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  1. AU="Arango, Alissa"
  2. AU=Manjili Rose H AU=Manjili Rose H
  3. AU=Chen Hongtao
  4. AU="Soto Alsar, Javier"
  5. AU="Eric Woode"
  6. AU="Zybina O"
  7. AU="Reynolds, Cecil R"
  8. AU="Shahidul Khan"
  9. AU="Vasisth, Rashi"
  10. AU="Raju Mandal"
  11. AU="Owen, Noel L"
  12. AU=Liu Xiaolei
  13. AU="Fırıncıoğluları, Ali"
  14. AU="Piepel, Christiane"
  15. AU="Saremi, Saeid"
  16. AU="Dunxian She"

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  1. Artikel ; Online: Variation in Oral Board Examination Accommodations Among Specialties.

    Rowe, Dana G / Charles, Antoinette J / Luo, Emily J / Arango, Alissa M / Herndon, James E / Hockenberry, Harrison / Shortell, Cynthia K / Goodwin, C Rory / Erickson, Melissa M

    JAMA network open

    2024  Band 7, Heft 5, Seite(n) e2410127

    Abstract: Importance: Board certification can have broad implications for candidates' career trajectories, and prior research has found sociodemographic disparities in pass rates. Barriers in the format and administration of the oral board examinations may ... ...

    Abstract Importance: Board certification can have broad implications for candidates' career trajectories, and prior research has found sociodemographic disparities in pass rates. Barriers in the format and administration of the oral board examinations may disproportionately affect certain candidates.
    Objective: To characterize oral certifying examination policies and practices of the 16 Accreditation Council for Graduate Medical Education (ACGME)-accredited specialties that require oral examinations.
    Design, setting, and participants: This cross-sectional study was conducted from March 1 to April 15, 2023, using data on oral examination practices and policies (examination format, dates, and setting; lactation accommodations; and accommodations for military deployment, family emergency, or medical leave) as well as the gender composition of the specialties' boards of directors obtained from websites, telephone calls and email correspondence with certifying specialists. The percentages of female residents and residents of racial and ethnic backgrounds who are historically underrepresented in medicine (URM) in each specialty as of December 31, 2021, were obtained from the Graduate Medical Education 2021 to 2022 report.
    Main outcome and measures: For each specialty, accommodation scores were measured by a modified objective scoring system (score range: 1-13, with higher scores indicating more accommodations). Poisson regression was used to assess the association between accommodation score and the diversity of residents in that specialty, as measured by the percentages of female and URM residents. Linear regression was used to assess whether gender diversity of a specialty's board of directors was associated with accommodation scores.
    Results: Included in the analysis were 16 specialties with a total of 46 027 residents (26 533 males [57.6%]) and 233 members of boards of directors (152 males [65.2%]). The mean (SD) total accommodation score was 8.28 (3.79), and the median (IQR) score was 9.25 (5.00-12.00). No association was found between test accommodation score and the percentage of female or URM residents. However, for each 1-point increase in the test accommodation score, the relative risk that a resident was female was 1.05 (95% CI, 0.96-1.16), and the relative risk that an individual was a URM resident was 1.04 (95% CI, 1.00-1.07). An association was found between the percentage of female board members and the accommodation score: for each 10% increase in the percentage of board members who were female, the accommodation score increased by 1.20 points (95% CI, 0.23-2.16 points; P = .03).
    Conclusions and relevance: This cross-sectional study found considerable variability in oral board examination accommodations among ACGME-accredited specialties, highlighting opportunities for improvement and standardization. Promoting diversity in leadership bodies may lead to greater accommodations for examinees in extenuating circumstances.
    Mesh-Begriff(e) Humans ; Cross-Sectional Studies ; Female ; Male ; Certification/statistics & numerical data ; United States ; Specialty Boards/statistics & numerical data ; Educational Measurement/statistics & numerical data ; Educational Measurement/methods ; Education, Medical, Graduate/statistics & numerical data ; Medicine/statistics & numerical data ; Adult
    Sprache Englisch
    Erscheinungsdatum 2024-05-01
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2024.10127
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Proof-of-concept trial of an amniotic fluid-derived extracellular vesicle biologic for treating high risk patients with mild-to-moderate acute COVID-19 infection.

    Bellio, Michael A / Bennett, Cassie / Arango, Alissa / Khan, Aisha / Xu, Xiumin / Barrera, Cesar / Friedewald, Vincent / Mitrani, Maria Ines

    Biomaterials and biosystems

    2021  Band 4, Seite(n) 100031

    Abstract: A pandemic brought on by COVID-19 has created a scalable health crisis. The search to help alleviate COVID-19-related complications through therapeutics has become a necessity. Zofin is an investigational, acellular biologic derived from full-term ... ...

    Abstract A pandemic brought on by COVID-19 has created a scalable health crisis. The search to help alleviate COVID-19-related complications through therapeutics has become a necessity. Zofin is an investigational, acellular biologic derived from full-term perinatal amniotic fluid that contains extracellular vesicles. Extracellular nanoparticles as such have been studied for their immunomodulatory benefits via cellular therapeutics and, if applied to COVID-19-related inflammation, could benefit patient outcome. Subjects (
    Sprache Englisch
    Erscheinungsdatum 2021-11-24
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2666-5344
    ISSN (online) 2666-5344
    DOI 10.1016/j.bbiosy.2021.100031
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Treatment of a COVID-19 long hauler with an amniotic fluid-derived extracellular vesicle biologic.

    Mitrani, Maria Ines / Bellio, Michael A / Meglin, Allen / Khan, Aisha / Xu, Xiumin / Haskell, Gwendolyn / Arango, Alissa / Shapiro, George C

    Respiratory medicine case reports

    2021  Band 34, Seite(n) 101502

    Abstract: Post-COVID-19 infection symptoms such as mental fog, tachycardia, and extreme fatigue are just a few of the symptoms wreaking havoc on patients' lives. Patients with long-term symptoms following COVID-19 are being called long haulers. To date, long ... ...

    Abstract Post-COVID-19 infection symptoms such as mental fog, tachycardia, and extreme fatigue are just a few of the symptoms wreaking havoc on patients' lives. Patients with long-term symptoms following COVID-19 are being called long haulers. To date, long haulers are receiving little to no guidance from physicians on their lingering COVID-19 symptoms with limited treatment options available. Zofin is an acellular biologic that contains the extracellular vesicle (EV) fraction of human amniotic fluid and is under investigation for use as a COVID-19 therapeutic. We obtained FDA and IRB approval to investigate the therapeutic use of Zofin in a single long hauler patient case experiencing prolonged shortness of breath and respiratory impairment. Administration of the EV product was shown to be safe. Furthermore, demonstrated respiratory improvements through chest X ray images and oxygen saturation measurement. The single patient IND studies were completed without any reported adverse events or safety concerns. Furthermore, these completed studies demonstrate the feasibility and a therapeutic potential of amniotic fluid-derived EVs for COVID-19 long hauler intervention.
    Sprache Englisch
    Erscheinungsdatum 2021-08-30
    Erscheinungsland England
    Dokumenttyp Case Reports
    ZDB-ID 2666110-X
    ISSN 2213-0071
    ISSN 2213-0071
    DOI 10.1016/j.rmcr.2021.101502
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Scoping review on the state of racial disparities literature in the treatment of neurosurgical disease: a call for action.

    Owolo, Edwin / Seas, Andreas / Bishop, Brandon / Sperber, Jacob / Petitt, Zoey / Arango, Alissa / Yoo, Seeley / Shah, Sharrieff / Duvall, Julia B / Johnson, Eli / Abu-Bonsrah, Nancy / Kaplan, Samantha / Eden, Sonia / Ashley, William W / Williamson, Theresa / Goodwin, C Rory

    Neurosurgical focus

    2023  Band 55, Heft 5, Seite(n) E3

    Abstract: Objective: Racial disparities are ubiquitous across medicine in the US. This study aims to assess the evidence of racial disparities within neurosurgery and across its subspecialties, with a specific goal of quantifying the distribution of articles ... ...

    Abstract Objective: Racial disparities are ubiquitous across medicine in the US. This study aims to assess the evidence of racial disparities within neurosurgery and across its subspecialties, with a specific goal of quantifying the distribution of articles devoted to either identifying, understanding, or reducing disparities.
    Methods: The authors searched the MEDLINE, EMBASE, and Scopus databases by using keywords to represent the concepts of neurosurgery, patients, racial disparities, and specific study types. Two independent reviewers screened the article titles and abstracts for relevance. A third reviewer resolved conflicts. Data were then extracted from the included articles and each article was categorized into one of three phases: identifying, understanding, or reducing disparities. This review was conducted in accordance with the PRISMA Extension for Scoping Reviews (PRISMA-ScR) guidelines.
    Results: Three hundred seventy-one studies published between 1985 and 2023 were included. The distribution of racial disparities literature was not equally spread among specialties, with spine representing approximately 48.3% of the literature, followed by tumor (22.1%) and general neurosurgery (12.9%). Most studies were dedicated to identifying racial disparities (83.6%). The proportion of literature devoted to understanding and reducing disparities was much lower (15.1% and 1.3%, respectively). Black patients were the most negatively impacted racial/ethnic group in the review (63.3%). The Hispanic or Latino ethnic group was the second most negatively impacted (25.1%). The following categories-other outcomes (28.0%), the offering of treatment (21.6%), complications (18.6%), and survival (16.7%)-represented the most frequently measured outcomes.
    Conclusions: Although strides have been taken to identify racial disparities within neurosurgery, fewer studies have focused on understanding and reducing these disparities. The tremendous rise of literature within this domain but the relative paucity of solutions necessitates the study of targeted interventions to provide equitable care for all patients undergoing neurosurgical treatment.
    Mesh-Begriff(e) Humans ; Ethnicity ; Healthcare Disparities ; Hispanic or Latino ; Neurosurgery ; Racial Groups ; Black or African American
    Sprache Englisch
    Erscheinungsdatum 2023-11-01
    Erscheinungsland United States
    Dokumenttyp Systematic Review ; Review ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2026589-X
    ISSN 1092-0684 ; 1092-0684
    ISSN (online) 1092-0684
    ISSN 1092-0684
    DOI 10.3171/2023.8.FOCUS23466
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Case Report: Administration of Amniotic Fluid-Derived Nanoparticles in Three Severely Ill COVID-19 Patients.

    Mitrani, Maria Ines / Bellio, Michael A / Sagel, Anthony / Saylor, Marie / Kapp, William / VanOsdol, Kathryn / Haskell, Gwendolyn / Stewart, Danique / Abdullah, Zanub / Santos, Ivan / Milberg, Julian / Arango, Alissa / Mitrani, Albert / Shapiro, George C

    Frontiers in medicine

    2021  Band 8, Seite(n) 583842

    Abstract: Rationale/Objectives: ...

    Abstract Rationale/Objectives:
    Sprache Englisch
    Erscheinungsdatum 2021-03-17
    Erscheinungsland Switzerland
    Dokumenttyp Case Reports
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.583842
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Amniotic fluid-derived extracellular vesicles: characterization and therapeutic efficacy in an experimental model of bronchopulmonary dysplasia.

    Bellio, Michael A / Young, Karen C / Milberg, Julian / Santos, Ivan / Abdullah, Zanub / Stewart, Danique / Arango, Alissa / Chen, Pingping / Huang, Jian / Williams, Kevin / Kelly, Kaitlyn / Sterling, Shanique / Khan, Aisha / Xu, Xiumin / Shapiro, George C / Mitrani, Maria Ines

    Cytotherapy

    2021  Band 23, Heft 12, Seite(n) 1097–1107

    Abstract: Background aims: Extracellular vesicles (EVs) are being tested for their use as novel therapeutics. However, the optimal source of EVs is currently under investigation. Amniotic fluid (AF) is a natural source of EVs that can be easily obtained for use ... ...

    Abstract Background aims: Extracellular vesicles (EVs) are being tested for their use as novel therapeutics. However, the optimal source of EVs is currently under investigation. Amniotic fluid (AF) is a natural source of EVs that can be easily obtained for use in regenerative medicine, yet AF-EV characterization has not been fully explored.
    Methods: Here the authors demonstrate AF as a rich source of EVs and identify the microRNA and proteomic cargo. Bioinformatics analysis of this cargo revealed multiple pathway targets, including immunomodulatory, anti-inflammatory and free radical scavenging networks. The authors further demonstrated the therapeutic potential of this EV product as a novel preventative agent for bronchopulmonary dysplasia (BPD).
    Results: Intra-tracheal administration of AF-EVs preserved alveolar development, attenuated vascular remodeling and pulmonary hypertension, decreased lung pro-inflammatory cytokine expression and reduced macrophage infiltration in an experimental BPD model.
    Conclusions: The authors' results suggest that AF is a viable biological fluid for EV harvest and that AF-EVs have strong therapeutic potential for pulmonary diseases, such as BPD, warranting further development to transition this novel EV product into the clinic.
    Mesh-Begriff(e) Amniotic Fluid ; Animals ; Bronchopulmonary Dysplasia/therapy ; Disease Models, Animal ; Extracellular Vesicles ; Humans ; Infant, Newborn ; Models, Theoretical ; Proteomics ; Rats, Sprague-Dawley ; Rats
    Sprache Englisch
    Erscheinungsdatum 2021-09-17
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2039821-9
    ISSN 1477-2566 ; 1465-3249
    ISSN (online) 1477-2566
    ISSN 1465-3249
    DOI 10.1016/j.jcyt.2021.07.011
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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