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  1. Article: Sweet syndrome in a patient receiving encorafenib and binimetinib therapy for malignant melanoma.

    Quach, Myiah / Antonelli, John P / LaSenna, Charlotte / Asel, Mackenzie / Pleva, Jennifer / Ma, Vincent T

    JAAD case reports

    2024  Volume 45, Page(s) 91–93

    Language English
    Publishing date 2024-02-04
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834220-3
    ISSN 2352-5126
    ISSN 2352-5126
    DOI 10.1016/j.jdcr.2024.01.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Rapid Life-Saving Response to Anti-PD-1 in a Solid Organ Transplant Recipient With Metastatic Cutaneous Squamous Cell Carcinoma: A Case Report and Review.

    Antonelli, John P / Quach, Myiah / Mahajan, Aparna / Pleva, Jennifer / Ma, Vincent T

    Journal of immunotherapy (Hagerstown, Md. : 1997)

    2024  

    Abstract: Summary: Anti-programmed cell death protein 1 (PD-1) therapy is considered effective in the treatment of metastatic or locally advanced cutaneous squamous cell carcinoma but the use of these agents in solid organ transplant recipients (SOTRs) is often ... ...

    Abstract Summary: Anti-programmed cell death protein 1 (PD-1) therapy is considered effective in the treatment of metastatic or locally advanced cutaneous squamous cell carcinoma but the use of these agents in solid organ transplant recipients (SOTRs) is often taken with caution. While anti-tumor effects without graft rejection have been reported, studies have shown high rates of fatal graft rejection with immune checkpoint therapy. In this case report, we present an SOTR patient with life-threatening, acute hypoxic respiratory failure due to rapidly progressive metastatic cutaneous squamous cell carcinoma with lung and pleural involvement. Modification of their immunosuppressive regimen and treatment with front-line anti-PD-1 inhibitor, pembrolizumab, led to rapid clinical response with near complete resolution of metastatic pulmonary disease and no long-term evidence of graft rejection. Our case report shows that front-line treatment with PD-1 inhibitors can be safely administered in SOTR patients with rapid metastatic disease control.
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1064067-8
    ISSN 1537-4513 ; 1053-8550 ; 1524-9557
    ISSN (online) 1537-4513
    ISSN 1053-8550 ; 1524-9557
    DOI 10.1097/CJI.0000000000000514
    Database MEDical Literature Analysis and Retrieval System OnLINE

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