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  1. Article ; Online: Virology, pathophysiology and neuroinvasion mechanisms of SARS-CoV-2

    Arash Pourgholaminejad / Samaneh Kazemi / Alia Saberi

    Romanian Journal of Neurology, Vol 20, Iss 3, Pp 288-

    A mini literature review

    2021  Volume 291

    Abstract: Coronavirus-2 (CoV-2) is known as a respiratory pathogen for which the accumulation of evidence suggest that the severe acute respiratory syndrome (SARS) can cause critical pathologies in vulnerable patients. The coronavirus disease-2019 (COVID-19) ... ...

    Abstract Coronavirus-2 (CoV-2) is known as a respiratory pathogen for which the accumulation of evidence suggest that the severe acute respiratory syndrome (SARS) can cause critical pathologies in vulnerable patients. The coronavirus disease-2019 (COVID-19) pandemic is an example of a multi-systemic infectious disease. In addition of respiratory manifestations and severe pneumonia related to COVID-19, The SARS-CoV-2 can penetrate into the central nervous system (CNS) and participate in the induction of neurological disorders and promote some neuropathies. Knowledge of the spectrum of SARS-CoV-2-associated pathophysiology and neuroinvasion pathways will lead to improved clinical outcomes and better treatment algorithms. The aim of this review is to summarize available knowledge on the identification of virology, neuroinvasion mechanisms and the pathophysiology of SARS-CoV-2 in the CNS.
    Keywords sars-cov-2 ; central nervous system ; pathophysiology ; Medicine ; R ; Neurology. Diseases of the nervous system ; RC346-429
    Subject code 610
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher Amaltea Medical Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Interleukin-17, C-reactive protein, Neutrophil-to-Lymphocyte ratio, Lymphocyte-to-Monocyte ratio, and lipid profiles in healthy menopausal women with or without hot flashes

    Nazila Didevar / Parvaneh Rezasoltani / Arash Pourgholaminejad / Ehsan Kazemnezhad Leyli / Tahereh Seyednoori / Ziba Zahiri Sorouri

    PLoS ONE, Vol 18, Iss 11, p e

    A cross-sectional study.

    2023  Volume 0291804

    Abstract: Introduction The reciprocation between systemic inflammatory markers (SIMs), dyslipidemia, and hot flashes (HFs) can play a part in the pathogenesis of endothelial dysfunction through menopause. This study intended to determine the association between ... ...

    Abstract Introduction The reciprocation between systemic inflammatory markers (SIMs), dyslipidemia, and hot flashes (HFs) can play a part in the pathogenesis of endothelial dysfunction through menopause. This study intended to determine the association between some SIMs, lipids, and HFs in healthy menopausal women. Materials and methods We designed a cross-sectional study in which 160 healthy menopausal women aged 40-60 were enrolled. Concerning their HFs status, they were stratified into two groups by consecutive sampling: without HFs (n = 40) and with HFs (n = 120). In addition to clinical variables and HFs experience, we measured the fasting serum levels of SIMs and lipid profiles (LPs), including Interleukin-17 (IL-17), high- sensitivity C-Reactive Protein (hs-CRP), Total Cholesterol (TC), Triglycerides (TG), Low-Density Lipoprotein Cholesterol (LDL-C), and High-Density Lipoprotein Cholesterol (HDL-C) in each group. Then, we calculated TC/HDL-C concerning the related variables and determined Neutrophil-to-Lymphocyte Ratio (NLR), and Lymphocyte-to-Monocyte Ratio (LMR), according to Complete Blood Count (CBC) quantitative parameters in each group. Furthermore, we used logistic regression analysis to assess the association between SIMs, LPs, and HFs. Settings We performed this study in a governmental teaching hospital, Guilan/Rasht, Iran, from April to September 2021. Results The two groups of menopausal women without and with HFs were not significantly different regarding the median of IL-17, hs-CRP, NLR, LMR, TG, HDL-C, and TC/HDL-C, and the mean of TC and LDL-C. Based on multiple logistic regression, TG levels appeared to be associated with the incidence of HFs (B = 0.004, P = 0.040, Odds Ratio:1.004, 95%CI:1.000-1.009). NLR seemed to have an increasing impact on the HFs severity, according to ordinal logistic regression (B = 0.779, P = 0.005, Odds Ratio = 2.180, 95%CI:1.270-3.744). Furthermore, hs-CRP negatively correlated with TG (r = -0.189, P = 0.039) and TC/HDL-C (r = -0.268, P = 0.003) in menopausal women with ...
    Keywords Medicine ; R ; Science ; Q
    Subject code 630
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Mesenchymal stem cells and their application in autoimmune disease treatment

    Mehrnaz Tayebi Kamardi / Arash Pourgholaminejad / Mohammadreza Baghban Eslaminejad / Fattah Sotoodehnejadnematalahi

    Tehran University Medical Journal, Vol 72, Iss 6, Pp 341-

    review article

    2014  Volume 351

    Abstract: Mesenchymal Stem Cells (MSCs) are well known as the regulator of the immune system. These multipotent non-hematopoietic progenitor cells have been originally isolated from bone marrow, and later on found in several other tissues, such as skeletal muscle, ...

    Abstract Mesenchymal Stem Cells (MSCs) are well known as the regulator of the immune system. These multipotent non-hematopoietic progenitor cells have been originally isolated from bone marrow, and later on found in several other tissues, such as skeletal muscle, umbilical cord blood, adipose and fetal liver tissues. Immunomodulatory effects of MSCs on a variety of immune cells such as T and B lymphocytes, Natural Killer cells (NK), neutrophils, macrophages and dendritic cells, has made a good candidate of them for the treatment of inflammatory disorders, particularly autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. In addition, several studies have indicated mechanisms by which MSCs could reduce immune cell proliferation and activation leading to immune tolerance induction. Since T lymphocytes are considered as the most important immune cells, effect of MSCs on the activity of these cells has a very special significance to direct immune response. Under various conditions, T-lymphocytes have different phenotype and performance and can be differentiated into particular subtype such as regulatory T cells. Both in vitro and in vivo studies have indicated that MSCs modulate innate and adaptive immune system by promoting generation of CD4+CD25+ T regulatory cells which have important role in immune tolerance induction and autoimmune disease prevention. MSCs are able to block pro-inflammatory and increase anti-inflammatory cytokines secretion. So such unique immunomodulatory features make MSCs ideal candidates for clinical application as immunosuppressants which can be considered for autoimmune diseases treatment. Therefore, in this short-review, we attempt to focus mainly on the existing information about MSCs in association with immunomodulatory function of them on the immune system. In addition, the possible mechanisms and the performance impact of MSCs in autoimmune diseases improvement are discussed here. However, increasing knowledge of how MSCs will influence on the immune system suppression, ...
    Keywords autoimmune diseases ; immunomodulatory ; mesenchymal stromal cells ; T-lymphocytes ; Medicine (General) ; R5-920
    Subject code 610
    Language Persian
    Publishing date 2014-09-01T00:00:00Z
    Publisher Tehran University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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