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  1. Article ; Online: Immunomodulatory potential of rapamycin-loaded mesoporous silica nanoparticles: pore size-dependent drug loading, release, and in vitro cellular responses.

    Pérez-Moreno, Ana M / Aranda, Carlos J / Torres, María José / Mayorga, Cristobalina / Paris, Juan L

    Drug delivery and translational research

    2024  

    Abstract: Rapamycin is a potent immunosuppressive drug that has been recently proposed for a wide range of applications beyond its current clinical use. For some of these proposed applications, encapsulation in nanoparticles is key to ensure therapeutic efficacy ... ...

    Abstract Rapamycin is a potent immunosuppressive drug that has been recently proposed for a wide range of applications beyond its current clinical use. For some of these proposed applications, encapsulation in nanoparticles is key to ensure therapeutic efficacy and safety. In this work, we evaluate the effect of pore size on mesoporous silica nanoparticles (MSN) as rapamycin nanocarriers. The successful preparation of MSN with 4 different pore sizes was confirmed by dynamic light scattering, zeta potential, transmission electron microscopy and N
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2590155-2
    ISSN 2190-3948 ; 2190-393X
    ISSN (online) 2190-3948
    ISSN 2190-393X
    DOI 10.1007/s13346-024-01575-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: IL-13: An essential cDC2s partner to maintain skin homeostasis.

    Fernández-Santamaría, Rubén / Cañas, José Antonio / Aranda, Carlos J

    Allergy

    2022  Volume 77, Issue 9, Page(s) 2869–2871

    MeSH term(s) Animals ; Dendritic Cells ; Homeostasis ; Humans ; Interleukin-13 ; Mice ; Mice, Inbred C57BL ; Skin
    Chemical Substances Interleukin-13
    Language English
    Publishing date 2022-06-20
    Publishing country Denmark
    Document type News ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.15407
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  3. Article ; Online: The Secret Life of IgE-Producing Cells.

    Aranda, Carlos J / Curotto de Lafaille, Maria A

    Immunity

    2019  Volume 50, Issue 2, Page(s) 285–287

    Abstract: IgE antibodies are essential mediators of allergies. In a recent study in Science, Croote et al. (2018) characterize IgE cells isolated from individuals allergic to peanuts. Their findings provide insight into the differentiation of IgE cells in humans ... ...

    Abstract IgE antibodies are essential mediators of allergies. In a recent study in Science, Croote et al. (2018) characterize IgE cells isolated from individuals allergic to peanuts. Their findings provide insight into the differentiation of IgE cells in humans and have implications for our understanding of allergic disease.
    MeSH term(s) Allergens ; B-Lymphocytes ; Humans ; Hypersensitivity ; Immunoglobulin E ; Transcriptome
    Chemical Substances Allergens ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2019-03-26
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2019.01.018
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  4. Article ; Online: CD23

    Ota, Miyo / Hoehn, Kenneth B / Fernandes-Braga, Weslley / Ota, Takayuki / Aranda, Carlos J / Friedman, Sara / Miranda-Waldetario, Mariana G C / Redes, Jamie / Suprun, Maria / Grishina, Galina / Sampson, Hugh A / Malbari, Alefiyah / Kleinstein, Steven H / Sicherer, Scott H / Curotto de Lafaille, Maria A

    Science translational medicine

    2024  Volume 16, Issue 733, Page(s) eadi0673

    Abstract: Food allergy is caused by allergen-specific immunoglobulin E (IgE) antibodies, but little is known about the B cell memory of persistent IgE responses. Here, we describe, in human pediatric peanut allergy, a population of ... ...

    Abstract Food allergy is caused by allergen-specific immunoglobulin E (IgE) antibodies, but little is known about the B cell memory of persistent IgE responses. Here, we describe, in human pediatric peanut allergy, a population of CD23
    MeSH term(s) Humans ; Child ; Peanut Hypersensitivity ; Memory B Cells ; Immunoglobulin G ; Food Hypersensitivity ; Allergens ; Immunoglobulin E
    Chemical Substances Immunoglobulin G ; Allergens ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2518854-9
    ISSN 1946-6242 ; 1946-6234
    ISSN (online) 1946-6242
    ISSN 1946-6234
    DOI 10.1126/scitranslmed.adi0673
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Immunoregulatory Effects of Porcine Plasma Protein Concentrates on Rat Intestinal Epithelial Cells and Splenocytes

    Hernández-Chirlaque, Cristina / Aranda, Carlos J / Ocón, Borja / Polo, Javier / Martínez-Augustin, Olga / Sánchez de Medina, Fermín

    Animals. 2021 Mar. 13, v. 11, no. 3

    2021  

    Abstract: Serum protein concentrates have been shown to exert in vivo anti-inflammatory effects. Specific effects on different cell types and their mechanism of action remain unraveled. We aimed to characterize the immunomodulatory effect of two porcine plasma ... ...

    Abstract Serum protein concentrates have been shown to exert in vivo anti-inflammatory effects. Specific effects on different cell types and their mechanism of action remain unraveled. We aimed to characterize the immunomodulatory effect of two porcine plasma protein concentrates, spray dried serum (SDS) and an immunoglobulin concentrate (IC), currently used as animal nutritional supplements with established in vivo immunomodulatory properties. Cytokine production by the intestinal epithelial cell line IEC18 and by primary cultures of rat splenocytes was studied. The molecular pathways involved were explored with specific inhibitors and gene knockdown. Our results indicate that both products induced GROα and MCP-1 production in IEC18 cells by a MyD88/NF-κB-dependent mechanism. Inhibition of TNF production was observed in rat primary splenocyte cultures. The immunoglobulin concentrate induced IL-10 expression in primary splenocytes and lymphocytes. The effect on TNF was independent of IL-10 production or the stimulation of NF-kB, MAPKs, AKT, or RAGE. In conclusion, SDS and IC directly regulate intestinal and systemic immune response in murine intestinal epithelial cells and in T lymphocytes and monocytes.
    Keywords blood serum ; cell lines ; epithelial cells ; gene targeting ; immune response ; immunoglobulins ; immunomodulation ; immunomodulators ; interleukin-10 ; mechanism of action ; mice ; monocytes ; rats ; splenocytes ; swine ; transcription factor NF-kappa B
    Language English
    Dates of publication 2021-0313
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-light
    ISSN 2076-2615
    DOI 10.3390/ani11030807
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: The memory of pathogenic IgE is contained within CD23

    Ota, Miyo / Hoehn, Kenneth B / Ota, Takayuki / Aranda, Carlos J / Friedman, Sara / Braga, Weslley F / Malbari, Alefiyah / Kleinstein, Steven H / Sicherer, Scott H / Curotto de Lafaille, Maria A

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Food allergy is caused by allergen-specific IgE antibodies but little is known about the B cell memory of persistent IgE responses. Here we describe in human pediatric peanut allergy CD23 : One-sentence summary: We describe a unique population of ... ...

    Abstract Food allergy is caused by allergen-specific IgE antibodies but little is known about the B cell memory of persistent IgE responses. Here we describe in human pediatric peanut allergy CD23
    One-sentence summary: We describe a unique population of IgG
    Language English
    Publishing date 2023-01-25
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.01.25.525506
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  7. Article ; Online: Allergen recognition by specific effector Th2 cells enables IL‐2‐dependent activation of regulatory T‐cell responses in humans

    Lozano‐Ojalvo, Daniel / Tyler, Scott R. / Aranda, Carlos J. / Wang, Julie / Sicherer, Scott / Sampson, Hugh A. / Wood, Robert A. / Burks, A. Wesley / Jones, Stacie M. / Leung, Donald Y. M. / de Lafaille, Maria Curotto / Berin, M. Cecilia

    Allergy. 2023 Mar., v. 78, no. 3, p. 697-713

    2023  , Page(s) 697–713

    Abstract: Type 2 allergen‐specific T cells are essential for the induction and maintenance of allergies to foods, and Tregs specific for these allergens are assumed to be involved in their resolution. However, it has not been convincingly demonstrated whether ... ...

    Abstract Type 2 allergen‐specific T cells are essential for the induction and maintenance of allergies to foods, and Tregs specific for these allergens are assumed to be involved in their resolution. However, it has not been convincingly demonstrated whether allergen‐specific Treg responses are responsible for the generation of oral tolerance in humans. We observed that sustained food allergen exposure in the form of oral immunotherapy resulted in increased frequency of Tregs only in individuals with lasting clinical tolerance. We sought to identify regulatory components of the CD4⁺ T‐cell response to food allergens by studying their functional activation over time in vitro and in vivo. Two subsets of Tregs expressing CD137 or CD25/OX40 were identified with a delayed kinetics of activation compared with clonally enriched pathogenic effector Th2 cells. Treg activation was dependent on IL‐2 derived from effector T cells. In vivo exposure to peanut in the form of an oral food challenge of allergic subjects induced a delayed and persistent activation of Tregs after initiation of the allergen‐specific Th2 response. The novel finding of our work is that a sustained wave of Treg activation is induced by the release of IL‐2 from Th2 effector cells, with the implication that therapeutic administration of IL‐2 could improve current OIT approaches.
    Keywords T-lymphocytes ; food allergens ; hypersensitivity ; immunotherapy ; interleukin-2 ; peanuts
    Language English
    Dates of publication 2023-03
    Size p. 697-713
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 435216-6
    ISSN 1365-2885 ; 0140-7783
    ISSN (online) 1365-2885
    ISSN 0140-7783
    DOI 10.1111/all.15512
    Database NAL-Catalogue (AGRICOLA)

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    Zs.A 2226: Show issues Location:
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  8. Article: Immunoregulatory Effects of Porcine Plasma Protein Concentrates on Rat Intestinal Epithelial Cells and Splenocytes.

    Hernández-Chirlaque, Cristina / Aranda, Carlos J / Ocón, Borja / Polo, Javier / Martínez-Augustin, Olga / Sánchez de Medina, Fermín

    Animals : an open access journal from MDPI

    2021  Volume 11, Issue 3

    Abstract: Serum protein concentrates have been shown to exert in vivo anti-inflammatory effects. Specific effects on different cell types and their mechanism of action remain unraveled. We aimed to characterize the immunomodulatory effect of two porcine plasma ... ...

    Abstract Serum protein concentrates have been shown to exert in vivo anti-inflammatory effects. Specific effects on different cell types and their mechanism of action remain unraveled. We aimed to characterize the immunomodulatory effect of two porcine plasma protein concentrates, spray dried serum (SDS) and an immunoglobulin concentrate (IC), currently used as animal nutritional supplements with established in vivo immunomodulatory properties. Cytokine production by the intestinal epithelial cell line IEC18 and by primary cultures of rat splenocytes was studied. The molecular pathways involved were explored with specific inhibitors and gene knockdown. Our results indicate that both products induced GROα and MCP-1 production in IEC18 cells by a MyD88/NF-κB-dependent mechanism. Inhibition of TNF production was observed in rat primary splenocyte cultures. The immunoglobulin concentrate induced IL-10 expression in primary splenocytes and lymphocytes. The effect on TNF was independent of IL-10 production or the stimulation of NF-kB, MAPKs, AKT, or RAGE. In conclusion, SDS and IC directly regulate intestinal and systemic immune response in murine intestinal epithelial cells and in T lymphocytes and monocytes.
    Language English
    Publishing date 2021-03-13
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani11030807
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  9. Article ; Online: Mice carrying an epithelial deletion of the glucocorticoid receptor NR3C1 develop a higher tumor load in experimental colitis-associated cancer.

    Arredondo-Amador, María / González, Raquel / Aranda, Carlos J / Martínez-Augustin, Olga / Sánchez de Medina, Fermín

    American journal of physiology. Gastrointestinal and liver physiology

    2021  Volume 321, Issue 6, Page(s) G705–G718

    Abstract: The glucocorticoid receptor NR3C1 is expressed in multiple cell types in the gut and elsewhere. Intestinal epithelial cells both produce and respond to glucocorticoids in different physiological and pathological contexts. In experimental colitis, ... ...

    Abstract The glucocorticoid receptor NR3C1 is expressed in multiple cell types in the gut and elsewhere. Intestinal epithelial cells both produce and respond to glucocorticoids in different physiological and pathological contexts. In experimental colitis, glucocorticoids have been shown to exert a dual role, dampening inflammation while producing a deterioration in animal status, including death. Mice with tamoxifen-inducible, intestinal epithelial-specific deletion of NR3C1 (NR3C1
    MeSH term(s) Animals ; Colitis, Ulcerative/complications ; Epithelial-Mesenchymal Transition ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Gene Deletion ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; Intestinal Neoplasms/etiology ; Intestinal Neoplasms/genetics ; Intestinal Neoplasms/metabolism ; Intestinal Neoplasms/pathology ; Mice ; Mice, Inbred C57BL ; Proto-Oncogene Proteins c-myc/genetics ; Proto-Oncogene Proteins c-myc/metabolism ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism ; Receptors, Glucocorticoid/genetics ; Receptors, Glucocorticoid/metabolism ; Tumor Burden
    Chemical Substances Lgr5 protein, mouse ; Myc protein, mouse ; NR3C1 protein, mouse ; Proto-Oncogene Proteins c-myc ; Receptors, G-Protein-Coupled ; Receptors, Glucocorticoid ; EGFR protein, mouse (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2021-10-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603840-2
    ISSN 1522-1547 ; 0193-1857
    ISSN (online) 1522-1547
    ISSN 0193-1857
    DOI 10.1152/ajpgi.00384.2020
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  10. Article ; Online: Epithelial deletion of the glucocorticoid receptor (Nr3c1) protects the mouse intestine against experimental inflammation.

    Arredondo-Amador, María / Aranda, Carlos J / Ocón, Borja / González, Raquel / Martínez-Augustin, Olga / Sánchez de Medina, Fermín

    British journal of pharmacology

    2021  Volume 178, Issue 12, Page(s) 2482–2495

    Abstract: Background and purpose: Glucocorticoids are the first line treatment for the flare-ups of inflammatory bowel disease, but they have significant limitations. The objective of this study is to investigate whether glucocorticoid epithelial actions ... ...

    Abstract Background and purpose: Glucocorticoids are the first line treatment for the flare-ups of inflammatory bowel disease, but they have significant limitations. The objective of this study is to investigate whether glucocorticoid epithelial actions contribute to such limitations.
    Experimental approach: Intestinal epithelium glucocorticoid receptor knockout mice (Nr3c1
    Key results: After 7 days of DSS Nr3c1
    Conclusions and implications: The intestinal epithelial glucocorticoid receptor has deleterious effects in experimental colitis induced by DSS, probably related to inhibition of epithelial proliferative responses leading to impaired wound healing and reduced endogenous corticosterone production.
    MeSH term(s) Animals ; Colitis/chemically induced ; Colitis/drug therapy ; Colitis/genetics ; Colon ; Dextran Sulfate ; Disease Models, Animal ; Inflammation ; Intestinal Mucosa ; Intestines ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, Glucocorticoid/genetics
    Chemical Substances NR3C1 protein, mouse ; Receptors, Glucocorticoid ; Dextran Sulfate (9042-14-2)
    Language English
    Publishing date 2021-05-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.15434
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