LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Back to previous search Search history
Advanced search

Your last searches

  1. AU="Antonio Colantuoni"
  2. AU="Barakat, Abdelhamid"
  3. AU="Cho, Anna"
  4. AU="Lafargeas, Philippe"
  5. AU="Durez, Patrick"
  6. AU="Chaturvedi, Shubhra"
  7. AU="Bhatt, Navin"
  8. AU="Qiongsi Zhang"
  9. AU="Gilbert, Mark R."
  10. AU="Baisden, Joseph M."
  11. AU="Manrique, Soraya Zorro"
  12. AU="Eibensteiner, Fabian"
  13. AU="Kharaishvili, Gvantsa"
  14. AU="Liu, Jianan"
  15. AU="Patel, Harshil"
  16. AU="Min, Thinzar"
  17. AU="Lei, Hui-Min"
  18. AU="Suradi, Haya H"
  19. AU="Chariyalertsak, Chonlisa"
  20. AU="Weber, Konrad P."
  21. AU="Huang, Yan-Jang S"
  22. AU="Karim, Siti Nurhana Abdul"
  23. AU="Jia, Chang-Qi"
  24. AU="Huang, Ziwen"
  25. AU="Benveniste, Marcelo F"
  26. AU="Gokden, Alper"
  27. AU=Naidoo Devashan
  28. AU="Grucza, Richard"

Search results

Result 1 - 7 of total 7

Search options

  1. Article ; Online: Mitochondrial Dynamics and Microglia as New Targets in Metabolism Regulation

    Martina Chiurazzi / Martina Di Maro / Mauro Cozzolino / Antonio Colantuoni

    International Journal of Molecular Sciences, Vol 21, Iss 3450, p

    2020  Volume 3450

    Abstract: Energy homeostasis regulation is essential for the maintenance of life. Neuronal hypothalamic populations are involved in the regulation of energy balance. In order play this role, they require energy: mitochondria, indeed, have a key role in ensuring a ... ...

    Abstract Energy homeostasis regulation is essential for the maintenance of life. Neuronal hypothalamic populations are involved in the regulation of energy balance. In order play this role, they require energy: mitochondria, indeed, have a key role in ensuring a constant energy supply to neurons. Mitochondria are cellular organelles that are involved in dynamic processes; their dysfunction has been associated with many diseases, such as obesity and type 2 diabetes, indicating their importance in cellular metabolism and bioenergetics. Food intake excess can induce mitochondrial dysfunction with consequent production of reactive oxygen species (ROS) and oxidative stress. Several studies have shown the involvement of mitochondrial dynamics in the modulation of releasing agouti-related protein (AgRP) and proopiomelanocortin (POMC) neuronal activity, although the mechanisms are still unclear. However, recent studies have shown that changes in mitochondrial metabolism, such as in inflammation, can contribute also to the activation of the microglial system in several diseases, especially degenerative diseases. This review is aimed to summarize the link between mitochondrial dynamics and hypothalamic neurons in the regulation of glucose and energy homeostasis. Furthermore, we focus on the importance of microglia activation in the pathogenesis of many diseases, such as obesity, and on the relationship with mitochondrial dynamics, although this process is still largely unknown.
    Keywords energy homeostasis ; hypothalamus ; mitochondrial dynamics ; microglia ; obesity ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Impact of Genetic Variations and Epigenetic Mechanisms on the Risk of Obesity

    Martina Chiurazzi / Mauro Cozzolino / Roberta Clara Orsini / Martina Di Maro / Matteo Nicola Dario Di Minno / Antonio Colantuoni

    International Journal of Molecular Sciences, Vol 21, Iss 9035, p

    2020  Volume 9035

    Abstract: Rare genetic obesity disorders are characterized by mutations of genes strongly involved in the central or peripheral regulation of energy balance. These mutations are effective in causing the early onset of severe obesity and insatiable hunger ( ... ...

    Abstract Rare genetic obesity disorders are characterized by mutations of genes strongly involved in the central or peripheral regulation of energy balance. These mutations are effective in causing the early onset of severe obesity and insatiable hunger (hyperphagia), suggesting that the genetic component can contribute to 40–70% of obesity. However, genes’ roles in the processes leading to obesity are still unclear. This review is aimed to summarize the current knowledge of the genetic causes of obesity, especially monogenic obesity, describing the role of epigenetic mechanisms in obesity and metabolic diseases. A comprehensive understanding of the underlying genetic and epigenetic mechanisms, with the metabolic processes they control, will permit adequate management and prevention of obesity.
    Keywords obesity ; monogenic obesity ; syndromic obesity ; polygenic obesity ; epigenetics ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article: Poly(styrene/pentafluorostyrene)‐block‐poly(vinyl alcohol/vinylpyrrolidone) amphiphilic block copolymers for kinetic gas hydrate inhibitors: Synthesis, micellization behavior, and methane hydrate kinetic inhibition

    Rajput, Faraz / Antonio Colantuoni / Milan Maric / Phillip Servio / Riadh Dhane / Salim Bayahya

    Journal of polymer science. 2018 Nov. 1, v. 56, no. 21

    2018  

    Abstract: Amphiphilic block copolymers of short poly(styrene) (PS) or poly(2,3,4,5,6‐pentafluorostyrene) (PPFS) segments with comparatively longer poly(vinyl acetate) or poly(vinylpyrrolidone) (PVP) segments are synthesized using a 2‐cyanopropan‐2‐yl N‐methyl‐N‐( ... ...

    Abstract Amphiphilic block copolymers of short poly(styrene) (PS) or poly(2,3,4,5,6‐pentafluorostyrene) (PPFS) segments with comparatively longer poly(vinyl acetate) or poly(vinylpyrrolidone) (PVP) segments are synthesized using a 2‐cyanopropan‐2‐yl N‐methyl‐N‐(pyridin‐4‐yl)dithiocarbamate switchable reversible addition–fragmentation chain transfer (RAFT) agent toward application as kinetic gas hydrate inhibitors (KHIs). Polymerization conditions are optimized to provide water‐soluble block copolymers by first polymerizing more activated monomers such as S and PFS to form a defined macro chain‐transfer agent (linear degree of polymerization with conversion, comparatively low dispersity) followed by chain extensions with less activated monomers VAc or VP by switching to the deprotonated form of the RAFT agent. The critical micelle concentrations of these amphiphilic block copolymers (after VAc unit hydrolysis to vinyl alcohol units) are measured using zeta surface potential measurements to estimate physical behavior once mixed with the hydrates. A PS‐poly(vinyl alcohol) block copolymer improved inhibition to 49% compared to the pure methane–water system with no KHIs. This inhibition was further reduced by 27% by substituting the PS with a more hydrophobic PPFS. A block copolymer of PS–PVP exhibited 20% greater inhibition than the PVP homopolymer and substituting PS with a more hydrophobic PPFS resulted in a 35% further decreased in methane KHI. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018, 56, 2445–2457, 56, 2445–2457
    Keywords alcohols ; composite polymers ; gas hydrate ; hydrolysis ; hydrophobicity ; methane ; micelles ; polymerization ; polyvinyl acetate ; styrene ; water solubility
    Language English
    Dates of publication 2018-1101
    Size p. 2445-2457.
    Publishing place John Wiley & Sons, Inc.
    Document type Article
    Note JOURNAL ARTICLE
    ISSN 0887-624X
    DOI 10.1002/pola.29219
    Database NAL-Catalogue (AGRICOLA)

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: COVID-19 Sepsis and Microcirculation Dysfunction

    Antonio Colantuoni / Romeo Martini / Patrizia Caprari / Marco Ballestri / Pier Leopoldo Capecchi / Agostino Gnasso / Rosalia Lo Presti / Antonella Marcoccia / Marco Rossi / Gregorio Caimi

    Frontiers in Physiology, Vol

    2020  Volume 11

    Abstract: The spreading of Coronavirus (SARS-CoV-2) pandemic, known as COVID-19, has caused a great number of fatalities all around the World. Up to date (2020 May 6) in Italy we had more than 28,000 deaths, while there were more than 205.000 infected. The ... ...

    Abstract The spreading of Coronavirus (SARS-CoV-2) pandemic, known as COVID-19, has caused a great number of fatalities all around the World. Up to date (2020 May 6) in Italy we had more than 28,000 deaths, while there were more than 205.000 infected. The majority of patients affected by COVID-19 complained only slight symptoms: fatigue, myalgia or cough, but more than 15% of Chinese patients progressed into severe complications, with acute respiratory distress syndrome (ARDS), needing intensive treatment. We tried to summarize data reported in the last months from several Countries, highlighting that COVID-19 was characterized by cytokine storm (CS) and endothelial dysfunction in severely ill patients, where the progression of the disease was fast and fatal. Endothelial dysfunction was the fundamental mechanism triggering a pro-coagulant state, finally evolving into intravascular disseminated coagulation, causing embolization of several organs and consequent multiorgan failure (MOF). The Italian Society of Clinical Hemorheology and Microcirculation was aimed to highlight the role of microcirculatory dysfunction in the pathogenetic mechanisms of COVID-19 during the spreading of the biggest challenges to the World Health.
    Keywords COVID-19 ; microcirculation ; endothelial cells ; angiotensin II ; thromboxane (TxB2) ; Physiology ; QP1-981 ; covid19
    Subject code 610
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Trigeminocardiac reflex by mandibular extension on rat pial microcirculation

    Dominga Lapi / Giuseppe Federighi / M Paola Fantozzi / Cristina Del Seppia / Sergio Ghione / Antonio Colantuoni / Rossana Scuri

    PLoS ONE, Vol 9, Iss 12, p e

    role of nitric oxide.

    2014  Volume 115767

    Abstract: In the present study we have extended our previous findings about the effects of 10 minutes of passive mandibular extension in anesthetized Wistar rats. By prolonging the observation time to 3 hours, we showed that 10 minutes mandibular extension caused ... ...

    Abstract In the present study we have extended our previous findings about the effects of 10 minutes of passive mandibular extension in anesthetized Wistar rats. By prolonging the observation time to 3 hours, we showed that 10 minutes mandibular extension caused a significant reduction of the mean arterial blood pressure and heart rate respect to baseline values, which persisted up to 160 minutes after mandibular extension. These effects were accompanied by a characteristic biphasic response of pial arterioles: during mandibular extension, pial arterioles constricted and after mandibular extension dilated for the whole observation period. Interestingly, the administration of the opioid receptor antagonist naloxone abolished the vasoconstriction observed during mandibular extension, while the administration of Nω-Nitro-L-arginine methyl ester, a nitric oxide synthase inhibitor, abolished the vasodilation observed after mandibular extension. Either drug did not affect the reduction of mean arterial blood pressure and heart rate induced by mandibular extension. By qRT-PCR, we also showed that neuronal nitric oxide synthase gene expression was significantly increased compared with baseline conditions during and after mandibular extension and endothelial nitric oxide synthase gene expression markedly increased at 2 hours after mandibular extension. Finally, western blotting detected a significant increase in neuronal and endothelial nitric oxide synthase protein expression. In conclusion mandibular extension caused complex effects on pial microcirculation involving opioid receptor activation and nitric oxide release by both neurons and endothelial vascular cells at different times.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: The Effects of Vaccinium myrtillus Extract on Hamster Pial Microcirculation during Hypoperfusion-Reperfusion Injury.

    Teresa Mastantuono / Noemy Starita / Daniela Sapio / Sabato Andrea D'Avanzo / Martina Di Maro / Espedita Muscariello / Marco Paterni / Antonio Colantuoni / Dominga Lapi

    PLoS ONE, Vol 11, Iss 4, p e

    2016  Volume 0150659

    Abstract: INTRODUCTION:The present study was aimed to assess the in vivo hamster pial microvessel alterations due to 30 min transient bilateral common carotid artery occlusion (BCCAO) and reperfusion (60 min); moreover, the neuroprotective effects of Vaccinium ... ...

    Abstract INTRODUCTION:The present study was aimed to assess the in vivo hamster pial microvessel alterations due to 30 min transient bilateral common carotid artery occlusion (BCCAO) and reperfusion (60 min); moreover, the neuroprotective effects of Vaccinium myrtillus extract, containing 34.7% of anthocyanins, were investigated. MATERIALS AND METHODS:Two groups of male hamsters were used: the first fed with control diet and the other with Vaccinium myrtillus supplemented diet. Hamster pial microcirculation was visualized by fluorescence microscopy through an open cranial window. Pial arterioles were classified according to Strahler's method. RESULTS:In age-matched control diet-fed hamsters, BCCAO caused a decrease in diameter of all arterioles. At the end of reperfusion, the reduction of diameter in order 3 arterioles was by 8.4 ± 3.1%, 10.8 ± 2.3% and 12.1 ± 1.1% of baseline in the 2, 4 and 6 month control diet-fed hamsters, respectively. Microvascular permeability and leukocyte adhesion were markedly enhanced, while perfused capillary length (PCL) decreased. The response to acetylcholine and papaverine topical application was impaired; 2'-7'-dichlorofluoresceine-diacetate assay demonstrated a significant ROS production. At the end of BCCAO, in age-matched Vaccinium myrtillussupplemented diet-fed hamsters, the arteriolar diameter did not significantly change compared to baseline. After 60 min reperfusion, order 3 arterioles dilated by 9.3 ± 2.4%, 10.6 ± 3.1% and 11.8 ± 2.7% of baseline in the 2, 4 and 6 month Vaccinium myrtillus supplemented diet-fed hamsters, respectively. Microvascular leakage and leukocyte adhesion were significantly reduced in all groups according to the time-dependent treatment, when compared with the age-matched control diet-fed hamsters. Similarly, the reduction in PCL was progressively prevented. Finally, the response to acetylcholine and papaverine topical application was preserved and there was no significant increase in ROS production in all groups. CONCLUSIONS:In conclusion, Vaccinium ...
    Keywords Medicine ; R ; Science ; Q
    Subject code 630
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article: Effects of Intentional Weight Loss on Physical and Cognitive Function in Middle-Aged and Older Obese Participants: A Pilot Study

    Siervo, Mario / Annamaria Papa / Antonio Colantuoni / Blossom C.M Stephan / Carla M Prado / Edy Muscariello / Gilda Nasti / Jonathan C.K Wells

    Journal of the American College of Nutrition. 2012 Apr. 1, v. 31, no. 2

    2012  

    Abstract: Objectives: Obesity is a risk factor for cognitive decline and dementia. Whether weight loss improves cognition in older obese adults is not known. The objective was to investigate the effects of intentional weight loss on physical and cognitive function ...

    Abstract Objectives: Obesity is a risk factor for cognitive decline and dementia. Whether weight loss improves cognition in older obese adults is not known. The objective was to investigate the effects of intentional weight loss on physical and cognitive function in middle-aged and older obese adults attending a weight loss clinic. Method: Eleven male and 39 female nonsmoking, adult obese (body mass index 30–50 kg/m ²) participants were recruited. Participants were stratified by age: middle aged (30–59 years) and older aged (≥60 years). The weight loss target for each subject was 8% to 12% of initial body weight. Information on anthropometry, bioelectrical impedance, hand-grip strength, Mini-Mental State Examination (MMSE), Short Portable Mental Status Questionnaire (SPMSQ), and Trail-Making Test (TMT) A and B were collected at baseline and after weight loss. Results: At baseline, older participants showed a nonsignificant trend for lower global cognitive function (MMSE, SPMSQ) and significantly slower processing speed (TMT-A). Twenty-one participants completed the weight loss study. The average weight loss relative to baseline was 9.7% ± 2.1%. Weight loss was associated with significant improvements in hand-grip strength and cognitive function (MMSE, TMT-A, and TMT-B). MMSE scores improved significantly only in older obese participants (p < 0.05). Conclusions: Weight loss in middle-aged and in older obese participants has a beneficial effect on cognitive and physical function. If confirmed in future trials, weight loss can significantly affect public health strategies for the prevention of dementia as well as on the clinical management of obesity.
    Keywords bioelectrical impedance ; body mass index ; cognition ; dementia ; females ; males ; middle-aged adults ; obesity ; public health ; questionnaires ; risk factors ; weight loss
    Language English
    Dates of publication 2012-0401
    Size p. 79-86.
    Publishing place Routledge
    Document type Article
    ZDB-ID 603204-7
    ISSN 1541-1087 ; 0731-5724
    ISSN (online) 1541-1087
    ISSN 0731-5724
    DOI 10.1080/07315724.2012.10720012
    Database NAL-Catalogue (AGRICOLA)

    Full text online

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 3905: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top