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  1. Article: Effects of Carbohydrate Intake on

    Santos, Najara A C / Martins, Mirilene M / Andrade, Alice O / Bastos, Alessandra S / Pontual, José D C / Araújo, Jéssica E / Rocha, Marina L / Medeiros, Jansen F / Araujo, Maisa S

    Insects

    2024  Volume 15, Issue 4

    Abstract: The maintenance of a highly productive colony of anopheline mosquitoes requires standardized methods in order to obtain a sufficient number of homogeneous individuals for malaria research. In this context, nutritional status may affect survival, ... ...

    Abstract The maintenance of a highly productive colony of anopheline mosquitoes requires standardized methods in order to obtain a sufficient number of homogeneous individuals for malaria research. In this context, nutritional status may affect survival, fecundity, and the capacity to support pathogen development. Here we assess the effects of carbohydrate sources on fecundity, survival, and susceptibility to
    Language English
    Publishing date 2024-03-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662247-6
    ISSN 2075-4450
    ISSN 2075-4450
    DOI 10.3390/insects15040240
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Novel Transmission-Blocking Antimalarials Identified by High-Throughput Screening of Plasmodium berghei Ookluc.

    Calit, Juliana / Araújo, Jessica E / Deng, Bingbing / Miura, Kazutoyo / Gaitán, Xiomara A / Araújo, Maisa da Silva / Medeiros, Jansen F / Long, Carole A / Simeonov, Anton / Eastman, Richard T / Bargieri, Daniel Y

    Antimicrobial agents and chemotherapy

    2023  Volume 67, Issue 4, Page(s) e0146522

    Abstract: Safe and effective malaria transmission-blocking chemotherapeutics would allow a community-level approach to malaria control and eradication efforts by targeting the mosquito sexual stage of the parasite life cycle. However, only a single drug, ... ...

    Abstract Safe and effective malaria transmission-blocking chemotherapeutics would allow a community-level approach to malaria control and eradication efforts by targeting the mosquito sexual stage of the parasite life cycle. However, only a single drug, primaquine, is currently approved for use in reducing transmission, and drug toxicity limits its widespread implementation. To address this limitation in antimalarial chemotherapeutics, we used a recently developed transgenic Plasmodium berghei line, Ookluc, to perform a series of high-throughput
    MeSH term(s) Animals ; Humans ; Antimalarials/pharmacology ; Antimalarials/therapeutic use ; Plasmodium berghei ; High-Throughput Screening Assays ; Malaria/prevention & control ; Primaquine/therapeutic use ; Plasmodium falciparum ; Malaria, Vivax/drug therapy ; Culicidae ; Malaria, Falciparum/drug therapy
    Chemical Substances Antimalarials ; Primaquine (MVR3634GX1)
    Language English
    Publishing date 2023-03-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/aac.01465-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Transmission-blocking activity of antimalarials for Plasmodium vivax malaria in Anopheles darlingi.

    Andrade, Alice O / Santos, Najara A C / Bastos, Alessandra S / Pontual, José D C / Araújo, Jéssica E / Silva, Alexia M V / Martinez, Leandro N / Lima, Alzemar A / Aguiar, Anna Caroline C / G Teles, Carolina B / Medeiros, Jansen F / Pereira, Dhelio B / Vinetz, Joseph M / Gazzinelli, Ricardo T / Araújo, Maisa S

    PLoS neglected tropical diseases

    2023  Volume 17, Issue 6, Page(s) e0011425

    Abstract: Malaria is caused by parasite of the genus Plasmodium and is still one of the most important infectious diseases in the world. Several biological characteristics of Plasmodium vivax contribute to the resilience of this species, including early gametocyte ...

    Abstract Malaria is caused by parasite of the genus Plasmodium and is still one of the most important infectious diseases in the world. Several biological characteristics of Plasmodium vivax contribute to the resilience of this species, including early gametocyte production, both of which lead to efficient malaria transmission to mosquitoes. This study evaluated the impact of currently used drugs on the transmission of P. vivax. Participants received one of the following treatments for malaria: i) chloroquine [10 mg/kg on day 1 and 7.5 mg/kg on day 2 and 3] co-administered with Primaquine [0.5 mg/kg/day for 7 days]; ii) Chloroquine [10 mg/kg on day 1 and 7.5 mg/kg on day 2 and 3] co-administered with one-dose of Tafenoquine [300 mg on day 1]; and iii) Artesunate and Mefloquine [100 mg and 200 mg on day 1, 2 and 3] co-administered with Primaquine [0.5 mg/kg/day for 14 days]. Patient blood was collected before treatment and 4 h, 24 h, 48 h and 72 h after treatment. The blood was used to perform a direct membrane feeding assay (DMFA) using Anopheles darlingi mosquitoes. The results showed 100% inhibition of the mosquito infection after 4 h using ASMQ+PQ, after 24 h for the combination of CQ+PQ and 48 h using CQ+TQ. The density of gametocytes declined over time in all treatment groups, although the decline was more rapid in the ASMQ+PQ group. In conclusion, it was possible to demonstrate the transmission-blocking efficacy of the malaria vivax treatment and that ASMQ+PQ acts faster than the two other treatments.
    MeSH term(s) Animals ; Humans ; Antimalarials/pharmacology ; Antimalarials/therapeutic use ; Primaquine/pharmacology ; Primaquine/therapeutic use ; Malaria, Vivax/drug therapy ; Malaria, Vivax/parasitology ; Anopheles/parasitology ; Chloroquine/pharmacology ; Chloroquine/therapeutic use ; Malaria/drug therapy ; Plasmodium vivax
    Chemical Substances Antimalarials ; Primaquine (MVR3634GX1) ; Chloroquine (886U3H6UFF)
    Language English
    Publishing date 2023-06-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2735
    ISSN (online) 1935-2735
    ISSN 1935-2735
    DOI 10.1371/journal.pntd.0011425
    Database MEDical Literature Analysis and Retrieval System OnLINE

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