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  1. Article ; Online: Monkeypox Mysteries of the New Outbreak in Non-Endemic Areas.

    Antunes, Francisco / Virgolino, Ana

    International journal of environmental research and public health

    2022  Volume 19, Issue 22

    Abstract: Monkeypox virus (MPXV) was declared by the World Health Organization (WHO) in mid-2022 to be a public health emergency of international concern, following its spread around the world after circulating in Western and Central Africa. This new outbreak is ... ...

    Abstract Monkeypox virus (MPXV) was declared by the World Health Organization (WHO) in mid-2022 to be a public health emergency of international concern, following its spread around the world after circulating in Western and Central Africa. This new outbreak is concentrated in men who have sex with men (MSM). Moreover, beyond the epidemiological change, compared with endemic countries, differences in clinical features and many other aspects have also been detected. These and other characteristics are unusual and still unclear. Based on the available data, the authors try to help to clarify some of the current major gaps in monkeypox knowledge to strengthen the outbreak response.
    MeSH term(s) Male ; Humans ; Mpox (monkeypox)/epidemiology ; Homosexuality, Male ; Sexual and Gender Minorities ; Monkeypox virus/physiology ; Disease Outbreaks
    Language English
    Publishing date 2022-11-12
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph192214881
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  2. Article ; Online: Joint optimization of headway and number of stops for bilateral bus rapid transit.

    Guo, Rongrong / Antunes, Francisco / Zhang, Jin / Yu, Jingcai / Li, Wenquan

    PloS one

    2024  Volume 19, Issue 3, Page(s) e0300286

    Abstract: The bilateral Bus Rapid Transit (BRT) system is a kind of BRT system in which the stops are located in the middle of the transit lane. By simultaneously serving transit lines in opposite directions, it is particularly designed to save space resources and ...

    Abstract The bilateral Bus Rapid Transit (BRT) system is a kind of BRT system in which the stops are located in the middle of the transit lane. By simultaneously serving transit lines in opposite directions, it is particularly designed to save space resources and enhance service quality. To improve the operational efficiency of the bilateral BRT, this paper optimizes the operational performance of bilateral BRT with elastic demand. The objective is to minimize the generalized time cost per passenger of the system by jointly optimizing the headway and number of stops of bilateral BRT. The cost includes the agency operating and user travel. The optimal design model is formulated as a mixed-integer program and solved using a fuzzy analytic hierarchy process (FAHP) and a genetic algorithm (GA). We conduct a case study and sensitivity analysis to show the effectiveness and reliability of the proposed approach. We conclude that the optimized minimum generalized cost per passenger is lower than the actual case for all demand levels, especially at off-peak hours, by about 22.5%. In addition, we find that the weights of agency and user costs have the most significant impact on headway, whereas the influence of walking, vehicle speed, and route length is minimal. In contrast, the optimal number of BRT stops is mostly influenced by the route length, and walking speed has essentially no effect on the optimal number of stops. Finally, we find that the generalized cost per passenger at peak hours is 10% to 15% smaller than at off-peak hours in various scenarios.
    MeSH term(s) Reproducibility of Results ; Travel ; Walking ; Motor Vehicles
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0300286
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  3. Article ; Online: Atazanavir sulfate + cobicistat for the treatment of HIV infection.

    Antunes, Francisco

    Expert review of anti-infective therapy

    2017  Volume 15, Issue 6, Page(s) 569–576

    Abstract: Introduction: During last two decades several drugs were developed to offer long-term benefits in terms of virologic efficacy, favourable tolerability and toxicity profiles in treatment of HIV infection. Pharmacokinetics boosting of protease inhibitor ... ...

    Abstract Introduction: During last two decades several drugs were developed to offer long-term benefits in terms of virologic efficacy, favourable tolerability and toxicity profiles in treatment of HIV infection. Pharmacokinetics boosting of protease inhibitor allows a higher genetic barrier, as few or no drug-resistant mutations are detected in patients with virologic failure. Areas covered: Atazanavir sulfate + cobicistat (ATV/c) was recently approved for the treatment of HIV-1 infection. Bioequivalence between cobicistat (COBI) and ritonavir (RTV) as a pharmacoenhancer of ATV was established. Additionally, randomized clinical trials demonstrated that ATV/c and ATV/ritonavir had comparable efficacy and safety profiles. Low rates of virologic failure and no ATV resistance mutations were observed in these clinical trials. Therefore, COBI shows increased advantages over RTV, such as no activity against HIV, fewer drug-drug interactions and better solubility, which promotes coformulation strategies with less pill burden, better tolerability, and, potentially, higher life-long treatment adherence. Expert commentary: ATV/c regimen supports its useas an effective treatment option for HIV-1 infected patients with increased cardiovascular disease and chronic kidney disease risk associated with aging. In addition, ATV/c is a new opportunity to expand the strategy of switch to a dual therapy to lower the risk of long-term toxicities as well as the advantage of its cost-benefit.
    Language English
    Publishing date 2017-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2181279-2
    ISSN 1744-8336 ; 1478-7210
    ISSN (online) 1744-8336
    ISSN 1478-7210
    DOI 10.1080/14787210.2017.1323634
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  4. Article: Enhancing decision-making support by mining social media data with social network analysis.

    Freire, Manuela / Antunes, Francisco / Costa, João Paulo

    Social network analysis and mining

    2023  Volume 13, Issue 1, Page(s) 86

    Abstract: This paper explores the use of social network analysis (SNA) on airlines' online social networks (OSNs) to extract valuable information for decision support, by analyzing interactions and discursive exchanges between users. The research is focused on ... ...

    Abstract This paper explores the use of social network analysis (SNA) on airlines' online social networks (OSNs) to extract valuable information for decision support, by analyzing interactions and discursive exchanges between users. The research is focused on fostering customer service of an airline company during a strike period, namely by detecting influential customers (whether satisfied or dissatisfied), address pending requests, and enhancing customer satisfaction, thus promoting issue-solving, and increasing responsiveness. The methodology involves analyzing data from the Facebook account of an airline company, using SNA to structure the data, and calculating metrics to detect possible situations to be addressed by customer service. The research concludes that it is possible to extract valuable information for decision support by analyzing the metrics that were built over the interactions and discursive exchanges between OSN users. SNA metrics enable to measure airline's call-center performance in terms of speed of answer and customer satisfaction, to identify active users requiring additional support, as well as highly influential customers who may impact on the overall customer satisfaction, thus helping to resolve issues more efficiently. This study provides both theoretical and practical implications: it contributes to the existing literature by integrating social interaction and SNA for decision support in airline's service context; and it provides practical insights into how companies can use SNA metrics to improve customer service. The research also highlights and corroborates the importance of monitoring social media interactions for decision-making and improving customer service.
    Language English
    Publishing date 2023-05-15
    Publishing country Germany
    Document type Case Reports
    ZDB-ID 2595306-0
    ISSN 1869-5469 ; 1869-5450
    ISSN (online) 1869-5469
    ISSN 1869-5450
    DOI 10.1007/s13278-023-01089-6
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  5. Article: Monkeypox: From A Neglected Tropical Disease to a Public Health Threat.

    Antunes, Francisco / Cordeiro, Rita / Virgolino, Ana

    Infectious disease reports

    2022  Volume 14, Issue 5, Page(s) 772–783

    Abstract: Since the first case of human monkeypox was diagnosed in 1970, the disease remained endemic in several countries in West and Central Africa. In 1996, there was a sudden increase in cases in the Democratic Republic of Congo (DRC), and since 2017 an ... ...

    Abstract Since the first case of human monkeypox was diagnosed in 1970, the disease remained endemic in several countries in West and Central Africa. In 1996, there was a sudden increase in cases in the Democratic Republic of Congo (DRC), and since 2017 an ongoing outbreak in Nigeria took place, probably related to the population growth, human invasion of MPXV animal habitat reservoirs, and the waning of the cross-protection offered from smallpox immunization, later ending in 1980. Since May 2022, an unprecedented outbreak of human monkeypox has rapidly spread around the world, outside endemic regions of Africa, through new modes of transmission, showing differences in clinical features compared with previous reports. The 2022 MPXV strain belongs to the clade of West Africa but diverges from the original strain, making the virus more transmissible. The authors review the main milestones in more than 50 years of history of human monkeypox, from a rare viral zoonotic infection to a public health emergency.
    Language English
    Publishing date 2022-09-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2036-7430
    ISSN 2036-7430
    DOI 10.3390/idr14050079
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  6. Article ; Online: Avanços na terapêutica anti-retrovírica.

    Antunes, Francisco

    Acta medica portuguesa

    2012  Volume 25, Issue 3, Page(s) 193–196

    Abstract: In spite of all the efforts that has been made in prevention and the success of antiretroviral therapy (ART), AIDS remains a serious public health problem. So, there is a need for development of new antiretrovirals (ARVs) and new therapeutic ... ...

    Title translation Advances in antiretroviral therapy.
    Abstract In spite of all the efforts that has been made in prevention and the success of antiretroviral therapy (ART), AIDS remains a serious public health problem. So, there is a need for development of new antiretrovirals (ARVs) and new therapeutic strategies. New ARVs are currently on advanced stages of clinical evaluation. New therapeutic strategies intend to evaluate the toxicity risk, drug resistance, drug-drug interactions, costs and adherence. Coformulations of fixed-dose drug combination are important advantages of ART that improve adherence, quality of life, evolving to better therapeutic results and reduction of health resources.
    MeSH term(s) Acquired Immunodeficiency Syndrome/drug therapy ; Anti-Retroviral Agents/therapeutic use ; Drug Therapy, Combination ; Humans
    Chemical Substances Anti-Retroviral Agents
    Language Portuguese
    Publishing date 2012-05
    Publishing country Portugal
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 603078-6
    ISSN 1646-0758 ; 0870-399X
    ISSN (online) 1646-0758
    ISSN 0870-399X
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  7. Article ; Online: Antiretroviral therapy for naïve and for treatment-experienced HIV patients, and prevention of HIV transmission.

    Antunes, Francisco

    Current opinion in HIV and AIDS

    2011  Volume 6 Suppl 1, Page(s) S1–2

    MeSH term(s) Anti-HIV Agents/administration & dosage ; Antiretroviral Therapy, Highly Active/methods ; Disease Transmission, Infectious/prevention & control ; Female ; HIV Infections/drug therapy ; HIV Infections/prevention & control ; HIV Infections/transmission ; Humans ; Male
    Chemical Substances Anti-HIV Agents
    Language English
    Publishing date 2011-12
    Publishing country United States
    Document type Editorial
    ZDB-ID 2502511-9
    ISSN 1746-6318 ; 1746-630X
    ISSN (online) 1746-6318
    ISSN 1746-630X
    DOI 10.1097/01.COH.0000410241.73270.df
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  8. Article: Candida auris

    Sabino, Raquel / Veríssimo, Cristina / Pereira, Álvaro Ayres / Antunes, Francisco

    Microorganisms

    2020  Volume 8, Issue 2

    Abstract: The emergence ... ...

    Abstract The emergence of
    Language English
    Publishing date 2020-01-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms8020181
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  9. Article ; Online: Candida auris: Emergência Recente de um Fungo Patogénico Multirresistente.

    Antunes, Francisco / Veríssimo, Cristina / Pereira, Álvaro Ayres / Sabino, Raquel

    Acta medica portuguesa

    2020  Volume 33, Issue 10, Page(s) 680–684

    Abstract: Candida auris was first described as a new species back in 2009. Although it differs markedly from other Candida species, this species can be misidentified as other yeasts in the routine microbiology laboratories. Therefore, its identification to species ...

    Title translation Candida auris: The Recent Emergence of a Multiresistant Pathogenic Fungi.
    Abstract Candida auris was first described as a new species back in 2009. Although it differs markedly from other Candida species, this species can be misidentified as other yeasts in the routine microbiology laboratories. Therefore, its identification to species level should be confirmed by reference laboratories. Candida auris exhibits potential to cause invasive infections, and frequently shows a multidrugresistance pattern, and it is associated with high mortality rates. Outbreaks caused by Candida auris and associated with health care institutions have been reported in several countries around the world, including some European countries, such as the United Kingdom and Spain. In Portugal, to our knowledge, there are no known infections or colonization cases caused by Candida auris. This species can survive in the environment for several weeks and once introduced into the hospital environment, the risk of transmission is high, requiring strict infection control measures in order to prevent transmission. This paper intends to raise the awareness of the emergence of this fungal species, as well as to discuss the consequences of this situation.
    MeSH term(s) Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Candida/drug effects ; Candida/isolation & purification ; Candidiasis/diagnosis ; Candidiasis/drug therapy ; Communicable Diseases, Emerging/microbiology ; Cross Infection/microbiology ; Drug Resistance, Fungal ; Drug Resistance, Multiple, Fungal/drug effects ; Europe ; Humans ; Virulence Factors
    Chemical Substances Antifungal Agents ; Virulence Factors
    Language Portuguese
    Publishing date 2020-10-01
    Publishing country Portugal
    Document type Journal Article ; Review
    ZDB-ID 603078-6
    ISSN 1646-0758 ; 0870-399X
    ISSN (online) 1646-0758
    ISSN 0870-399X
    DOI 10.20344/amp.12419
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  10. Article ; Online: Sighs during sleep in multiple system atrophy.

    Parreira, Sara / Antunes, Francisco / Coelho, Miguel / Bentes, Carla / Peralta, Rita

    Sleep medicine

    2020  Volume 78, Page(s) 75–80

    Abstract: Sighs are physiological phenomena and may occasionally occur during sleep in healthy young adults. Although inspiratory sighs are considered a diagnostic red flag for the parkinsonian form of multiple system atrophy (MSA), its frequency and ... ...

    Abstract Sighs are physiological phenomena and may occasionally occur during sleep in healthy young adults. Although inspiratory sighs are considered a diagnostic red flag for the parkinsonian form of multiple system atrophy (MSA), its frequency and characteristics are unclear. We aimed to define sigh frequency during sleep recordings in patients with MSA compared to Parkinson's disease (PD) patients, as well as evaluate possible associated breathing disorders or autonomic changes. We analyzed 9 polysomnography's from patients with MSA and 9 from matched PD patients. The proportion of MSA patients (both MSA-P and MSA-C) with sleep-related sighs was significantly higher than that of PD patients, and these occurred predominantly in stages N1 and N2. The median sigh index in sleep and wakefulness were also significantly higher in MSA, although with a significant inter-subject variability. Higher sigh indexes were not associated to other breathing disturbances or with longer disease duration. In MSA, 12% of sighs were associated with oxygen desaturation, while none of the events in PD patients presented with significant changes in oxygen saturation. Respiratory events followed 45% of sighs in MSA, predominantly central sleep apneas, and 29% of sighs in PD, predominantly hypopneas. Our data suggests that high sigh frequencies during sleep should also be considered a red flag for MSA, and future studies should aim to determine whether increased sighing frequency during sleep is specific for this disorder.
    MeSH term(s) Apnea ; Humans ; Multiple System Atrophy/complications ; Respiration ; Sleep ; Wakefulness ; Young Adult
    Language English
    Publishing date 2020-12-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2012041-2
    ISSN 1878-5506 ; 1389-9457
    ISSN (online) 1878-5506
    ISSN 1389-9457
    DOI 10.1016/j.sleep.2020.12.013
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