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  1. Book ; Online: AR Signaling in Human Malignancies: Prostate Cancer and Beyond

    Antonarakis, Emmanuel S.

    2018  

    Abstract: The notion that androgens and androgen receptor (AR) signaling are the hallmarks of prostate cancer oncogenesis and disease progression is generally well accepted. What is more poorly understood is the role of AR signaling in other human malignancies. ... ...

    Abstract The notion that androgens and androgen receptor (AR) signaling are the hallmarks of prostate cancer oncogenesis and disease progression is generally well accepted. What is more poorly understood is the role of AR signaling in other human malignancies. This Special Issue of Cancers initially reviews the role of AR in advanced prostate cancer, and then explores the potential importance of AR signaling in other epithelial malignancies. The first few articles focus on the use of novel AR-targeting therapies in castration-resistant prostate cancer and the mechanisms of resistance to novel antiandrogens, and they also outline the interaction between AR and other cellular pathways, including PI3 kinase signaling, transcriptional regulation, angiogenesis, stromal factors, Wnt signaling, and epigenetic regulation in prostate cancer. The next several articles review the possible role of androgens and AR signaling in breast cancer, bladder cancer, salivary gland cancer, and hepatocellular carcinoma, as well as the potential treatment implications of using antiandrogen therapies in these non-prostatic malignancies
    Keywords Medicine (General)
    Size 1 electronic resource (244 p.)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020097225
    ISBN 9783038427407 ; 9783038427391 ; 3038427403 ; 303842739X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Genetics and genomics of prostate cancer and therapeutic implications.

    Antonarakis, Emmanuel S

    The Prostate

    2022  Volume 82 Suppl 1, Page(s) S1–S2

    MeSH term(s) Genomics ; Humans ; Male ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/therapy
    Language English
    Publishing date 2022-06-03
    Publishing country United States
    Document type Editorial
    ZDB-ID 604707-5
    ISSN 1097-0045 ; 0270-4137
    ISSN (online) 1097-0045
    ISSN 0270-4137
    DOI 10.1002/pros.24397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Rucaparib for metastatic castration-resistant prostate cancer: did TRITON3 deliver a trifecta?

    Elias, Roy / Antonarakis, Emmanuel S

    Translational cancer research

    2023  Volume 12, Issue 10, Page(s) 2448–2453

    Language English
    Publishing date 2023-10-03
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2901601-0
    ISSN 2219-6803 ; 2218-676X
    ISSN (online) 2219-6803
    ISSN 2218-676X
    DOI 10.21037/tcr-23-1279
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Combining Poly(ADP)-Ribose Polymerase Inhibitors With Abiraterone in Castration-Resistant Prostate Cancer: Is Biomarker Testing Necessary?

    Antonarakis, Emmanuel S / Abida, Wassim

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2023  Volume 41, Issue 18, Page(s) 3291–3294

    MeSH term(s) Male ; Humans ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Ribose/therapeutic use ; Biomarkers
    Chemical Substances Poly(ADP-ribose) Polymerase Inhibitors ; abiraterone (G819A456D0) ; Ribose (681HV46001) ; Biomarkers
    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.23.00270
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Olaparib for DNA repair-deficient prostate cancer - one for all, or all for one?

    Antonarakis, Emmanuel S

    Nature reviews. Clinical oncology

    2020  Volume 17, Issue 8, Page(s) 455–456

    MeSH term(s) DNA Repair/genetics ; Humans ; Male ; Phthalazines/therapeutic use ; Piperazines/therapeutic use ; Prostatic Neoplasms, Castration-Resistant
    Chemical Substances Phthalazines ; Piperazines ; olaparib (WOH1JD9AR8)
    Language English
    Publishing date 2020-05-12
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2491410-1
    ISSN 1759-4782 ; 1759-4774
    ISSN (online) 1759-4782
    ISSN 1759-4774
    DOI 10.1038/s41571-020-0395-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The evolving landscape of PARP inhibitors in castration-resistant prostate cancer: a spotlight on treatment combinations.

    Teply, Benjamin A / Antonarakis, Emmanuel S

    Expert review of clinical pharmacology

    2022  Volume 15, Issue 11, Page(s) 1293–1304

    Abstract: Introduction: PARP inhibition in prostate cancer has become a standard-of-care option for men with metastatic castration-resistant prostate cancer (mCRPC) with deficiency in homologous recombination repair (HRRd). The benefit varies based upon the ... ...

    Abstract Introduction: PARP inhibition in prostate cancer has become a standard-of-care option for men with metastatic castration-resistant prostate cancer (mCRPC) with deficiency in homologous recombination repair (HRRd). The benefit varies based upon the characteristics of the PARP inhibitor used and the underlying HRR defect. Optimal patient selection remains a clinical challenge, and investigations are underway to identify effective combination therapies to expand the population that benefits.
    Areas covered: We review the clinical development of the FDA-approved PARP inhibitors olaparib and rucaparib. Additionally, we explore the status of other PARP inhibitors that remain experimental in prostate cancer, based upon review of published abstracts, articles, and clinicaltrials.gov. Most new studies, including phase 3 trials for talazoparib and rucaparib, involve combinations with novel androgen receptor signaling inhibitors. We review the landscape of emerging PARP inhibitor-based combination therapies.
    Expert opinion: For men with
    MeSH term(s) Humans ; Male ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; DNA Repair ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Prostatic Neoplasms, Castration-Resistant/genetics ; Prostatic Neoplasms, Castration-Resistant/pathology ; Clinical Trials, Phase III as Topic
    Chemical Substances Antineoplastic Agents ; Poly(ADP-ribose) Polymerase Inhibitors
    Language English
    Publishing date 2022-11-02
    Publishing country England
    Document type Review ; Journal Article
    ISSN 1751-2441
    ISSN (online) 1751-2441
    DOI 10.1080/17512433.2022.2140656
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The growing role of rucaparib in contemporary treatment of metastatic prostate cancer: a review of efficacy and guidance for side effect management.

    Rao, Arpit / Antonarakis, Emmanuel S

    Expert review of anticancer therapy

    2022  Volume 22, Issue 7, Page(s) 671–679

    Abstract: Introduction: In May 2020, the approval of rucaparib - a poly-ADP-ribose polymerase (PARP) inhibitor - in the USA marked the arrival of a new class of targeted therapeutics for a subset of metastatic castration-resistant prostate cancer patients whose ... ...

    Abstract Introduction: In May 2020, the approval of rucaparib - a poly-ADP-ribose polymerase (PARP) inhibitor - in the USA marked the arrival of a new class of targeted therapeutics for a subset of metastatic castration-resistant prostate cancer patients whose tumors harbor germline or somatic
    Areas covered: We focus on rucaparib's pharmacology, key clinical trials that support its current indication, the competitive landscape, and our considerations for management of adverse events. We also review the ongoing clinical trials that may expand its utility in prostate cancer in our expert opinion. Finally, we discuss the opportunities that exist for further development of this class of targeted agents in prostate cancer.
    Expert opinion: We believe that the time has come to develop functional assays of HRR proficiency or deficiency in order to better guide PARP inhibitor selection for patients with prostate cancer and beyond.
    MeSH term(s) Antineoplastic Agents/adverse effects ; Humans ; Indoles/adverse effects ; Male ; Poly(ADP-ribose) Polymerase Inhibitors/adverse effects ; Poly(ADP-ribose) Polymerases ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms, Castration-Resistant/drug therapy
    Chemical Substances Antineoplastic Agents ; Indoles ; Poly(ADP-ribose) Polymerase Inhibitors ; rucaparib (8237F3U7EH) ; Poly(ADP-ribose) Polymerases (EC 2.4.2.30)
    Language English
    Publishing date 2022-05-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2112544-2
    ISSN 1744-8328 ; 1473-7140
    ISSN (online) 1744-8328
    ISSN 1473-7140
    DOI 10.1080/14737140.2022.2081154
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5907: Show issues Location:
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  8. Article ; Online: B7-H3 and Prostate Cancer: New Therapeutic Dance Partners.

    Shenderov, Eugene / Antonarakis, Emmanuel S

    European urology

    2022  Volume 83, Issue 3, Page(s) 239–240

    MeSH term(s) Male ; Humans ; Dance Therapy ; Prostatic Neoplasms/therapy
    Language English
    Publishing date 2022-11-05
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2022.10.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 294: Show issues

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  9. Article ; Online: A New Molecular Taxonomy to Predict Immune Checkpoint Inhibitor Sensitivity in Prostate Cancer.

    Antonarakis, Emmanuel S

    The oncologist

    2019  Volume 24, Issue 4, Page(s) 430–432

    Abstract: Immune checkpoint agents have not yet been approved for use in advanced prostate cancer. This commentary summarizes the challenges related to this issue, in light of a recently reported case of a patient with DNA mismatch‐repair deficient castration‐ ... ...

    Abstract Immune checkpoint agents have not yet been approved for use in advanced prostate cancer. This commentary summarizes the challenges related to this issue, in light of a recently reported case of a patient with DNA mismatch‐repair deficient castration‐resistant prostate cancer who responded to single‐agent pembrolizumab treatment.
    MeSH term(s) Biomarkers, Tumor ; DNA Mismatch Repair ; Humans ; Male ; Prostatic Neoplasms, Castration-Resistant ; Sensitivity and Specificity
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2019-01-09
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 1409038-7
    ISSN 1549-490X ; 1083-7159
    ISSN (online) 1549-490X
    ISSN 1083-7159
    DOI 10.1634/theoncologist.2018-0819
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Targeting lineage plasticity in prostate cancer.

    Antonarakis, Emmanuel S

    The Lancet. Oncology

    2019  Volume 20, Issue 10, Page(s) 1338–1340

    MeSH term(s) Carboplatin ; Humans ; Male ; Prostatic Neoplasms ; Prostatic Neoplasms, Castration-Resistant ; Taxoids
    Chemical Substances Taxoids ; cabazitaxel (51F690397J) ; Carboplatin (BG3F62OND5)
    Language English
    Publishing date 2019-09-09
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(19)30497-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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