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  1. Article ; Online: Solid supports and supported liquid membranes for different liquid phase microextraction and electromembrane extraction configurations. A review.

    Ocaña-González, Juan Antonio / Aranda-Merino, Noemí / Pérez-Bernal, Juan Luis / Ramos-Payán, María

    Journal of chromatography. A

    2023  Volume 1691, Page(s) 463825

    Abstract: Liquid phase microextraction (LPME) and electromembrane microextraction (EME) can be considered as two of the most popular techniques in sample treatment today. Both techniques can be configurated as membrane-assisted techniques to carry out the ... ...

    Abstract Liquid phase microextraction (LPME) and electromembrane microextraction (EME) can be considered as two of the most popular techniques in sample treatment today. Both techniques can be configurated as membrane-assisted techniques to carry out the extraction. These supports provide the required geometry and stability on the contact surface between two phases (donor and acceptor) and improve the reproducibility of sample treatment techniques. These solid support pore space, once is filled with organic solvents, act as a selective barrier acting as a supported liquid membrane (SLM). The SLM nature is a fundamental parameter, and its selection is critical to carry out successful extractions. There are numerous SLMs that have been successfully employed in a wide variety of application fields. The latter is due to the specificity of the selected organic solvents, which allows the extraction of compounds of a very different nature. In the last decade, solid supports and SLM have evolved towards "green" and environmentally friendly materials and solvents. In this review, solid supports implemented in LPME and EME will be discussed and summarized, as well as their applications. Moreover, the advances and modifications of the solid supports and the SLMs to improve the extraction efficiencies, recoveries and enrichment factors are discussed. Hollow fiber and flat membranes, including microfluidic systems, will be considered depending on the technique, configuration, or device used.
    MeSH term(s) Liquid Phase Microextraction/methods ; Reproducibility of Results ; Membranes, Artificial ; Solvents
    Chemical Substances Membranes, Artificial ; Solvents
    Language English
    Publishing date 2023-01-28
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1171488-8
    ISSN 1873-3778 ; 0021-9673
    ISSN (online) 1873-3778
    ISSN 0021-9673
    DOI 10.1016/j.chroma.2023.463825
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 813: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Bioavailability of flumequine and diclofenac in mice exposed to a metal-drug chemical cocktail. Evaluation of the protective role of selenium.

    Aranda-Merino, Noemí / Marín-Garrido, Antonio / Román-Hidalgo, Cristina / Ramos-Payán, María / Abril, Nieves / Fernández-Torres, Rut / Bello-López, Miguel Ángel

    British journal of pharmacology

    2023  

    Abstract: Background and purpose: Organisms, including humans, are subjected to the simultaneous action of a wide variety of pollutants, the effects of which should not be considered in isolation, as many synergies and antagonisms have been found between many of ... ...

    Abstract Background and purpose: Organisms, including humans, are subjected to the simultaneous action of a wide variety of pollutants, the effects of which should not be considered in isolation, as many synergies and antagonisms have been found between many of them. Therefore, this work proposes an in vivo study to evaluate the effect of certain metal contaminants on the bioavailability and metabolism of pharmacologically active compounds. Because the most frequent entry vector is through ingestion, the influence of the gut microbiota and the possible protective effects of selenium has been additionally evaluated.
    Experimental approach: A controlled exposure experiment in mammals (Mus musculus) to a "chemical cocktail" consisting of metals and pharmaceuticals (diclofenac and flumequine). The presence of selenium has also been evaluated as an antagonist. Mouse plasma samples were measured by UPLC-QTOF. A targeted search of 48 metabolites was also performed.
    Key results: Metals significantly affected the FMQ plasma levels when the gut microbiota was depleted. Hydroxy FMQ decreased if metals were present. Selenium minimized this decrease. The 3-hydroxy DCF metabolite was not found in any case. Changes in some metabolic pathways are discussed.
    Conclusions and implications: The presence of metals in the mouse diet as well as the prior treatment of mice with an antibiotic mixture (Abxs), which deplete the gut microbiota, has a decisive effect on the bioavailability and metabolism of the tested pharmaceuticals and dietary selenium minimize some of their effects.
    Language English
    Publishing date 2023-12-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.16312
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  3. Article: Comparison of three electromembrane-based extraction systems for NSAIDs analysis in human urine samples

    Aranda-Merino, Noemí / Ramos-Payán, María / Callejón-Mochón, Manuel / Villar-Navarro, Mercedes / Fernández-Torres, Rut

    Analytical and bioanalytical chemistry. 2020 Oct., v. 412, no. 25

    2020  

    Abstract: A comparative study on the extraction efficiency of five non-steroidal anti-inflammatories was carried out using three different electromembrane extraction (EME) devices with different geometries. The employed setups were (a) a hollow fiber configuration ...

    Abstract A comparative study on the extraction efficiency of five non-steroidal anti-inflammatories was carried out using three different electromembrane extraction (EME) devices with different geometries. The employed setups were (a) a hollow fiber configuration (HF-EME), (b) a microfluidic device that allows working in semi-dynamic mode (μF-EME), and (c) a static miniaturized flat membrane device (FM-EME). Each system was applied to the extraction of salicylic acid (SAC), ketoprofen (KTP), naproxen (NAX), diclofenac (DIC), and ibuprofen (IBU) and subsequent determination by high-performance liquid chromatography with UV and fluorescence detection (HPLC/UV-DAD-FLD). Voltage, pH composition, and extraction time were optimized for all devices. Additionally, volume ratio was investigated for HF-EME and FM-EME and flow rate for the microfluidic device. HF-EME provides the best result in terms of sensitivity with a limit of detection (LOD) between 0.1 and 1.5 ng mL⁻¹ for SAC and KTP, respectively, while LODs for μF-EME were between 100 ng mL⁻¹ and 400 ng mL⁻¹ for SAC and DIC, respectively; however, a lower amount of sample was required. Finally, the obtained results, in terms of enrichment factors and extraction recoveries, were discussed to establish the advantages and disadvantages of each device. The proposed EME methods were successfully applied to the determination of the target analytes in fortified human urine samples. Graphical abstract
    Keywords analytical chemistry ; chemical species ; comparative study ; detection limit ; diclofenac ; electric potential difference ; fluorescence ; high performance liquid chromatography ; humans ; ibuprofen ; ketoprofen ; pH ; salicylic acid ; urine
    Language English
    Dates of publication 2020-10
    Size p. 6811-6822.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    Note NAL-AP-2-clean
    ISSN 1618-2642
    DOI 10.1007/s00216-020-02804-4
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  4. Article ; Online: Chitosan biofilms: Insights for the selective electromembrane extraction of fluoroquinolones from biological samples.

    Román-Hidalgo, Cristina / Aranda-Merino, Noemí / López-Pérez, Germán / Sánchez-Coronilla, Antonio / Villar-Navarro, Mercedes / Martín-Valero, María Jesús

    Analytica chimica acta

    2021  Volume 1179, Page(s) 338832

    Abstract: A selective electromembrane extraction procedure for the extraction of Enrofloxacin, Marbofloxacin and Flumequine, usually employed as antibiotic in veterinarian use, is proposed by using a chitosan biofilm, composed by 60% (w/w) chitosan and 40% (w/w) ... ...

    Abstract A selective electromembrane extraction procedure for the extraction of Enrofloxacin, Marbofloxacin and Flumequine, usually employed as antibiotic in veterinarian use, is proposed by using a chitosan biofilm, composed by 60% (w/w) chitosan and 40% (w/w) Aliquat®336, as active biopolymeric support. The interaction mechanism occurring between the target drugs and the biopolymer has been deeply studied using the Quantum Theory of Atoms in Molecules. The obtained results show the interaction between the extracted fluoroquinolones and the biomembrane is stabilized by two hydrogen bonds formed between both the carboxyl and keto groups of the drugs with both the amine and hydroxyl groups of glucosamine in the biopolymer. The energetic results agree with the high extraction efficiency obtained for Marbofloxacin, Enrofloxacin and Flumequine in terms of enrichment factors (83, 82 and 58, respectively) in presence of other fluoroquinolones. Under optimum conditions, the proposed electromembrane extraction method exhibits wide linear ranges of 4.2-200 μg L
    Language English
    Publishing date 2021-07-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1483436-4
    ISSN 1873-4324 ; 0003-2670
    ISSN (online) 1873-4324
    ISSN 0003-2670
    DOI 10.1016/j.aca.2021.338832
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  5. Article: Monitoring of pharmaceuticals in aquatic biota (Procambarus clarkii) of the Doñana National Park (Spain)

    Kazakova, Julia / Villar-Navarro, Mercedes / Ramos-Payán, María / Aranda-Merino, Noemí / Román-Hidalgo, Cristina / Bello-López, Miguel Ángel / Fernández-Torres, Rut

    Journal of environmental management. 2021 Nov. 01, v. 297

    2021  

    Abstract: In this work the presence of different pharmaceuticals at Doñana National Park (Spain) and their main entry sources (input source or entry points) have been stated over the 2011–2016 years period. Twenty-three selected pharmaceuticals (corresponding to ... ...

    Abstract In this work the presence of different pharmaceuticals at Doñana National Park (Spain) and their main entry sources (input source or entry points) have been stated over the 2011–2016 years period. Twenty-three selected pharmaceuticals (corresponding to eight therapeutic families) were evaluated in crayfish and water samples from Doñana National Park (Spain) (six sampling points selected in order to cover different possible pollution sources into and surrounding the Park). The multiresidue determination was carried out using enzymatic-microwave assisted extraction prior to high performance liquid chromatography mass spectrometry detection. Sulphonamides (sulfadiazine, sulfamerazine, sulfamethazine, and sulfamethoxazole); trimethoprim, an antibiotic that is frequently co-administered with sulfamethoxazole; amphenicols (chloramphenicol, florfenicol and thiamphenicol); fluoroquinolones (ciprofloxacin, enrofloxacin, flumequine, danofloxacin, gatifloxacin, norfloxacin, marbofloxacin and grepafloxacin); penicillins (amoxicillin); tetracyclines (chlortetracycline and oxytetracycline); non-steroidal anti-inflammatory drugs (salicylic acid and ibuprofen); beta-blocker drugs (atenolol); and antiepileptics (carbamazepine) were analysed. Ciprofloxacin, ibuprofen, salicylic acid, flumequine, and carbamazepine were detected and/or quantified at some of the selected sampling points. A clear ecotoxicological risk to the ecosystem was demonstrated from the occurrence of ciprofloxacin in samples obtained after the punctual and massive presence of people inside the Park. Furthermore, flumequine and carbamazepine have been detected in Procambarus clarkii specimens in concentrations around 30 ng g⁻¹ and 14 ng g⁻¹, respectively, and their occurrence in the specimens could indicate the persistence of the discharge sources. The main source of pharmaceuticals into the Park might be the livestock farming activities, and the influence of urban wastewaters from surrounding villages does not seem to be very important.
    Keywords Procambarus clarkii ; amoxicillin ; anticonvulsants ; beta-adrenergic antagonists ; chlortetracycline ; ciprofloxacin ; crayfish ; danofloxacin ; ecosystems ; ecotoxicology ; enrofloxacin ; environmental management ; florfenicol ; flumequine ; high performance liquid chromatography ; ibuprofen ; livestock ; marbofloxacin ; mass spectrometry ; multiresidue analysis ; national parks ; norfloxacin ; oxytetracycline ; people ; pollution ; risk ; salicylic acid ; sulfadiazine ; sulfamerazine ; sulfamethazine ; sulfamethoxazole ; therapeutics ; trimethoprim ; wastewater ; Spain
    Language English
    Dates of publication 2021-1101
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 184882-3
    ISSN 1095-8630 ; 0301-4797
    ISSN (online) 1095-8630
    ISSN 0301-4797
    DOI 10.1016/j.jenvman.2021.113314
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    In stock of ZB MED Bonn / Germany

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  6. Article ; Online: Comparison of three electromembrane-based extraction systems for NSAIDs analysis in human urine samples.

    Aranda-Merino, Noemí / Ramos-Payán, María / Callejón-Mochón, Manuel / Villar-Navarro, Mercedes / Fernández-Torres, Rut

    Analytical and bioanalytical chemistry

    2020  Volume 412, Issue 25, Page(s) 6811–6822

    Abstract: A comparative study on the extraction efficiency of five non-steroidal anti-inflammatories was carried out using three different electromembrane extraction (EME) devices with different geometries. The employed setups were (a) a hollow fiber configuration ...

    Abstract A comparative study on the extraction efficiency of five non-steroidal anti-inflammatories was carried out using three different electromembrane extraction (EME) devices with different geometries. The employed setups were (a) a hollow fiber configuration (HF-EME), (b) a microfluidic device that allows working in semi-dynamic mode (μF-EME), and (c) a static miniaturized flat membrane device (FM-EME). Each system was applied to the extraction of salicylic acid (SAC), ketoprofen (KTP), naproxen (NAX), diclofenac (DIC), and ibuprofen (IBU) and subsequent determination by high-performance liquid chromatography with UV and fluorescence detection (HPLC/UV-DAD-FLD). Voltage, pH composition, and extraction time were optimized for all devices. Additionally, volume ratio was investigated for HF-EME and FM-EME and flow rate for the microfluidic device. HF-EME provides the best result in terms of sensitivity with a limit of detection (LOD) between 0.1 and 1.5 ng mL
    MeSH term(s) Anti-Inflammatory Agents, Non-Steroidal/urine ; Chromatography, High Pressure Liquid/methods ; Humans ; Hydrogen-Ion Concentration ; Limit of Detection ; Membranes, Artificial ; Spectrometry, Fluorescence/methods ; Spectrophotometry, Ultraviolet/methods
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Membranes, Artificial
    Language English
    Publishing date 2020-07-21
    Publishing country Germany
    Document type Comparative Study ; Journal Article
    ZDB-ID 201093-8
    ISSN 1618-2650 ; 0016-1152 ; 0372-7920
    ISSN (online) 1618-2650
    ISSN 0016-1152 ; 0372-7920
    DOI 10.1007/s00216-020-02804-4
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    In stock of ZB MED Bonn / Germany

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  7. Article ; Online: Monitoring of pharmaceuticals in aquatic biota (Procambarus clarkii) of the Doñana National Park (Spain).

    Kazakova, Julia / Villar-Navarro, Mercedes / Ramos-Payán, María / Aranda-Merino, Noemí / Román-Hidalgo, Cristina / Bello-López, Miguel Ángel / Fernández-Torres, Rut

    Journal of environmental management

    2021  Volume 297, Page(s) 113314

    Abstract: In this work the presence of different pharmaceuticals at Doñana National Park (Spain) and their main entry sources (input source or entry points) have been stated over the 2011-2016 years period. Twenty-three selected pharmaceuticals (corresponding to ... ...

    Abstract In this work the presence of different pharmaceuticals at Doñana National Park (Spain) and their main entry sources (input source or entry points) have been stated over the 2011-2016 years period. Twenty-three selected pharmaceuticals (corresponding to eight therapeutic families) were evaluated in crayfish and water samples from Doñana National Park (Spain) (six sampling points selected in order to cover different possible pollution sources into and surrounding the Park). The multiresidue determination was carried out using enzymatic-microwave assisted extraction prior to high performance liquid chromatography mass spectrometry detection. Sulphonamides (sulfadiazine, sulfamerazine, sulfamethazine, and sulfamethoxazole); trimethoprim, an antibiotic that is frequently co-administered with sulfamethoxazole; amphenicols (chloramphenicol, florfenicol and thiamphenicol); fluoroquinolones (ciprofloxacin, enrofloxacin, flumequine, danofloxacin, gatifloxacin, norfloxacin, marbofloxacin and grepafloxacin); penicillins (amoxicillin); tetracyclines (chlortetracycline and oxytetracycline); non-steroidal anti-inflammatory drugs (salicylic acid and ibuprofen); beta-blocker drugs (atenolol); and antiepileptics (carbamazepine) were analysed. Ciprofloxacin, ibuprofen, salicylic acid, flumequine, and carbamazepine were detected and/or quantified at some of the selected sampling points. A clear ecotoxicological risk to the ecosystem was demonstrated from the occurrence of ciprofloxacin in samples obtained after the punctual and massive presence of people inside the Park. Furthermore, flumequine and carbamazepine have been detected in Procambarus clarkii specimens in concentrations around 30 ng g
    MeSH term(s) Animals ; Astacoidea ; Biota ; Ecosystem ; Environmental Monitoring ; Humans ; Parks, Recreational ; Pharmaceutical Preparations ; Spain ; Water Pollutants, Chemical/analysis
    Chemical Substances Pharmaceutical Preparations ; Water Pollutants, Chemical
    Language English
    Publishing date 2021-07-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 184882-3
    ISSN 1095-8630 ; 0301-4797
    ISSN (online) 1095-8630
    ISSN 0301-4797
    DOI 10.1016/j.jenvman.2021.113314
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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