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  1. Article ; Online: Predictors of psychopathology response in atypical anorexia nervosa following inpatient treatment: A propensity score matching study of weight suppression and weight loss speed.

    Meneguzzo, Paolo / Antoniades, Athos / Garolla, Alice / Tozzi, Federica / Todisco, Patrizia

    The International journal of eating disorders

    2024  Volume 57, Issue 4, Page(s) 1002–1007

    Abstract: Introduction: This study examines weight suppression (WS) and weight loss speed (WLS) in atypical anorexia nervosa (AN) and its implications for treatment outcomes, compared to people with AN and bulimia nervosa (BN).: Method: A mixed cross-sectional ...

    Abstract Introduction: This study examines weight suppression (WS) and weight loss speed (WLS) in atypical anorexia nervosa (AN) and its implications for treatment outcomes, compared to people with AN and bulimia nervosa (BN).
    Method: A mixed cross-sectional and prospective design was employed, assessing WS and WLS in people with atypical AN, AN, and BN. Participants were matched for age, gender, age of onset, and disorder duration. Clinical measurements and eating disorders questionnaire (EDE-Q) scores were employed to evaluate the response to treatment.
    Results: Individuals with atypical individuals exhibited WS patterns similar to AN, distinct from BN. Rapid WLS predicted clinical responses in atypical AN and BN, underscoring its treatment relevance. Atypical AN showed higher eating psychopathology scores than AN or BN, emphasizing the need for a reframed diagnosis.
    Discussion: Understanding atypical AN's connection to restrictive behaviors and weight loss informs screening, assessment, and treatment practices. Recognition of atypical AN's severity and adoption of tailored approaches are essential for recovery. This study highlights the significance of WS and WLS in atypical AN treatment outcomes, offering insights into clinical practice and care. The proposal to reframe atypical AN as a restrictive eating disorder emphasizes its clinical relevance.
    Public significance statement: The phenomenon of weight suppression, involving the discrepancy between past highest weight and current weight, has garnered attention due to cultural pressures emphasizing fitness and appearance. This study focuses on its implications in atypical anorexia nervosa, aiming to uncover the relationship between WS, its speed, and treatment outcomes. The investigation contributes insights into tailored interventions for atypical anorexia nervosa and enriches the understanding of this complex disorder's dynamics.
    MeSH term(s) Humans ; Anorexia Nervosa/diagnosis ; Anorexia Nervosa/therapy ; Body Weight/physiology ; Cross-Sectional Studies ; Inpatients ; Propensity Score ; Weight Loss/physiology ; Bulimia Nervosa/diagnosis ; Bulimia Nervosa/therapy
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603170-5
    ISSN 1098-108X ; 0276-3478
    ISSN (online) 1098-108X
    ISSN 0276-3478
    DOI 10.1002/eat.24135
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Gut microbiota and treatment-resistant schizophrenia: many questions, fewer answers.

    Manchia, Mirko / Squassina, Alessio / Tozzi, Federica / Antoniades, Athos / Carpiniello, Bernardo

    Pharmacogenomics

    2022  Volume 23, Issue 5, Page(s) 277–280

    MeSH term(s) Antipsychotic Agents/therapeutic use ; Gastrointestinal Microbiome ; Humans ; Schizophrenia/drug therapy ; Schizophrenia/genetics ; Schizophrenia, Treatment-Resistant
    Chemical Substances Antipsychotic Agents
    Language English
    Publishing date 2022-03-03
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2019513-8
    ISSN 1744-8042 ; 1462-2416
    ISSN (online) 1744-8042
    ISSN 1462-2416
    DOI 10.2217/pgs-2022-0018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Preparing for the next pandemic by understanding the impact of COVID-19 mitigation measures on patients with eating Disorders: observations from an inpatient setting.

    Todisco, Patrizia / Meneguzzo, Paolo / Garolla, Alice / Antoniades, Athos / Vogazianos, Paris / Tozzi, Federica

    International journal of psychiatry in clinical practice

    2023  Volume 27, Issue 4, Page(s) 323–329

    Abstract: Objective: The COVID-19 pandemic overwhelmed eating disorder (ED) services worldwide. Data suggests a worsening of psychopathology and an increased request for specialised treatments. Still, the studies are mostly based on experimental protocols with ... ...

    Abstract Objective: The COVID-19 pandemic overwhelmed eating disorder (ED) services worldwide. Data suggests a worsening of psychopathology and an increased request for specialised treatments. Still, the studies are mostly based on experimental protocols with underpowered short-term opportunistic experimental designs. Thus, this study aims to assess the clinical and psychological differences between patients admitted to a specialised ED Unit before and after the COVID-19 breakout.
    Methods: Consecutive patients admitted from June 2014 to February 2022 in a specialised EDs Unit were enrolled. A total sample of 498 individuals was enrolled in this retrospective study, collecting demographic and psychopathological data at admission.
    Results: An increase in the admission of patients with anorexia nervosa has been reported, with lower age and higher levels of specific and general psychopathology, especially linked to body uneasiness.
    Conclusions: Results are put into the context of the preparation for the next pandemic that may require similar mitigation measures as COVID-19 to ensure the impact on existing and new patients. Covering an extended period with validated tools, our results might help psychiatric services to reassess their treatment pathways after the pandemic, helping clinicians to delineate future treatment interventions.KEYPOINTSAfter the COVID-19 breakdown, there was an increase in the admission of patients with anorexia nervosa to specialised services.More severe psychopathology was not accompanied by lower body mass index.Specialised eating disorders services should face sudden changes in patients' requests for treatment.Understanding the impact of the Covid-19 pandemic and the resulting mitigation measures taken can lead to better preparations for the next pandemic.
    MeSH term(s) Humans ; Pandemics ; COVID-19 ; Inpatients ; Retrospective Studies ; Feeding and Eating Disorders
    Language English
    Publishing date 2023-06-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1465531-7
    ISSN 1471-1788 ; 1365-1501
    ISSN (online) 1471-1788
    ISSN 1365-1501
    DOI 10.1080/13651501.2023.2221318
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Understanding dropout and non-participation in follow-up evaluation for the benefit of patients and research: evidence from a longitudinal observational study on patients with eating disorders.

    Todisco, Patrizia / Meneguzzo, Paolo / Garolla, Alice / Diomidous, Eva / Antoniades, Athos / Vogazianos, Paris / Tozzi, Federica

    Eating disorders

    2022  Volume 31, Issue 4, Page(s) 337–352

    Abstract: Treatment outcomes in eating disorders (EDs) are still an open field for clinicians and researchers. Besides difficulties in egosyntonic-linked treatment engagements, dropout is one of the most crucial elements that cause a reduction in the treatment ... ...

    Abstract Treatment outcomes in eating disorders (EDs) are still an open field for clinicians and researchers. Besides difficulties in egosyntonic-linked treatment engagements, dropout is one of the most crucial elements that cause a reduction in the treatment efficacy. Thus, the aim of this study is to evaluate factors that could contribute to high dropout rates and non-participation in follow-up evaluation in patients with ED. This study used a large sample of patients from a specialized ED ward and day hospital (DH). A sample of 428 individuals was recruited for this study. Psychological and demographic data were collected at the time of hospitalization and discharge from the facilities. These data were used to explore a possible link between dropout and follow-up non-participation. Specially, the random forest was used to rank demographic and psychological features in importance and evaluate the top results with regression analyses for statistical significance. A dropout rate of 12.14% during inpatient and DH treatment was found. Anger-hostility and general psychopathology were found to be predictors of dropout during treatment, while the duration of the hospitalization predicted non-participation at the six-month follow-up. Specific psychological features should be considered before and during treatments for patients with EDs to reduce dropout rates. The duration of the hospitalization should also be evaluated as a relevant healthcare element that could affect engagement and, accordingly, outcome.
    MeSH term(s) Humans ; Follow-Up Studies ; Patient Dropouts/psychology ; Feeding and Eating Disorders/therapy ; Treatment Outcome ; Longitudinal Studies
    Language English
    Publishing date 2022-10-22
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 1209799-8
    ISSN 1532-530X ; 1064-0266 ; 1067-1633
    ISSN (online) 1532-530X
    ISSN 1064-0266 ; 1067-1633
    DOI 10.1080/10640266.2022.2135738
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: High Throughput Sequencing Technologies as a New Toolbox for Deep Analysis, Characterization and Potentially Authentication of Protection Designation of Origin Cheeses?

    Kamilari, Elena / Tomazou, Marios / Antoniades, Athos / Tsaltas, Dimitrios

    International journal of food science

    2019  Volume 2019, Page(s) 5837301

    Abstract: Protected Designation of Origin (PDO) labeling of cheeses has been established by the European Union (EU) as a quality policy that assures the authenticity of a cheese produced in a specific region by applying traditional production methods. However, ... ...

    Abstract Protected Designation of Origin (PDO) labeling of cheeses has been established by the European Union (EU) as a quality policy that assures the authenticity of a cheese produced in a specific region by applying traditional production methods. However, currently used scientific methods for differentiating and establishing PDO are limited in terms of time, cost, accuracy and their ability to identify through quantifiable methods PDO fraud. Cheese microbiome is a dynamic community that progressively changes throughout ripening, contributing via its metabolism to unique qualitative and sensorial characteristics that differentiate each cheese. High Throughput Sequencing (HTS) methodologies have enabled the more precise identification of the microbial communities developed in fermented cheeses, characterization of their population dynamics during the cheese ripening process, as well as their contribution to the development of specific organoleptic and physio-chemical characteristics. Therefore, their application may provide an additional tool to identify the key microbial species that contribute to PDO cheeses unique sensorial characteristics and to assist to define their typicityin order to distinguish them from various fraudulent products. Additionally, they may assist the cheese-makers to better evaluate the quality, as well as the safety of their products. In this structured literature review indications are provided on the potential for defining PDO enabling differentiating factors based on distinguishable microbial communities shaped throughout the ripening procedures associated to cheese sensorial characteristics, as revealed through metagenomic and metatranscriptomic studies. Conclusively, HTS applications, even though still underexploited, have the potential to demonstrate how the cheese microbiome can affect the ripening process and sensorial characteristics formation via the catabolism of the available nutrients and interplay with other compounds of the matrix and/or production of microbial origin metabolites and thus their further quality enhancement.
    Language English
    Publishing date 2019-11-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2760370-2
    ISSN 2314-5765
    ISSN 2314-5765
    DOI 10.1155/2019/5837301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: High Throughput Sequencing Technologies as a New Toolbox for Deep Analysis, Characterization and Potentially Authentication of Protection Designation of Origin Cheeses?

    Kamilari, Elena / Tomazou, Marios / Antoniades, Athos / Tsaltas, Dimitrios

    International Journal of Food Sciences. 2019 Nov. 20, v. 2019

    2019  

    Abstract: Protected Designation of Origin (PDO) labeling of cheeses has been established by the European Union (EU) as a quality policy that assures the authenticity of a cheese produced in a specific region by applying traditional production methods. However, ... ...

    Abstract Protected Designation of Origin (PDO) labeling of cheeses has been established by the European Union (EU) as a quality policy that assures the authenticity of a cheese produced in a specific region by applying traditional production methods. However, currently used scientific methods for differentiating and establishing PDO are limited in terms of time, cost, accuracy and their ability to identify through quantifiable methods PDO fraud. Cheese microbiome is a dynamic community that progressively changes throughout ripening, contributing via its metabolism to unique qualitative and sensorial characteristics that differentiate each cheese. High Throughput Sequencing (HTS) methodologies have enabled the more precise identification of the microbial communities developed in fermented cheeses, characterization of their population dynamics during the cheese ripening process, as well as their contribution to the development of specific organoleptic and physio-chemical characteristics. Therefore, their application may provide an additional tool to identify the key microbial species that contribute to PDO cheeses unique sensorial characteristics and to assist to define their typicityin order to distinguish them from various fraudulent products. Additionally, they may assist the cheese-makers to better evaluate the quality, as well as the safety of their products. In this structured literature review indications are provided on the potential for defining PDO enabling differentiating factors based on distinguishable microbial communities shaped throughout the ripening procedures associated to cheese sensorial characteristics, as revealed through metagenomic and metatranscriptomic studies. Conclusively, HTS applications, even though still underexploited, have the potential to demonstrate how the cheese microbiome can affect the ripening process and sensorial characteristics formation via the catabolism of the available nutrients and interplay with other compounds of the matrix and/or production of microbial origin metabolites and thus their further quality enhancement.
    Keywords European Union ; cheese ripening ; cheeses ; fraud ; high-throughput nucleotide sequencing ; issues and policy ; metabolism ; metabolites ; metagenomics ; microbial communities ; microbiome ; nutrient availability ; population dynamics ; protected designation of origin ; transcriptomics
    Language English
    Dates of publication 2019-1120
    Publishing place Hindawi
    Document type Article
    ZDB-ID 2760370-2
    ISSN 2314-5765 ; 2356-7015
    ISSN (online) 2314-5765
    ISSN 2356-7015
    DOI 10.1155/2019/5837301
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: eHealth Interventions for Anxiety Management Targeting Young Children and Adolescents: Exploratory Review.

    Tozzi, Federica / Nicolaidou, Iolie / Galani, Anastasia / Antoniades, Athos

    JMIR pediatrics and parenting

    2018  Volume 1, Issue 1, Page(s) e5

    Abstract: Background: Advances in technology are progressively more relevant to the clinical practice of psychology and mental health services generally. Studies indicate that technology facilitates the delivery of interventions, such as cognitive behavioral ... ...

    Abstract Background: Advances in technology are progressively more relevant to the clinical practice of psychology and mental health services generally. Studies indicate that technology facilitates the delivery of interventions, such as cognitive behavioral therapy, in the treatment of psychological disorders in adults, such as depression, anxiety, obsessive-compulsive disorder, panic symptoms, and eating disorders. Fewer data exist for computer-based (stand-alone, self-help) and computer-assisted (in combination with face-to-face therapy, or therapist guided) programs for youth.
    Objective: Our objective was to summarize and critically review the literature evaluating the acceptability and efficacy of using technology with treatment and prevention programs for anxiety in young children and adolescents. The aim was to improve the understanding of what would be critical for future development of effective technology-based interventions.
    Methods: We conducted an exploratory review of the literature through searches in 3 scientific electronic databases (PsycINFO, ScienceDirect, and PubMed). We used keywords in various combinations: child or children, adolescent, preschool children, anxiety, intervention or treatment or program, smartphone applications or apps, online or Web-based tool, computer-based tool, internet-based tool, serious games, cognitive behavioral therapy or CBT, biofeedback, and mindfulness. For inclusion, articles had to (1) employ a technological therapeutic tool with or without the guidance of a therapist; (2) be specific for treatment or prevention of anxiety disorders in children or adolescents; (3) be published between 2000 and 2018; and (4) be published in English and in scientific peer-reviewed journals.
    Results: We identified and examined 197 articles deemed to be relevant. Of these, we excluded 164 because they did not satisfy 1 or more of the requirements. The final review comprised 19 programs. Published studies demonstrated promising results in reducing anxiety, especially relative to the application of cognitive behavioral therapy with technology. For those programs demonstrating efficacy, no difference was noted when compared with traditional interventions. Other approaches have been applied to technology-based interventions with inconclusive results. Most programs were developed to be used concurrently with traditional treatments and lacked long-term evaluation. Very little has been done in terms of prevention interventions.
    Conclusions: Future development of eHealth programs for anxiety management in children will have to address several unmet needs and overcome key challenges. Although developmental stages may limit the applicability to preschool children, prevention should start in early ages. Self-help formats and personalization are highly relevant for large-scale dissemination. Automated data collection should be built in for program evaluation and effectiveness assessment. And finally, a strategy to stimulate motivation to play and maintain high adherence should be carefully considered.
    Language English
    Publishing date 2018-05-10
    Publishing country Canada
    Document type Journal Article ; Review
    ISSN 2561-6722
    ISSN (online) 2561-6722
    DOI 10.2196/pediatrics.7248
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Exercise and Occupational Stress among Firefighters.

    Soteriades, Elpidoforos S / Vogazianos, Paris / Tozzi, Federica / Antoniades, Athos / Economidou, Eleftheria C / Psalta, Lilia / Spanoudis, George

    International journal of environmental research and public health

    2022  Volume 19, Issue 9

    Abstract: The aim of our study was to evaluate the potential association between physical activity and occupational stress among firefighters. Data were collected from Cypriot firefighters through a web-based battery of internationally validated questionnaires ... ...

    Abstract The aim of our study was to evaluate the potential association between physical activity and occupational stress among firefighters. Data were collected from Cypriot firefighters through a web-based battery of internationally validated questionnaires completed anonymously (COPSOQ, DASS). A total of 430 firefighters (response rate 68%) completed the survey (age range: 21-60 years). More than half of the firefighters (54%) reported either no or minimal physical activity. A total of 11% of firefighters reported moderate to extremely severe stress based on the DASS-S scale. Using multivariable-adjusted logistic regression models, we showed that firefighters who exercised had 50% lower risk of occupational stress, and using a categorical model, we found that every hour per week of increased physical activity among firefighters was associated with 16% lower risk of occupational stress after adjusting for age, education, smoking, and body mass index (OR = 1.16;
    MeSH term(s) Adult ; Body Mass Index ; Firefighters/psychology ; Humans ; Mental Health ; Middle Aged ; Occupational Health ; Occupational Stress/epidemiology ; Occupational Stress/psychology ; Surveys and Questionnaires ; Young Adult
    Language English
    Publishing date 2022-04-20
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19094986
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Data structuring may prevent ambiguity and improve personalized medical prognosis.

    Libertin, Claudia R / Kempaiah, Prakasha / Gupta, Yash / Fair, Jeanne M / van Regenmortel, Marc H V / Antoniades, Athos / Rivas, Ariel L / Hoogesteijn, Almira L

    Molecular aspects of medicine

    2022  Volume 91, Page(s) 101142

    Abstract: Topics expected to influence personalized medicine (PM), where medical decisions, practices, and treatments are tailored to the individual patient, are reviewed. Lack of discrimination due to different biological conditions that express similar values of ...

    Abstract Topics expected to influence personalized medicine (PM), where medical decisions, practices, and treatments are tailored to the individual patient, are reviewed. Lack of discrimination due to different biological conditions that express similar values of numerical variables (ambiguity) is regarded to be a major potential barrier for PM. This material explores possible causes and sources of ambiguity and offers suggestions for mitigating the impacts of uncertainties. Three causes of ambiguity are identified: (1) delayed adoption of innovations, (2) inadequate emphases, and (3) inadequate processes used when new medical practices are developed and validated. One example of the first problem is the relative lack of medical research on "compositional data" -the type that characterizes leukocyte data. This omission results in erroneous use of data abundantly utilized in medicine, such as the blood cell differential. Emphasis on data output ‒not biomedical interpretation that facilitates the use of clinical data‒ exemplifies the second type of problems. Reliance on tools generated in other fields (but not validated within biomedical contexts) describes the last limitation. Because reductionism is associated with these problems, non-reductionist alternatives are reviewed as potential remedies. Data structuring (converting data into information) is considered a key element that may promote PM. To illustrate a process that includes data-information-knowledge and decision-making, previously published data on COVID-19 are utilized. It is suggested that ambiguity may be prevented or ameliorated. Provided that validations are grounded on biomedical knowledge, approaches that describe certain criteria - such as non-overlapping data intervals of patients that experience different outcomes, immunologically interpretable data, and distinct graphic patterns - can inform, at personalized bases, earlier and/or with fewer observations.
    MeSH term(s) Humans ; COVID-19/epidemiology ; Precision Medicine/methods ; Leukocytes
    Language English
    Publishing date 2022-09-15
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 197640-0
    ISSN 1872-9452 ; 0098-2997
    ISSN (online) 1872-9452
    ISSN 0098-2997
    DOI 10.1016/j.mam.2022.101142
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Impulsive behaviors and clinical outcomes following a flexible intensive inpatient treatment for eating disorders: findings from an observational study.

    Todisco, Patrizia / Meneguzzo, Paolo / Garolla, Alice / Antoniades, Athos / Vogazianos, Paris / Tozzi, Federica

    Eating and weight disorders : EWD

    2020  Volume 26, Issue 3, Page(s) 869–877

    Abstract: Purpose: The aim of the study was to assess the differences between impulsive and non-impulsive patients in response to a multidisciplinary intensive inpatient treatment for eating disorders (EDs).: Methods: 320 patients with EDs were consecutively ... ...

    Abstract Purpose: The aim of the study was to assess the differences between impulsive and non-impulsive patients in response to a multidisciplinary intensive inpatient treatment for eating disorders (EDs).
    Methods: 320 patients with EDs were consecutively recruited in an eating disorders unit (EDU). They were assessed by clinical interviews and self-reported questionnaires. The treatment was characterized by a patient-centric approach and included both an intensive and comprehensive standardized multidisciplinary program based on cognitive-behavioral therapy and a flexible and personalized component according to the needs and the history of each patient.
    Results: Impulsive ED patients showed greater improvement in specific psychopathological areas, in particular: interpersonal sensitivity of Symptom Checklist-90 (SCL-90) (p = 0.007); Eating Disorder Examination Questionnaire (EDE-Q) Global Score (p = 0.009), EDE-Q eating concern (p < 0.001) and EDE-Q shape concern (p = 0.025). The two groups also showed a different pattern on the Body Uneasiness Test, with impulsive patients uniquely showing improvement on Global Severity Index (p = 0.006), body image concern (p = 0.008), compulsive self monitoring (p = 0.002), and weight phobia (p = 0.037).
    Discussion: Results support the hypothesis that patients with impulsive behaviors might benefit from treatments characterized by a standardized cognitive behavioral therapy implemented by third-wave interventions according to each patient's clinical profile. Personalized treatment approaches could be an answer to the complexity of ED, addressing individual psychopathology. Further studies are needed to confirm these preliminary findings.
    Level of evidence: III, cohort or case-control analytic studies.
    MeSH term(s) Feeding and Eating Disorders/therapy ; Humans ; Impulsive Behavior ; Inpatients ; Psychometrics ; Surveys and Questionnaires
    Language English
    Publishing date 2020-05-19
    Publishing country Germany
    Document type Journal Article ; Observational Study
    ZDB-ID 2038625-4
    ISSN 1590-1262 ; 1124-4909
    ISSN (online) 1590-1262
    ISSN 1124-4909
    DOI 10.1007/s40519-020-00916-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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