frequency and mortality by age group and risk category in the California Teachers Study. Methods: Using data from study questionnaires from 93,438 women between the ages of 40 and 85 and linkages to the California Cancer Registry and other indices, overall and breast cancer-specific mortality by mammography frequency were estimated using multivariable Cox proportional hazards models, stratified by age group and risk category at baseline as determined by the Gail breast cancer risk model. Results: During the follow-up period of 20 years, overall mortality risk was lower in women who had annual or biennial mammography compared to less frequent or no mammography in all age groups. Annual mammography was associated with lower overall mortality risk compared to biennial mammography among women age 50-85. This difference was especially apparent in women age 60-74, regardless of estimated Gail risk category at baseline. Breast cancer-specific mortality was lower among women who had annual mammography compared to biennial or less frequent mammography among women age 60-74, regardless of their baseline risk. Conclusions: Our findings suggest that at least biennial mammography is beneficial to most women age 40-85 and that annual mammography is more beneficial than biennial mammography to most women age 50-85 in terms of overall mortality.
MeSH term(s)	Adult ; Age Factors ; Aged ; Aged, 80 and over ; Breast/diagnostic imaging ; Breast Neoplasms/diagnosis ; Breast Neoplasms/mortality ; California/epidemiology ; Early Detection of Cancer/standards ; Early Detection of Cancer/statistics & numerical data ; Female ; Follow-Up Studies ; Humans ; Longitudinal Studies ; Mammography/standards ; Mammography/statistics & numerical data ; Middle Aged ; Practice Guidelines as Topic ; Prospective Studies ; Risk Assessment/statistics & numerical data ; Time Factors
Language	English
Publishing date	2021-12-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-021-09071-1
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Article ; Online: Perception matters: Stressful life events increase breast cancer risk.

Fischer, Avital / Ziogas, Argyrios / Anton-Culver, Hoda

Journal of psychosomatic research

2018 Volume 110, Page(s) 46–53

Abstract: Objective: The relationship between psychological stress and breast cancer risk is unclear. The present study sought to understand how stressfulness appraisal of salient Life Events (LEs) influences breast cancer risk.: Methods: A case-control design ...

Abstract	Objective: The relationship between psychological stress and breast cancer risk is unclear. The present study sought to understand how stressfulness appraisal of salient Life Events (LEs) influences breast cancer risk. Methods: A case-control design was used and included 664 female cases identified through the Cancer Surveillance Program of Orange County, CA and 203 female population-based controls. A LE questionnaire determined if events occurred prior to breast cancer diagnosis and if these events were considered to be stressful or not. Multivariate unconditional logistic regression was used to calculate ORs while adjusting for known breast cancer covariates. Results: Cumulative adverse LEs perceived as stressful were associated with increased breast cancer risk in a dose response fashion (OR = 1.63, 95% CI = 1.00-2.66, P Conclusions: This study underscores the importance of stressfulness appraisal when determining the effect of major LEs on breast cancer risk. Our results support incorporating assessments of perceived stressfulness in future epidemiological investigation of this topic.
MeSH term(s)	Breast Neoplasms/psychology ; Case-Control Studies ; Female ; Humans ; Life Change Events ; Middle Aged ; Perception ; Risk Factors ; Stress, Psychological/psychology
Language	English
Publishing date	2018-03-26
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80166-5
ISSN	1879-1360 ; 0022-3999
ISSN (online)	1879-1360
ISSN	0022-3999
DOI	10.1016/j.jpsychores.2018.03.010
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Article ; Online: Associations of sleep duration with cardiometabolic outcomes in American Indians and Alaska Natives and other race/ethnicities: results from the BRFSS.

Nuyujukian, Daniel S / Anton-Culver, Hoda / Manson, Spero M / Jiang, Luohua

Sleep health

2019 Volume 5, Issue 4, Page(s) 344–351

Abstract: Objectives: This study assessed the associations between short and long sleep duration and prevalence of cardiometabolic outcomes in American Indians and Alaska Natives (AI/ANs) and compared these associations to those evident among other race/ ... ...

Abstract	Objectives: This study assessed the associations between short and long sleep duration and prevalence of cardiometabolic outcomes in American Indians and Alaska Natives (AI/ANs) and compared these associations to those evident among other race/ethnicities. Methods: We analyzed data from the 2013-2014 Behavioral Risk Factor Surveillance System. In total, 14,536 AI/ANs, 729,962 non-Hispanic whites, 71,765 blacks, and 59,472 Hispanics were included. Logistic regressions were conducted to compute unadjusted and adjusted odds ratios (OR) for the associations of interest. Results: Among AI/ANs, 38.6% reported sleeping <7 hours per night (short sleepers) while 39.3% reported 8+ hours of sleep (long sleepers). After adjusting for age and gender, both short and long sleep durations were associated with higher odds of reporting diabetes, stroke, coronary heart disease and heart attack in almost all race/ethnic groups. After multiple adjustments, the sleep-diabetes association was more pronounced (OR = 1.71 and OR = 1.56 for short and long sleepers, respectively) among AI/ANs than other race/ethnicities. Conclusions: Future studies are warranted to examine race/ethnic variability in the association between sleep duration and cardiometabolic outcomes.
MeSH term(s)	Adolescent ; Adult ; Aged ; Alaska Natives/statistics & numerical data ; Behavioral Risk Factor Surveillance System ; Cardiovascular Diseases/ethnology ; Ethnicity/statistics & numerical data ; Female ; Humans ; Indians, North American/statistics & numerical data ; Male ; Metabolic Syndrome/ethnology ; Middle Aged ; Prevalence ; Racial Groups/statistics & numerical data ; Sleep ; Time Factors ; Young Adult
Language	English
Publishing date	2019-04-13
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2813299-3
ISSN	2352-7226 ; 2352-7218
ISSN (online)	2352-7226
ISSN	2352-7218
DOI	10.1016/j.sleh.2019.02.003
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Article ; Online: Factors Associated with Longitudinal Changes in Mammographic Density in a Multiethnic Breast Screening Cohort of Postmenopausal Women.

Park, Hannah Lui / Ziogas, Argyrios / Feig, Stephen A / Kirmizi, Roza Lorin / Lee, Christie Jiwon / Alvarez, Andrea / Lucia, Rachel McFarland / Goodman, Deborah / Larsen, Kathryn M / Kelly, Richard / Anton-Culver, Hoda

The breast journal

2023 Volume 2023, Page(s) 2794603

Abstract: Background: Breast density is an important risk factor for breast cancer and is known to be associated with characteristics such as age, race, and hormone levels; however, it is unclear what factors contribute to changes in breast density in ... ...

Abstract	Background: Breast density is an important risk factor for breast cancer and is known to be associated with characteristics such as age, race, and hormone levels; however, it is unclear what factors contribute to changes in breast density in postmenopausal women over time. Understanding factors associated with density changes may enable a better understanding of breast cancer risk and facilitate potential strategies for prevention. Methods: This study investigated potential associations between personal factors and changes in mammographic density in a cohort of 3,392 postmenopausal women with no personal history of breast cancer between 2011 and 2017. Self-reported information on demographics, breast and reproductive history, and lifestyle factors, including body mass index (BMI), alcohol intake, smoking, and physical activity, was collected by an electronic intake form, and breast imaging reporting and database system (BI-RADS) mammographic density scores were obtained from electronic medical records. Factors associated with a longitudinal increase or decrease in mammographic density were identified using Fisher's exact test and multivariate conditional logistic regression. Results: 7.9% of women exhibited a longitudinal decrease in mammographic density, 6.7% exhibited an increase, and 85.4% exhibited no change. Longitudinal changes in mammographic density were correlated with age, race/ethnicity, and age at menopause in the univariate analysis. In the multivariate analysis, Asian women were more likely to exhibit a longitudinal increase in mammographic density and less likely to exhibit a decrease compared to White women. On the other hand, obese women were less likely to exhibit an increase and more likely to exhibit a decrease compared to normal weight women. Women who underwent menopause at age 55 years or older were less likely to exhibit a decrease in mammographic density compared to women who underwent menopause at a younger age. Besides obesity, lifestyle factors (alcohol intake, smoking, and physical activity) were not associated with longitudinal changes in mammographic density. Conclusions: The associations we observed between Asian race/obesity and longitudinal changes in BI-RADS density in postmenopausal women are paradoxical in that breast cancer risk is lower in Asian women and higher in obese women. However, the association between later age at menopause and a decreased likelihood of decreasing in BI-RADS density over time is consistent with later age at menopause being a risk factor for breast cancer and suggests a potential relationship between greater cumulative lifetime estrogen exposure and relative stability in breast density after menopause. Our findings support the complexity of the relationships between breast density, BMI, hormone exposure, and breast cancer risk.
MeSH term(s)	Female ; Humans ; Middle Aged ; Breast Density ; Breast Neoplasms/diagnosis ; Mammography/adverse effects ; Postmenopause ; Risk Factors ; Estrogens ; Obesity/complications
Chemical Substances	Estrogens
Language	English
Publishing date	2023-10-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	1289960-4
ISSN	1524-4741 ; 1075-122X
ISSN (online)	1524-4741
ISSN	1075-122X
DOI	10.1155/2023/2794603
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Zs.A 4483: Show issues

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Article ; Online: Cancer risk in different generations of Middle Eastern immigrants to California, 1988-2013.

Ziadeh, Clara / Ziogas, Argyrios / Anton-Culver, Hoda

International journal of cancer

2017 Volume 141, Issue 11, Page(s) 2260–2269

Abstract: The objective of this study is to compare cancer risk among different generations of Middle Eastern immigrants (ME) and non-Hispanic whites (NHW) in California between 1988 and 2013. We used data from the California Cancer Registry to identify invasive ... ...

Abstract	The objective of this study is to compare cancer risk among different generations of Middle Eastern immigrants (ME) and non-Hispanic whites (NHW) in California between 1988 and 2013. We used data from the California Cancer Registry to identify invasive primary incident cancer cases in three population groups: (i) first-generation ME immigrants, (ii) second- or subsequent-generations ME immigrants, and (iii) NHW. Proportional incidence ratio (PIR) was used to compare cancer risk of the 15 selected most common cancers in the 3 population groups taking into consideration time since immigration for first-generation ME immigrants. First generation ME immigrants were more likely to be at increased risk of stomach (PIR= 3.13) and hepatobiliary (PIR = 2.27) cancers in females and thyroid (PIR = 2.19) and stomach (PIR = 2.13) cancers in males in comparison with NHW. Second- or subsequent-generations ME immigrants were at increased risk of thyroid cancer (PIR = 1.43 in females and 2.00 in males) in comparison with NHW, and malignant melanoma cancer (PIR = 4.53 in females and 4.61 in males) in comparison with first-generation ME immigrants. The risk levels of breast, thyroid and bladder cancers in ME first generation were significantly higher compared to NHW regardless of time spent in the United States suggesting the role of genetic predisposition, and/or cultural characteristics associated with these cancers. The results suggest that differences in cancer risk between ME first-generation immigrants and NHW change in second or subsequent generations, approaching the risk level of NHW and indicating the impact of acculturation in this immigrant population.
MeSH term(s)	Arabs/statistics & numerical data ; California/epidemiology ; Emigrants and Immigrants/statistics & numerical data ; Female ; Humans ; Incidence ; Male ; Middle East ; Neoplasms/epidemiology ; Registries ; Risk Factors
Language	English
Publishing date	2017-08-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	218257-9
ISSN	1097-0215 ; 0020-7136
ISSN (online)	1097-0215
ISSN	0020-7136
DOI	10.1002/ijc.30928
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Zs.A 478: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Negative Valence Life Events Promote Breast Cancer Development.

Fischer, Avital / Ziogas, Argyrios / Anton-Culver, Hoda

Clinical breast cancer

2017 Volume 18, Issue 4, Page(s) e521–e528

Abstract: Background: The influence of stress on breast cancer risk remains unknown. The goal of the present study was to determine the effect of stress in the form of salient positive and negative valence life events (LEs) on primary invasive breast cancer risk. ...

Abstract	Background: The influence of stress on breast cancer risk remains unknown. The goal of the present study was to determine the effect of stress in the form of salient positive and negative valence life events (LEs) on primary invasive breast cancer risk. We hypothesized that salient negative LEs would increase breast cancer risk and salient positive LEs would attenuate this increased risk. Patients and methods: We used a case-control design with 664 cases identified through the Cancer Surveillance Program of Orange County and 203 population-based controls. Participants completed a risk factor questionnaire, which included a LE section. Fourteen salient LEs of positive or negative valence were used to quantify stress exposure. A baseline model was constructed, and odds ratios (ORs) were calculated using multivariate unconditional logistic regression. Results: Negative LEs were associated with increased breast cancer risk. The OR for ≥ 4 negative LEs showed a 2.81-fold increase in breast cancer risk (OR, 2.81; 95% confidence interval [CI], 1.47-5.36). A significant dose-response relationship between lifetime negative valence LEs and breast cancer risk was found. Previous personal illness increased breast cancer risk by 3.6-fold (OR, 3.60; 95% CI, 2.50-5.20). In contrast, abortion was associated with a 45% decrease in breast cancer risk (OR, 0.55; 95% CI, 0.34-0.89). Salient positive LEs did not have a significant effect on breast cancer risk. However, they seemed to buffer the adverse effect of salient negative LEs on breast cancer risk. Conclusion: The findings from the present study support the role of salient negative LEs in promoting breast cancer development, with a possible buffering effect of salient positive LEs.
MeSH term(s)	Adult ; Aged ; Breast Neoplasms/epidemiology ; Breast Neoplasms/psychology ; California/epidemiology ; Case-Control Studies ; Female ; Humans ; Life Change Events ; Middle Aged ; Population Surveillance ; Risk Factors ; Stress, Psychological/epidemiology ; Surveys and Questionnaires ; Young Adult
Language	English
Publishing date	2017-11-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2106734-X
ISSN	1938-0666 ; 1526-8209
ISSN (online)	1938-0666
ISSN	1526-8209
DOI	10.1016/j.clbc.2017.10.017
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