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  1. Article ; Online: Basin-Scale Streamflow Projections for Greater Pamba River Basin, India Integrating GCM Ensemble Modelling and Flow Accumulation-Weighted LULC Overlay in Deep Learning Environment

    Arathy Nair Geetha Raveendran Nair / Shamla Dilama Shamsudeen / Meera Geetha Mohan / Adarsh Sankaran

    Sustainability, Vol 15, Iss 14148, p

    2023  Volume 14148

    Abstract: Accurate prediction of future streamflow in flood-prone regions is crucial for effective flood management and disaster mitigation. This study presents an innovative approach for streamflow projections in deep learning (DL) environment by integrating the ... ...

    Abstract Accurate prediction of future streamflow in flood-prone regions is crucial for effective flood management and disaster mitigation. This study presents an innovative approach for streamflow projections in deep learning (DL) environment by integrating the quantitative Land-Use Land-Cover (LULC) overlaid with flow accumulation values and the various Global Climate Model (GCM) simulated data. Firstly, the Long Short Term Memory (LSTM) model was developed for the streamflow prediction of Greater Pamba River Basin (GPRB) in Kerala, India for 1985 to 2015 period, considering the climatic inputs. Then, the flow accumulation-weighted LULC integration was considered in modelling, which substantially improves the accuracy of streamflow predictions including the extremes of all the three stations, as the model accounts for the geographical variety of land cover types towards the streamflow at the sub-basin outlets. Subsequently, Reliability Ensemble Averaging (REA) technique was used to create an ensemble of three candidate GCM products to illustrate the spectrum of uncertainty associated with climate projections. Future LULC changes are accounted in regional scale based on the sub-basin approach by means of Cellular-Automata Markov Model and used for integrating with the climatic indices. The basin-scale streamflow projection is done under three climate scenarios of SSP126, SSP245 and SSP585 respectively for lowest, moderate and highest emission conditions. This work is a novel approach of integrating quantified LULC with flow accumulation and other climatic inputs in a DL environment against the conventional techniques of hydrological modelling. The DL model can adapt and account for shifting hydrological responses induced by changes in climatic and LULC inputs. The integration of flow accumulation with changes in LULC was successful in capturing the flow dynamics in long-term. It also identifies regions that are more likely to experience increased flooding in the near future under changing climate scenarios and supports ...
    Keywords LULC ; Global Climate Model ; Reliability Ensemble Averaging ; Long Short Term Memory ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 550
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Experimental Infection of North American Sheep with Ehrlichia ruminantium

    Arathy Nair / Paidashe Hove / Huitao Liu / Ying Wang / Ada G. Cino-Ozuna / Jamie Henningson / Charan K. Ganta / Roman R. Ganta

    Pathogens, Vol 10, Iss 451, p

    2021  Volume 451

    Abstract: Ehrlichia ruminantium , a tick-borne rickettsial, causes heartwater in ruminants resulting from vascular damage. Severity of heartwater varies greatly in ruminant species and breeds, age of animals and for diverse geographic E . ruminantium strains. E. ... ...

    Abstract Ehrlichia ruminantium , a tick-borne rickettsial, causes heartwater in ruminants resulting from vascular damage. Severity of heartwater varies greatly in ruminant species and breeds, age of animals and for diverse geographic E . ruminantium strains. E. ruminantium and a tick vector, Amblyomma variegatum , originating from Africa, are well established in certain Caribbean islands two centuries ago. Besides the possibility of introduction of heartwater through African exotic animal importation, presence of the pathogen, and the tick vector in the Caribbean pose a high risk to ruminants in the USA and other western hemisphere countries. Scientific evidence supporting the heartwater threat to nonendemic regions, however, is lacking. We describe the first infection study in sheep reared in the USA with seven E. ruminantium strains. All infected sheep exhibited clinical signs characteristic of subacute to subclinical disease, which included labored breathing, depression, coughing, and nasal discharges. Gross and microscopic lesions consistent with heartwater disease including edema and hemorrhage were observed in several organs. Pathogen-specific IgG antibody response was detected in animals infected with all seven strains, while molecular analysis confirmed the pathogen presence only when infected with in vitro cultures. This is the first infection study demonstrating severe heartwater in sheep reared in North America.
    Keywords rickettsials ; Anaplasmataceae pathogens ; tick-borne diseases ; heartwater ; Cowdria ruminantium ; Medicine ; R
    Subject code 630
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Targeted mutagenesis in Anaplasma marginale to define virulence and vaccine development against bovine anaplasmosis.

    Paidashe Hove / Swetha Madesh / Arathy Nair / Deborah Jaworski / Huitao Liu / Jonathan Ferm / Michael D Kleinhenz / Margaret A Highland / Andrew K Curtis / Johann F Coetzee / Susan M Noh / Ying Wang / Dominica Genda / Roman R Ganta

    PLoS Pathogens, Vol 18, Iss 5, p e

    2022  Volume 1010540

    Abstract: Tick-borne Anaplasma species are obligate, intracellular, bacterial pathogens that cause important diseases globally in people, agricultural animals, and dogs. Targeted mutagenesis methods are yet to be developed to define genes essential for these ... ...

    Abstract Tick-borne Anaplasma species are obligate, intracellular, bacterial pathogens that cause important diseases globally in people, agricultural animals, and dogs. Targeted mutagenesis methods are yet to be developed to define genes essential for these pathogens. In addition, vaccines conferring protection against diseases caused by Anaplasma species are not available. Here, we describe a targeted mutagenesis method for deletion of the phage head-to-tail connector protein (phtcp) gene in Anaplasma marginale. The mutant did not cause disease and exhibited attenuated growth in its natural host (cattle). We then assessed its ability to confer protection against wild-type A. marginale infection challenge. Additionally, we compared vaccine protection with the mutant to that of whole cell A. marginale inactivated antigens as a vaccine (WCAV) candidate. Upon infection challenge, non-vaccinated control cattle developed severe disease, with an average 57% drop in packed cell volume (PCV) between days 26-31 post infection, an 11% peak in erythrocytic infection, and apparent anisocytosis. Conversely, following challenge, all animals receiving the live mutant did not develop clinical signs or anemia, or erythrocyte infection. In contrast, the WCAV vaccinees developed similar disease as the non-vaccinees following A. marginale infection, though the peak erythrocyte infection reduced to 6% and the PCV dropped 43%. This is the first study describing targeted mutagenesis and its application in determining in vivo virulence and vaccine development for an Anaplasma species pathogen. This study will pave the way for similar research in related Anaplasma pathogens impacting multiple hosts.
    Keywords Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Subject code 630
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Amelioration of doxorubicin induced cardio-and hepato-toxicity by carotenoids

    R Indu / T S Azhar / Arathy Nair / Cherupally Krishnan Krishnan Nair

    Journal of Cancer Research and Therapeutics, Vol 10, Iss 1, Pp 62-

    2014  Volume 67

    Abstract: Aim of Study: The aim of this study is to explore the ability of the carotenoids (CARs) to offer protection against acute cardiotoxicity and hepatotoxicity induced by doxorubicin (DOX) (25 mg/kg) in tumor bearing Swiss albino mice. Materials and Methods: ...

    Abstract Aim of Study: The aim of this study is to explore the ability of the carotenoids (CARs) to offer protection against acute cardiotoxicity and hepatotoxicity induced by doxorubicin (DOX) (25 mg/kg) in tumor bearing Swiss albino mice. Materials and Methods: Tumor bearing Swiss albino mice administered with DOX (25 mg/kg, i.p) and two doses of CARs (50 and 100 μg/kg). 24 h after administration of the drugs, histopathological evaluation of tumor, liver and heart tissues carried out. Furthermore, various antioxidant parameters in these tissues were investigated. Serum marker enzymes for tissue injury were examined. Results: Administration of CARs prevented the depletion of antioxidants in the heart and liver, thereby protecting the tissue damage and release of marker enzymes. However, similar antioxidant depletion was not observed in the tumor tissue. CARs prevented DOX induced variation in tissue architecture in heart and liver tissues. However, CARs did not influence DOX induced alterations in the tumor. Conclusion: Administration of CARs could prevent DOX induced acute toxicity to heart and liver.
    Keywords Antioxidant status ; cardiotoxicity ; carotenoids ; doxorubicin ; hepatotoxicity ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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