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  1. Article ; Online: Complete Uterine Septum, Double Cervix and Vaginal Septum (U2b C2 V1)

    Luca Parodi / Ilda Hoxhaj / Giorgia Dinoi / Mariateresa Mirandola / Federica Pozzati / Ghergana Topouzova / Antonia Carla Testa / Giovanni Scambia / Ursula Catena

    Journal of Clinical Medicine, Vol 12, Iss 1, p

    Hysteroscopic Management and Fertility Outcomes—A Systematic Review

    2022  Volume 189

    Abstract: Background: complete uterine septum, double cervix and vaginal septum is a rare complex Müllerian anomaly affecting patients’ quality of life in terms of fertility and pelvic pain. The aim of our review is to gather the studies concerning the diagnosis ... ...

    Abstract Background: complete uterine septum, double cervix and vaginal septum is a rare complex Müllerian anomaly affecting patients’ quality of life in terms of fertility and pelvic pain. The aim of our review is to gather the studies concerning the diagnosis and treatment this complex malformation and to describe the related fertility outcomes. Methods: this study was conducted in 2022, according to the criteria of Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) and the protocol was submitted to the International Prospective Register for Systematic Reviews (PROSPERO). PubMed, Scopus and Web of Science electronic databases were searched to find eligible articles. In total, 538 articles were identified through literature research. A total of ten articles satisfied the eligibility criteria and were included in the systematic review. Results: 86 affected women were evaluated, and 71 of them were treated. Almost all patients included in our research presented with primary infertility or with a history of recurrent miscarriages; half of all patients also reported dyspareunia. After surgical treatment, 47 pregnancies were achieved: 41 live birth and ongoing pregnancies and six spontaneous miscarriages occurred; a significantly lower miscarriage rate was reported after surgical treatment. Conclusion: hysteroscopic treatment of U2b C2 V1 anomaly can be safely performed, leading to favorable fertility outcomes, measured as the achievement of pregnancy and a reduction in miscarriage rate.
    Keywords U2bC2V1 ; Müllerian malformation ; uterine malformation ; hysteroscopy ; metroplasty ; infertility ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Building a Personalized Medicine Infrastructure for Gynecological Oncology Patients in a High-Volume Hospital

    Nicolò Bizzarri / Camilla Nero / Francesca Sillano / Francesca Ciccarone / Marika D’Oria / Alfredo Cesario / Simona Maria Fragomeni / Antonia Carla Testa / Francesco Fanfani / Gabriella Ferrandina / Domenica Lorusso / Anna Fagotti / Giovanni Scambia

    Journal of Personalized Medicine, Vol 12, Iss 3, p

    2021  Volume 3

    Abstract: Gynecological cancers require complex intervention since patients have specific needs to be addressed. Centralization to high-volume centers improves the oncological outcomes of patients with gynecological cancers. Research in gynecological oncology is ... ...

    Abstract Gynecological cancers require complex intervention since patients have specific needs to be addressed. Centralization to high-volume centers improves the oncological outcomes of patients with gynecological cancers. Research in gynecological oncology is increasing thanks to modern technologies, from the comprehensive molecular characterization of tumors and individual pathophenotypes. Ongoing studies are focusing on personalizing therapies by integrating information across genomics, proteomics, and metabolomics with the genetic makeup and immune system of the patient. Hence, several challenges must be faced to provide holistic benefit to the patient. Personalized approaches should also recognize the unmet needs of each patient to successfully deliver the promise of personalized care, in a multidisciplinary effort. This may provide the greatest opportunity to improve patients’ outcomes. Starting from a narrative review on gynecological oncology patients’ needs, this article focuses on the experience of building a research and care infrastructure for personalized patient management.
    Keywords gynecologic oncology ; patient-centered care ; personalized medicine ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Germline BRCA 1-2 status prediction through ovarian ultrasound images radiogenomics

    Camilla Nero / Francesca Ciccarone / Luca Boldrini / Jacopo Lenkowicz / Ida Paris / Ettore Domenico Capoluongo / Antonia Carla Testa / Anna Fagotti / Vincenzo Valentini / Giovanni Scambia

    Scientific Reports, Vol 10, Iss 1, Pp 1-

    a hypothesis generating study (PROBE study)

    2020  Volume 11

    Abstract: Abstract Radiogenomics is a specific application of radiomics where imaging features are linked to genomic profiles. We aim to develop a radiogenomics model based on ovarian US images for predicting germline BRCA1/2 gene status in women with healthy ... ...

    Abstract Abstract Radiogenomics is a specific application of radiomics where imaging features are linked to genomic profiles. We aim to develop a radiogenomics model based on ovarian US images for predicting germline BRCA1/2 gene status in women with healthy ovaries. From January 2013 to December 2017 a total of 255 patients addressed to germline BRCA1/2 testing and pelvic US documenting normal ovaries, were retrospectively included. Feature selection for univariate analysis was carried out via correlation analysis. Multivariable analysis for classification of germline BRCA1/2 status was then carried out via logistic regression, support vector machine, ensemble of decision trees and automated machine learning pipelines. Data were split into a training (75%) and a testing (25%) set. The four strategies obtained a similar performance in terms of accuracy on the testing set (from 0.54 of logistic regression to 0.64 of the auto-machine learning pipeline). Data coming from one of the tested US machine showed generally higher performances, particularly with the auto-machine learning pipeline (testing set specificity 0.87, negative predictive value 0.73, accuracy value 0.72 and 0.79 on training set). The study shows that a radiogenomics model on machine learning techniques is feasible and potentially useful for predicting gBRCA1/2 status in women with healthy ovaries.
    Keywords Medicine ; R ; Science ; Q
    Subject code 006
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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