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  1. Article ; Online: Schistosomiasis detected during appendectomy.

    Kraef, Christian / Arand, Jonas / Veletzky, Luzia / Schäfer, Hansjoerg / Jordan, Sabine / Schmiedel, Stefan / Ramharter, Michael

    Lancet (London, England)

    2018  Volume 391, Issue 10139, Page(s) 2546

    MeSH term(s) Abdominal Pain/etiology ; Adolescent ; Animals ; Anthelmintics/administration & dosage ; Appendectomy ; Appendicitis/complications ; Appendicitis/surgery ; Biopsy ; Humans ; Incidental Findings ; Liver/parasitology ; Male ; Praziquantel/administration & dosage ; Real-Time Polymerase Chain Reaction ; Schistosoma haematobium/isolation & purification ; Schistosomiasis haematobia/complications ; Schistosomiasis haematobia/diagnosis ; Schistosomiasis haematobia/drug therapy ; Semen/parasitology
    Chemical Substances Anthelmintics ; Praziquantel (6490C9U457)
    Language English
    Publishing date 2018-07-05
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(18)31329-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.5: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 94: Show issues

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  2. Article ; Online: Transjugular Intrahepatic Portosystemic Shunt (TIPS) for primary and secondary prophylaxis of variceal bleeding in hepatic schistosomiasis.

    Kraef, Christian / Arand, Jonas / Galaski, Johanna / Jordan, Sabine / Kluwe, Johannes / Lohse, Ansgar W / Addo, Marylyn M / Ramharter, Michael / Schmiedel, Stefan

    Travel medicine and infectious disease

    2019  Volume 30, Page(s) 130–132

    MeSH term(s) Adolescent ; Adult ; Female ; Gastrointestinal Hemorrhage/parasitology ; Gastrointestinal Hemorrhage/prevention & control ; Humans ; Liver/parasitology ; Liver/pathology ; Male ; Middle Aged ; Portasystemic Shunt, Transjugular Intrahepatic ; Schistosomiasis/complications ; Schistosomiasis/diagnosis ; Tertiary Care Centers ; Treatment Outcome
    Language English
    Publishing date 2019-01-11
    Publishing country Netherlands
    Document type Case Reports ; Letter
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2019.01.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6236: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Lithocholic bile acid induces apoptosis in human nephroblastoma cells: a non-selective treatment option.

    Trah, Julian / Arand, Jonas / Oh, Jun / Pagerols-Raluy, Laia / Trochimiuk, Magdalena / Appl, Birgit / Heidelbach, Hannah / Vincent, Deirdre / Saleem, Moin A / Reinshagen, Konrad / Mühlig, Anne K / Boettcher, Michael

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 20349

    Abstract: Lithocholic bile acid (LCA) has been reported to selectively kill cancer cells within many tumor cell lines including neuroblastoma or glioblastoma. Wilms' tumor shares similarities with neuro- and glioblastoma. Hence, the aim of the study was to ... ...

    Abstract Lithocholic bile acid (LCA) has been reported to selectively kill cancer cells within many tumor cell lines including neuroblastoma or glioblastoma. Wilms' tumor shares similarities with neuro- and glioblastoma. Hence, the aim of the study was to evaluate the effects of LCA on nephroblastoma. To test the effects of LCA, nephroblastoma cell line WT CLS1 was used. SK NEP1 was tested as well. It was originally classified as a nephroblastoma cell line but was meanwhile reclassified as an ewing sarcoma cell line. As control cell lines HEK 293 from embryonic kidney and RC 124 from adult kidney tissue as well as podocytes were used. The effects were evaluated using proliferation assay, caspase activity assay, FACS and Western blot. LCA showed a dose and time-dependent selective effect inducing apoptosis in nephroblastoma cells. However, these effects were not limited to the nephroblastoma cell line but also affected control kidney cell lines and the sarcoma cells; only podocytes are significantly less affected by LCA (at dosages < 200 µm). There were no significant differences regarding the TGR5 receptor expression. The study showed that LCA has a strong, yet unselective effect on all used in vitro cell-lines, sparing the highly differentiated podocytes in lower concentrations. Further studies are needed to verify our results before dismissing LCA as an anti-cancer drug.
    MeSH term(s) Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Apoptosis/genetics ; Caspase 3/genetics ; Caspase 3/metabolism ; Caspase 7/genetics ; Caspase 7/metabolism ; Cell Differentiation/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Epithelial Cells/drug effects ; Epithelial Cells/pathology ; Gene Expression Regulation, Neoplastic/drug effects ; HEK293 Cells ; Humans ; Lithocholic Acid/pharmacology ; Podocytes/drug effects ; Podocytes/pathology ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism
    Chemical Substances Antineoplastic Agents ; GPBAR1 protein, human ; Receptors, G-Protein-Coupled ; Lithocholic Acid (5QU0I8393U) ; CASP3 protein, human (EC 3.4.22.-) ; CASP7 protein, human (EC 3.4.22.-) ; Caspase 3 (EC 3.4.22.-) ; Caspase 7 (EC 3.4.22.-)
    Language English
    Publishing date 2020-11-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-77436-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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