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  1. Article: Complete Response With Trametinib in Advanced Low-Grade Serous Ovarian Carcinoma: A Case Report.

    Antunes Meireles, Pedro / Mira, Beatriz / Vaz, Fátima

    Cureus

    2024  Volume 16, Issue 2, Page(s) e53600

    Abstract: Low-grade serous ovarian carcinoma (LGSOC) is an uncommon subtype of ovarian cancer, and it is usually associated with reduced sensitivity to chemotherapy and worse outcomes. We present a case involving a 45-year-old female patient diagnosed with stage ... ...

    Abstract Low-grade serous ovarian carcinoma (LGSOC) is an uncommon subtype of ovarian cancer, and it is usually associated with reduced sensitivity to chemotherapy and worse outcomes. We present a case involving a 45-year-old female patient diagnosed with stage III-C low-grade serous ovarian carcinoma (LGSOC) in 2013. She achieved a complete response for 29 months after undergoing platinum-based chemotherapy and interval cytoreduction. However, in 2016, both local and distant relapses were observed. As there was no benefit from hormonal therapy and the patient refused chemotherapy, bevacizumab was initiated, resulting in disease stabilization for 30 months. At disease progression, trametinib was proposed, and the patient experienced an ongoing sustained complete response for over 36 months. To the best of our knowledge, this is the first report, outside of a clinical trial, regarding a complete response with single agent MEK inhibitor therapy in a patient with recurrent LGSOC, with unknown BRAF V600E mutation. We present the following case in accordance with the CAse REports (CARE) checklist.
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.53600
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Ectopic Cushing's Syndrome Secondary to Acinic Cell Carcinoma of the Parotid Gland: A Case Report.

    Antunes Meireles, Pedro Miguel / Pessoa, Diana / Pinheiro, Sara / Filipe, Juliana Faria / Rito, Miguel / Sargento, Isabel

    Case reports in oncology

    2023  Volume 16, Issue 1, Page(s) 532–536

    Abstract: We present a case report of a patient with a rare high-grade transformation of an acinic cell carcinoma (ACC) of the parotid gland, who developed Cushing's syndrome (CS) as a result of ectopic secretion of adrenocorticotropic hormone by the tumour. The ... ...

    Abstract We present a case report of a patient with a rare high-grade transformation of an acinic cell carcinoma (ACC) of the parotid gland, who developed Cushing's syndrome (CS) as a result of ectopic secretion of adrenocorticotropic hormone by the tumour. The hypercortisolism was successfully treated with metyrapone, and the ACC was treated with local radiotherapy and a combined six cycles of gemcitabine and cisplatin, having achieved a partial response to the tumour. A multidisciplinary approach and combined medical treatment with radiotherapy and were essential for disease control and CS management. ACC should be considered in the differential diagnosis of ectopic CS.
    Language English
    Publishing date 2023-07-13
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2458961-5
    ISSN 1662-6575
    ISSN 1662-6575
    DOI 10.1159/000530445
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Sweet Taste Dysgeusia in a Patient with Indapamide-Related Hyponatremia: Case Report and Review of the Literature.

    Gaspar, Pedro / Bessa, Filipe / Antunes Meireles, Pedro / Parreira, Inês / Mota, Catarina

    Cureus

    2021  Volume 13, Issue 2, Page(s) e13079

    Abstract: Sweet taste dysgeusia is a rare symptom where patients experience all food as having a sweet taste. While its cause is still unknown, it has been increasingly reported in the setting of lung cancer and syndrome of inappropriate secretion of antidiuretic ... ...

    Abstract Sweet taste dysgeusia is a rare symptom where patients experience all food as having a sweet taste. While its cause is still unknown, it has been increasingly reported in the setting of lung cancer and syndrome of inappropriate secretion of antidiuretic hormone-related hyponatremia. In this case report, we present what we believe to be the first case of sweet taste dysgeusia in a non-cancer context. We will briefly review and summarize all published cases describing this symptom and also reflect upon the nature of this condition focusing on the role of serum sodium levels in sweet taste receptor modulation.
    Language English
    Publishing date 2021-02-02
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.13079
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Comparing Prognosis for

    Antunes Meireles, Pedro / Fragoso, Sofia / Duarte, Teresa / Santos, Sidónia / Bexiga, Catarina / Nejo, Priscila / Luís, Ana / Mira, Beatriz / Miguel, Isália / Rodrigues, Paula / Vaz, Fátima

    Cancers

    2023  Volume 15, Issue 23

    Abstract: Background: Germline pathogenic variants (PV) in : Methods: Prospective follow-up was proposed for patients with a diagnosed : Results: For a mean follow-up time of 113.0 months, : Conclusions: Testing positive for ... ...

    Abstract Background: Germline pathogenic variants (PV) in
    Methods: Prospective follow-up was proposed for patients with a diagnosed
    Results: For a mean follow-up time of 113.0 months,
    Conclusions: Testing positive for a
    Language English
    Publishing date 2023-12-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15235699
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The Effect of Chronic and Inhospital Exposure to Renin-Angiotensin System Inhibitors on the Outcome and Inflammatory State of Coronavirus Disease 2019 Adult Inpatients.

    Gaspar, Pedro / Parreira, Inês / Antunes Meireles, Pedro / Bessa, Filipe / Dias Silva, Virgílio / Abrantes, Ana Mafalda / Pais de Lacerda, António / Mota, Catarina

    International journal of hypertension

    2021  Volume 2021, Page(s) 5517441

    Abstract: Background: Controversies exist about the effect of renin-angiotensin system inhibitors (RASi) on coronavirus disease 2019 (COVID-19) outcome. The inhospital use of RASi and its effect on inflammatory sate are still poorly studied during the COVID-19 ... ...

    Abstract Background: Controversies exist about the effect of renin-angiotensin system inhibitors (RASi) on coronavirus disease 2019 (COVID-19) outcome. The inhospital use of RASi and its effect on inflammatory sate are still poorly studied during the COVID-19 pandemic.
    Objectives: We aimed to compare the impact of previous and inhospital RASi exposure on the outcome and inflammatory response of COVID-19 patients.
    Methods: Single-centre, ambispective analysis of hospitalized adult COVID-19 patients at Hospital de Santa Maria, Lisbon, between March and August 2020 was performed. We excluded asymptomatic patients and those admitted due to another disease. The primary outcome was inhospital all-cause mortality. Illness severity was assessed based on the development of acute respiratory distress syndrome/acute lung injury (ARDS/ALI), intensive care unit (ICU) admission, and need for invasive mechanical ventilation (IMV). We used C-reactive protein (CRP), ferritin, and interleukin 6 (IL-6) as surrogate markers of the inflammatory response.
    Results: From a total of 432 patients, 279 were selected, among whom 133 (47.7%) were receiving a RASi. Chronic treatment with RASi was not associated with the risk of death (OR 1.24, 95% CI 0.66-2.31,
    Conclusion: Previous and inhospital exposure to RASi was not associated with mortality nor severity of COVID-19. This study supports current guidance on RASi management during the COVID-19 pandemic.
    Language English
    Publishing date 2021-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573167-1
    ISSN 2090-0392 ; 2090-0384
    ISSN (online) 2090-0392
    ISSN 2090-0384
    DOI 10.1155/2021/5517441
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Malabsorption Syndrome due to Intestinal Amyloidosis as Presentation of Renal Cell Carcinoma.

    Bessa, Filipe / Gaspar, Pedro / Antunes Meireles, Pedro / Parreira, Maria Inês / Serrazina Pedro, Juliana / Teixeira da Silva, Marisa / Meneses, João / Victorino, Rui / Mota, Catarina

    Case reports in gastrointestinal medicine

    2020  Volume 2020, Page(s) 8854620

    Abstract: Renal cell carcinoma accounts for approximately 3% of adult malignancies. Designated in the literature as "the great masquerader," the great diversity of clinical manifestations is associated with the several paraneoplastic syndromes that potentially ... ...

    Abstract Renal cell carcinoma accounts for approximately 3% of adult malignancies. Designated in the literature as "the great masquerader," the great diversity of clinical manifestations is associated with the several paraneoplastic syndromes that potentially accompany it. Paraneoplastic amyloidosis is described in about 3-8% of cases, only exceptionally as an initial manifestation, with uncommon gastrointestinal involvement. A rare case of malabsorption by intestinal amyloidosis is presented as initial manifestation of renal cell carcinoma, emphasizing the need for early recognition of these paraneoplastic conditions.
    Language English
    Publishing date 2020-09-05
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2627636-7
    ISSN 2090-6536 ; 2090-6528
    ISSN (online) 2090-6536
    ISSN 2090-6528
    DOI 10.1155/2020/8854620
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Humoral Immune Response of SARS-CoV-2-Infected Patients with Cancer: Influencing Factors and Mechanisms.

    Esperança-Martins, Miguel / Gonçalves, Lisa / Soares-Pinho, Inês / Gomes, Andreia / Serrano, Marta / Blankenhaus, Birte / Figueiredo-Campos, Patrícia / Catarina-Marques, Ana / Castro-Barbosa, Ana / Cardoso, Ana / Antunes-Meireles, Pedro / Atalaia-Barbacena, Henrique / Gaspar, Pedro / Howell-Monteiro, Patrícia / Pais-de-Lacerda, António / Mota, Catarina / Veldhoen, Marc

    The oncologist

    2021  Volume 26, Issue 9, Page(s) e1619–e1632

    Abstract: Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients with cancer show worse outcomes compared with patients without cancer. The humoral immune response (HIR) of patients with cancer against SARS-CoV-2 is not well ... ...

    Abstract Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients with cancer show worse outcomes compared with patients without cancer. The humoral immune response (HIR) of patients with cancer against SARS-CoV-2 is not well characterized. To better understand it, we conducted a serological study of hospitalized patients with cancer infected with SARS-CoV-2.
    Materials and methods: This was a unicentric, retrospective study enrolling adult patients with SARS-CoV-2 admitted to a central hospital from March 15 to June 17, 2020, whose serum samples were quantified for anti-SARS-CoV-2 receptor-binding domain or spike protein IgM, IgG, and IgA antibodies. The aims of the study were to assess the HIR to SARS-CoV-2; correlate it with different cancer types, stages, and treatments; clarify the interplay between the HIR and clinical outcomes of patients with cancer; and compare the HIR of SARS-CoV-2-infected patients with and without cancer.
    Results: We included 72 SARS-CoV-2-positive subjects (19 with cancer, 53 controls). About 90% of controls revealed a robust serological response. Among patients with cancer, a strong response was verified in 57.9%, with 42.1% showing a persistently weak response. Treatment with chemotherapy within 14 days before positivity was the only factor statistically shown to be associated with persistently weak serological responses among patients with cancer. No significant differences in outcomes were observed between patients with strong and weak responses. All IgG, IgM, IgA, and total Ig antibody titers were significantly lower in patients with cancer compared with those without.
    Conclusion: A significant portion of patients with cancer develop a proper HIR. Recent chemotherapy treatment may be associated with weak serological responses among patients with cancer. Patients with cancer have a weaker SARS-CoV-2 antibody response compared with those without cancer.
    Implications for practice: These results place the spotlight on patients with cancer, particularly those actively treated with chemotherapy. These patients may potentially be more vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, so it is important to provide oncologists further theoretical support (with concrete examples and respective mechanistic correlations) for the decision of starting, maintaining, or stopping antineoplastic treatments (particularly chemotherapy) not only on noninfected but also on infected patients with cancer in accordance with cancer type, stage and prognosis, treatment agents, treatment setting, and SARS-CoV-2 infection risks.
    MeSH term(s) Antibodies, Viral ; COVID-19 ; Humans ; Immunity, Humoral ; Immunoglobulin G ; Neoplasms/complications ; Neoplasms/drug therapy ; Retrospective Studies ; SARS-CoV-2
    Chemical Substances Antibodies, Viral ; Immunoglobulin G
    Language English
    Publishing date 2021-06-03
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1409038-7
    ISSN 1549-490X ; 1083-7159
    ISSN (online) 1549-490X
    ISSN 1083-7159
    DOI 10.1002/onco.13828
    Database MEDical Literature Analysis and Retrieval System OnLINE

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