Article: Biomarcadores en cáncer de testículo.
Archivos espanoles de urologia
2022 Volume 75, Issue 2, Page(s) 113–117
Abstract: Objective: To review the current situationof biomarkers used in the diagnosis, prognosis,treatment response and relapse of testicular cancer.: Methods: A non systematic review was performedof clinical guidelines and articles published within thelast ... ...
Title translation | Biomarkers in testicular cancer. |
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Abstract | Objective: To review the current situationof biomarkers used in the diagnosis, prognosis,treatment response and relapse of testicular cancer. Methods: A non systematic review was performedof clinical guidelines and articles published within thelast years regarding biomarkers in testicular cancer. Results: The most commonly used biomarkersare alphafetoprotein (AFP) and beta human corionicgonadotropin (β-HCG).The enzyme lactate dehydrogenase (LDH) is presentin multiple tissues and is elevated in advancedgerminal tumors. A few micro molecules of RNA (micro-RNA) have demonstrated to be specifically elevatedin testicular germinal tumors. However, its clincalbenefit, as well as its standardization is currently underinvestigation. Conclusions: Classic biomarkers AFP, β-HCG,and LDH are of some utility confirming the diagnosisif they are elevated. However, its limited sensibility isnot enough to rely the diagnosis on themselves. Thereare promising results with Micro-RNA but its daily usedoes not seem imminent. |
MeSH term(s) | Chorionic Gonadotropin ; Humans ; L-Lactate Dehydrogenase ; Male ; Neoplasms, Germ Cell and Embryonal/diagnosis ; Prognosis ; Testicular Neoplasms/diagnosis ; Testicular Neoplasms/pathology |
Chemical Substances | Chorionic Gonadotropin ; L-Lactate Dehydrogenase (EC 1.1.1.27) |
Language | Spanish |
Publishing date | 2022-03-29 |
Publishing country | Spain |
Document type | Journal Article |
ZDB-ID | 211673-x |
ISSN | 0004-0614 |
ISSN | 0004-0614 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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