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  1. Article ; Online: HLA-E gene polymorphisms in chronic hepatitis C: Impact on HLA-E liver expression and disease severity.

    Araújo, Roberta Chaves / Bertol, Bruna Cristina / César Dias, Fabricio / Debortoli, Guilherme / Almeida, Patrícia Holanda / Fernandes Souza, Fernanda / Villanova, Marcia Guimarães / Ramalho, Leandra Naira Zambelli / Candolo Martinelli, Ana Lourdes / Cruz Castelli, Érick da / Mendes Junior, Celso Teixeira / Antonio Donadi, Eduardo

    Human immunology

    2021  Volume 82, Issue 3, Page(s) 177–185

    Abstract: Hepatitis C virus usually produces chronic infection and liver damage. Considering that: i) the human leukocyte antigen-E (HLA-E) molecule may modulate the immune response, and ii) little is known about the role of HLA-E gene variability on chronic ... ...

    Abstract Hepatitis C virus usually produces chronic infection and liver damage. Considering that: i) the human leukocyte antigen-E (HLA-E) molecule may modulate the immune response, and ii) little is known about the role of HLA-E gene variability on chronic hepatitis C, we studied the impact of HLA-E polymorphisms on the magnitude of HLA-E liver expression and severity of hepatitis C. HLA-E variability was evaluated in terms of: i) single nucleotide polymorphism (SNP) alleles and genotypes along the gene (beginning of the promoter region, coding region and 3'UTR), and ii) ensemble of SNPs that defines the coding region alleles, considered individually or as genotypes. The comparisons of the HLA-E variation sites between patients and controls revealed no significant results. The HLA-E + 424 T > C (rs1059510), +756 G > A (rs1264457) and + 3777 G > A (rs1059655) variation sites and the HLA-E*01:01:01:01 and HLA-E*01:03:02:01 alleles, considered at single or double doses, were associated with the magnitude of HLA-E liver expression in Kupfer cell, steatosis, inflammatory activity and liver fibrosis. Although these associations were lost after corrections for multiple comparisons, these variable sites may propitiate biological clues for the understanding of the mechanisms associated with hepatitis C severity.
    MeSH term(s) Adult ; Aged ; Disease Progression ; Female ; Gene Expression Regulation ; Gene Frequency ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genotype ; Hepacivirus/physiology ; Hepatitis C, Chronic/genetics ; Histocompatibility Antigens Class I/genetics ; Histocompatibility Antigens Class I/metabolism ; Humans ; Liver/metabolism ; Liver/pathology ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Young Adult ; HLA-E Antigens
    Chemical Substances Histocompatibility Antigens Class I
    Language English
    Publishing date 2021-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 801524-7
    ISSN 1879-1166 ; 0198-8859
    ISSN (online) 1879-1166
    ISSN 0198-8859
    DOI 10.1016/j.humimm.2021.01.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1597: Show issues Location:
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  2. Article: Abnormal cell-cycle expression of the proteins p27, mdm2 and cathepsin B in oral squamous-cell carcinoma infected with human papillomavirus

    Cristina Mazon, Renata / Rovigatti Gerbelli, Thaís / Benatti Neto, Carlos / de Oliveira, Maria Rita Brancini / Antonio Donadi, Eduardo / Guimarães Gonçalves, Maria Alice / Garcia Soares, Edson / Patrícia Klay, Carla / Tersariol, Ivarne / Aparecida Pinhal, Maria / Resende, Luis / Pienna Soares, Christiane

    Acta histochemica. 2011 Feb., v. 113, no. 2

    2011  

    Abstract: Since the role of human papillomavirus (HPV) infection in oral carcinogenesis is still unclear, the purpose of this study was to verify the association between the expression of p27, mdm2 and cathepsin B and by HPV-related oral lesions. Fifty-five oral ... ...

    Abstract Since the role of human papillomavirus (HPV) infection in oral carcinogenesis is still unclear, the purpose of this study was to verify the association between the expression of p27, mdm2 and cathepsin B and by HPV-related oral lesions. Fifty-five oral biopsies were studied and HPV detection and typing (6/11, 16, 18, 31 and 33) were performed using polymerase chain reaction techniques. The distribution p27, mdm2 and cathepsin B was determined by immunohistochemistry. Twenty-one (38%) out of the 55 oral lesions tested positive for HPV, of which 6 (33%) were HPV 6/11, 1 (5%) was HPV 16, 14 (72%) were HPV 18 and none was HPV 33/31. Among the 55 biopsies, immunopostivity for p27, mdm2 and cathepsin B was observed in 17 (30.9%), 37 (67.2%) and 37 (67.2%), respectively. Among 21 HPV-positive oral lesions, immunopostivity of mdm2, p27 and cathepsin B was found, respectively, in 6 (33%) out of 18 benign lesions (BL), 4 (22%) out of 18 potential malignant epithelial lesions (PMEL) and 11 (57.9%) out of 19 malignant lesions (ML). High-risk HPV types may be associated with oral carcinoma, by cell-cycle control dysregulation, contributing to oral carcinogenesis and the overexpression of mdm2, p27 and cathepsin B.
    Keywords Papillomaviridae ; biopsy ; carcinogenesis ; carcinoma ; cathepsin B ; cell cycle ; humans ; immunohistochemistry ; polymerase chain reaction ; proteins
    Language English
    Dates of publication 2011-02
    Size p. 109-116.
    Publishing place Elsevier GmbH
    Document type Article
    ZDB-ID 77-2
    ISSN 1618-0372 ; 0065-1281
    ISSN (online) 1618-0372
    ISSN 0065-1281
    DOI 10.1016/j.acthis.2009.08.008
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  3. Article ; Online: Abnormal cell-cycle expression of the proteins p27, mdm2 and cathepsin B in oral squamous-cell carcinoma infected with human papillomavirus.

    Cristina Mazon, Renata / Rovigatti Gerbelli, Thaís / Benatti Neto, Carlos / de Oliveira, Maria Rita Brancini / Antonio Donadi, Eduardo / Guimarães Gonçalves, Maria Alice / Garcia Soares, Edson / Patrícia Klay, Carla / Tersariol, Ivarne / Aparecida Pinhal, Maria / Resende, Luis / Pienna Soares, Christiane

    Acta histochemica

    2011  Volume 113, Issue 2, Page(s) 109–116

    Abstract: Since the role of human papillomavirus (HPV) infection in oral carcinogenesis is still unclear, the purpose of this study was to verify the association between the expression of p27, mdm2 and cathepsin B and by HPV-related oral lesions. Fifty-five oral ... ...

    Abstract Since the role of human papillomavirus (HPV) infection in oral carcinogenesis is still unclear, the purpose of this study was to verify the association between the expression of p27, mdm2 and cathepsin B and by HPV-related oral lesions. Fifty-five oral biopsies were studied and HPV detection and typing (6/11, 16, 18, 31 and 33) were performed using polymerase chain reaction techniques. The distribution p27, mdm2 and cathepsin B was determined by immunohistochemistry. Twenty-one (38%) out of the 55 oral lesions tested positive for HPV, of which 6 (33%) were HPV 6/11, 1 (5%) was HPV 16, 14 (72%) were HPV 18 and none was HPV 33/31. Among the 55 biopsies, immunopositivity for p27, mdm2 and cathepsin B was observed in 17 (30.9%), 37 (67.2%) and 37 (67.2%), respectively. Among 21 HPV-positive oral lesions, immunopositivity of mdm2, p27 and cathepsin B was found, respectively, in 6 (33%) out of 18 benign lesions (BL), 4 (22%) out of 18 potential malignant epithelial lesions (PMEL) and 11 (57.9%) out of 19 malignant lesions (ML). High-risk HPV types may be associated with oral carcinoma, by cell-cycle control dysregulation, contributing to oral carcinogenesis and the overexpression of mdm2, p27 and cathepsin B.
    MeSH term(s) Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/virology ; Cathepsin B/analysis ; Cathepsin B/biosynthesis ; Cathepsin B/genetics ; Cell Cycle/genetics ; Cyclin-Dependent Kinase Inhibitor p27/analysis ; Cyclin-Dependent Kinase Inhibitor p27/biosynthesis ; Cyclin-Dependent Kinase Inhibitor p27/genetics ; Humans ; Immunohistochemistry ; Mouth Neoplasms/genetics ; Mouth Neoplasms/virology ; Papillomavirus Infections/complications ; Papillomavirus Infections/genetics ; Proto-Oncogene Proteins c-mdm2/analysis ; Proto-Oncogene Proteins c-mdm2/biosynthesis ; Proto-Oncogene Proteins c-mdm2/genetics ; Reverse Transcriptase Polymerase Chain Reaction
    Chemical Substances Cyclin-Dependent Kinase Inhibitor p27 (147604-94-2) ; Proto-Oncogene Proteins c-mdm2 (EC 2.3.2.27) ; Cathepsin B (EC 3.4.22.1)
    Language English
    Publishing date 2011-02
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 77-2
    ISSN 1618-0372 ; 0065-1281
    ISSN (online) 1618-0372
    ISSN 0065-1281
    DOI 10.1016/j.acthis.2009.08.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

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