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  1. Article ; Online: Icatibant in viral infections.

    Mustonen, Jukka / Antonen, Jaakko / Vaheri, Antti

    Infectious diseases (London, England)

    2023  Volume 55, Issue 6, Page(s) 444–445

    MeSH term(s) Humans ; Bradykinin ; Treatment Outcome ; Virus Diseases/drug therapy ; Bradykinin B2 Receptor Antagonists
    Chemical Substances icatibant (7PG89G35Q7) ; Bradykinin (S8TIM42R2W) ; Bradykinin B2 Receptor Antagonists
    Language English
    Publishing date 2023-04-17
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2839775-7
    ISSN 2374-4243 ; 2374-4235
    ISSN (online) 2374-4243
    ISSN 2374-4235
    DOI 10.1080/23744235.2023.2200563
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  2. Article ; Online: Low utility of ocular screening in sarcoidosis in Finland.

    Joukainen, Elli / Antonen, Jaakko / Leinonen, Sanna

    Acta ophthalmologica

    2023  Volume 102, Issue 4, Page(s) 435–440

    Abstract: Purpose: Systematic ocular screening is recommended in sarcoidosis, because of a high rate of ocular involvement. The purpose of this study was to determine whether ocular screening is useful in sarcoidosis in a Finnish university hospital population ... ...

    Abstract Purpose: Systematic ocular screening is recommended in sarcoidosis, because of a high rate of ocular involvement. The purpose of this study was to determine whether ocular screening is useful in sarcoidosis in a Finnish university hospital population with 0.5 M inhabitants.
    Methods: Patient charts of patients with sarcoidosis, without a history of ocular sarcoidosis, without ocular inflammatory symptoms, and with a comprehensive eye exam from January 2014 to January 2021 at Tays Eye Centre, Tampere, Finland, were studied.
    Results: Five of 262 patients (2%) were diagnosed with asymptomatic uveitis. No other types of ocular sarcoidosis were found. Anterior uveitis without complications was present in three patients, unilaterally in two and bilaterally in one patient. Posterior uveitis was present in two patients, a unilateral choroidal granuloma requiring treatment in one and bilateral punched-out chorioretinal lesions in the other patient.
    Conclusions: With this low rate of ocular involvement requiring treatment in sarcoidosis, systematic screening for asymptomatic ocular sarcoidosis does not seem useful in a Finnish population. In Tays Eye Centre, systematic screening of ocular sarcoidosis was discontinued in 2021.
    MeSH term(s) Humans ; Sarcoidosis/diagnosis ; Sarcoidosis/epidemiology ; Finland/epidemiology ; Male ; Female ; Middle Aged ; Retrospective Studies ; Adult ; Aged ; Uveitis/diagnosis ; Uveitis/epidemiology ; Mass Screening/methods ; Incidence ; Visual Acuity
    Language English
    Publishing date 2023-09-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2408333-1
    ISSN 1755-3768 ; 1755-375X
    ISSN (online) 1755-3768
    ISSN 1755-375X
    DOI 10.1111/aos.15749
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  3. Book ; Thesis: Immunobiology of human immunodeficiency virus (HIV) infection

    Antonen, Jaakko

    (Acta Universitatis Tamperensis : Ser. A ; 227A)

    1987  

    Series title Acta Universitatis Tamperensis : Ser. A ; 227A
    Acta Universitatis Tamperensis
    Acta Universitatis Tamperensis ; Ser. A
    Collection Acta Universitatis Tamperensis
    Acta Universitatis Tamperensis ; Ser. A
    Keywords Acquired Immunodeficiency Syndrome / immunology ; Aids ; Immunbiologie
    Subject Immunobiologie ; Acquired immune deficiency syndrome ; Erworbenes Immundefektsyndrom
    Language English
    Size getr. Zählung : graph. Darst.
    Publishing country Finland
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Tampere, Univ., Diss., 1987
    HBZ-ID HT003176872
    ISBN 951-44-2126-4 ; 978-951-44-2126-6
    Database Catalogue ZB MED Medicine, Health

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  4. Article ; Online: Erosive vulvo-vaginal lichen planus treated with rituximab: A case report.

    Lagerstedt, Maria / Kotaniemi-Talonen, Laura / Antonen, Jaakko / Vaalasti, Annikki

    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

    2021  Volume 156, Issue 1, Page(s) 172–173

    Language English
    Publishing date 2021-07-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80149-5
    ISSN 1879-3479 ; 0020-7292
    ISSN (online) 1879-3479
    ISSN 0020-7292
    DOI 10.1002/ijgo.13814
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  5. Article ; Online: Increased Incidence of Cutaneous Vasculitic Ulcers: 30-year Results from a Population-based Retrospective Study.

    Kimpimäki, Teija / Huotari-Orava, Riitta / Antonen, Jaakko / Vaalasti, Annikki

    Acta dermato-venereologica

    2017  Volume 97, Issue 5, Page(s) 653–654

    Language English
    Publishing date 2017--08
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 80007-7
    ISSN 1651-2057 ; 0001-5555
    ISSN (online) 1651-2057
    ISSN 0001-5555
    DOI 10.2340/00015555-2608
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  6. Article: The evolving treatment of ANCA-associated vasculitides.

    Sauranen, Jukka / Salmela, Anna / Kahlos, Katriina / Antonen, Jaakko / Ekstrand, Agneta / Pettersson, Tom

    Duodecim; laaketieteellinen aikakauskirja

    2016  Volume 132, Issue 16, Page(s) 1449–1455

    Abstract: Prevention of organ damage and maintenance of long-term remission are the principal goals for treatment of ANCA-associated vasculitides. This can be accomplished by early diagnosis and swift initiation of remission-inducing agents. Outcome has improved ... ...

    Abstract Prevention of organ damage and maintenance of long-term remission are the principal goals for treatment of ANCA-associated vasculitides. This can be accomplished by early diagnosis and swift initiation of remission-inducing agents. Outcome has improved but relapses and glucocorticoid- and cyclophosphamide-related toxicity are still major concerns. For remission induction in generalized disease a combination of glucocorticoids and cyclophosphamide or rituximab is used. Rituximab is suitable especially for younger patients with fertility concerns and when cyclophosphamide avoidance otherwise is desirable. In the treatment of relapses and refractory disease, rituximab has proved effective. As maintenance treatment rituximab prevents relapses more effectively than azathioprine.
    MeSH term(s) Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/diagnosis ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/drug therapy ; Cyclophosphamide/adverse effects ; Cyclophosphamide/therapeutic use ; Drug Therapy, Combination ; Early Diagnosis ; Glucocorticoids/adverse effects ; Glucocorticoids/therapeutic use ; Humans ; Immunologic Factors/adverse effects ; Immunologic Factors/therapeutic use ; Immunosuppressive Agents/adverse effects ; Immunosuppressive Agents/therapeutic use ; Remission Induction ; Rituximab/adverse effects ; Rituximab/therapeutic use
    Chemical Substances Glucocorticoids ; Immunologic Factors ; Immunosuppressive Agents ; Rituximab (4F4X42SYQ6) ; Cyclophosphamide (8N3DW7272P)
    Language English
    Publishing date 2016
    Publishing country Finland
    Document type Journal Article ; Review
    ZDB-ID 127604-9
    ISSN 0012-7183
    ISSN 0012-7183
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  7. Article ; Online: A controlled survey of less typical long-term consequences after an extensive waterborne epidemic.

    Laine, Janne / Laine, Outi / Lumio, Jukka / Antonen, Jaakko / Toikkanen, Salla / Virtanen, Mikko J / Kuusi, Markku

    BMC infectious diseases

    2017  Volume 17, Issue 1, Page(s) 161

    Abstract: Background: Extensive backflow of treated wastewater caused household water contamination in a Finnish town in 2007. The drinking water of 9 500 residents became heavily polluted with faecal microbes, resulting in a large gastroenteritis epidemic. Cases ...

    Abstract Background: Extensive backflow of treated wastewater caused household water contamination in a Finnish town in 2007. The drinking water of 9 500 residents became heavily polluted with faecal microbes, resulting in a large gastroenteritis epidemic. Cases of reactive arthritis, milder joint symptoms and prolonged gastrointestinal symptoms were observed after the outbreak. A follow-up survey was performed to study less familiar long-term health consequences within a year from the outbreak.
    Methods: The contaminated group comprised a sample of residents of the area with polluted water supply (N = 323) and the control group a sample of residents in a nearby municipality (N = 186). The presence of 20 general symptoms or complaints was inquired by a mail survey. Quarterly prevalence of each symptom or complaint was measured. Twelve of these proceeded to further analysis.
    Results: The response rate was 53% (323/615) in the contaminated group and 54% (186/343) in the control group. Rash, eye irritation, heartburn and weight loss were more prevalent in the contaminated group during the first year quarter. In the last year quarter, only eye irritation was significantly more common in the contaminated group.
    Conclusion: The excess prevalence of four complaints at the first year quarter can be explained by acute gastroenteritis or intensive water chlorination. The excess prevalence of eye irritation at the fourth year quarter cannot be explained by chlorination anymore but might be a sign of co-existing reactive joint disease. In general, long-term consequences of the outbreak can be considered minor in terms of the surveyed symptoms or complaints.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Case-Control Studies ; Child ; Child, Preschool ; Disease Outbreaks/statistics & numerical data ; Drinking Water/adverse effects ; Drinking Water/microbiology ; Female ; Finland/epidemiology ; Follow-Up Studies ; Gastroenteritis/diagnosis ; Gastroenteritis/epidemiology ; Gastroenteritis/etiology ; Health Surveys ; Humans ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Prevalence ; Surveys and Questionnaires ; Waste Water ; Water Microbiology ; Water Pollution/adverse effects ; Waterborne Diseases/diagnosis ; Waterborne Diseases/epidemiology ; Waterborne Diseases/etiology ; Young Adult
    Chemical Substances Drinking Water ; Waste Water
    Language English
    Publishing date 2017-02-21
    Publishing country England
    Document type Journal Article
    ISSN 1471-2334
    ISSN (online) 1471-2334
    DOI 10.1186/s12879-017-2260-9
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  8. Article ; Online: A severe case of Puumala hantavirus infection successfully treated with bradykinin receptor antagonist icatibant.

    Antonen, Jaakko / Leppänen, Ilona / Tenhunen, Jyrki / Arvola, Pertti / Mäkelä, Satu / Vaheri, Antti / Mustonen, Jukka

    Scandinavian journal of infectious diseases

    2013  Volume 45, Issue 6, Page(s) 494–496

    Abstract: A patient with severe capillary leakage syndrome caused by a Puumala hantavirus infection was treated with a single dose of icatibant, a bradykinin receptor antagonist, with a dramatic positive response. We suggest that this drug should be tested in a ... ...

    Abstract A patient with severe capillary leakage syndrome caused by a Puumala hantavirus infection was treated with a single dose of icatibant, a bradykinin receptor antagonist, with a dramatic positive response. We suggest that this drug should be tested in a larger number of patients with severe hantavirus infection.
    MeSH term(s) Adult ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Bradykinin/analogs & derivatives ; Bradykinin/therapeutic use ; Bradykinin Receptor Antagonists ; Capillary Leak Syndrome/drug therapy ; Capillary Leak Syndrome/virology ; Hantavirus Infections/drug therapy ; Humans ; Male
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Bradykinin Receptor Antagonists ; icatibant (7PG89G35Q7) ; Bradykinin (S8TIM42R2W)
    Language English
    Publishing date 2013-06
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 390956-6
    ISSN 1651-1980 ; 0036-5548
    ISSN (online) 1651-1980
    ISSN 0036-5548
    DOI 10.3109/00365548.2012.755268
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  9. Article ; Online: Outcome of reactive arthritis after an extensive Finnish waterborne gastroenteritis outbreak: a 1-year prospective follow-up study.

    Uotila, Terhi M / Antonen, Jaakko A / Paakkala, Antti S / Mustonen, Jukka T / Korpela, Markku M

    Clinical rheumatology

    2013  Volume 32, Issue 8, Page(s) 1139–1145

    Abstract: The purpose of the study was to assess the 1-year outcome of definitive reactive arthritis (ReA) after a waterborne outbreak. A cohort of 21 patients (15 females and 6 males, median age 54 years) with ReA related to an extensive waterborne outbreak in ... ...

    Abstract The purpose of the study was to assess the 1-year outcome of definitive reactive arthritis (ReA) after a waterborne outbreak. A cohort of 21 patients (15 females and 6 males, median age 54 years) with ReA related to an extensive waterborne outbreak in Finland was clinically followed-up by rheumatologists with visits at baseline, at 1 month and 3, 6 and 12 months. Although the outcome was in general favourable, 1/3 of the patients had chronic course; 7 (33 %) of the 21 patients needed disease-modifying anti-rheumatic drugs (DMARDs) and even 8 (38 %) of them used glucocorticoids at 12 months. Four (19 %) were using non-steroidal anti-inflammatory drugs and nine (43 %) other analgesics. Many patients had articular pain and impaired physical function still at 12 months, even though inflammatory parameters and the number of swollen joints were low. Only one patient (5 %) was human leucocyte antigen-B27-positive. She had the most severe ReA and also additional infectious arthritis caused by Salmonella serotype enteritidis leading to osteonecrosis of her hip joint with subsequent need for arthroplasty. ReA as observed in our study was overall fairly mild, but in many individuals, postinfectious arthralgia and DMARD use continued at least up to 1 year.
    MeSH term(s) Adult ; Aged ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Antirheumatic Agents/therapeutic use ; Arthralgia/etiology ; Arthralgia/therapy ; Arthritis, Reactive/etiology ; Arthritis, Reactive/therapy ; Disease Outbreaks ; Female ; Finland/epidemiology ; Follow-Up Studies ; Gastroenteritis/complications ; Gastroenteritis/epidemiology ; Glucocorticoids/therapeutic use ; Humans ; Inflammation ; Male ; Middle Aged ; Osteonecrosis/microbiology ; Prospective Studies ; Sewage ; Treatment Outcome ; Water Microbiology ; Water Pollutants/adverse effects ; Water Supply
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Antirheumatic Agents ; Glucocorticoids ; Sewage ; Water Pollutants
    Language English
    Publishing date 2013-04-05
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604755-5
    ISSN 1434-9949 ; 0770-3198
    ISSN (online) 1434-9949
    ISSN 0770-3198
    DOI 10.1007/s10067-013-2247-x
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  10. Article: Endothelial nitric oxide synthase +894 polymorphism is associated with recurrent salivary gland swelling and early onset in patients with primary Sjogren's syndrome.

    Pertovaara, Marja / Antonen, Jaakko / Hurme, Mikko

    Annals of the rheumatic diseases

    2007  Volume 66, Issue 10, Page(s) 1400–1401

    MeSH term(s) Age of Onset ; Aged ; Female ; Genetic Predisposition to Disease/genetics ; Humans ; Male ; Middle Aged ; Nitric Oxide Synthase Type III/genetics ; Polymorphism, Genetic/genetics ; Salivary Glands/pathology ; Sjogren's Syndrome/genetics
    Chemical Substances Nitric Oxide Synthase Type III (EC 1.14.13.39)
    Language English
    Publishing date 2007-10
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/ard.2007.069385
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