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  1. AU="Aparicio-Yuste, Raul"
  2. AU="Jiang, Gengbo"
  3. AU=Murrell Dedee F AU=Murrell Dedee F
  4. AU=Gupta Riya
  5. AU="Elmasry, Dalia M A" AU="Elmasry, Dalia M A"
  6. AU=Rosa Rafael Fabiano Machado
  7. AU="Bhatia, Vishwas"
  8. AU="Buchwitz, Michael"
  9. AU="Sadrozinski, H-F W."
  10. AU="Allan, Rachel"
  11. AU="Ma, Jiele"
  12. AU="Bizjak, Isabella"
  13. AU="Pelucchi, Paride"
  14. AU="Krug, Anne Barbara"
  15. AU="Pikridas, M"
  16. AU="Adams, Jonathan D"
  17. AU="Esquivel-Muelbert, A."
  18. AU="Khan, Meraj Alam"
  19. AU="Bullard, Stevan"
  20. AU="Wang, Peter H"
  21. AU="Preto, Jordane"
  22. AU="Pierce, Shaketha"
  23. AU="Sankar, Jishnu"
  24. AU="Yahagi, Naohisa"
  25. AU=Pinho Juliana
  26. AU="Brennan, Anna"
  27. AU="Lee, Theresa M"
  28. AU="Chunqing Ou"
  29. AU="Gwynn, Simon"
  30. AU="Holper, Sarah"
  31. AU="Haider, Farag Ibrahim"
  32. AU="Rice, Jordin L"
  33. AU="Gong, Xingguo"
  34. AU=Rother Magdalena B.
  35. AU="Petrov, Ksenia"
  36. AU="Rijneveld, R"
  37. AU=Lopez-Martinez Briceida
  38. AU=Astone Pia
  39. AU="Amaral, V"

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  1. Artikel ; Online: Spatiotemporal characterization of endothelial cell motility and physical forces during exposure to

    Muenkel, Marie / Aparicio-Yuste, Raul / Tal, Michal Caspi / Kraiczy, Peter / Bastounis, Effie E

    STAR protocols

    2022  Band 3, Heft 4, Seite(n) 101832

    Abstract: Cell motility and biomechanics are critical in various (patho)physiological processes, including the regulation of vascular barrier integrity, which can be subverted by bacterial pathogens. Here, we present a protocol on how to expose endothelial cells ( ... ...

    Abstract Cell motility and biomechanics are critical in various (patho)physiological processes, including the regulation of vascular barrier integrity, which can be subverted by bacterial pathogens. Here, we present a protocol on how to expose endothelial cells (ECs) to vector-borne
    Mesh-Begriff(e) Borrelia burgdorferi/physiology ; Endothelial Cells/metabolism ; Biomechanical Phenomena
    Sprache Englisch
    Erscheinungsdatum 2022-11-09
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2022.101832
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: A Stiff Extracellular Matrix Favors the Mechanical Cell Competition that Leads to Extrusion of Bacterially-Infected Epithelial Cells.

    Aparicio-Yuste, Raúl / Muenkel, Marie / Clark, Andrew G / Gómez-Benito, María J / Bastounis, Effie E

    Frontiers in cell and developmental biology

    2022  Band 10, Seite(n) 912318

    Abstract: Cell competition refers to the mechanism whereby less fit cells ("losers") are sensed and eliminated by more fit neighboring cells ("winners") and arises during many processes including intracellular bacterial infection. Extracellular matrix (ECM) ... ...

    Abstract Cell competition refers to the mechanism whereby less fit cells ("losers") are sensed and eliminated by more fit neighboring cells ("winners") and arises during many processes including intracellular bacterial infection. Extracellular matrix (ECM) stiffness can regulate important cellular functions, such as motility, by modulating the physical forces that cells transduce and could thus modulate the output of cellular competitions. Herein, we employ a computational model to investigate the previously overlooked role of ECM stiffness in modulating the forceful extrusion of infected "loser" cells by uninfected "winner" cells. We find that increasing ECM stiffness promotes the collective squeezing and subsequent extrusion of infected cells due to differential cell displacements and cellular force generation. Moreover, we discover that an increase in the ratio of uninfected to infected cell stiffness as well as a smaller infection focus size, independently promote squeezing of infected cells, and this phenomenon is more prominent on stiffer compared to softer matrices. Our experimental findings validate the computational predictions by demonstrating increased collective cell extrusion on stiff matrices and glass as opposed to softer matrices, which is associated with decreased bacterial spread in the basal cell monolayer
    Sprache Englisch
    Erscheinungsdatum 2022-06-22
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.912318
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

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