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  1. Article ; Online: In Commemoration of the 20th Anniversary of MRMS.

    Aoki, Shigeki

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine

    2022  Volume 21, Issue 1, Page(s) 7–8

    Language English
    Publishing date 2022-02-28
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2217833-8
    ISSN 1880-2206 ; 1880-2206
    ISSN (online) 1880-2206
    ISSN 1880-2206
    DOI 10.2463/mrms.con.2021-1000
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: [Importance of HLA in Determining Individual Differences in the Onset of Adverse Drug Reactions].

    Aoki, Shigeki

    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

    2021  Volume 141, Issue 8, Page(s) 1001–1007

    Abstract: Individuals vary in their susceptibility to adverse reactions to medications, some of which can be potentially life-threatening. Idiosyncratic drug toxicity (IDT) has been shown to be strongly associated to specific polymorphisms in genes encoding human ... ...

    Abstract Individuals vary in their susceptibility to adverse reactions to medications, some of which can be potentially life-threatening. Idiosyncratic drug toxicity (IDT) has been shown to be strongly associated to specific polymorphisms in genes encoding human leukocyte antigens (HLAs) by recent genome-wide association studies. However, the pathogenic mechanisms governing such reactions remain unclarified, at least in part because of a lack of suitable experimental animal models to assess IDT. This review describes our work on the specific allele/drug combination of HLA-B*57:01 and abacavir, an antiretroviral drug targeting the human immunodeficiency virus. As abacavir is known to trigger an HLA-dependent immune response, we engineered a transgenic mouse model-HLA-Tg-by partially substituting the mouse HLA sequence for the corresponding human sequence. Local abacavir exposure was found to trigger a significant immune response in an HLA-dependent manner, and oral administration induced liver injury partially via concurrent activation of the innate immune system. Additionally, we developed a technique for evaluating structural alterations in HLA complexes resulting from drug exposure based on phage display to ensure specificity. Further scrutiny of the mechanism(s) underlying drug-induced immune reactions using the HLA-Tg model, as well as enhanced methods for predicting adverse event incidence, are anticipated to help resolve issues surrounding HLA-associated drug hypersensitivity.
    MeSH term(s) Alleles ; Animals ; Anti-HIV Agents/adverse effects ; Anti-HIV Agents/immunology ; Dideoxynucleosides/adverse effects ; Dideoxynucleosides/immunology ; Disease Models, Animal ; Drug Hypersensitivity/genetics ; Drug Hypersensitivity/immunology ; Drug-Related Side Effects and Adverse Reactions/genetics ; Drug-Related Side Effects and Adverse Reactions/immunology ; Genome-Wide Association Study ; HLA Antigens/genetics ; HLA Antigens/immunology ; HLA-B Antigens ; Humans ; Individuality ; Mice ; Polymorphism, Genetic
    Chemical Substances Anti-HIV Agents ; Dideoxynucleosides ; HLA Antigens ; HLA-B Antigens ; abacavir (WR2TIP26VS)
    Language Japanese
    Publishing date 2021-07-30
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 200514-1
    ISSN 1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    ISSN (online) 1347-5231
    ISSN 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    DOI 10.1248/yakushi.21-00120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 643: Show issues Location:
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  3. Article ; Online: Automated three-dimensional major white matter bundle segmentation using diffusion magnetic resonance imaging.

    Andica, Christina / Kamagata, Koji / Aoki, Shigeki

    Anatomical science international

    2023  Volume 98, Issue 3, Page(s) 318–336

    Abstract: White matter bundle segmentation using diffusion magnetic resonance imaging fiber tractography enables detailed evaluation of individual white matter tracts three-dimensionally, and plays a crucial role in studying human brain anatomy, function, ... ...

    Abstract White matter bundle segmentation using diffusion magnetic resonance imaging fiber tractography enables detailed evaluation of individual white matter tracts three-dimensionally, and plays a crucial role in studying human brain anatomy, function, development, and diseases. Manual extraction of streamlines utilizing a combination of the inclusion and exclusion of regions of interest can be considered the current gold standard for extracting white matter bundles from whole-brain tractograms. However, this is a time-consuming and operator-dependent process with limited reproducibility. Several automated approaches using different strategies to reconstruct the white matter tracts have been proposed to address the issues of time, labor, and reproducibility. In this review, we discuss few of the most well-validated approaches that automate white matter bundle segmentation with an end-to-end pipeline, including TRActs Constrained by UnderLying Anatomy (TRACULA), Automated Fiber Quantification, and TractSeg.
    MeSH term(s) Humans ; White Matter/diagnostic imaging ; White Matter/anatomy & histology ; Diffusion Tensor Imaging/methods ; Reproducibility of Results ; Diffusion Magnetic Resonance Imaging ; Brain/diagnostic imaging ; Image Processing, Computer-Assisted/methods
    Language English
    Publishing date 2023-04-05
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 2079994-9
    ISSN 1447-073X ; 1447-6959 ; 0022-7722
    ISSN (online) 1447-073X
    ISSN 1447-6959 ; 0022-7722
    DOI 10.1007/s12565-023-00715-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 219: Show issues Location:
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  4. Article ; Online: Surface-based Analyses of Diffusional Kurtosis Imaging in Amyotrophic Lateral Sclerosis: Relationship with Onset Subtypes.

    Kamiya, Kouhei / Hanashiro, Sayori / Kano, Osamu / Uchida, Wataru / Kamagata, Koji / Aoki, Shigeki / Hori, Masaaki

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine

    2024  

    Abstract: Purpose: Here, we aimed to characterize the cortical and subcortical microstructural alterations in the brains of patients with amyotrophic lateral sclerosis (ALS). In particular, we compared these features between bulbar-onset ALS (b-ALS) and limb- ... ...

    Abstract Purpose: Here, we aimed to characterize the cortical and subcortical microstructural alterations in the brains of patients with amyotrophic lateral sclerosis (ALS). In particular, we compared these features between bulbar-onset ALS (b-ALS) and limb-onset ALS (l-ALS).
    Methods: Diffusion MRI data (b = 0, 700, 2000 ms/mm
    Results: At both the mid-cortical and subcortical surfaces, b-ALS was associated with significantly greater MD, smaller FA, and smaller MK in the motor and premotor areas than HC. In contrast, the patients with l-ALS showed relatively moderate differences relative to HCs. The ALS Functional Rating Scale-Revised bulbar subscore was significantly correlated with the diffusion metrics in Brodmann Area 4.
    Conclusion: The distribution of abnormalities over the cerebral hemispheres and the more severe microstructural alteration in b-ALS compared to l-ALS were in good agreement with findings from postmortem histology. Our results suggest the feasibility of surface-based DKI analyses for exploring brain microstructural pathologies in ALS. The observed differences between b-ALS and l-ALS and their correlations with functional bulbar impairment support the clinical relevance of DKI measurement in the cortical and juxtacortical regions of patients with ALS.
    Language English
    Publishing date 2024-01-30
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2217833-8
    ISSN 1880-2206 ; 1880-2206
    ISSN (online) 1880-2206
    ISSN 1880-2206
    DOI 10.2463/mrms.mp.2023-0138
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Pathological changes in various organs in HLA-B*57:01 transgenic mice with abacavir-induced skin eruption.

    Kazaoka, Akira / Kumagai, Kazuyoshi / Matsushita, Junya / Aida, Tetsuo / Kuwahara, Saki / Aoki, Shigeki / Ito, Kousei

    Toxicological research

    2024  Volume 40, Issue 2, Page(s) 223–235

    Abstract: Several patients with cutaneous adverse drug reactions exhibit extracutaneous organ damages, and it becomes severe in a few patients resulting in death due to multiorgan failure. Understanding the sequential changes in various organs in patients with ... ...

    Abstract Several patients with cutaneous adverse drug reactions exhibit extracutaneous organ damages, and it becomes severe in a few patients resulting in death due to multiorgan failure. Understanding the sequential changes in various organs in patients with cutaneous eruption following drug administration will help understand disease onset and progression, aiding the development of prevention strategies and interventions. Therefore, we aimed to understand the effects of abacavir (ABC) on various organs in patients with ABC-induced eruptions by evaluating its effects in a mouse model. We found pathological changes in various organs of HLA-B*57:01 transgenic mice (B*57:01-Tg) following oral administration of ABC (20 mg/body/day). B*57:01-Tg exhibited a significant body weight decrease from day 1 of ABC administration, and reddening of the auricle was observed from day 5, and approximately 2/3 mice died by day 7. Histopathological examination revealed severe thymic atrophy after day 3, infiltration of inflammatory cells, predominantly lymphocytes with neutrophils, not only in the skin but also in the liver, kidney, and lung after day 5, and an increased number of lymphocytes with enlarged nuclei and granulocytic hematopoiesis were observed in the spleen after day 5. Blood chemistry revealed that albumin/globulin ratio was below 1.0 on day 5, reflecting a systemic inflammatory response, and the aspartate aminotransferase concentration rose to 193 ± 93.0 U/L on day 7, suggesting that cell damage may have occurred in various organs including liver accompanying inflammatory cell infiltration. These examinations of a mouse model of ABC-induced skin eruption show that disorders in various organs other than the skin should be considered and provide insights into the unexpected early systemic responses dependent on HLA-B*57:01.
    Supplementary information: The online version contains supplementary material available at 10.1007/s43188-023-00220-1.
    Language English
    Publishing date 2024-01-06
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2727978-9
    ISSN 2234-2753 ; 1976-8257
    ISSN (online) 2234-2753
    ISSN 1976-8257
    DOI 10.1007/s43188-023-00220-1
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  6. Article ; Online: The partial volume effect of choroid plexus in pathogenesis of Alzheimer's disease.

    Saito, Yuya / Kamagata, Koji / Uchida, Wataru / Takabayashi, Kaito / Aoki, Shigeki

    Alzheimer's & dementia : the journal of the Alzheimer's Association

    2023  Volume 19, Issue 10, Page(s) 4756–4757

    MeSH term(s) Humans ; Alzheimer Disease/pathology ; Choroid Plexus/metabolism ; Choroid Plexus/pathology ; Amyloid beta-Peptides/metabolism
    Chemical Substances Amyloid beta-Peptides
    Language English
    Publishing date 2023-05-26
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2211627-8
    ISSN 1552-5279 ; 1552-5260
    ISSN (online) 1552-5279
    ISSN 1552-5260
    DOI 10.1002/alz.13123
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    Zs.A 6316: Show issues Location:
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  7. Article ; Online: The improvement technique for reproducibility of diffusion tensor image analysis along the perivascular space (DTI-ALPS) for evaluating interstitial fluid diffusivity and glymphatic function.

    Saito, Yuya / Kamagata, Koji / Uchida, Wataru / Takabayashi, Kaito / Aoki, Shigeki

    Japanese journal of radiology

    2023  Volume 41, Issue 9, Page(s) 1029–1030

    MeSH term(s) Humans ; Extracellular Fluid ; Reproducibility of Results ; Brain/diagnostic imaging ; Diffusion Magnetic Resonance Imaging ; Image Processing, Computer-Assisted
    Language English
    Publishing date 2023-05-10
    Publishing country Japan
    Document type Letter ; Comment
    ZDB-ID 2488907-6
    ISSN 1867-108X ; 1867-1071
    ISSN (online) 1867-108X
    ISSN 1867-1071
    DOI 10.1007/s11604-023-01421-2
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    Zs.A 2249: Show issues Location:
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  8. Article ; Online: Improved reproducibility of diffusion tensor image analysis along the perivascular space (DTI‑ALPS) index calculated by manual and automated methods.

    Saito, Yuya / Kamagata, Koji / Uchida, Wataru / Takabayashi, Kaito / Aoki, Shigeki

    Japanese journal of radiology

    2023  Volume 41, Issue 9, Page(s) 1033–1034

    MeSH term(s) Humans ; Reproducibility of Results ; Image Processing, Computer-Assisted ; Image Enhancement/methods
    Language English
    Publishing date 2023-04-28
    Publishing country Japan
    Document type Letter ; Comment
    ZDB-ID 2488907-6
    ISSN 1867-108X ; 1867-1071
    ISSN (online) 1867-108X
    ISSN 1867-1071
    DOI 10.1007/s11604-023-01429-8
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  9. Article ; Online: Conjugation of human serum albumin and flucloxacillin provokes specific immune response in HLA-B*57:01 transgenic mice.

    Gao, Yuying / Song, Binbin / Aoki, Shigeki / Ito, Kousei

    Immunology letters

    2022  Volume 249, Page(s) 5–11

    Abstract: Flucloxacillin (FLX) induces adverse liver reactions, which has been reported to be related to human leukocyte antigen (HLA)-B*57:01. In a previous study, abacavir-induced hypersensitivity was induced in HLA-B*57:01-transgenic mice (B*57:01-Tg), ... ...

    Abstract Flucloxacillin (FLX) induces adverse liver reactions, which has been reported to be related to human leukocyte antigen (HLA)-B*57:01. In a previous study, abacavir-induced hypersensitivity was induced in HLA-B*57:01-transgenic mice (B*57:01-Tg), originally constructed by our group (Susukida et al., 2021). In this study, B*57:01-Tg mice were used to reproduce FLX-induced liver injury. However, treatment of B*57:01-Tg mice with FLX alone did not increase serum ALT levels. Immune-deficient B*57:01-Tg/PD-1
    MeSH term(s) Animals ; CD8-Positive T-Lymphocytes ; Chemical and Drug Induced Liver Injury, Chronic ; Floxacillin/pharmacology ; HLA-B Antigens/genetics ; Humans ; Lymphocyte Activation ; Mice ; Mice, Transgenic ; Oligodeoxyribonucleotides/pharmacology ; Programmed Cell Death 1 Receptor ; Serum Albumin, Human/pharmacology
    Chemical Substances HLA-B Antigens ; HLA-B57 antigen ; Oligodeoxyribonucleotides ; Programmed Cell Death 1 Receptor ; Floxacillin (43B2M34G2V) ; Serum Albumin, Human (ZIF514RVZR)
    Language English
    Publishing date 2022-08-10
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 445150-8
    ISSN 1879-0542 ; 0165-2478
    ISSN (online) 1879-0542
    ISSN 0165-2478
    DOI 10.1016/j.imlet.2022.08.002
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    Zs.A 1512: Show issues Location:
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  10. Article ; Online: TARC/CCL17 Expression Is Associated with CD8

    Gao, Yuying / Kuwahara, Saki / Kazaoka, Akira / Ito, Kousei / Aoki, Shigeki

    Biological & pharmaceutical bulletin

    2022  Volume 45, Issue 9, Page(s) 1347–1353

    Abstract: Abacavir (ABC)-induced hypersensitivity (AHS) is strongly associated with human leukocyte antigen (HLA)-B*57 : 01 expression. Previous studies have demonstrated the feasibility of applying the HLA-transgenic mouse model in this context. ABC-induced ... ...

    Abstract Abacavir (ABC)-induced hypersensitivity (AHS) is strongly associated with human leukocyte antigen (HLA)-B*57 : 01 expression. Previous studies have demonstrated the feasibility of applying the HLA-transgenic mouse model in this context. ABC-induced adverse reactions were observed in HLA-B*57 : 01 transgenic (B*57 : 01-Tg) mice. Moreover, regulating immune tolerance could result in severe AHS that mimics symptoms observed in the clinical setting, which were modeled in CD4
    MeSH term(s) Animals ; CD8-Positive T-Lymphocytes/immunology ; Chemokine CCL17/genetics ; Chemokines ; Cyclopropanes/adverse effects ; Dermatitis, Atopic ; Dideoxyadenosine/adverse effects ; Dideoxyadenosine/analogs & derivatives ; HLA-B Antigens/genetics ; Humans ; Mice ; Mice, Transgenic ; Programmed Cell Death 1 Receptor
    Chemical Substances Ccl17 protein, mouse ; Chemokine CCL17 ; Chemokines ; Cyclopropanes ; HLA-B Antigens ; Programmed Cell Death 1 Receptor ; Dideoxyadenosine (4Q86AH641A) ; abacavir (WR2TIP26VS)
    Language English
    Publishing date 2022-08-21
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1150271-x
    ISSN 1347-5215 ; 0918-6158
    ISSN (online) 1347-5215
    ISSN 0918-6158
    DOI 10.1248/bpb.b22-00313
    Database MEDical Literature Analysis and Retrieval System OnLINE

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