Article: Characterization and distribution of niosomes containing ursolic acid coated with chitosan layer.
Research in pharmaceutical sciences
2021 Volume 16, Issue 6, Page(s) 660–673
Abstract: Background and purpose: Ursolic acid (UA) exhibits anti-hepatocarcinoma and hepatoprotective activities, thus promising as an effective oral cancer therapy. However, its poor solubility and permeability lead to low oral bioavailability. In this study, ... ...
| Abstract | Background and purpose: Ursolic acid (UA) exhibits anti-hepatocarcinoma and hepatoprotective activities, thus promising as an effective oral cancer therapy. However, its poor solubility and permeability lead to low oral bioavailability. In this study, we evaluated the effect of different ratios of Span Experimental approach: UA niosomes (Nio-UA) were composed of Span Findings/results: The results showed that increasing the UA amount increased the particle size of Nio-UA. However, the higher the UA amount added to niosomes, the lower the encapsulation efficiency. The highest physical stability was achieved by preparing niosomes at a molar ratio of 3:2:10 for Span Conclusion and implications: It can be concluded that the ratio of Span |
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| Language | English |
| Publishing date | 2021-10-15 |
| Publishing country | Iran |
| Document type | Journal Article |
| ZDB-ID | 2400156-9 |
| ISSN | 1735-9414 ; 1735-5362 |
| ISSN (online) | 1735-9414 |
| ISSN | 1735-5362 |
| DOI | 10.4103/1735-5362.327512 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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