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  1. Article ; Online: Can oligodendrocyte precursor cells be a therapeutic target for mitigating cognitive decline in cerebrovascular disease?

    Arai, Ken

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    2020  Volume 40, Issue 8, Page(s) 1735–1736

    Abstract: Oligodendrocyte precursor cells (OPCs) give rise to mature myelin-forming oligodendrocytes during white matter development. In adult brains, some populations of OPCs remain to renew oligodendrocyte pools and myelin. Two recent studies highlight the ... ...

    Abstract Oligodendrocyte precursor cells (OPCs) give rise to mature myelin-forming oligodendrocytes during white matter development. In adult brains, some populations of OPCs remain to renew oligodendrocyte pools and myelin. Two recent studies highlight the importance of OPCs in white matter homeostasis. Genetic tracing studies suggest that age-related decline in OPCs may contribute to diminished myelin renewal and memory deficits in mouse models. Single cell transcriptomics and imaging may now define specific subsets of OPCs involved in process elaboration, motility and myelination. These advances raise the possibility of pursuing OPCs as novel therapeutic targets for vascular cognitive impairment.
    MeSH term(s) Aging/drug effects ; Aging/pathology ; Animals ; Cerebrovascular Disorders/drug therapy ; Cognitive Dysfunction/prevention & control ; Humans ; Myelin Sheath/pathology ; Oligodendrocyte Precursor Cells/drug effects ; Oligodendrocyte Precursor Cells/pathology ; Oligodendroglia/drug effects ; Oligodendroglia/pathology ; White Matter/drug effects ; White Matter/pathology
    Language English
    Publishing date 2020-07-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 604628-9
    ISSN 1559-7016 ; 0271-678X
    ISSN (online) 1559-7016
    ISSN 0271-678X
    DOI 10.1177/0271678X20929432
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1663: Show issues Location:
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  2. Article ; Online: Use of a Box-cut Osteotomy Preserving Collateral Ligaments in Costal Osteochondral Graft Reconstruction of Proximal Interphalangeal Joint Cartilage Defects.

    Ushijima, Takahiro / Arai, Ken

    The journal of hand surgery Asian-Pacific volume

    2022  Volume 27, Issue 2, Page(s) 389–393

    Abstract: We report two patients with reconstruction of osteochondral defects of the proximal interphalangeal joint (PIPJ) using a costal osteochondral graft (COG). A box-cut osteotomy was done at the end of the phalanx preserving the lateral cortices and the ... ...

    Abstract We report two patients with reconstruction of osteochondral defects of the proximal interphalangeal joint (PIPJ) using a costal osteochondral graft (COG). A box-cut osteotomy was done at the end of the phalanx preserving the lateral cortices and the insertion of the collateral ligaments. A COG was harvested from the rib, moulded and press fit into the groove formed by the box-cut osteotomy. The COG was fixed with mini screws in the coronal plane (dorsal to palmar) and the fixation off-loaded with an external fixator. This technique maintained the collateral ligament in-situ and is useful in reconstruction of chondral defects of the PIPJ.
    MeSH term(s) Cartilage/transplantation ; Collateral Ligaments/surgery ; Finger Joint/surgery ; Humans ; Osteotomy ; Ribs/transplantation
    Language English
    Publishing date 2022-04-19
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2848651-1
    ISSN 2424-8363 ; 2424-8355
    ISSN (online) 2424-8363
    ISSN 2424-8355
    DOI 10.1142/S2424835522720158
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5911: Show issues Location:
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  3. Article ; Online: Stroke

    Arai, Ken

    Stroke

    2017  Volume 48, Issue 8, Page(s) e193–e194

    Language English
    Publishing date 2017-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.117.017876
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Stroke Literature Synopses: Basic Science (2017/May).

    Arai, Ken

    Stroke

    2017  Volume 48, Issue 8, Page(s) e193–e194

    Language English
    Publishing date 2017-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.117.017876
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 448: Show issues Location:
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  5. Article ; Online: Wiring and plumbing: Oligodendrocyte precursors and angiogenesis in the oligovascular niche.

    Arai, Ken / Lo, Eng H

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    2021  Volume 41, Issue 8, Page(s) 2132–2133

    Abstract: For efficient stroke recovery, the entire neurovascular unit must be repaired. A recent study underscores this concept by highlighting the importance of cellular crosstalk for white mater remodeling. In developing brains and in brains injured by hypoxia, ...

    Abstract For efficient stroke recovery, the entire neurovascular unit must be repaired. A recent study underscores this concept by highlighting the importance of cellular crosstalk for white mater remodeling. In developing brains and in brains injured by hypoxia, interactions between oligodendrocyte precursors and endothelium play an essential role for physiological and compensatory angiogenesis. Further studies are warranted to build on these emerging findings in the oligovascular niche in order to identify novel therapeutic targets for stroke and other CNS diseases.
    MeSH term(s) Animals ; Cell Communication ; Mice ; Mice, Knockout ; Neovascularization, Physiologic ; Oligodendrocyte Precursor Cells/cytology ; Oligodendrocyte Precursor Cells/metabolism ; White Matter/blood supply ; White Matter/growth & development ; Wnt Proteins/deficiency ; Wnt Proteins/genetics
    Chemical Substances Wnt Proteins
    Language English
    Publishing date 2021-05-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604628-9
    ISSN 1559-7016 ; 0271-678X
    ISSN (online) 1559-7016
    ISSN 0271-678X
    DOI 10.1177/0271678X211014979
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1663: Show issues Location:
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  6. Article ; Online: Stroke Literature Synopses: Basic Science.

    Arai, Ken

    Stroke

    2016  Volume 47, Issue 7, Page(s) e187

    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.116.013426
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 448: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article ; Online: Stroke Literature Synopses: Basic Science.

    Arai, Ken

    Stroke

    2015  Volume 46, Issue 12, Page(s) e250

    MeSH term(s) Animals ; Biomedical Research/trends ; Brain Ischemia/genetics ; Brain Ischemia/metabolism ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Stroke/genetics ; Stroke/metabolism
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2015
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.115.011347
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 448: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article ; Online: Stroke literature synopses: basic science.

    Arai, Ken

    Stroke

    2015  Volume 46, Issue 6, Page(s) e133

    Language English
    Publishing date 2015
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.115.009403
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 448: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: Stroke Literature Synopses: Basic Science.

    Arai, Ken

    Stroke

    2015  Volume 46, Issue 8, Page(s) e180

    Language English
    Publishing date 2015
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.115.009941
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 448: Show issues Location:
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  10. Article ; Online: Stroke literature synopses: basic science.

    Arai, Ken

    Stroke

    2015  Volume 46, Issue 4, Page(s) e78

    Language English
    Publishing date 2015-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.115.008759
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 448: Show issues Location:
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