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Article ; Online: Unilateral vocal cord finding on PET-CT in a small cell lung cancer patient - another cause?

Cardoso, Catarina Gouveia / Araújo, David

The American journal of the medical sciences

2022 Volume 364, Issue 4, Page(s) e4–e5

MeSH term(s)	Humans ; Lung Neoplasms/diagnostic imaging ; Positron Emission Tomography Computed Tomography ; Small Cell Lung Carcinoma/complications ; Small Cell Lung Carcinoma/diagnostic imaging ; Tomography, X-Ray Computed ; Vocal Cords/diagnostic imaging
Language	English
Publishing date	2022-05-08
Publishing country	United States
Document type	Letter
ZDB-ID	82078-7
ISSN	1538-2990 ; 0002-9629
ISSN (online)	1538-2990
ISSN	0002-9629
DOI	10.1016/j.amjms.2022.05.004
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Article ; Conference proceedings: Sustained macrophage alterations during chronic injury regression beget increased susceptibility to infections

Peiseler, Moritz / Wang, Yuting / Araujo David, Bruna / Rastogi, Tashi / Horn, Paul / Tacke, Frank / Kubes, Paul / Heymann, Felix

Zeitschrift für Gastroenterologie

2024 Volume 62, Issue 01

Event/congress	40. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber, Haus der Technik e.V., Essen, 2024-01-26
Language	German
Publishing date	2024-01-01
Publisher	Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	201387-3
ISSN	1439-7803 ; 0044-2771 ; 0172-8504
ISSN (online)	1439-7803
ISSN	0044-2771 ; 0172-8504
DOI	10.1055/s-0043-1777471
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Zs.A 111: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.A 111/X: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Development and perceived usability evaluation of an interactive smartphone application for the teaching of hemodynamics and evaluation of arterial pulse pressure variation.

Barbosa, Orivaldo Alves / Marçal, Edgar / Araújo, David Augusto Batista Sá / Melo, Lucas Severo / Rocha, Hermano Alexandre Lima

BMC medical informatics and decision making

2023 Volume 23, Issue 1, Page(s) 31

Abstract: Background: The use of fluids is the most frequently used therapy for circulatory shock. Its inadequate use has adverse effects, requiring hemodynamic goals, highlighting the use of pulse pressure variation due to its high accuracy. One of the problems ... ...

Abstract	Background: The use of fluids is the most frequently used therapy for circulatory shock. Its inadequate use has adverse effects, requiring hemodynamic goals, highlighting the use of pulse pressure variation due to its high accuracy. One of the problems related to this method is the difficulties in measuring the pulse pressure variation (PPV) in most monitors for clinical use. We assessed the qualitative aspects of perceived usability of a smartphone application (app), which, based on a photograph of the patient's arterial pulse wave, can help measure PPV and help in the diagnosis and management of shock cases. Methods: To assess the software perceived usability, we used the System Usability Scale (SUS) applied to 30 physicians in 2 tertiary hospitals in Brazil. The software accuracy was measured using a sequence of 3 images with different values of pulse pressure variation, comparing the obtained values with the gold standard. The educational interface of the app was evaluated qualitativelyfrom the spontaneous testimonies of the selected test participants.The project was approved by the Research Ethics Committee of Centro Universitário Christus. Results: The analysis showed an average SUS of 86.3 points on a scale of 1-100 (above 80.3 is considered the best in terms of interface). The assessment of the application's accuracy when evaluating pulse pressure variation showed that the average variation of the measurements taken by the participants was small, with a good measure of repeatability and reproducibility. The app's educational interface was qualitatively evaluated, being praised by the users. Conclusions: It can be concluded that the developed mobile application showed excellent qualitative aspects of perceived usability results. More studies with this app will be required to evaluate the potential to help professionals with hemodynamic evaluation in emergency and intensive care settings.
MeSH term(s)	Humans ; Mobile Applications ; Blood Pressure ; Smartphone ; Reproducibility of Results ; Hemodynamics
Language	English
Publishing date	2023-02-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2046490-3
ISSN	1472-6947 ; 1472-6947
ISSN (online)	1472-6947
ISSN	1472-6947
DOI	10.1186/s12911-023-02131-5
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Article ; Online: Hepatic C-X-C chemokine receptor type 6-expressing innate lymphocytes limit detrimental myeloid hyperactivation in acute liver injury.

Heymann, Felix / Mossanen, Jana C / Peiseler, Moritz / Niemietz, Patricia M / Araujo David, Bruna / Krenkel, Oliver / Liepelt, Anke / Batista Carneiro, Matheus / Kohlhepp, Marlene S / Kubes, Paul / Tacke, Frank

Hepatology communications

2023 Volume 7, Issue 4

Abstract: Background: Acute liver failure (ALF) is characterized by rapid clinical deterioration and high mortality. Acetaminophen (APAP or paracetamol) overdose is a leading cause of ALF, resulting in hepatocellular necrosis with subsequent inflammation, ... ...

Abstract	Background: Acute liver failure (ALF) is characterized by rapid clinical deterioration and high mortality. Acetaminophen (APAP or paracetamol) overdose is a leading cause of ALF, resulting in hepatocellular necrosis with subsequent inflammation, inflicting further liver damage. Infiltrating myeloid cells are early drivers of liver inflammation. However, the role of the abundant population of liver-resident innate lymphocytes, which commonly express the chemokine receptor CXCR6, is incompletely understood in ALF. Methods: We investigated the role of CXCR6-expressing innate lymphocytes using the model of acute APAP toxicity in mice deficient in CXCR6 (Cxcr6gfp/gfp). Results: APAP-induced liver injury was strongly aggravated in Cxcr6gfp/gfp mice compared with wild-type counterparts. Immunophenotyping using flow cytometry revealed a reduction in liver CD4+T cells, natural killer (NK) cells, and most prominently, NKT cells, whereas CXCR6 was dispensable for CD8+ T-cell accumulation. CXCR6-deficient mice exhibited excessive neutrophil and inflammatory macrophage infiltration. Intravital microscopy revealed dense cellular clusters of neutrophils in necrotic liver tissue, with higher numbers of clustering neutrophils in Cxcr6gfp/gfp mice. Gene expression analysis linked hyperinflammation in CXCR6 deficiency to increased IL-17 signaling. Although reduced in overall numbers, CXCR6-deficient mice had a shift in NKT cell subsets with increased RORγt-expressing NKT17 cells as a likely source of IL-17. In patients with ALF, we found a prominent accumulation of IL-17-expressing cells. Accordingly, CXCR6-deficient mice lacking IL-17 (Cxcr6gfp/gfpx Il17-/-) had ameliorated liver damage and reduced inflammatory myeloid infiltrates. Conclusions: Our study identifies a crucial role of CXCR6-expressing liver innate lymphocytes as orchestrators in acute liver injury containing IL-17-mediated myeloid cell infiltration. Hence, strengthening the CXCR6-axis or downstream inhibition of IL-17 could yield novel therapeutics in ALF.
MeSH term(s)	Animals ; Mice ; Acetaminophen/toxicity ; Inflammation ; Interleukin-17 ; Killer Cells, Natural ; Receptors, CXCR6/metabolism ; Chemical and Drug Induced Liver Injury/immunology ; T-Lymphocytes
Chemical Substances	Acetaminophen (362O9ITL9D) ; Interleukin-17 ; Cxcr6 protein, mouse ; Receptors, CXCR6
Language	English
Publishing date	2023-03-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2471-254X
ISSN (online)	2471-254X
DOI	10.1097/HC9.0000000000000102
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Book ; Online: CS-Mixer

Cui, Jonathan / Araujo, David A. / Saha, Suman / Kabir, Md. Faisal

A Cross-Scale Vision MLP Model with Spatial-Channel Mixing

2023

Abstract: Despite their simpler information fusion designs compared with Vision Transformers and Convolutional Neural Networks, Vision MLP architectures have demonstrated strong performance and high data efficiency in recent research. However, existing works such ... ...

Abstract	Despite their simpler information fusion designs compared with Vision Transformers and Convolutional Neural Networks, Vision MLP architectures have demonstrated strong performance and high data efficiency in recent research. However, existing works such as CycleMLP and Vision Permutator typically model spatial information in equal-size spatial regions and do not consider cross-scale spatial interactions. Further, their token mixers only model 1- or 2-axis correlations, avoiding 3-axis spatial-channel mixing due to its computational demands. We therefore propose CS-Mixer, a hierarchical Vision MLP that learns dynamic low-rank transformations for spatial-channel mixing through cross-scale local and global aggregation. The proposed methodology achieves competitive results on popular image recognition benchmarks without incurring substantially more compute. Our largest model, CS-Mixer-L, reaches 83.2% top-1 accuracy on ImageNet-1k with 13.7 GFLOPs and 94 M parameters. Comment: 8 pages, 5 figures, developed under Penn State University's Multi-Campus Research Experience for Undergraduates Symposium, 2023. This work has been submitted to the IEEE for possible publication. Copyright may be transferred without notice, after which this version may no longer be accessible
Keywords	Computer Science - Computer Vision and Pattern Recognition
Subject code	006
Publishing date	2023-08-25
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Determinants of late neonatal nosocomial infection: a case-control study in Ceará.

Lima, Carmen Sulinete Suliano da Costa / Rocha, Hermano Alexandre Lima / Araújo, David Augusto Batista Sá / Silva, Cláudia

Revista de saude publica

2022 Volume 56, Page(s) 40

Abstract: Objectives: To assess the determining factors of late healthcare-associated infections (HAIs) and bacterial multiple drug resistance in neonatal intensive care.: Methods: This is a case-control study, conducted between January 2013 and December 2017, ...

Abstract	Objectives: To assess the determining factors of late healthcare-associated infections (HAIs) and bacterial multiple drug resistance in neonatal intensive care. Methods: This is a case-control study, conducted between January 2013 and December 2017, in a neonatal intensive care unit in the state of Ceará, Brazil. Newborns showing late HAIs were considered cases and those without infection, the control. Variables with p-values ≤ 0.05 in our initial bivariate regressive analysis were included in a non-conditional hierarchical logistic model for multivariate analysis. P-values below 0.01 were considered significant. Results: Of the 1,132 participants, 427 (37.7%) showed late healthcare-associated infections. Of these, 54 (12.6%), positive blood cultures, of which 14.9% contained multidrug-resistant bacteria. Bivariate analysis showed the protective effect of the feminine phenotype (OR = 0.71; 95%CI: 0.56-0.90) and of gestational ages ≥ 34 weeks (OR = 0.48; 95%CI: 0.30-0.75). In earlier-born preterm infants, late infections were 18 times more likely in those with less than 30 week-gestations (OR = 18.61; 95%CI: 9.84-35.22) and four times higher in those weighing less than 1,500 g (OR = 4.18; 95%CI: 3.12-5.61). Mechanical ventilation increased infection odds by more than seven times (OR = 7.14; 95%CI: 5.26-9.09); as did parenteral nutrition (OR = 5.88; 95%CI: 4.54-7.69); central venous catheters (OR = 10.00; 95%CI: 6.66-16.66); the number of catheters used (OR = 3.93; 95%CI: 3.02-5.12); surgery (OR = 4.00; 95%CI: 2.27-7.14); and hospitalization time (OR = 1.06; 95%CI: 1.05-1.07). The association between preterm infants with less than 30 week-gestations (OR = 5.62; 95%CI: 1.83-17.28); mechanical ventilation (OR = 1.84; 95%CI: 1.26-2.68); central venous catheters (OR = 2.48; 95%CI: 1.40-4.37); and hospitalization time (OR = 1.06; 95%CI: 1.05-1.07) remained significant after adjustment. Among deaths, 41 (55.4%) were associated with late infections. Conclusion: Better practices should be adopted in caring for the premature, as well as in the rational use of procedures, to avoid late healthcare-associated infections, preventable deaths, and risks of bacterial multiple drug resistance and environmental contamination.
MeSH term(s)	Brazil/epidemiology ; Case-Control Studies ; Cross Infection/epidemiology ; Humans ; Infant, Newborn ; Infant, Premature ; Risk Factors
Language	Portuguese
Publishing date	2022-05-27
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	732179-x
ISSN	1518-8787 ; 0034-8910
ISSN (online)	1518-8787
ISSN	0034-8910
DOI	10.11606/s1518-8787.2022056003291
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Zs.B 864: Show issues

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Article ; Online: Coverage and determinants of childhood vaccination during the COVID-19 pandemic in Fortaleza, Northeastern Brazil: a longitudinal analysis.

Araújo, David Augusto Batista Sá / Correia, Luciano Lima / Lima, Pedro Lucas Grangeiro de Sá Barreto / Vasconcelos, Sophia Costa / Farías-Antúnez, Simone / Gomes, Yuri Valentim Carneiro / Nogueira, Denise Lima / Castro, Márcia C / Machado, Marcia Maria Tavares

Cadernos de saude publica

2024 Volume 40, Issue 1, Page(s) e00074723

Abstract: Brazil has seen a decrease in vaccination coverage since 2016. This study analyzes the immunization status of children born during the COVID-19 pandemic in Fortaleza, Northeastern Brazil. This is a longitudinal analysis that included vaccination data of ... ...

Abstract	Brazil has seen a decrease in vaccination coverage since 2016. This study analyzes the immunization status of children born during the COVID-19 pandemic in Fortaleza, Northeastern Brazil. This is a longitudinal analysis that included vaccination data of 313 children aged 12 and 18 months. Vaccination cards were checked for dose application considering the schedule of immunization recommended by the Brazilian Ministry of Health. Factors associated with no retention of vaccination cards and incomplete immunization by 18 months were identified by Tobit regression analysis. About 73% of mothers presented their child's vaccination card. Non-availability of vaccination cards was associated with maternal age < 25 years and mothers with paid jobs. Only 33% and 45% of the children aged 12 and 18 months had all vaccines up to date, respectively. For 3-dose vaccines, the delay rate was around 10% for the first dose application, but 40% for the third dose. Despite delays, most children with available vaccine cards had coverage above 90% by 18 months of age. Adjusted factors associated with incomplete vaccination included living in a household with more than one child (p = 0.010) and monthly income of less than one minimum wage (p = 0.006). Therefore, delays in child vaccine application were high during the COVID-19 pandemic but a considerable uptake by 18 months of age was found. Poorer families with more than one child were particularly at risk of not fully immunizing their children and should be the target of public policies.
MeSH term(s)	Humans ; Child ; Infant ; Brazil/epidemiology ; Pandemics/prevention & control ; Immunization Programs ; COVID-19/epidemiology ; COVID-19/prevention & control ; Vaccination ; Vaccines
Chemical Substances	Vaccines
Language	English
Publishing date	2024-02-02
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	1115730-6
ISSN	1678-4464 ; 0102-311X
ISSN (online)	1678-4464
ISSN	0102-311X
DOI	10.1590/0102-311XEN074723
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Article ; Online: Easy resolution of severe obstructive kidney injury.

Cabral, Catia / Novais, António / Araújo, David / Mosca, Ana

Revista da Associacao Medica Brasileira (1992)

2019 Volume 65, Issue 3, Page(s) 333–335

Abstract: Chronic constipation is a common diagnosis with a high prevalence in the elderly. Constipation affects the quality of life of sick individuals, bringing several clinical complications. ...

Abstract	Chronic constipation is a common diagnosis with a high prevalence in the elderly. Constipation affects the quality of life of sick individuals, bringing several clinical complications.
MeSH term(s)	Aged, 80 and over ; Chronic Disease ; Constipation/chemically induced ; Constipation/complications ; Constipation/diagnostic imaging ; Female ; Humans ; Laxatives/adverse effects ; Renal Insufficiency/diagnostic imaging ; Renal Insufficiency/etiology ; Tomography, X-Ray Computed ; Ureter/diagnostic imaging ; Ureter/pathology
Chemical Substances	Laxatives
Language	English
Publishing date	2019-04-11
Publishing country	Brazil
Document type	Case Reports
ZDB-ID	2027973-5
ISSN	1806-9282 ; 0104-4230
ISSN (online)	1806-9282
ISSN	0104-4230
DOI	10.1590/1806-9282.65.3.333
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Article ; Online: Pneumothorax Due to Ascaris lumbricoides Larvae.

Santos, Vanessa / Maciel, João / Guimarães, Susana / Araújo, David

Archivos de bronconeumologia

2019 Volume 55, Issue 7, Page(s) 392

MeSH term(s)	Adult ; Albendazole/therapeutic use ; Animals ; Anthelmintics/therapeutic use ; Ascariasis/complications ; Ascaris lumbricoides/growth & development ; Ascaris lumbricoides/isolation & purification ; Dyspnea/etiology ; Female ; Humans ; Larva ; Pleural Effusion/etiology ; Pleural Effusion/therapy ; Pleurodesis ; Pneumothorax/diagnostic imaging ; Pneumothorax/drug therapy ; Pneumothorax/parasitology ; Pneumothorax/surgery ; Thoracic Surgery, Video-Assisted ; Tomography, X-Ray Computed
Chemical Substances	Anthelmintics ; Albendazole (F4216019LN)
Language	Spanish
Publishing date	2019-04-08
Document type	Case Reports ; Journal Article
ZDB-ID	733126-5
ISSN	1579-2129 ; 0300-2896
ISSN (online)	1579-2129
ISSN	0300-2896
DOI	10.1016/j.arbres.2018.10.005
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Zs.B 2655: Show issues

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Article ; Online: Domestic violence patterns in postpartum women who delivered during the COVID-19 pandemic.

Correia, Luciano Lima / Machado, Márcia Maria Tavares / Vieira-Meyer, Anya Pimentel Gomes Fernandes / Araújo, David Augusto Batista Sá / Gomes, Emanuel de Assis Bertulino Martins / Saldanha, Anyelle Barroso / Rodrigues, Rita de Cássia Rebouças / Gomes, Yuri Valentim Carneiro / Castro, Márcia Caldas

Revista brasileira de epidemiologia = Brazilian journal of epidemiology

2024 Volume 27, Page(s) e240022

Abstract: Objective: To longitudinally assess domestic violence (DV) during the postpartum period, identifying types, patterns and determinants of DV, according to mothers' reports in Fortaleza, Brazil.: Methods: Data from the Iracema-COVID cohort study ... ...

Abstract	Objective: To longitudinally assess domestic violence (DV) during the postpartum period, identifying types, patterns and determinants of DV, according to mothers' reports in Fortaleza, Brazil. Methods: Data from the Iracema-COVID cohort study interviewed at home mothers who gave birth in the first wave of COVID-19, at 18 and 24 months after birth. Patterns of reported DV were classified as follows: no DV, interrupted DV, started DV and persistent DV. Adjusted multinomial logistic regressions were used to assess factors associated with persistent DV. Results: DV was reported by 19 and 24% of the mothers at 18 and 24 months postpartum, respectively, a 5 percentage points increase. Persistent DV was present in 11% of the households in the period. The most frequent forms of DV were verbal aggression, reported by 17-20% of the mothers at 18 and 24 months, respectively; drunkenness or use of drugs at home, present in 3-5% of the households; physical aggression, reported by 1.2-1.6% of the mothers. Households with two or more forms of DV increased from 2 to 12% in the period. Adjusted factors associated with persistent DV were maternal common mental disorder, family headed by the mother and head of family's poor schooling. Food insecurity was associated with starting DV. Conclusion: Prevalence of DV was considerably high in the postpartum period. DV prevention policies should rely on improving care to women's mental health; preventing food insecurity; and fostering the educational level of young people of both sexes.
MeSH term(s)	Humans ; Female ; COVID-19/epidemiology ; Brazil/epidemiology ; Postpartum Period ; Adult ; Domestic Violence/statistics & numerical data ; Young Adult ; Longitudinal Studies ; Socioeconomic Factors ; Pandemics ; Risk Factors ; Adolescent ; Mothers/statistics & numerical data ; Mothers/psychology ; SARS-CoV-2
Language	English
Publishing date	2024-04-19
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2183366-7
ISSN	1980-5497 ; 1980-5497
ISSN (online)	1980-5497
ISSN	1980-5497
DOI	10.1590/1980-549720240022
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