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  1. Article ; Online: Sirolimus to treat SARS-CoV-2 infection

    Antonio Romanelli / Silvia Mascolo

    Journal of Research in Clinical Medicine, Vol 8, Iss 1, Pp 44-

    an old drug for a new disease

    2020  Volume 44

    Keywords sirolimus ; sars-cov-2 ; covid-19 ; Medicine (General) ; R5-920
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Tabriz University of Medical Sciences Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Impact of COVID-19 Pandemic and Lockdown Measures on the Nutrition Plan Service Cohort

    Mariana Di Lorenzo / Silvia Mascolo / Antonio Romanelli

    Iranian Journal of Diabetes and Obesity, Vol 13, Iss 3, Pp 117-

    2021  Volume 124

    Abstract: Objective: This study analyses the patientschr('39') factors can influence the attitude to follow or not the therapeutic weight-loss plan after national lockdown measures adopted from March 2020 to May 2020. Materials and Methods: Patients that visited a ...

    Abstract Objective: This study analyses the patientschr('39') factors can influence the attitude to follow or not the therapeutic weight-loss plan after national lockdown measures adopted from March 2020 to May 2020. Materials and Methods: Patients that visited a private nutritional center in March 2020 were included in this retrospective observational study. All relevant characteristics were noted. In May 2020, patients who did not attend the follow-up visit were labeled as "abandoned". Variation in Body Mass Index (BMI) was noted in the second visit. Univariate logistic regression was performed to test the influence on dependent variables (lost follow-up). Odds Ratio (OR) was calculated. According to BMI distribution, we performed a Student T-test (α= 0.05) or Wilcoxon test (α= 0.05) to test BMI variation in patients that attended the follow-up visit. A P-value< 0.05 was considered statistically significant. Results: Our population consisted of 77 patients, and 26 patients (33.8%, CI95% 23.4-45.4%) were labelled as "abandoned". Age≥ 54 years old (OR= 8.9048, CI95%:1.888-41.9822, P-value= 0.0057) and suffering from hypertension (OR= 4.8706, CI95%:1.4284-16.6076, P-value= 0.0114) were factors associated with the abandon follow-up visits. Wilcoxon test for BMI variation resulted statistically significant (May BMI 29.5 kg/m2 vs March BMI 29.4 kg/m2, P-value= 0.0094). Conclusion: Age and hypertension are related to the risk of abandoning healthcare services after ending the national lockdown. The losing follow-up phenomenon could worsen clinical conditions and reduce life expectancy. An increase in BMI during lockdown should be interpreted as a personal difficulty in complying with therapeutic prescriptions.
    Keywords covid-19 ; pandemic ; lockdown ; obesity ; diet ; Medicine ; R
    Subject code 610 ; 616
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher Shahid Sadoughi University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Major bleeding after pronation in severe COVID-19 patient

    Rosanna Carmela De Rosa / Michele Gallifuoco / Antonio Romanelli / Antonio Corcione

    Journal of Research in Clinical Medicine, Vol 9, Iss 1, Pp 4-

    2021  Volume 4

    Abstract: Contrarily to SARS and MERS, the evidence suggests that thromboembolic events are common in patients with COVID-19 pneumonia. The clinical course of severe COVID-19 patients can be complicated with coagulopathy, causing fatal thromboembolic events and ... ...

    Abstract Contrarily to SARS and MERS, the evidence suggests that thromboembolic events are common in patients with COVID-19 pneumonia. The clinical course of severe COVID-19 patients can be complicated with coagulopathy, causing fatal thromboembolic events and requiring adequate treatment with anticoagulant therapy. However, the clinicians should be alerted about the increase of bleeding related to aggressive anticoagulation protocols, especially in critically ill patients who undergo traumatic maneuvers. Here, we reported the case of a 55-year-old woman with symptomatic COVID-19 pneumonia, admitted to the ICU and treated with anticoagulant therapy complicated by major bleeding, probably related to prone position for ARDS treatment.
    Keywords anticoagulant therapy ; ards ; bleeding ; covid-19 ; thrombosis ; Medicine (General) ; R5-920
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher Tabriz University of Medical Sciences Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Estimation of Occupational Exposure to Asbestos in Italy by the Linkage of Mesothelioma Registry (ReNaM) and National Insurance Archives. Methodology and Results

    Chiara Airoldi / Daniela Ferrante / Lucia Miligi / Sara Piro / Giorgia Stoppa / Enrica Migliore / Elisabetta Chellini / Antonio Romanelli / Carlo Sciacchitano / Carolina Mensi / Domenica Cavone / Elisa Romeo / Stefania Massari / Alessandro Marinaccio / Corrado Magnani

    International Journal of Environmental Research and Public Health, Vol 17, Iss 3, p

    2020  Volume 1020

    Abstract: The identification and monitoring of occupational cancer is an important aspect of occupational health protection. The Italian law on the protection of workers (D. Leg. 81/2008) includes different cancer monitoring systems for high and low etiologic ... ...

    Abstract The identification and monitoring of occupational cancer is an important aspect of occupational health protection. The Italian law on the protection of workers (D. Leg. 81/2008) includes different cancer monitoring systems for high and low etiologic fraction tumors. Record linkage between cancer registries and administrative data is a convenient procedure for occupational cancer monitoring. We aim to: (i) Create a list of industries with asbestos exposure and (ii) identify cancer cases who worked in these industries. The Italian National Mesothelioma Registry (ReNaM) includes information on occupational asbestos exposure of malignant mesothelioma (MM) cases. We developed using data from seven Italian regions a methodology for listing the industries with potential exposure to asbestos linking ReNaM to Italian National Social Security Institute (INPS) data. The methodology is iterative and adjusts for imprecision and inaccuracy in reporting firm names at interview. The list of asbestos exposing firms was applied to the list of cancer cases (all types associated or possibly associated with asbestos according to International Agency for Research on Cancer (IARC) monograph 100C) in two Italian regions for the indication of possible asbestos exposure. Eighteen percent of the cancer cases showed at least one work period in firms potentially exposing to asbestos, 48% of which in regions different from where the cases lived at diagnosis. The methodology offers support for the preliminary screening of asbestos exposing firms in the occupational history of cancer cases.
    Keywords occupational cancer ; record linkage ; asbestos ; mesothelioma ; lung cancer ; ovarian cancer ; larynx cancer ; gastrointestinal cancer ; Medicine ; R
    Language English
    Publishing date 2020-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Asbestos Exposure and Malignant Mesothelioma in Construction Workers—Epidemiological Remarks by the Italian National Mesothelioma Registry (ReNaM)

    Alessandra Binazzi / Davide Di Marzio / Marina Verardo / Enrica Migliore / Lucia Benfatto / Davide Malacarne / Carolina Mensi / Dario Consonni / Silvia Eccher / Guido Mazzoleni / Vera Comiati / Corrado Negro / Antonio Romanelli / Elisabetta Chellini / Alessia Angelini / Iolanda Grappasonni / Gabriella Madeo / Elisa Romeo / Annamaria Di Giammarco /
    Francesco Carrozza / Italo F. Angelillo / Domenica Cavone / Luigi Vimercati / Michele Labianca / Federico Tallarigo / Rosario Tumino / Massimo Melis / Michela Bonafede / Alberto Scarselli / Alessandro Marinaccio / on behalf of the ReNaM Working Group

    International Journal of Environmental Research and Public Health, Vol 19, Iss 235, p

    2022  Volume 235

    Abstract: Notwithstanding the ban in 1992, asbestos exposure for workers in the construction sector in Italy remains a concern. The purpose of this study is to describe the characteristics of malignant mesothelioma (MM) cases recorded by the Italian registry ( ... ...

    Abstract Notwithstanding the ban in 1992, asbestos exposure for workers in the construction sector in Italy remains a concern. The purpose of this study is to describe the characteristics of malignant mesothelioma (MM) cases recorded by the Italian registry (ReNaM) among construction workers. Incident mesothelioma cases with a definite asbestos exposure have been analyzed. Characteristics of cases and territorial clusters of crude rates of MM in construction workers have been described, as well as the relation between asbestos use before the ban and the historical trend of workforce in the construction sector in Italy. ReNaM has collected 31,572 incident MM cases in the period from 1993 to 2018 and asbestos exposure has been assessed for 24,864 (78.2%) cases. An occupational exposure has been reported for 17,191 MM cases (69.1% of subjects with a definite asbestos exposure). Among them, 3574 had worked in the construction sector, with an increasing trend from 15.8% in the 1993–98 period to 23.9% in 2014–2018 and a ubiquitous territorial distribution. The large use of asbestos in construction sector before the ban makes probability of exposure for workers a real concern still today, particularly for those working in maintenance and removal of old buildings. There is a clear need to assess, inform, and prevent asbestos exposure in this sector.
    Keywords mesothelioma ; asbestos ; construction workers ; national mesothelioma registry ; Italy ; Medicine ; R
    Subject code 690
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Association between asbestos exposure and pericardial and tunica vaginalis testis malignant mesothelioma

    Alessandro Marinaccio / Dario Consonni / Carolina Mensi / Dario Mirabelli / Enrica Migliore / Corrado Magnani / Davide Di Marzio / Valerio Gennaro / Guido Mazzoleni / Paolo Girardi / Corrado Negro / Antonio Romanelli / Elisabetta Chellini / Iolanda Grappasonni / Gabriella Madeo / Elisa Romeo / Valeria Ascoli / Francesco Carrozza / Italo Francesco Angelillo /
    Domenica Cavone / Rosario Tumino / Massimo Melis / Stefania Curti / Giovanni Brandi / Stefano Mattioli / Sergio Iavicoli / ReNaM Working Group

    Scandinavian Journal of Work, Environment & Health, Vol 46, Iss 6, Pp 609-

    a case–control study and epidemiological remarks

    2020  Volume 617

    Abstract: OBJECTIVES: The purposes of this study are to describe the epidemiology of pericardial and tunica vaginalis testis mesothelioma and assess the role of asbestos exposure for these rare diseases. METHODS: Based on incident pericardial and tunica vaginalis ... ...

    Abstract OBJECTIVES: The purposes of this study are to describe the epidemiology of pericardial and tunica vaginalis testis mesothelioma and assess the role of asbestos exposure for these rare diseases. METHODS: Based on incident pericardial and tunica vaginalis testis mesothelioma cases collected from the Italian national mesothelioma registry (ReNaM) in the period 1993–2015, incidence rates, survival median period and prognostic factors have been evaluated. A case–control study has been performed to analyze the association with asbestos exposure (occupational and non-occupational) for these diseases. RESULTS: Between 1993 and 2015, 58 pericardial (20 women and 38 men) and 80 tunica vaginalis testis mesothelioma cases have been registered with a mean annual standardized (world standard population as reference) incidence rates of 0.049 (per million) in men and 0.023 in women for the pericardial site, and 0.095 for tunica vaginalis testis mesothelioma. Occupational exposure to asbestos was significantly associated with the risk of the diseases [odds ratio (OR) 3.68, 95% confidence interval (CI) 1.85–7.31 and OR 3.42, 95% CI 1.93–6.04 in pericardial and tunica vaginalis testis mesothelioma, respectively]. The median survival was 2.5 months for pericardial and 33.0 months for tunica vaginalis testis mesotheliomas. Age was the main predictive factor for survival for both anatomical sites. CONCLUSIONS: For the first time in an analytical study, asbestos exposure was associated with pericardial and tunica vaginalis testis mesothelioma risk, supporting the causal role of asbestos for all anatomical sites. The extreme rarity of the diseases, the poor survival and the prognostic role of age have been confirmed based on population and nationwide mesothelioma registry data.
    Keywords epidemiology ; exposure ; asbestos ; mesothelioma ; case–control study ; italy ; malignant mesothelioma ; rare disease ; national registry ; pericardial and tunica vaginalis testis ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Nordic Association of Occupational Safety and Health (NOROSH)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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