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Article ; Online: Oscillometry in severe asthma: the state of the art and future perspectives.

Menzella, Francesco / Antonicelli, Leonardo / Cottini, Marcello / Imeri, Gianluca / Corsi, Lorenzo / Di Marco, Fabiano

2023 Volume 17, Issue 7, Page(s) 563–575

Abstract: Introduction: Approximately 3-10% of people with asthma have severe asthma (SA). Patients with SA have greater impairment in daily life and much higher costs. Even if asthma affects the entire bronchial tree, small airways have been recognized as the ... ...

Abstract	Introduction: Approximately 3-10% of people with asthma have severe asthma (SA). Patients with SA have greater impairment in daily life and much higher costs. Even if asthma affects the entire bronchial tree, small airways have been recognized as the major site of airflow limitation. There are several tools for studying small airway dysfunction (SAD), but certainly the most interesting is oscillometry. Despite several studies, the clinical usefulness of oscillometry in asthma is still in question. This paper aims to provide evidence supporting the use of oscillometry to improve the management of SA in clinical practice. Areas covered: In the ATLANTIS study, SAD was strongly evident across all severity. Various tools are available for evaluation of SAD, and certainly an integrated use of these can provide complete and detailed information. However, the most suitable method is oscillometry, implemented for clinical routine by using either small pressure impulses or small pressure sinusoidal waves. Expert opinion: Oscillometry, despite its different technological implementations is the best tool for determining the impact of SAD on asthma and its control. Oscillometry will also be increasingly useful for choosing the appropriate drug, and there is ample room for a more widespread diffusion in clinical practice.
MeSH term(s)	Humans ; Oscillometry/methods ; Spirometry/methods ; Asthma/diagnosis ; Asthma/therapy ; Lung
Language	English
Publishing date	2023-07-20
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2479146-5
ISSN	1747-6356 ; 1747-6348
ISSN (online)	1747-6356
ISSN	1747-6348
DOI	10.1080/17476348.2023.2237872
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Article ; Online: Safety and Adherence to Venom Immunotherapy During COVID-19 Pandemic.

Bilò, M Beatrice / Braschi, M Chiara / Piga, Mario A / Antonicelli, Leonardo / Martini, Matteo

The journal of allergy and clinical immunology. In practice

2020 Volume 9, Issue 2, Page(s) 702–708

Abstract: Background: According to expert consensus, the time interval between Hymenoptera venom immunotherapy (VIT) injections can be extended up to 12 weeks, without significant impact on efficacy and safety. However, the coronavirus disease 2019 pandemic ... ...

Abstract	Background: According to expert consensus, the time interval between Hymenoptera venom immunotherapy (VIT) injections can be extended up to 12 weeks, without significant impact on efficacy and safety. However, the coronavirus disease 2019 pandemic caused longer delays, and no recommendations are available to manage this huge extension. Objectives: To provide advice on how to resume VIT safely after a long delay from the last injection considering the potential risk factors for side effects, without starting again with the induction phase. Methods: All the patients who delayed VIT because of the pandemic were consecutively enrolled in this single-center study. The time extension was decided according to their risk profile (eg, long prepandemic time interval, severe pre-VIT reaction, older age, multitreatments), and correlation analyses were performed to find potential risk factors of side effects. Results: The mean delay from the pre- (7 weeks) to the postpandemic VIT interval (15.5 weeks) was 8.5 weeks. The total amount of the prepandemic VIT maintenance dose was safely administered in 1 day in 78% of patients, whereas only 3, of 87, experienced side effects, and their potential risk factors were identified in bee venom allergy and recent VIT initiation. Conclusions: In a real-world setting, long VIT delays may be safe and well tolerated, but more caution should be paid in resuming VIT in patients with long prepandemic maintenance interval, severe pre-VIT reaction, recent VIT initiation, older age, multidrug treatments, and bee venom allergy. This is useful in any case of long, unplanned, and unavoidable VIT delay.
MeSH term(s)	Adult ; Aged ; Bee Venoms/immunology ; COVID-19/epidemiology ; Desensitization, Immunologic/adverse effects ; Desensitization, Immunologic/methods ; Female ; Humans ; Hypersensitivity, Immediate/therapy ; Male ; Middle Aged ; Pandemics ; SARS-CoV-2 ; Treatment Adherence and Compliance
Chemical Substances	Bee Venoms
Language	English
Publishing date	2020-11-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2843237-X
ISSN	2213-2201 ; 2213-2198
ISSN (online)	2213-2201
ISSN	2213-2198
DOI	10.1016/j.jaip.2020.11.030
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Article ; Online: High long-term efficacy of venom immunotherapy after discontinuation.

Martini, Matteo / Corsi, Alice / Agolini, Stefano / Marchionni, Aureliano / Antonicelli, Leonardo / Bilò, Maria Beatrice

Allergy

2020 Volume 75, Issue 7, Page(s) 1793–1796

MeSH term(s)	Animals ; Bee Venoms ; Desensitization, Immunologic ; Humans ; Hymenoptera ; Immunotherapy ; Insect Bites and Stings/therapy ; Wasp Venoms
Chemical Substances	Bee Venoms ; Wasp Venoms
Language	English
Publishing date	2020-03-09
Publishing country	Denmark
Document type	Letter
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1111/all.14224
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Article ; Online: ANCA-negative EGPA: only eosinophils without vasculitis? Insights from anti-T2 biologics.

Piga, Mario Andrea / Fraticelli, Paolo / Antonicelli, Leonardo / Garritani, Maria Stella / Ghirelli, Giulia / Martini, Matteo / Di Vincenzo, Angelica / Danieli, Maria Giovanna / Moroncini, Gianluca / Bilò, Maria Beatrice

Frontiers in immunology

2023 Volume 14, Page(s) 1325299

Abstract: The pathogenic role of p-ANCA in eosinophilic granulomatosis with polyangiitis (EGPA) is a long-standing matter of debate. In this work, we report our real-life experience with EGPA patients, treated with biologics targeting type 2 (T2)-eosinophilic ... ...

Abstract	The pathogenic role of p-ANCA in eosinophilic granulomatosis with polyangiitis (EGPA) is a long-standing matter of debate. In this work, we report our real-life experience with EGPA patients, treated with biologics targeting type 2 (T2)-eosinophilic inflammation (Mepolizumab, Benralizumab, Dupilumab). Interestingly, we observed EGPA extrarespiratory relapses only in p-ANCA-positive patients (2/5 cutaneous vasculitis, 3/5 constitutional symptoms), with new rise of p-ANCA and normal eosinophil blood count. Notably, revising our cohort with the new ACR 2022 criteria, these five patients were the only ones to satisfy the entry criterion of vasculitis' defined diagnosis at disease onset. These observations may suggest that biologics, selectively turning off T2 inflammation, may have unmasked p-ANCA exclusive role in the pathogenesis of vasculitis in EGPA. Therefore, we raise the question whether EGPA vasculitis exists only in p-ANCA-positive patients, and whether p-ANCA-negative disease is "only eosinophils without vasculitis".
MeSH term(s)	Humans ; Eosinophils/pathology ; Antibodies, Antineutrophil Cytoplasmic ; Churg-Strauss Syndrome ; Granulomatosis with Polyangiitis/diagnosis ; Biological Products ; Inflammation/pathology
Chemical Substances	Antibodies, Antineutrophil Cytoplasmic ; Biological Products
Language	English
Publishing date	2023-11-27
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1325299
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Article ; Online: Forced oscillation technique as method to document and monitor the efficacy of mepolizumab in treating severe eosinophilic asthma.

Antonicelli, Leonardo / Tontini, Chiara / Marchionni, Aureliano / Lucchetti, Beatrice / Garritani, Maria Stella / Bilò, Maria Beatrice

Allergy

2019 Volume 75, Issue 2, Page(s) 433–436

MeSH term(s)	Airway Resistance ; Anti-Asthmatic Agents/pharmacology ; Anti-Asthmatic Agents/therapeutic use ; Antibodies, Monoclonal, Humanized/pharmacology ; Antibodies, Monoclonal, Humanized/therapeutic use ; Asthma/complications ; Asthma/drug therapy ; Eosinophilia/complications ; Eosinophilia/drug therapy ; Humans ; Interleukin-5/antagonists & inhibitors ; Leukocyte Count ; Prospective Studies ; Treatment Outcome
Chemical Substances	Anti-Asthmatic Agents ; Antibodies, Monoclonal, Humanized ; IL5 protein, human ; Interleukin-5 ; mepolizumab (90Z2UF0E52)
Language	English
Publishing date	2019-10-24
Publishing country	Denmark
Document type	Letter
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1111/all.13938
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Article ; Online: Long-term residential exposure to air pollution and risk of chronic respiratory diseases in Italy: The BIGEPI study.

Marchetti, Pierpaolo / Miotti, Jessica / Locatelli, Francesca / Antonicelli, Leonardo / Baldacci, Sandra / Battaglia, Salvatore / Bono, Roberto / Corsico, Angelo / Gariazzo, Claudio / Maio, Sara / Murgia, Nicola / Pirina, Pietro / Silibello, Camillo / Stafoggia, Massimo / Torroni, Lorena / Viegi, Giovanni / Verlato, Giuseppe / Marcon, Alessandro

The Science of the total environment

2023 Volume 884, Page(s) 163802

Abstract: Long-term exposure to air pollution has adverse respiratory health effects. We investigated the cross-sectional relationship between residential exposure to air pollutants and the risk of suffering from chronic respiratory diseases in some Italian cities. ...

Abstract	Long-term exposure to air pollution has adverse respiratory health effects. We investigated the cross-sectional relationship between residential exposure to air pollutants and the risk of suffering from chronic respiratory diseases in some Italian cities. In the BIGEPI project, we harmonised questionnaire data from two population-based studies conducted in 2007-2014. By combining self-reported diagnoses, symptoms and medication use, we identified cases of rhinitis (n = 965), asthma (n = 328), chronic bronchitis/chronic obstructive pulmonary disease (CB/COPD, n = 469), and controls (n = 2380) belonging to 13 cohorts from 8 Italian cities (Pavia, Turin, Verona, Terni, Pisa, Ancona, Palermo, Sassari). We derived mean residential concentrations of fine particulate matter (PM
MeSH term(s)	Humans ; Rhinitis ; Nitrogen Dioxide ; Respiration Disorders/chemically induced ; Respiration Disorders/epidemiology ; Air Pollution ; Asthma/chemically induced ; Asthma/epidemiology ; Pulmonary Disease, Chronic Obstructive ; Air Pollutants/adverse effects ; Italy/epidemiology ; Drug-Related Side Effects and Adverse Reactions ; Environmental Exposure ; Environmental Pollutants ; Particulate Matter
Chemical Substances	Nitrogen Dioxide (S7G510RUBH) ; Air Pollutants ; Environmental Pollutants ; Particulate Matter
Language	English
Publishing date	2023-04-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.163802
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Article: Patients and doctors group meetings: an innovative way to explore severe asthma backstage.

Caminati, Marco / Camiciottoli, Gianna / Baiardini, Ilaria / Antonicelli, Leonardo / Beghè, Bianca / Crimi, Nunzio / Favero, Elisabetta / Stanziola, Anna Agnese / Valenti, Giuseppe / Visca, Dina / Del Giacco, Stefano

Multidisciplinary respiratory medicine

2022 Volume 17, Page(s) 854

Abstract: Severe asthma patients' life is heavily influenced by the disease, which has impact on personal and professional choices or general lifestyle. Despite the available tools to help physicians investigating the patient-reported outcomes there is a need for ... ...

Abstract	Severe asthma patients' life is heavily influenced by the disease, which has impact on personal and professional choices or general lifestyle. Despite the available tools to help physicians investigating the patient-reported outcomes there is a need for a more standardised and structured approach to include the evaluation of quality of life together with the emotions of patients into the routine clinical interaction. We hereby report the use of an active listening and insight approach to understand the emotions of patients with severe asthma through dedicated in-person meetings involving a group of patients with their doctors, caregivers and an external moderator. The initiative "Patients insight meeting" was organized within 17 specialist referral centres for severe asthma in Italy in 2019 and involved 149 patients. Insights related to 4 different items were collected and a task force composed by the external moderators produced a general report including the suggestions from the participating centres. This experience of group-meetings involving both patients and doctors together represents an innovative way to investigate real life experience and the emotions of asthmatic patients, highlighting unmet needs related to patient's experience of his/her disease that need to be included in severe asthmatics' management strategy.
Language	English
Publishing date	2022-09-05
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2677839-7
ISSN	2049-6958 ; 1828-695X
ISSN (online)	2049-6958
ISSN	1828-695X
DOI	10.4081/mrm.2022.854
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Article ; Online: The Association of Self-Reported Birthweight with Lung Function and Respiratory Diseases: Results from a Multi-Centre, Multi-Case Control Study in Italy.

Tocco Tussardi, Ilaria / Tfaily, Ahmad / Locatelli, Francesca / Antonicelli, Leonardo / Battaglia, Salvatore / Bono, Roberto / Corsico, Angelo G / Murgia, Nicola / Pirina, Pietro / Ferrari, Marcello / Tardivo, Stefano / Jarvis, Deborah L / Verlato, Giuseppe

International journal of environmental research and public health

2022 Volume 19, Issue 22

Abstract: Early life conditions are associated with lung function and the development of respiratory and non-respiratory illnesses. The relationship with birthweight (BW), however, is conflicting. We examined associations of self-reported BW with lung function and ...

Abstract	Early life conditions are associated with lung function and the development of respiratory and non-respiratory illnesses. The relationship with birthweight (BW), however, is conflicting. We examined associations of self-reported BW with lung function and the development of respiratory and also non-respiratory diseases within the GEIRD (Gene-Environment Interaction in Respiratory Diseases) project, an Italian multi-centre, multi-case control study involving cases of COPD, asthma, allergic rhinitis and controls. Multinomial logistic regression was performed with case/control status as response variable; BW as main determinant; and adjusting for sex, age and smoking status. Of the 2287 participants reporting BW, 6.4% (n = 147) had low BW (<2500 g), and this proportion was greater in women than men (7.8% vs. 5.1%;
MeSH term(s)	Male ; Humans ; Female ; Adult ; Case-Control Studies ; Birth Weight ; Self Report ; Respiration Disorders/epidemiology ; Italy/epidemiology ; Lung
Language	English
Publishing date	2022-11-16
Publishing country	Switzerland
Document type	Multicenter Study ; Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph192215062
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Article ; Online: Does sensitization to foods in adults occur always in the gut?

Asero, Riccardo / Antonicelli, Leonardo

International archives of allergy and immunology

2011 Volume 154, Issue 1, Page(s) 6–14

Abstract: It is widely accepted that, under normal conditions, the contact between allergens and the immune system via the gut results in immune tolerance. Thus, it is rather surprising that normal adults may become sensitized to foods that they have consumed a ... ...

Abstract	It is widely accepted that, under normal conditions, the contact between allergens and the immune system via the gut results in immune tolerance. Thus, it is rather surprising that normal adults may become sensitized to foods that they have consumed a number of times without any consequence. However, the medical literature is crowded with reports suggesting that sensitization to food allergens may occur outside the intestinal tract in many instances. The present article reviews and discusses current data suggesting, either directly or indirectly, a possible initiation of food allergy in the respiratory tract or in the skin in the light of recent findings about mechanisms of tolerance and sensitization.
MeSH term(s)	Adult ; Allergens/immunology ; Food Hypersensitivity/immunology ; Gastrointestinal Tract/immunology ; Humans ; Immune Tolerance ; Plants, Edible/adverse effects ; Plants, Edible/immunology ; Skin/immunology
Chemical Substances	Allergens
Language	English
Publishing date	2011
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1108932-5
ISSN	1423-0097 ; 1018-2438
ISSN (online)	1423-0097
ISSN	1018-2438
DOI	10.1159/000319203
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Article ; Online: Safety of a 2-day ultrarush immunotherapy in vespid allergic patients: Focus on elevated serum tryptase.

Bilò, Maria Beatrice / Corsi, Alice / Agolini, Stefano / Tontini, Chiara / Antonicelli, Leonardo

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

2018 Volume 121, Issue 1, Page(s) 130–132

MeSH term(s)	Anaphylaxis/diagnosis ; Anaphylaxis/immunology ; Anaphylaxis/pathology ; Anaphylaxis/prevention & control ; Animals ; Biomarkers/blood ; Bites and Stings/diagnosis ; Bites and Stings/drug therapy ; Bites and Stings/immunology ; Bites and Stings/pathology ; Drug Administration Schedule ; Female ; Humans ; Hymenoptera/chemistry ; Hymenoptera/immunology ; Immunotherapy/methods ; Male ; Mast Cells/drug effects ; Mast Cells/immunology ; Mast Cells/pathology ; Mastocytosis, Systemic/diagnosis ; Mastocytosis, Systemic/drug therapy ; Mastocytosis, Systemic/immunology ; Mastocytosis, Systemic/pathology ; Prospective Studies ; Time Factors ; Treatment Outcome ; Tryptases/blood ; Tryptases/immunology ; Wasp Venoms/therapeutic use
Chemical Substances	Biomarkers ; Wasp Venoms ; Tryptases (EC 3.4.21.59)
Language	English
Publishing date	2018-03-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	1228189-x
ISSN	1534-4436 ; 0003-4738 ; 1081-1206
ISSN (online)	1534-4436
ISSN	0003-4738 ; 1081-1206
DOI	10.1016/j.anai.2018.03.021
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