Article ; Online: Effects of Creatine Supplementation on Renal Function: A Systematic Review and Meta-Analysis.
2019 Volume 29, Issue 6, Page(s) 480–489
Abstract: Creatine supplements are intended to improve performance, but there are indications that it can overwhelm liver and kidney functions, reduce the quality of life, and increase mortality. Therefore, this is the first systematic review and meta-analysis ... ...
| Abstract | Creatine supplements are intended to improve performance, but there are indications that it can overwhelm liver and kidney functions, reduce the quality of life, and increase mortality. Therefore, this is the first systematic review and meta-analysis study that aimed to investigate creatine supplements and their possible renal function side effects. After evaluating 290 non-duplicated studies, 15 were included in the qualitative analysis and 6 in the quantitative analysis. The results of the meta-analysis suggest that creatine supplementation did not significantly alter serum creatinine levels (standardized mean difference = 0.48, 95% confidence interval 0.24-0.73, P = .001, I |
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| MeSH term(s) | Creatine/adverse effects ; Creatinine/blood ; Dietary Supplements/adverse effects ; Humans ; Kidney/drug effects ; Kidney/physiology ; Kidney Diseases/chemically induced ; PubMed ; Quality of Life ; Urea/blood | |||||
| Chemical Substances | Urea (8W8T17847W) ; Creatinine (AYI8EX34EU) ; Creatine (MU72812GK0) | |||||
| Language | English | |||||
| Publishing date | 2019-07-30 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review | |||||
| ZDB-ID | 1080003-7 | |||||
| ISSN | 1532-8503 ; 1051-2276 | |||||
| ISSN (online) | 1532-8503 | |||||
| ISSN | 1051-2276 | |||||
| DOI | 10.1053/j.jrn.2019.05.004 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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