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  1. Article ; Online: Correction To: Increased expression of heme oxygenase-1 suppresses airway branching morphogenesis in fetal mouse lungs exposed to inflammation.

    Arai, Yukio / Ito, Masato / Tanaka, Kosuke / Ozawa, Junichi / Motojima, Yukiko / Matsuoka, Kikumi / Igarashi, Kazuhiko / Namba, Fumihiko

    Pediatric research

    2023  Volume 94, Issue 4, Page(s) 1582

    Language English
    Publishing date 2023-06-12
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-023-02663-6
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    In stock of ZB MED Cologne/Königswinter

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  2. Article: Thioredoxin-1 Ameliorates Oxygen-Induced Retinopathy in Newborn Mice through Modulation of Proinflammatory and Angiogenic Factors.

    Ozawa, Junichi / Tanaka, Kosuke / Arai, Yukio / Haga, Mitsuhiro / Miyahara, Naoyuki / Miyamoto, Ai / Nishimura, Eri / Namba, Fumihiko

    Antioxidants (Basel, Switzerland)

    2022  Volume 11, Issue 5

    Abstract: Oxygen-induced retinopathy (OIR) is an animal model for retinopathy of prematurity, which is a leading cause of blindness in children. Thioredoxin-1 (TRX) is a small redox protein that has cytoprotective and anti-inflammatory properties in response to ... ...

    Abstract Oxygen-induced retinopathy (OIR) is an animal model for retinopathy of prematurity, which is a leading cause of blindness in children. Thioredoxin-1 (TRX) is a small redox protein that has cytoprotective and anti-inflammatory properties in response to oxidative stress. The purpose of this study was to determine the effect of TRX on OIR in newborn mice. From postnatal day 7, C57BL/6 wild type (WT) and TRX transgenic (TRX-Tg) mice were exposed to either 21% or 75% oxygen for 5 days. Avascular and neovascular regions of the retinas were investigated using fluorescence immunostaining. Fluorescein isothiocyanate-dextran and Hoechst staining were used to measure retinal vascular leakage. mRNA expression levels of proinflammatory and angiogenic factors were analyzed using quantitative polymerase chain reaction. Retinal histological changes were detected using immunohistochemistry. In room air, the WT mice developed well-organized retinas. In contrast, exposing WT newborn mice to hyperoxia hampered retinal development, increasing the retinal avascular and neovascular areas. After hyperoxia exposure, TRX-Tg mice had enhanced retinal avascularization compared with WT mice. TRX-Tg mice had lower retinal neovascularization and retinal permeability during recovery from hyperoxia compared with WT mice. In the early stages after hyperoxia exposure, VEGF-A and CXCL-2 expression levels decreased, while IL-6 expression levels increased in WT newborn mice. Conversely, no differences in gene expressions were observed in the TRX-Tg mouse retina. IGF-1 and Angpt1 levels did not decrease during recovery from hyperoxia in TRX-Tg newborn mice. As a result, overexpression of TRX improves OIR in newborn mice by modulating proinflammatory and angiogenic factors.
    Language English
    Publishing date 2022-04-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11050899
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  3. Article ; Online: Increased expression of heme oxygenase-1 suppresses airway branching morphogenesis in fetal mouse lungs exposed to inflammation.

    Arai, Yukio / Ito, Masato / Tanaka, Kosuke / Ozawa, Junichi / Motojima, Yukiko / Matsuoka, Kikumi / Igarashi, Kazuhiko / Namba, Fumihiko

    Pediatric research

    2019  Volume 87, Issue 3, Page(s) 494–500

    Abstract: Background: Intrauterine inflammation affects fetal lung development. BTB and CNC homology 1 (Bach1) is a transcriptional repressor of heme oxygenase-1 (HO-1) and interleukin-6 (IL-6) genes. We investigated the role of Bach1 in the development of fetal ... ...

    Abstract Background: Intrauterine inflammation affects fetal lung development. BTB and CNC homology 1 (Bach1) is a transcriptional repressor of heme oxygenase-1 (HO-1) and interleukin-6 (IL-6) genes. We investigated the role of Bach1 in the development of fetal mouse lungs exposed to lipopolysaccharide (LPS) using a whole fetal lung tissue culture system.
    Methods: We isolated and cultured embryonic day 12.5 fetal mouse lungs from pregnant Bach1 knockout (
    Results: Branching morphogenesis was observed in Bach1
    Conclusion: The ablation of Bach1 suppresses airway branching morphogenesis after LPS exposure by increased basal expression levels of HO-1.
    MeSH term(s) Animals ; Basic-Leucine Zipper Transcription Factors/deficiency ; Basic-Leucine Zipper Transcription Factors/genetics ; Basic-Leucine Zipper Transcription Factors/metabolism ; Female ; Gene Expression Regulation, Developmental ; Heme Oxygenase-1/genetics ; Heme Oxygenase-1/metabolism ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Lipopolysaccharides/pharmacology ; Lung/drug effects ; Lung/embryology ; Lung/enzymology ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice, Inbred C57BL ; Mice, Knockout ; Morphogenesis ; Organ Culture Techniques ; Pneumonia/embryology ; Pneumonia/enzymology ; Pregnancy ; Signal Transduction ; Up-Regulation
    Chemical Substances BACH1 protein, human ; Basic-Leucine Zipper Transcription Factors ; Interleukin-6 ; Lipopolysaccharides ; Membrane Proteins ; interleukin-6, mouse ; lipopolysaccharide, E coli O55-B5 ; Heme Oxygenase-1 (EC 1.14.14.18) ; Hmox1 protein, mouse (EC 1.14.14.18)
    Language English
    Publishing date 2019-10-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-019-0588-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 564: Show issues Location:
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  4. Article ; Online: Difference in pyruvic acid metabolism between neonatal and adult mouse lungs exposed to hyperoxia.

    Tanaka, Kosuke / Watanabe, Takaaki / Ozawa, Junichi / Ito, Masato / Nagano, Nobuhiko / Arai, Yukio / Miyake, Fuyu / Matsumura, Shun / Kobayashi, Shingo / Itakura, Ryuta / Namba, Fumihiko

    PloS one

    2020  Volume 15, Issue 9, Page(s) e0238604

    Abstract: Objective: Neonatal lungs are more tolerant to hyperoxic injury than are adult lungs. This study investigated differences in the response to hyperoxic exposure between neonatal and adult mouse lungs using metabolomics analysis with capillary ... ...

    Abstract Objective: Neonatal lungs are more tolerant to hyperoxic injury than are adult lungs. This study investigated differences in the response to hyperoxic exposure between neonatal and adult mouse lungs using metabolomics analysis with capillary electrophoresis time-of-flight mass spectrometry (CE- TOFMS).
    Methods: Neonatal and adult mice were exposed to 21% or 95% O2 for four days. Subsequently, lung tissue samples were collected and analyzed by CE-TOFMS. Pyruvate dehydrogenase (PDH) enzyme activity was determined using a microplate assay kit. PDH kinase (Pdk) 1, Pdk2, Pdk3, and Pdk4 mRNA expression levels were determined using quantitative reverse transcription-polymerase chain reaction. Pdk4 protein expression was quantified by Western blotting and Pdk4 protein localization was evaluated by immunohistochemistry.
    Results: Levels of 3-phosphoglyceric acid, 2-phosphoglyceric acid, phosphoenolpyruvic acid, and lactic acid were significantly elevated in the lungs of hyperoxia-exposed versus normoxia-exposed adult mice, whereas no significant differences were observed with hyperoxia exposure in neonatal mice. PDH activity was reduced in the lungs of adult mice only. Pdk4 mRNA expression levels after hyperoxic exposure were significantly elevated in adult mice compared with that in neonatal mice. Conversely, gene expression levels of Pdk1, Pdk2, and Pdk3 did not differ after hyperoxic exposure in either neonatal or adult mice. Pdk4 protein levels were also significantly increased in adult mouse lungs exposed to hyperoxia and were localized mainly to the epithelium of terminal bronchiole.
    Conclusions: Specific metabolites associated with glycolysis and gluconeogenesis were altered after hyperoxia exposure in the lungs of adult mice, but not in neonates, which was likely a result of reduced PDH activity due to Pdk4 mRNA upregulation under hyperoxia.
    MeSH term(s) Age Factors ; Animals ; Animals, Newborn ; Gene Expression ; Gluconeogenesis ; Glycolysis ; Hyperoxia/metabolism ; Lung/metabolism ; Lung/pathology ; Mice ; Mice, Inbred C57BL ; Pyruvate Dehydrogenase (Acetyl-Transferring) Kinase/metabolism ; Pyruvic Acid/metabolism ; RNA, Messenger/metabolism
    Chemical Substances Pyruvate Dehydrogenase (Acetyl-Transferring) Kinase ; RNA, Messenger ; Pyruvic Acid (8558G7RUTR)
    Language English
    Publishing date 2020-09-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0238604
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  5. Article: Longitudinal changes in brain CT scans and development of dementia in Down's syndrome.

    Ikeda, Masayuki / Arai, Yukio

    European neurology

    2002  Volume 47, Issue 4, Page(s) 205–208

    Abstract: To determine the relationship of the development of dementia to longitudinal changes in brain CT scans in patients with Down's syndrome (DS), we studied 14 Japanese DS patients at an interval of 10 years. The age at entry to the study was 35.7 +/- 9.9 ( ... ...

    Abstract To determine the relationship of the development of dementia to longitudinal changes in brain CT scans in patients with Down's syndrome (DS), we studied 14 Japanese DS patients at an interval of 10 years. The age at entry to the study was 35.7 +/- 9.9 (mean +/- SD) years in 1989 when we did the first CT scans. We performed the second CT scans in 1999 and quantitatively compared them with those taken in 1989. The 4 oldest of the patients (the demented group, 55.3 +/- 1.4 years of age in 1999) developed symptoms of cognitive decline before 1999. The younger 10 (the non-demented group, 41.9 +/- 9.0 years of age in 1999) remained stable in cognitive function until 1999. Despite the clear difference between the demented and the non-demented group in brain atrophy in 1999, CT measures of the demented group were similar to those of the non-demented group in 1989. These results indicate that age is a better predictor of dementia than imaging studies and that CT does not show a quantitative difference between the demented and the non-demented group before the onset of dementia.
    MeSH term(s) Adult ; Brain/diagnostic imaging ; Cross-Sectional Studies ; Dementia/complications ; Dementia/diagnosis ; Disease Progression ; Down Syndrome/complications ; Down Syndrome/diagnosis ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Tomography, X-Ray Computed
    Language English
    Publishing date 2002
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 209426-5
    ISSN 1421-9913 ; 0014-3022
    ISSN (online) 1421-9913
    ISSN 0014-3022
    DOI 10.1159/000057900
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 575: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Genetic ablation of Bach1 gene enhances recovery from hyperoxic lung injury in newborn mice via transient upregulation of inflammatory genes.

    Ito, Masato / Nagano, Nobuhiko / Arai, Yukio / Ogawa, Ryo / Kobayashi, Shingo / Motojima, Yukiko / Go, Hayato / Tamura, Masanori / Igarashi, Kazuhiko / Dennery, Phyllis A / Namba, Fumihiko

    Pediatric research

    2017  Volume 81, Issue 6, Page(s) 926–931

    Abstract: Background: BTB and CNC homology 1 (Bach1) is a transcriptional repressor of heme oxygenase (HO)-1. The effects of Bach1 disruption on hyperoxic lung injury in newborn mice have not been determined. We aimed to investigate the role of Bach1 in the ... ...

    Abstract Background: BTB and CNC homology 1 (Bach1) is a transcriptional repressor of heme oxygenase (HO)-1. The effects of Bach1 disruption on hyperoxic lung injury in newborn mice have not been determined. We aimed to investigate the role of Bach1 in the newborns exposed to hyperoxia.
    Methods: Bach1
    Results: After 10 d recovery from neonatal hyperoxia, Bach1
    Conclusion: Bach1
    Language English
    Publishing date 2017-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/pr.2017.17
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  7. Article: Longitudinal Changes in Brain CT Scans and Development of Dementia in Down’s Syndrome

    Ikeda, Masayuki / Arai, Yukio

    European Neurology

    2002  Volume 47, Issue 4, Page(s) 205–208

    Abstract: To determine the relationship of the development of dementia to longitudinal changes in brain CT scans in patients with Down’s syndrome (DS), we studied 14 Japanese DS patients at an interval of 10 years. The age at entry to the study was 35.7 ± 9.9 ( ... ...

    Institution Department of Clinical Research, National Saigata Hospital, Ohgata-machi, Niigata Ranzan Institute for the Mentally Retarded, Ranzanmachi Arai Children’s Clinic, Kumagaya, Saitama, Japan
    Abstract To determine the relationship of the development of dementia to longitudinal changes in brain CT scans in patients with Down’s syndrome (DS), we studied 14 Japanese DS patients at an interval of 10 years. The age at entry to the study was 35.7 ± 9.9 (mean ± SD) years in 1989 when we did the first CT scans. We performed the second CT scans in 1999 and quantitatively compared them with those taken in 1989. The 4 oldest of the patients (the demented group, 55.3 ± 1.4 years of age in 1999) developed symptoms of cognitive decline before 1999. The younger 10 (the non-demented group, 41.9 ± 9.0 years of age in 1999) remained stable in cognitive function until 1999. Despite the clear difference between the demented and the non-demented group in brain atrophy in 1999, CT measures of the demented group were similar to those of the non-demented group in 1989. These results indicate that age is a better predictor of dementia than imaging studies and that CT does not show a quantitative difference between the demented and the non-demented group before the onset of dementia.
    Keywords Down’s syndrome ; Alzheimer’s disease ; Dementia ; x-ray computed tomography
    Language English
    Publishing date 2002-05-17
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Original Paper
    ZDB-ID 209426-5
    ISSN 1421-9913 ; 0014-3022
    ISSN (online) 1421-9913
    ISSN 0014-3022
    DOI 10.1159/000057900
    Database Karger publisher's database

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