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Article ; Online: Evidence for Hesperidin as an Effective Factor in Initiating the Intrinsic Pathway of Apoptosis in KG1a Leukemia Cells.

Novinbahador, Tannaz / Araj-Khodaei, Mostafa / Mahdavi, Majid

2022 Volume 42, Issue 2, Page(s) 165–171

Abstract: Acute myeloid leukemia (AML) is the most common subtype of leukemia, accounting for 62% of all leukemia fatalities. As a polyphenol glycoside, hesperidin triggers the apoptotic pathway, which might positively affect combating cancer cells. In this study, ...

Abstract	Acute myeloid leukemia (AML) is the most common subtype of leukemia, accounting for 62% of all leukemia fatalities. As a polyphenol glycoside, hesperidin triggers the apoptotic pathway, which might positively affect combating cancer cells. In this study, we investigated the pro-apoptotic effects of hesperidin in KG1a cells. The MTT assay was used to determine the IC
MeSH term(s)	Humans ; Survivin ; Hesperidin/pharmacology ; Caspase 3/metabolism ; bcl-2-Associated X Protein/pharmacology ; Cell Line, Tumor ; Apoptosis ; Leukemia, Myeloid, Acute/genetics ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Proto-Oncogene Proteins c-bcl-2/pharmacology ; Cell Proliferation
Chemical Substances	Survivin ; Hesperidin (E750O06Y6O) ; Caspase 3 (EC 3.4.22.-) ; bcl-2-Associated X Protein ; Proto-Oncogene Proteins c-bcl-2
Language	English
Publishing date	2022-12-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1379845-5
ISSN	1092-874X ; 1091-5818
ISSN (online)	1092-874X
ISSN	1091-5818
DOI	10.1177/10915818221146468
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Article ; Online: Effects of saffron (Crocus sativus L.) on anthropometric and cardiometabolic indices in overweight and obese patients: A systematic review and meta-analysis of randomized controlled trials.

Tahmasbi, Fateme / Araj-Khodaei, Mostafa / Mahmoodpoor, Ata / Sanaie, Sarvin

Phytotherapy research : PTR

2022 Volume 36, Issue 9, Page(s) 3394–3414

Abstract: The worldwide prevalence of obesity is approximately tripled between 1975 and 2016 according to World Health Organization; therefore, obesity is now considered a global pandemic that needs academic and clinical focus. In search of antiobesity agents, ... ...

Abstract	The worldwide prevalence of obesity is approximately tripled between 1975 and 2016 according to World Health Organization; therefore, obesity is now considered a global pandemic that needs academic and clinical focus. In search of antiobesity agents, Crocus sativus, known widely as saffron, has been praised for its beneficial effects. Several randomized controlled trials (RCTs) have been conducted to investigate the weight lowering effect of saffron. Following PRISMA guidelines, several medical databases were comprehensively searched for RCTs with a population consisting of obese individuals. A random-effects meta-analysis was used to pool estimates across studies, and standardized mean difference (SMD) was used to synthesize quantitative results. Twenty-five RCTs met the inclusion criteria. Meta-analysis showed a nonsignificant decrease for weight (-0.32 kg; CI: -3.15, 2.51; p = 0.82), BMI (-0.06 kg/m
MeSH term(s)	Cardiovascular Diseases ; Crocus ; Dietary Supplements ; Humans ; Obesity/drug therapy ; Overweight/drug therapy ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2022-07-22
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ZDB-ID	639136-9
ISSN	1099-1573 ; 0951-418X
ISSN (online)	1099-1573
ISSN	0951-418X
DOI	10.1002/ptr.7530
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Article: Effects of saffron (Crocus sativus L.) on anthropometric and cardiometabolic indices in overweight and obese patients: A systematic review and meta‐analysis of randomized controlled trials

Tahmasbi, Fateme / Araj‐Khodaei, Mostafa / Mahmoodpoor, Ata / Sanaie, Sarvin

Phytotherapy research. 2022 Sept., v. 36, no. 9

2022

Abstract	The worldwide prevalence of obesity is approximately tripled between 1975 and 2016 according to World Health Organization; therefore, obesity is now considered a global pandemic that needs academic and clinical focus. In search of antiobesity agents, Crocus sativus, known widely as saffron, has been praised for its beneficial effects. Several randomized controlled trials (RCTs) have been conducted to investigate the weight lowering effect of saffron. Following PRISMA guidelines, several medical databases were comprehensively searched for RCTs with a population consisting of obese individuals. A random‐effects meta‐analysis was used to pool estimates across studies, and standardized mean difference (SMD) was used to synthesize quantitative results. Twenty‐five RCTs met the inclusion criteria. Meta‐analysis showed a nonsignificant decrease for weight (−0.32 kg; CI: −3.15, 2.51; p = 0.82), BMI (−0.06 kg/m²;CI:‐1.04,0.93; p = .91), waist circumference (−1.23 cm; CI: −4.14, 1.68; p = .41), and hip circumference (−0.38 cm; CI: −5.99, 5.23; p = .89) and a significant decrease of waist‐to‐hip ratio (SMD = −0.41; CI: −0.73, −0.09; p = .01; I² = 0%). The mean difference in fasting blood sugar showed a significant reduction in patients with metabolic syndrome (SMD = −0.30; 95% CI: −0.63, 0.03; p = .07; I² = 0.37%) but a nonsignificant change in the HbA1C level (WMD = 0.05; 95% CI: 0.32, 0.41; p = .79). Despite bearing several limitations, mainly as a result of heterogeneity among included studies, the available evidence indicates saffron supplementation shows promising effects on some cardiometabolic factors among overweight to obese patients; however, further investigations and high‐quality evidence are required for more generalizable and comprehensive results.
Keywords	Crocus sativus ; World Health Organization ; blood glucose ; hip circumference ; meta-analysis ; metabolic syndrome ; obesity ; pandemic ; phytotherapy ; research ; saffron ; systematic review ; waist circumference ; waist-to-hip ratio
Language	English
Dates of publication	2022-09
Size	p. 3394-3414.
Publishing place	John Wiley & Sons, Ltd.
Document type	Article
Note	REVIEW
ZDB-ID	639136-9
ISSN	1099-1573 ; 0951-418X
ISSN (online)	1099-1573
ISSN	0951-418X
DOI	10.1002/ptr.7530
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Article ; Online: The effect of

Abdollahi, Ali / Adelibahram, Faeze / Ghassab-Abdollahi, Nafiseh / Araj-Khodaei, Mostafa / Parsian, Zahra / Mirghafourvand, Mojgan

Journal of complementary & integrative medicine

2022 Volume 20, Issue 3, Page(s) 521–529

Abstract: Diabetes is one of the most common endocrine disorders that increases the economic burden on the public health system. In this regard, understanding the effect of available herbs on diabetes can be useful. This systematic review was performed to ... ...

Abstract	Diabetes is one of the most common endocrine disorders that increases the economic burden on the public health system. In this regard, understanding the effect of available herbs on diabetes can be useful. This systematic review was performed to determine the effect of
Language	English
Publishing date	2022-01-25
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2197618-1
ISSN	1553-3840 ; 2194-6329
ISSN (online)	1553-3840
ISSN	2194-6329
DOI	10.1515/jcim-2021-0425
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Article ; Online: The Effects of

Seyedi-Sahebari, Sepideh / Farhang, Sara / Araj-Khodaei, Mostafa / Akhondzadeh, Shahin / Naseri, Amirreza / Sanaie, Sarvin / Frounchi, Negin

Journal of attention disorders

2023 Volume 28, Issue 1, Page(s) 14–24

Abstract: Background and aim: Crocus sativus: Method: This study includes clinical trial studies that assessed the efficacy and/or safety of saffron in ADHD patients. Non-English papers, review articles, commentaries, letters, observational studies, thesis, ... ...

Abstract	Background and aim: Crocus sativus Method: This study includes clinical trial studies that assessed the efficacy and/or safety of saffron in ADHD patients. Non-English papers, review articles, commentaries, letters, observational studies, thesis, animal studies, in-vitro studies, and conference abstracts were not included. The risk of bias in randomized studies was evaluated based on the Cochrane RoB.2, and risk of bias in pre-post intervention studies was assessed using the ROBINS-I tool. Results: Four studies met our inclusion criteria with a total of 118 patients. The results manifested an efficient role of saffron as either an adjuvant therapy to MPH or a single therapy against ADHD, without significant safety issues. Discussion: Saffron demonstrates promise in improving ADHD symptoms, with an acceptable safety profile. Future well-designed multicentral studies are suggested.
MeSH term(s)	Animals ; Humans ; Crocus ; Attention Deficit Disorder with Hyperactivity/drug therapy
Language	English
Publishing date	2023-10-21
Publishing country	United States
Document type	Systematic Review ; Journal Article
ZDB-ID	2004350-8
ISSN	1557-1246 ; 1087-0547
ISSN (online)	1557-1246
ISSN	1087-0547
DOI	10.1177/10870547231203176
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Article: The effect of cognitive-behavioral counseling with or without

Rahmani, Narges / Araj-Khodaei, Mostafa / Mohammad-Alizadeh-Charandabi, Sakineh / Esmaeilpour, Khalil / Montazeri, Maryam / Mirghafourvand, Mojgan

Sleep and biological rhythms

2023 Volume 21, Issue 3, Page(s) 337–346

Abstract: Sleep disorder is very common during pregnancy. Non-pharmacological treatments are a priority to improve the sleep pattern. This study aimed to determine the effect of cognitive-behavioral counseling with or ... ...

Abstract	Sleep disorder is very common during pregnancy. Non-pharmacological treatments are a priority to improve the sleep pattern. This study aimed to determine the effect of cognitive-behavioral counseling with or without
Language	English
Publishing date	2023-02-05
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2185804-4
ISSN	1479-8425 ; 1446-9235
ISSN (online)	1479-8425
ISSN	1446-9235
DOI	10.1007/s41105-023-00451-7
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Article: Saffron reduces some inflammation and oxidative stress markers in donepezil-treated mild-to-moderate Alzheimer's Disease patients: A randomized double-blind placebo-control trial

Rasi Marzabadi, Leila / Fazljou, Seyyed Mohammad Bagher / Araj-Khodaei, Mostafa / Sadigh-Eteghad, Saeed / Naseri, Amirreza / Talebi, Mahnaz

Journal of herbal medicine. 2022 July, v. 34

2022

Abstract: Mounting evidence indicates the possible positive effects of Crocus sativus (saffron) on cognitive function in patients with Alzheimer’s Disease (AD). This study assessed the effects of saffron on cognitive outcomes and circulatory markers in patients ... ...

Abstract	Mounting evidence indicates the possible positive effects of Crocus sativus (saffron) on cognitive function in patients with Alzheimer’s Disease (AD). This study assessed the effects of saffron on cognitive outcomes and circulatory markers in patients with mild-to-moderate AD. Sixty adults with mild-to-moderate AD were found eligible to take part in a 12-week, randomized double-blind placebo-control clinical trial with a parallel-group design. Volunteers were randomized to receive donepezil plus either saffron capsule at 15 mg/twice a day dose or placebo (n = 30 each). The main outcomes of this study were the changes in the mini-mental state examination (MMSE) score, serum inflammatory markers (IL-1β, IL-6, and TNF-α), and serum antioxidant and oxidative stress status markers (glutathione peroxidase (GPx), superoxide dismutase (SOD), malondialdehyde (MDA), and total antioxidant capacity (TAC)). MMSE score of the patients in the saffron group was not significantly different from the placebo group (p = 0.303). When compared to the placebo treatment, saffron administration significantly decreased IL-1β (p = 0.036) and MDA (p = 0.021) levels and increased TAC (p = 0.032) in the serum sample of mild-to-moderate AD patients. This study showed no additional effects of saffron supplementation on cognitive outcomes in donepezil-treated mild-to-moderate AD patients; however, patients in the saffron group had improved inflammatory, antioxidant, and oxidative stress profiles compared with the placebo group, which may prove the beneficial effects of the additive on circulatory markers in AD patients.
Keywords	Alzheimer disease ; Crocus sativus ; antioxidant activity ; antioxidants ; blood serum ; clinical trials ; cognition ; glutathione peroxidase ; herbal medicines ; inflammation ; interleukin-6 ; malondialdehyde ; oxidative stress ; placebos ; saffron
Language	English
Dates of publication	2022-07
Publishing place	Elsevier GmbH
Document type	Article
ISSN	2210-8033
DOI	10.1016/j.hermed.2022.100574
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Relative Strengths of Three Linearizations of Receptor Availability: Saturation, Inhibition, and Occupancy Plots.

Khodaii, Javad / Araj-Khodaei, Mostafa / Vafaee, Manouchehr S / Wong, Dean F / Gjedde, Albert

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

2021 Volume 63, Issue 2, Page(s) 294–301

Abstract: We derived three widely used linearizations from the definition of receptor availability in molecular imaging with positron emission tomography (PET). The purpose of the present research was to determine the convergence of the results of the 3 methods in ...

Abstract	We derived three widely used linearizations from the definition of receptor availability in molecular imaging with positron emission tomography (PET). The purpose of the present research was to determine the convergence of the results of the 3 methods in terms of 3 parameters-occupancy (s), distribution volume of the nondisplaceable reference binding compartment (V
MeSH term(s)	Brain/metabolism ; Linear Models ; Positron-Emission Tomography/methods ; Radiopharmaceuticals/metabolism ; Tomography, X-Ray Computed
Chemical Substances	Radiopharmaceuticals
Language	English
Publishing date	2021-06-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80272-4
ISSN	1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
ISSN (online)	1535-5667
ISSN	0097-9058 ; 0161-5505 ; 0022-3123
DOI	10.2967/jnumed.117.204453
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Article: The role of hippocampal GABAA receptors on anxiolytic effects of Echium amoenum extract in a mice model of restraint stress

Farajdokht, Fereshteh / Vosoughi, Armin / Ziaee, Mojtaba / Araj-Khodaei, Mostafa / Mahmoudi, Javad / Sadigh-Eteghad, Saeed

Molecular biology reports. 2020 Sept., v. 47, no. 9

2020

Abstract: Echium amoenum (EA), a popular medicinal plant in Persian medicine, has anxiolytic, antioxidant, sedative, and anti-inflammatory effects. This study examined whether GABA-ergic signaling is involved in the anxiolytic effects of EA in mice. Sixty BALB/c ... ...

Abstract	Echium amoenum (EA), a popular medicinal plant in Persian medicine, has anxiolytic, antioxidant, sedative, and anti-inflammatory effects. This study examined whether GABA-ergic signaling is involved in the anxiolytic effects of EA in mice. Sixty BALB/c mice (25–30 g) were divided into six groups (n = 10) as follows: the (I) control group received 10 ml/kg normal saline (NS). In the stress groups, the animals underwent 14 consecutive days of restraint stress (RS), and received following treatments simultaneously; (II) RS + NS; (III) RS + Diaz (Diazepam); (IV) RS + EA; (V) RS + Flu (Flumazenil) + EA; (VI) RS + Flu + Diaz. Behavioral tests including the open field test (OFT) and elevated plus maze (EPM) were performed to evaluate anxiety-like behaviors and the effects of the regimens. The plasma level of corticosterone and the hippocampal protein expressions of IL-1β, TNF-α, CREB, and BDNF, as well as p-GABAA/GABAA ratio, were also assessed. The findings revealed that chronic administration of EA alone produced anxiolytic effects in both behavioral tests, while diazepam alone or in combination with Flu failed to decrease the anxiety-like behaviors. Furthermore, the p-GABAA/GABAA and p-CREB/CREB ratios, and protein levels of BDNF were significantly increased in the EA-received group. On the other hand, plasma corticosterone levels and the hippocampal IL-1β and TNF-α levels were significantly decreased by EA. However, pre-treatment with GABAA receptors (GABAA Rs) antagonist, Flu, reversed the anxiolytic and molecular effects of EA in the RS-subjected animals. Our findings confirmed that alternation of GABAAR is involved in the effects of EA against RS-induced anxiety-like behaviors, HPA axis activation, and neuroinflammation.
Keywords	Echium amoenum ; antagonists ; antioxidants ; corticosterone ; diazepam ; medicinal plants ; medicine ; molecular biology ; tranquilizers
Language	English
Dates of publication	2020-09
Size	p. 6487-6496.
Publishing place	Springer Netherlands
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-020-05699-7
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Article ; Online: Neck pain: global epidemiology, trends and risk factors.

Kazeminasab, Somaye / Nejadghaderi, Seyed Aria / Amiri, Parastoo / Pourfathi, Hojjat / Araj-Khodaei, Mostafa / Sullman, Mark J M / Kolahi, Ali-Asghar / Safiri, Saeid

BMC musculoskeletal disorders

2022 Volume 23, Issue 1, Page(s) 26

Abstract: Background: Neck pain is one of the most common musculoskeletal disorders, having an age-standardised prevalence rate of 27.0 per 1000 population in 2019. This literature review describes the global epidemiology and trends associated with neck pain, ... ...

Abstract	Background: Neck pain is one of the most common musculoskeletal disorders, having an age-standardised prevalence rate of 27.0 per 1000 population in 2019. This literature review describes the global epidemiology and trends associated with neck pain, before exploring the psychological and biological risk factors associated with the initiation and progression of neck pain. Methods: The PubMed database and Google Scholar search engine were searched up to May 21, 2021. Studies were included that used human subjects and evaluated the effects of biological or psychological factors on the occurrence or progression of neck pain, or reported its epidemiology. Results: Psychological risk factors, such as long-term stress, lack of social support, anxiety, and depression are important risk factors for neck pain. In terms of the biological risks, neck pain might occur as a consequence of certain diseases, such as neuromusculoskeletal disorders or autoimmune diseases. There is also evidence that demographic characteristics, such as age and sex, can influence the prevalence and development of neck pain, although further research is needed. Conclusions: The findings of the present study provide a comprehensive and informative overview that should be useful for the prevention, diagnosis, and management of neck pain.
MeSH term(s)	Anxiety ; Humans ; Neck Pain/diagnosis ; Neck Pain/epidemiology ; Risk Factors
Language	English
Publishing date	2022-01-03
Publishing country	England
Document type	Journal Article ; Review
ISSN	1471-2474
ISSN (online)	1471-2474
DOI	10.1186/s12891-021-04957-4
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