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Article ; Online: Type II Fractures in Older Adults: Can They Be Treated Conservatively?: A Single-Center Experience and Review of the Literature.

Aquila, Filippo / Tacconi, Leonello / Baldo, Sara

2018 Volume 118, Page(s) e938–e945

Abstract: Background: Odontoid fractures are the most common acute cervical spinal fractures in the geriatric population. Their rate is increasing along with the rising age of the elderly population. Whereas conservative management with external immobilization is ...

Abstract	Background: Odontoid fractures are the most common acute cervical spinal fractures in the geriatric population. Their rate is increasing along with the rising age of the elderly population. Whereas conservative management with external immobilization is reported as the treatment of choice for type I and III odontoid fractures, there are no clear indications concerning the best treatment for type II fractures. In younger patients surgical management is considered the best choice, but in older adults the rate of good outcomes worsens and operative risk because of comorbidities increases. Methods: We report our retrospective single-center experience with conservative treatment of type II odontoid fractures in an elderly population, focusing on both radiologic and functional outcomes to compare our results with the recent literature. Results: Among the 21 selected subjects with a minimum follow-up of 18 months, 19 (90.5%) showed a satisfactory clinical outcome, with an adequate bony healing in 10 cases and nonsymptomatic pseudarthrosis in 9 patients. All these patients were satisfied with the conservative results and could stop use of the collar. Two patients (9.5%) did not show any improvement and had to keep the collar indefinitely. Conclusions: Our study was limited because it was a retrospective review, with a limited number of patients. Nevertheless, the clinical and radiologic outcomes of our patients differ from the results of other studies, suggesting that conservative management of these fractures in this population does not necessarily lead to a bad clinical outcome or delayed surgery.
MeSH term(s)	Aged ; Aged, 80 and over ; Braces/trends ; Conservative Treatment/methods ; Conservative Treatment/trends ; Female ; Follow-Up Studies ; Humans ; Male ; Odontoid Process/diagnostic imaging ; Odontoid Process/injuries ; Retrospective Studies ; Spinal Fractures/diagnostic imaging ; Spinal Fractures/therapy ; Treatment Outcome
Language	English
Publishing date	2018-07-20
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2018.07.105
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Article: Pathophysiological Role of Synovitis in Hemophilic Arthropathy Development: A Two-Hit Hypothesis.

Calcaterra, Ilenia / Iannuzzo, Gabriella / Dell'Aquila, Francesco / Di Minno, Matteo Nicola Dario

Frontiers in physiology

2020 Volume 11, Page(s) 541

Abstract: Despite an increasing access to prophylaxis with clotting factor concentrates, arthropathy still represents the main chronic complication of hemophilia. Whereas previous studies described hemophilic arthropathy (HA) as a degenerative arthropathy, somehow ...

Abstract	Despite an increasing access to prophylaxis with clotting factor concentrates, arthropathy still represents the main chronic complication of hemophilia. Whereas previous studies described hemophilic arthropathy (HA) as a degenerative arthropathy, somehow resembling osteoarthritis (OA), most recent evidence suggests that complex inflammatory and immunologic mechanisms are also involved in the pathophysiology of HA. In the present review, we described available data on major mechanisms leading to arthropathic changes in patients with hemophilia, with a specific focus on the role of synovium. The presence of hemosiderin in the joint space induces synovium proliferation, thus leading to formation of several lytic enzymes determining chondrocytes apoptosis and proteoglycans levels reduction. This leads to a direct joint "chemical" damage representing early damages in the pathogenesis of HA (first hit). In parallel, synovial membrane and synovial endothelial cells become a dynamic reservoir of inflammatory cells and mediators, and propagate the inflammatory response (second hit), switching the process from a chemical damage to an inflammatory damage. Overall, consistent data pointed out synovitis as the keystone in HA pathophysiology. This opens novel potential therapeutic targets in this clinical setting.
Language	English
Publishing date	2020-06-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2020.00541
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Article: Characterization and distribution of niosomes containing ursolic acid coated with chitosan layer.

Miatmoko, Andang / Safitri, Shofi Ameliah / Aquila, Fayruz / Cahyani, Devy Maulidya / Hariawan, Berlian Sarasitha / Hendrianto, Eryk / Hendradi, Esti / Sari, Retno

Research in pharmaceutical sciences

2021 Volume 16, Issue 6, Page(s) 660–673

Abstract: Background and purpose: Ursolic acid (UA) exhibits anti-hepatocarcinoma and hepatoprotective activities, thus promising as an effective oral cancer therapy. However, its poor solubility and permeability lead to low oral bioavailability. In this study, ... ...

Abstract	Background and purpose: Ursolic acid (UA) exhibits anti-hepatocarcinoma and hepatoprotective activities, thus promising as an effective oral cancer therapy. However, its poor solubility and permeability lead to low oral bioavailability. In this study, we evaluated the effect of different ratios of Span Experimental approach: UA niosomes (Nio-UA) were composed of Span Findings/results: The results showed that increasing the UA amount increased the particle size of Nio-UA. However, the higher the UA amount added to niosomes, the lower the encapsulation efficiency. The highest physical stability was achieved by preparing niosomes at a molar ratio of 3:2:10 for Span Conclusion and implications: It can be concluded that the ratio of Span
Language	English
Publishing date	2021-10-15
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2400156-9
ISSN	1735-9414 ; 1735-5362
ISSN (online)	1735-9414
ISSN	1735-5362
DOI	10.4103/1735-5362.327512
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Article ; Online: Enhanced Half-Life Recombinant Factor VIII Concentrates for Hemophilia A: Final Results from Extension Studies.

Di Minno, Matteo Nicola Dario / Minno, Alessandro Di / Calcaterra, Ilenia / Cimino, Ernesto / Dell'Aquila, Francesco / Franchini, Massimo

Seminars in thrombosis and hemostasis

2021 Volume 48, Issue 2, Page(s) 253–255

MeSH term(s)	Factor IX ; Factor VIII/therapeutic use ; Half-Life ; Hemophilia A/drug therapy ; Humans
Chemical Substances	Factor VIII (9001-27-8) ; Factor IX (9001-28-9)
Language	English
Publishing date	2021-12-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	196901-8
ISSN	1098-9064 ; 0094-6176
ISSN (online)	1098-9064
ISSN	0094-6176
DOI	10.1055/s-0041-1740148
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Article ; Online: Predictors of complications in initially haemodynamically stable patients admitted in a modern coronary care unit.

Campanile, Alfonso / Ciccarelli, Michele / Galasso, Gennaro / Dell'Aquila, Ferruccio / Procaccini, Vincenza / Vigorito, Francesco / Vecchione, Carmine / Ravera, Amelia

Journal of cardiovascular medicine (Hagerstown, Md.)

2021 Volume 22, Issue 7, Page(s) 553–559

Abstract: Aims: Resource optimization in the intensive cardiac care unit (ICCU) is, nowadays, of great importance because of the increasing number of acute cardiovascular patients requiring high-intensity level-of-care. Because of natural limits in ICCU bed ... ...

Abstract	Aims: Resource optimization in the intensive cardiac care unit (ICCU) is, nowadays, of great importance because of the increasing number of acute cardiovascular patients requiring high-intensity level-of-care. Because of natural limits in ICCU bed availability, understanding, which patients will really benefit from in a such a critical care setting, is of paramount importance. In our study, we analysed a heterogeneous ICCU population with initially stable haemodynamic conditions, in order to find potential predictors of severe complications. Methods: Nine hundred and fifty patients admitted to our ICCU during the year 2019 were screened in order to detect those with a stable haemodynamic condition at admission. Data were extrapolated from an internal database. Comorbidity burden was expressed by the Charlson Comorbidity Index (CCI). Our primary end point was defined by a combination of severe complications requiring critical care, and in-hospital death. Results: Ninety-eight patients (14.1% of 695 stable patients identified) developed severe complications. After a multivariable logistic regression analysis, four predictors were identified: signs of congestive heart failure [OR: 9.25, 95% confidence interval (CI): 5.61-15.25; P < 0.001], SBP 120 mmHg or less (OR: 2.10, 95% CI: 1.27-3.47; P = 0.004), haemoglobin level 13 g/dl or less (OR: 1.75, 95% CI: 1.03-2.95; P = 0.037), and the CCI above 3 (OR: 2.27, 95% CI: 1.13-4.56; P = 0.022). Conclusion: In our study, 73% of patients showed a stable haemodynamic condition on admission. Severe complications occurred in 14.1% of these patients, and signs of heart failure were the main determinants of the outcome. SBP, haemoglobin level, and the CCI concurred in the prediction of severe complications during the hospital stay.
MeSH term(s)	Aged ; Comorbidity ; Coronary Care Units/methods ; Coronary Care Units/organization & administration ; Diagnostic Tests, Routine/methods ; Female ; Heart Failure/diagnosis ; Heart Failure/epidemiology ; Heart Failure/physiopathology ; Heart Failure/therapy ; Hemodynamics ; Hospital Mortality ; Humans ; Italy/epidemiology ; Male ; Medical Overuse/prevention & control ; Outcome and Process Assessment, Health Care ; Patient Selection ; Predictive Value of Tests ; Prognosis ; Triage/methods ; Triage/standards
Language	English
Publishing date	2021-06-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2223461-5
ISSN	1558-2035 ; 1558-2027
ISSN (online)	1558-2035
ISSN	1558-2027
DOI	10.2459/JCM.0000000000001173
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Zs.A 5210: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 559: Show issues

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Article ; Online: Liver-directed gene therapy for ornithine aminotransferase deficiency.

Boffa, Iolanda / Polishchuk, Elena / De Stefano, Lucia / Dell'Aquila, Fabio / Nusco, Edoardo / Marrocco, Elena / Audano, Matteo / Pedretti, Silvia / Caterino, Marianna / Bellezza, Ilaria / Ruoppolo, Margherita / Mitro, Nico / Cellini, Barbara / Auricchio, Alberto / Brunetti-Pierri, Nicola

EMBO molecular medicine

2023 Volume 15, Issue 4, Page(s) e17033

Abstract: Gyrate atrophy of choroid and retina (GACR) is a chorioretinal degeneration caused by pathogenic variants in the gene encoding ornithine aminotransferase (OAT), an enzyme mainly expressed in liver. Affected patients have increased ornithine ... ...

Abstract	Gyrate atrophy of choroid and retina (GACR) is a chorioretinal degeneration caused by pathogenic variants in the gene encoding ornithine aminotransferase (OAT), an enzyme mainly expressed in liver. Affected patients have increased ornithine concentrations in blood and other body fluids and develop progressive constriction of vision fields leading to blindness. Current therapies are unsatisfactory and better treatments are highly needed. In two mouse models of OAT deficiency that recapitulates biochemical and retinal changes of GACR, we investigated the efficacy of an intravenously injected serotype 8 adeno-associated (AAV8) vector expressing OAT under the control of a hepatocyte-specific promoter. Following injections, OAT-deficient mice showed reductions of ornithine concentrations in blood and eye cups compared with control mice injected with a vector expressing green fluorescent protein. AAV-injected mice showed improved electroretinogram response and partial restoration of retinal structure up to one-year post-injection. In summary, hepatic OAT expression by AAV8 vector was effective at correction of hyperornithinemia and improved function and structure of the retina. In conclusion, this study provides proof-of-concept of efficacy of liver-directed AAV-mediated gene therapy of GACR.
MeSH term(s)	Animals ; Mice ; Gyrate Atrophy/genetics ; Gyrate Atrophy/pathology ; Ornithine-Oxo-Acid Transaminase/genetics ; Ornithine-Oxo-Acid Transaminase/metabolism ; Retinal Degeneration/genetics ; Retinal Degeneration/pathology ; Ornithine/genetics ; Ornithine/metabolism ; Genetic Therapy ; Liver/pathology
Chemical Substances	Ornithine-Oxo-Acid Transaminase (EC 2.6.1.13) ; Ornithine (E524N2IXA3)
Language	English
Publishing date	2023-01-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2467145-9
ISSN	1757-4684 ; 1757-4676
ISSN (online)	1757-4684
ISSN	1757-4676
DOI	10.15252/emmm.202217033
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Zs.A 6784: Show issues

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Article ; Online: Single-Cell Molecular Characterization to Partition the Human Glioblastoma Tumor Microenvironment Genetic Background.

Lessi, Francesca / Franceschi, Sara / Morelli, Mariangela / Menicagli, Michele / Pasqualetti, Francesco / Santonocito, Orazio / Gambacciani, Carlo / Pieri, Francesco / Aquila, Filippo / Aretini, Paolo / Mazzanti, Chiara Maria

Cells

2022 Volume 11, Issue 7

Abstract: Background: Glioblastoma (GB) is a devastating primary brain malignancy. The recurrence of GB is inevitable despite the standard treatment of surgery, chemotherapy, and radiation, and the median survival is limited to around 15 months. The barriers to ... ...

Abstract	Background: Glioblastoma (GB) is a devastating primary brain malignancy. The recurrence of GB is inevitable despite the standard treatment of surgery, chemotherapy, and radiation, and the median survival is limited to around 15 months. The barriers to treatment include the complex interactions among the different cellular components inhabiting the tumor microenvironment. The complex heterogeneous nature of GB cells is helped by the local inflammatory tumor microenvironment, which mostly induces tumor aggressiveness and drug resistance. Methods: By using fluorescent multiple labeling and a DEPArray cell separator, we recovered several single cells or groups of single cells from populations of different origins from IDH-WT GB samples. From each GB sample, we collected astrocytes-like (GFAP+), microglia-like (IBA1+), stem-like cells (CD133+), and endothelial-like cells (CD105+) and performed Copy Number Aberration (CNA) analysis with a low sequencing depth. The same tumors were subjected to a bulk CNA analysis. Results: The tumor partition in its single components allowed single-cell molecular subtyping which revealed new aspects of the GB altered genetic background. Conclusions: Nowadays, single-cell approaches are leading to a new understanding of GB physiology and disease. Moreover, single-cell CNAs resource will permit new insights into genome heterogeneity, mutational processes, and clonal evolution in malignant tissues.
MeSH term(s)	Brain Neoplasms/genetics ; Genetic Background ; Glioblastoma/pathology ; Humans ; Microglia/pathology ; Tumor Microenvironment/genetics
Language	English
Publishing date	2022-03-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11071127
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Article ; Online: Prognostic significance of smudge cell percentage in chronic lymphocytic leukemia. Facts or artifacts? Methodological considerations and literature review.

La Gioia, Antonio / Chiarugi, Paolo / Fumi, Maurizio / Fiorini, Fabiana / Giampietro, Celeste / Michelucci, Enrico / Veroni, Franca / Fiorini, Marcello / Aquila, Francesca / Rocco, Vincenzo / Pellegrini, Giovanni

Clinical chemistry and laboratory medicine

2022 Volume 60, Issue 11, Page(s) e246–e249

MeSH term(s)	Artifacts ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis ; Lymphocyte Count ; Lymphocytes ; Prognosis
Language	English
Publishing date	2022-08-29
Publishing country	Germany
Document type	Letter ; Review
ZDB-ID	1418007-8
ISSN	1437-4331 ; 1434-6621 ; 1437-8523
ISSN (online)	1437-4331
ISSN	1434-6621 ; 1437-8523
DOI	10.1515/cclm-2022-0658
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Article ; Online: Enhanced Half-Life Recombinant Factor VIII Concentrates for Hemophilia A: Insights from Pivotal and Extension Studies.

Di Minno, Matteo Nicola Dario / Di Minno, Alessandro / Calcaterra, Ilenia / Cimino, Ernesto / Dell'Aquila, Francesco / Franchini, Massimo

Seminars in thrombosis and hemostasis

2020 Volume 47, Issue 1, Page(s) 32–42

Abstract: The development of enhanced half-life recombinant factor VIII (EHL-rFVIII) concentrates has improved the management of hemophilia. Furthermore, the chance of maintaining higher trough levels has allowed higher protection from bleeding and, in turn, ... ...

Abstract	The development of enhanced half-life recombinant factor VIII (EHL-rFVIII) concentrates has improved the management of hemophilia. Furthermore, the chance of maintaining higher trough levels has allowed higher protection from bleeding and, in turn, improved safely performance for certain types of physical activity. The first technology used to improve the pharmacokinetic profile of factor VIII (FVIII) was fusion with the Fc domain of immunoglobulin G. More recently, conjugation to hydrophilic polymers of polyethylene glycol (PEG) has been demonstrated to prolong plasma half-life of FVIII by means of a reduction in clearance of the molecule due to steric hindrance by PEG covering the protein. Here we report results of a systematic review of pivotal studies on EHL-rFVIII concentrates. Significant heterogeneity is observed among different studies on EHL-rFVIII concentrates, and direct comparisons should be avoided. The annualized bleeding rate has ranged between 1.2 and 1.9 in different EHL-rFVIII concentrates, with a progressive further decrease during extension phases of pivotal studies. Zero bleeding was reported by 40 to 45% of patients. Overall, the emerging treatment options seem to be highly effective and safe, associated with a decreased dosing interval to twice weekly or less, which reduces, but does not entirely eliminate, the burden of treatment. Overall, further information is needed from real-life settings to permit differentiation between EHL-FVIII concentrates and for individualizing treatment.
MeSH term(s)	Adolescent ; Adult ; Child ; Factor VIII/pharmacology ; Factor VIII/therapeutic use ; Half-Life ; Hemophilia A/drug therapy ; Humans ; Middle Aged ; Young Adult
Chemical Substances	Factor VIII (9001-27-8)
Language	English
Publishing date	2020-12-21
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	196901-8
ISSN	1098-9064 ; 0094-6176
ISSN (online)	1098-9064
ISSN	0094-6176
DOI	10.1055/s-0040-1718887
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Article: Retinal and Choriocapillaris Vascular Changes in Patients Affected by Different Clinical Phenotypes of β-Thalassemia: An Optical Coherence Tomography Angiography Study.

Cennamo, Gilda / Montorio, Daniela / Mazzella, Giuliano / Ricchi, Paolo / Costantini, Silvia / Spasiano, Anna / Filosa, Aldo / Storino, Maria Rosaria / Aquila, Francesca / Tranfa, Fausto / Grosso, Michela

Biology

2021 Volume 10, Issue 4

Abstract: In this cross-sectional study we assessed the vascular alterations in retinal and choriocapillaris perfusion in patients affected by β-thalassemia, by means of optical coherence tomography angiography (OCTA). A total of 124 eyes of 62 patients (mean age ... ...

Abstract	In this cross-sectional study we assessed the vascular alterations in retinal and choriocapillaris perfusion in patients affected by β-thalassemia, by means of optical coherence tomography angiography (OCTA). A total of 124 eyes of 62 patients (mean age 44.74 ± 5.79 years old) affected by β-thalassemia (transfusion dependent thalassemia (TDT), non-transfusion dependent thalassemia (NTDT) and minor) were compared to 40 eyes of twenty healthy subjects. We evaluated the vessel density (VD) in superficial capillary plexus, deep capillary plexus, radial peripapillary capillary, choriocapillaris and the foveal avascular zone area. The TDT group showed a statistically significant reduction in retinal and choriocapillaris VD respect to controls and the other groups (
Language	English
Publishing date	2021-03-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology10040276
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