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  1. Article ; Online: Factors associated with multimodal care practices for cancer cachexia among registered dietitians.

    Amano, Koji / Koshimoto, Saori / Arakawa, Sayaka / Oyamada, Shunsuke / Ishiki, Hiroto / Morita, Tatsuya / Takeuchi, Takashi / Satomi, Eriko / Mori, Naoharu

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2024  Volume 32, Issue 4, Page(s) 213

    Abstract: Purpose: This study aimed to determine factors associated with multimodal care practices for cancer cachexia among registered dietitians (RDs) working in cancer care.: Methods: A secondary analysis was performed using RDs' data. Data on knowledge, ... ...

    Abstract Purpose: This study aimed to determine factors associated with multimodal care practices for cancer cachexia among registered dietitians (RDs) working in cancer care.
    Methods: A secondary analysis was performed using RDs' data. Data on knowledge, skills, and confidence in multimodal care were obtained. Nine items regarding multimodal care practices were evaluated. Subjects were divided into two groups based on their answers associated with the nine items. Comparisons were obtained using the Mann-Whitney U test or chi-squared test. Multiple regression analysis was performed to identify the critical factors involved in practicing multimodal care by determining the variables with significant differences between the two groups.
    Results: Two hundred thirty-two RDs were included in this study. Significant differences were observed in their primary area of practice (p = 0.023), the number of clinical guidelines used (p < 0.001), the number of items used in cancer cachexia assessment (p = 0.002), the number of symptoms used in cancer cachexia assessment (p = 0.039), training for cancer cachexia (p < 0.001), knowledge of cancer cachexia (p < 0.001), and confidence in cancer cachexia management (p < 0.001). The number of symptoms used in cancer cachexia assessment (B = 0.42, p = 0.019), knowledge of cancer cachexia (B = 6.60, p < 0.001), and confidence in cancer cachexia management (B = 4.31, p = 0.010) were identified as critical factors according to the multiple regression analysis.
    Conclusion: The RDs' knowledge and confidence in cancer cachexia management were associated with their multimodal care practices.
    MeSH term(s) Humans ; Cachexia/etiology ; Cachexia/therapy ; Nutritionists ; Neoplasms/complications ; Knowledge
    Language English
    Publishing date 2024-03-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-024-08417-2
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  2. Article ; Online: Efficacy of osimertinib in a patient with leptomeningeal metastasis and EGFR uncommon S768I mutation.

    Okuno, Takae / Arakawa, Sayaka / Yoshida, Tatsuya / Ohe, Yuichiro

    Lung cancer (Amsterdam, Netherlands)

    2020  Volume 143, Page(s) 95–96

    MeSH term(s) Acrylamides/therapeutic use ; Aged ; Aniline Compounds/therapeutic use ; Antineoplastic Agents/therapeutic use ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; ErbB Receptors/genetics ; Female ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Meningeal Carcinomatosis/drug therapy ; Meningeal Carcinomatosis/genetics ; Meningeal Carcinomatosis/secondary ; Mutation ; Prognosis
    Chemical Substances Acrylamides ; Aniline Compounds ; Antineoplastic Agents ; osimertinib (3C06JJ0Z2O) ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2020-03-18
    Publishing country Ireland
    Document type Case Reports ; Letter
    ZDB-ID 632771-0
    ISSN 1872-8332 ; 0169-5002
    ISSN (online) 1872-8332
    ISSN 0169-5002
    DOI 10.1016/j.lungcan.2020.03.016
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  3. Article ; Online: Perspectives of registered dietitians and factors associated with their personal accomplishment in the management of cancer cachexia.

    Koshimoto, Saori / Amano, Koji / Mori, Naoharu / Oyamada, Shunsuke / Arakawa, Sayaka / Ishiki, Hiroto / Satomi, Eriko / Morita, Tatsuya / Takeuchi, Takashi

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2023  Volume 31, Issue 2, Page(s) 124

    Abstract: Purpose: Registered dietitians (RDs) have the potential in cancer cachexia management. We investigated RDs' knowledge on cancer cachexia and assessed the effects of factors on RDs' perception of playing an important role in cancer cachexia management.!## ...

    Abstract Purpose: Registered dietitians (RDs) have the potential in cancer cachexia management. We investigated RDs' knowledge on cancer cachexia and assessed the effects of factors on RDs' perception of playing an important role in cancer cachexia management.
    Methods: This is a secondary analysis of a survey examining the perspectives of health care professionals on cancer cachexia management. We sent the questionnaire to 451 RDs. RDs were divided into two groups: RDs with and without the perception. Comparisons were made using the Mann-Whitney U test or chi-square test. To examine the effects of factors on the perception, estimated crude and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for the logistic regression model were calculated.
    Results: A total of 237 RDs were analyzed. Significant differences were observed in the number of cancer patients/month, the primary area of practice, the number of clinical guidelines used, the number of items used, the number of symptoms used, and training for cancer cachexia management (p values all < 0.05). After adjustments, the factors of cancer care experience ≥ 20 years (OR 8.32, 95% CI 1.22-56.70; p = 0.030), the number of patients/month ≥ 50 (OR 27.35, 95% CI 3.99-187.24; p = 0.001), using the clinical guidelines (OR 2.69, 95% CI 1.29-5.61; p = 0.008), the number of items ≥ 5 (OR 3.52, 95% CI 1.47-8.40; p = 0.005), and receiving training (OR 3.91, 95% CI 1.77-8.67; p = 0.001) significantly associated with the perception.
    Conclusion: Specific knowledge and training as well as abundant experience were associated with the perception.
    MeSH term(s) Humans ; Cachexia/etiology ; Cachexia/therapy ; Nutritionists ; Surveys and Questionnaires ; Health Personnel ; Neoplasms/complications
    Language English
    Publishing date 2023-01-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-023-07593-x
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  4. Article ; Online: Investigating the efficacy and safety of olanzapine prophylaxis for opioid-induced nausea and vomiting (JORTC-PAL20): a study protocol for an open-label, single-arm exploratory study.

    Satomi, Eriko / Kobayashi, Tomomi / Ishikawa, Ayaka / Arakawa, Sayaka / Ishiki, Hiroto / Amano, Koji / Sakiyama, Naomi / Ariyoshi, Keisuke / Kihara, Kota / Oyamada, Shunsuke / Mizushima, Akio

    BMJ open

    2024  Volume 14, Issue 2, Page(s) e076575

    Abstract: Introduction: In opioid therapy for cancer pain, opioid-induced nausea and vomiting (OINV) occur in 20%-40% of patients during initial opioid treatment or increasing opioid doses. OINV result in failure to achieve pain relief due to poor opioid ... ...

    Abstract Introduction: In opioid therapy for cancer pain, opioid-induced nausea and vomiting (OINV) occur in 20%-40% of patients during initial opioid treatment or increasing opioid doses. OINV result in failure to achieve pain relief due to poor opioid adherence. Therefore, antiemetics are used to prevent OINV, but their efficacy and safety in this context have not yet been fully elucidated. Olanzapine is a promising antiemetic for the prophylaxis of chemotherapy-induced nausea and vomiting.
    Methods and analysis: This single-arm, single-centre exploratory study will evaluate the prophylactic antiemetic efficacy and safety of 5 mg olanzapine in patients with cancer pain who are withholding initial regular opioid therapy. Thirty-five patients will be enrolled. The primary endpoint is the proportion of patients achieving complete control (CC) of OINV during 5 days of opioid treatment. CC was defined as the absence of emetic episodes, no need for rescue medication to treat nausea, and minimal or no nausea (3 or less on an 11-point categorical scale). Secondary endpoints include the complete response, defined as no emetic episodes and no use of rescue medication during the overall assessment period, the time from opioid initiation to first emetic episode, the time from opioid initiation to first rescue antiemetic administration, and adverse events graded by Patient-Reported Outcome (PRO) Common Terminology Criteria for Adverse Events (CTCAE) version 1.0 and CTCAE version 5.0.
    Ethics and dissemination: This study protocol was approved by National Cancer Center Hospital Certified Review Board. The results will be used as preliminary data to conduct a validation study.
    Trial registration number: Japan Registry of Clinical Trials (jRCT) jRCTs031220008.
    MeSH term(s) Humans ; Antiemetics/adverse effects ; Olanzapine/therapeutic use ; Analgesics, Opioid/adverse effects ; Emetics/adverse effects ; Cancer Pain/drug therapy ; Vomiting/chemically induced ; Vomiting/drug therapy ; Vomiting/prevention & control ; Nausea/chemically induced ; Nausea/prevention & control ; Nausea/drug therapy
    Chemical Substances Antiemetics ; Olanzapine (N7U69T4SZR) ; Analgesics, Opioid ; Emetics
    Language English
    Publishing date 2024-02-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-076575
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  5. Article ; Online: Malignancy-related ascites in palliative care units: prognostic factor analysis.

    Kadono, Toru / Ishiki, Hiroto / Yokomichi, Naosuke / Ito, Tetsuya / Maeda, Isseki / Hatano, Yutaka / Miura, Tomofumi / Hamano, Jun / Yamaguchi, Takashi / Ishikawa, Ayaka / Suzuki, Yuka / Arakawa, Sayaka / Amano, Koji / Satomi, Eriko / Mori, Masanori

    BMJ supportive & palliative care

    2024  Volume 13, Issue e3, Page(s) e1292–e1299

    Abstract: Objectives: The prognostic factors in patients with malignancy-related ascites (MA) have been poorly investigated. This study aimed to evaluate both the prognostic impact of MA on terminally ill patients with cancer and the prognostic factors in those ... ...

    Abstract Objectives: The prognostic factors in patients with malignancy-related ascites (MA) have been poorly investigated. This study aimed to evaluate both the prognostic impact of MA on terminally ill patients with cancer and the prognostic factors in those with MA.
    Methods: This was a post hoc analysis of a multicentre, prospective cohort study. Patients with advanced cancer admitted to palliative care units at 23 institutions and aged≥18 years were enrolled between January and December 2017. Overall survival (OS) was compared according to MA. A multivariate analysis was conducted to explore prognostic factors in patients with MA.
    Results: Of 1896 eligible patients, gastrointestinal and hepatobiliary pancreatic cancers accounted for 42.5%. 568 (30.0%) of the total had MA. Patients with MA had significantly shorter OS than those without MA (median, 14 vs 22 days, respectively; HR, 1.55; 95% CI, 1.39 to 1.72; p<0.01). A multivariate analysis showed that MA was a poor prognostic factor (HR, 1.30; 95% CI, 1.13 to 1.50; p<0.01) and that among patients with MA, significant poor prognostic factors were liver metastasis, moderately to severely reduced oral intake, delirium, oedema, gastric cancer, high serum creatinine, high serum C reactive protein, high serum total bilirubin, dyspnoea and fatigue, while significant good prognostic factors were female sex, good performance status, high serum albumin and colorectal cancer.
    Conclusions: MA had a negative impact on survival in terminally ill patients with cancer. A multivariate analysis revealed several prognostic factors in patients with terminal cancer and MA.
    MeSH term(s) Humans ; Female ; Male ; Prognosis ; Palliative Care ; Prospective Studies ; Ascites/etiology ; Liver Neoplasms ; Retrospective Studies
    Language English
    Publishing date 2024-01-08
    Publishing country England
    Document type Journal Article
    ISSN 2045-4368
    ISSN (online) 2045-4368
    DOI 10.1136/spcare-2023-004286
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  6. Article ; Online: Small Cell Cancer Transformation of Lung Adenocarcinoma During Durvalumab Treatment After Chemoradiotherapy.

    Arakawa, Sayaka / Yoshida, Tatsuya / Nakayama, Yuko / Motoi, Noriko / Ohe, Yuichiro

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

    2020  Volume 15, Issue 8, Page(s) e145–e146

    MeSH term(s) Adenocarcinoma of Lung/drug therapy ; Antibodies, Monoclonal/therapeutic use ; Chemoradiotherapy/adverse effects ; Humans ; Lung Neoplasms/drug therapy
    Chemical Substances Antibodies, Monoclonal ; durvalumab (28X28X9OKV)
    Language English
    Publishing date 2020-07-19
    Publishing country United States
    Document type Letter
    ZDB-ID 2432037-7
    ISSN 1556-1380 ; 1556-0864
    ISSN (online) 1556-1380
    ISSN 1556-0864
    DOI 10.1016/j.jtho.2019.12.117
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  7. Article: Clinical role and safety of tapentadol in patients with cancer: A single-center experience.

    Kubo, Emi / Ishiki, Hiroto / Abe, Kentaro / Kaku, Sawako / Yokota, Sayuri / Arakawa, Sayaka / Kiuchi, Daisuke / Amano, Koji / Satomi, Eriko

    Journal of opioid management

    2022  Volume 18, Issue 3, Page(s) 273–280

    Abstract: Objective: To evaluate real-world data on the use of tapentadol (TAP) in cancer patients.: Design: Single-center retrospective study.: Setting: Curative/palliative.: Patients, participants: Patients who started TAP between October 2014 and ... ...

    Abstract Objective: To evaluate real-world data on the use of tapentadol (TAP) in cancer patients.
    Design: Single-center retrospective study.
    Setting: Curative/palliative.
    Patients, participants: Patients who started TAP between October 2014 and December 2018 at our institution.
    Main outcome measure(s): The primary outcome was the reason for TAP initiation. Secondary outcomes included prescription duration, TAP cessation rate, reason for cessation, and adverse events (AEs). Since the palliative care team (PCT) tended to prescribe to cancer patients with intractable pain more often than patients in usual care, and also tended to prescribe opioids based on their characteristics, we decided to compare patients with and without PCT intervention.
    Results: There were 175 patients who first received TAP during the study period, of whom 81 patients (46.3 percent) were male. The median age was 60 years. TAP was prescribed for opioid-naive patients in 45 (26 percent) cases and opioid switch in 130 (74 percent) cases. When comparing the PCT group (n = 121) and the non-PCT group (n = 54) using univariate analysis, the PCT group had a higher opioid switch rate (81.8 percent vs 57.4 percent, p < .001), higher proportion of patients with neuropathic pain (NP) (65.3 percent vs 16.7 percent, p < .001), and a higher proportion of patients with a history of nausea (41.3 percent vs 18.5 percent, p < .01). The cessation rate due to AEs was 8 percent overall.
    Conclusions: Palliative care physicians prescribed TAP for patients with NP or a history of nausea. Opioid-naive patients were preferred by oncologists. TAP has good tolerability in both groups, with a low dropout rate due to AEs.
    MeSH term(s) Analgesics, Opioid/adverse effects ; Female ; Humans ; Male ; Middle Aged ; Nausea/chemically induced ; Nausea/complications ; Neoplasms/complications ; Retrospective Studies ; Tapentadol
    Chemical Substances Analgesics, Opioid ; Tapentadol (H8A007M585)
    Language English
    Publishing date 2022-06-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2397614-7
    ISSN 1551-7489
    ISSN 1551-7489
    DOI 10.5055/jom.2022.0719
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  8. Article ; Online: Factors Associated With Practice of Multimodal Care for Cancer Cachexia Among Physicians and Nurses Engaging in Cancer Care.

    Amano, Koji / Arakawa, Sayaka / Hopkinson, Jane B / Baracos, Vickie E / Oyamada, Shunsuke / Koshimoto, Saori / Mori, Naoharu / Ishiki, Hiroto / Morita, Tatsuya / Takeuchi, Takashi / Satomi, Eriko

    JCO oncology practice

    2023  Volume 19, Issue 8, Page(s) 602–609

    Abstract: Purpose: Multimodal care for cancer cachexia is needed. This study examined factors associated with practicing multimodal cachexia care among physicians and nurses engaging in cancer care.: Methods: This was a preplanned secondary analysis of a ... ...

    Abstract Purpose: Multimodal care for cancer cachexia is needed. This study examined factors associated with practicing multimodal cachexia care among physicians and nurses engaging in cancer care.
    Methods: This was a preplanned secondary analysis of a survey investigating clinicians' perspectives on cancer cachexia. Data of physicians and nurses were used. Data on knowledge, skills, and confidence in multimodal cachexia care were obtained. Nine items on practicing multimodal cachexia care were evaluated. Participants were divided into two groups as practicing multimodal cachexia care (above median value for the nine items) or not. Comparisons were made using the Mann-Whitney U test or chi-square test. Multiple regression analysis was performed to identify the factors of practicing the multimodal care.
    Results: Total of 233 physicians and 245 nurses were included. Significant differences were observed between the groups: female sex (
    Conclusion: Specialization in palliative care, specific knowledge, and confidence were associated with the practice of multimodal care for cancer cachexia.
    MeSH term(s) Humans ; Female ; Cachexia/therapy ; Cachexia/complications ; Neoplasms/complications ; Neoplasms/therapy ; Palliative Care ; Physicians ; Nurses
    Language English
    Publishing date 2023-05-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3028198-2
    ISSN 2688-1535 ; 2688-1527
    ISSN (online) 2688-1535
    ISSN 2688-1527
    DOI 10.1200/OP.23.00043
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  9. Article ; Online: RB1 loss induced small cell lung cancer transformation as acquired resistance to pembrolizumab in an advanced NSCLC patient.

    Arakawa, Sayaka / Yoshida, Tatsuya / Shirasawa, Masayuki / Takayanagi, Daisuke / Yagishita, Shigehiro / Motoi, Noriko / Ohe, Yuichiro

    Lung cancer (Amsterdam, Netherlands)

    2020  Volume 151, Page(s) 101–103

    MeSH term(s) Antibodies, Monoclonal, Humanized/pharmacology ; Antibodies, Monoclonal, Humanized/therapeutic use ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Drug Resistance, Neoplasm ; Humans ; Lung Neoplasms/drug therapy ; Retinoblastoma Binding Proteins/genetics ; Small Cell Lung Carcinoma ; Ubiquitin-Protein Ligases/genetics
    Chemical Substances Antibodies, Monoclonal, Humanized ; RB1 protein, human ; Retinoblastoma Binding Proteins ; pembrolizumab (DPT0O3T46P) ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
    Language English
    Publishing date 2020-11-20
    Publishing country Ireland
    Document type Letter
    ZDB-ID 632771-0
    ISSN 1872-8332 ; 0169-5002
    ISSN (online) 1872-8332
    ISSN 0169-5002
    DOI 10.1016/j.lungcan.2020.11.016
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  10. Article ; Online: Corrigendum to "Leptin enhances cytokine/chemokine production by normal lung fibroblasts by binding to leptin receptor" [Allergol Int 68S (2019) S3-S8].

    Watanabe, Kaoru / Suzukawa, Maho / Arakawa, Sayaka / Kobayashi, Koichi / Igarashi, Sayaka / Tashimo, Hiroyuki / Nagai, Hideaki / Tohma, Shigeto / Nagase, Takahide / Ohta, Ken

    Allergology international : official journal of the Japanese Society of Allergology

    2021  Volume 70, Issue 3, Page(s) 404

    Language English
    Publishing date 2021-05-08
    Publishing country England
    Document type Published Erratum
    ZDB-ID 1336498-4
    ISSN 1440-1592 ; 1323-8930
    ISSN (online) 1440-1592
    ISSN 1323-8930
    DOI 10.1016/j.alit.2021.04.005
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